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1. 发明授权

US08735091B2 Methods for inactivation and extraction of acid-fast bacteria for characterization and/or identification using mass spectrometry 有权
标题翻译：灭活和提取用于表征和/或鉴定使用质谱法的耐酸细菌的方法
公开(公告)号：US08735091B2
公开(公告)日：2014-05-27
申请号：US13828119
申请日：2013-03-14
申请人： Jones M. Hyman , Parampal Deol , Elizabeth Miller , Victoria Girard , Amber Gates , Sandrine Mailler , Maud Arsac , John Walsh
发明人： Jones M. Hyman , Parampal Deol , Elizabeth Miller , Victoria Girard , Amber Gates , Sandrine Mailler , Maud Arsac , John Walsh
IPC分类号： C12Q1/24
CPC分类号： G01N1/4077 , C12Q1/24 , G01N33/5695 , G01N33/6851 , G01N2333/35 , G01N2333/355 , G01N2560/00
摘要： The present invention is directed to a method for inactivation and/or extraction of acid-fast bacteria (e.g., mycobacteria or nocardia), the method comprising the following sequential steps: (a) acquiring a test sample known to contain or that may contain acid-fast bacteria and suspending the test sample in a container containing ethanol and beads; (b) bead beating and/or vortexing the container to break up clumps and/or disrupt acid-fast bacteria cells in the container; and (c) subsequently incubating the suspension for at least about 3 minutes at room temperature to inactivate any acid-fast bacteria contained in the test sample. In accordance with the present invention, the test sample can subsequently be pelleted by centrifugation, resuspended with formic acid, acetonitrile added, and subjected to mass spectrometry for characterization and/or identification of the acid-fast bacteria.
摘要翻译：本发明涉及一种灭活和/或提取酸性抗菌（例如分枝杆菌或诺卡氏菌）的方法，该方法包括以下顺序步骤：（a）获得已知含有或可含有酸的测试样品将试样悬浮在含有乙醇和珠粒的容器中; （b）珠子打浆和/或涡旋容器以分解块和/或破坏容器中的耐酸细菌细胞; 和（c）随后在室温下将悬浮液温育至少约3分钟以灭活测试样品中所含的任何耐酸细菌。根据本发明，随后通过离心将测试样品沉淀，用甲酸重悬浮，加入乙腈，并进行质谱鉴定和/或鉴定耐酸细菌。

2. 发明申请

US20130309714A1 Methods for Inactiviation And Extraction of Acid-Fast Bacteria for Characterization And/Or Identification Using Mass Spectrometry 有权
标题翻译：使用质谱法鉴定和/或鉴定酸快速细菌的灭活和提取方法
公开(公告)号：US20130309714A1
公开(公告)日：2013-11-21
申请号：US13828119
申请日：2013-03-14
申请人： Jones Hyman , Parampal Deol , Elizabeth Miller , Victoria Girard , Amber Gates , Sandrine Mailler , Maud Arsac , John Walsh
发明人： Jones Hyman , Parampal Deol , Elizabeth Miller , Victoria Girard , Amber Gates , Sandrine Mailler , Maud Arsac , John Walsh
IPC分类号： G01N1/40
CPC分类号： G01N1/4077 , C12Q1/24 , G01N33/5695 , G01N33/6851 , G01N2333/35 , G01N2333/355 , G01N2560/00
摘要： The present invention is directed to a method for inactivation and/or extraction of acid-fast bacteria (e.g., mycobacteria or nocardia), the method comprising the following sequential steps: (a) acquiring a test sample known to contain or that may contain acid-fast bacteria and suspending the test sample in a container containing ethanol and beads; (b) bead beating and/or vortexing the container to break up clumps and/or disrupt acid-fast bacteria cells in the container; and (c) subsequently incubating the suspension for at least about 3 minutes at room temperature to inactivate any acid-fast bacteria contained in the test sample. In accordance with the present invention, the test sample can subsequently be pelleted by centrifugation, resuspended with formic acid, acetonitrile added, and subjected to mass spectrometry for characterization and/or identification of the acid-fast bacteria.
摘要翻译：本发明涉及一种灭活和/或提取酸性抗菌（例如分枝杆菌或诺卡氏菌）的方法，该方法包括以下顺序步骤：（a）获得已知含有或可含有酸的测试样品将试样悬浮在含有乙醇和珠粒的容器中; （b）珠子打浆和/或涡旋容器以分解块和/或破坏容器中的耐酸细菌细胞; 和（c）随后在室温下将悬浮液温育至少约3分钟以灭活测试样品中所含的任何耐酸细菌。根据本发明，随后通过离心将测试样品沉淀，用甲酸重悬浮，加入乙腈，并进行质谱鉴定和/或鉴定耐酸细菌。

3. 发明申请

US20060161122A1 Absorbent article with multi-zone acquisition 审中-公开
标题翻译：多区域采集吸收制品
公开(公告)号：US20060161122A1
公开(公告)日：2006-07-20
申请号：US11299290
申请日：2005-12-08
申请人： Edward Erdman , Dane Jackson , Elizabeth Miller
发明人： Edward Erdman , Dane Jackson , Elizabeth Miller
IPC分类号： A61F13/15
CPC分类号： A61F13/53747
摘要： An absorbent article is provided that includes a liquid pervious top layer, a liquid impervious back layer and an absorbent core disposed therebetween. A plurality of acquisition members are disposed between the top layer and the core. The acquisition members are disposed parallel with a longitudinal length of the core in a configuration that retards strikethrough time. A portion of the top layer may be deformed to form a predetermined pattern. The predetermined pattern may be in spatial alignment with the acquisition members in a configuration that retards strikethrough time. Alternatively, the absorbent article includes a film layer disposed between the core and the back layer.
摘要翻译：提供了一种吸收性物品，其包括液体可透过的顶层，不透液体的背层和设置在其间的吸收芯。多个采集构件设置在顶层和芯之间。所述采集构件与所述芯的纵向长度平行设置，所述构造延迟去除线时间。顶层的一部分可以变形以形成预定图案。在延迟删除线时间的配置中，预定图案可以与采集构件空间对准。或者，吸收性物品包括设置在芯部和背面层之间的膜层。

4. 发明申请

US20120035074A1 METHODS TO DETERMINE ATHEROSCLEROSIS REGRESSION, PLAQUE STABILIZTION AND CARDIOVASCULAR RISK 有权
标题翻译：确定甲状腺功能亢进症，PLAQUE STABILIZATION和心脏血管风险的方法
公开(公告)号：US20120035074A1
公开(公告)日：2012-02-09
申请号：US13262597
申请日：2010-04-02
申请人： Joseph L. Witztum , Sotirios Tsimikas , Elizabeth Miller
发明人： Joseph L. Witztum , Sotirios Tsimikas , Elizabeth Miller
IPC分类号： C40B30/04 , G01N33/577 , C40B40/10 , G01N33/566
CPC分类号： C07K16/18 , G01N33/6893 , G01N33/92 , G01N2405/00 , G01N2800/323 , G01N2800/52
摘要： Provided herein are compositions and methods for examining the progression, regression or risk of individuals at risk for developing coronary artery disease (CAD).
摘要翻译：本文提供了用于检查发展成冠状动脉疾病（CAD）风险的个体的进展，回归或风险的组合物和方法。

5. 发明申请

US20080148234A1 Data Synchronization Mechanism for Change-Request-Management Repository Interoperation 有权
标题翻译：变更请求管理信息库互操作数据同步机制
公开(公告)号：US20080148234A1
公开(公告)日：2008-06-19
申请号：US11612703
申请日：2006-12-19
申请人： Geoffrey M. Clemm , Elizabeth Miller , Lorelei Ngooi , Richard L. Piazza
发明人： Geoffrey M. Clemm , Elizabeth Miller , Lorelei Ngooi , Richard L. Piazza
IPC分类号： G06F9/44
CPC分类号： G06F17/30377
摘要： Computer method and apparatus for managing software configuration repositories are disclosed. In a plurality of repositories each repository holds a respective set of change-request objects. One of the repositories in the plurality is a primary repository, and the other repositories are working repositories. In the primary repository, there is a respective proxy object for each change-request object of interest in a working repository. Each proxy object has a corresponding associated change-request object in the primary repository. For a given proxy object, changes made to the respective change-request object of interest in the working repository are mapped to the associated change-request object in the primary repository and vice versa.
摘要翻译：公开了用于管理软件配置库的计算机方法和装置。在多个存储库中，每个存储库保存相应的一组改变请求对象。多个存储库中的一个是主存储库，其他存储库是工作存储库。在主存储库中，对于工作存储库中感兴趣的每个更改请求对象都有一个相应的代理对象。每个代理对象在主存储库中都有一个对应的关联的更改请求对象。对于给定的代理对象，对工作存储库中感兴趣的相应变更请求对象所做的更改映射到主存储库中的相关联的更改请求对象，反之亦然。

6. 发明申请

US20070239125A9 Absorbent article with multi-zone acquisition 审中-公开
标题翻译：多区域采集吸收制品
公开(公告)号：US20070239125A9
公开(公告)日：2007-10-11
申请号：US11299290
申请日：2005-12-08
申请人： Edward Erdman , Dane Jackson , Elizabeth Miller
发明人： Edward Erdman , Dane Jackson , Elizabeth Miller
IPC分类号： A61F13/15
CPC分类号： A61F13/53747
摘要： An absorbent article is provided that includes a liquid pervious top layer, a liquid impervious back layer and an absorbent core disposed therebetween. A plurality of acquisition members are disposed between the top layer and the core. The acquisition members are disposed parallel with a longitudinal length of the core in a configuration that retards strikethrough time. A portion of the top layer may be deformed to form a predetermined pattern. The predetermined pattern may be in spatial alignment with the acquisition members in a configuration that retards strikethrough time. Alternatively, the absorbent article includes a film layer disposed between the core and the back layer.
摘要翻译：提供了一种吸收性物品，其包括液体可透过的顶层，不透液体的背层和设置在其间的吸收芯。多个采集构件设置在顶层和芯之间。所述采集构件与所述芯的纵向长度平行设置，所述构造延迟去除线时间。顶层的一部分可以变形以形成预定图案。在延迟删除线时间的配置中，预定图案可以与采集构件空间对准。或者，吸收性物品包括设置在芯部和背面层之间的膜层。

7. 外观设计

USD485353S1 Surface pattern for a disposable absorbent article 失效
标题翻译：一次性吸收制品的表面图案
公开(公告)号：USD485353S1
公开(公告)日：2004-01-13
申请号：US29170266
申请日：2002-11-04
申请人： Elizabeth Miller , Kimberly H. Babusik
设计人： Elizabeth Miller , Kimberly H. Babusik

8. 发明申请

US20090238399A1 MINIATURE STEREO AUDIO EARPHONES 失效
标题翻译：微型立体声音响耳机
公开(公告)号：US20090238399A1
公开(公告)日：2009-09-24
申请号：US12051197
申请日：2008-03-19
申请人： Elizabeth Miller
发明人： Elizabeth Miller
IPC分类号： H04R19/00
CPC分类号： H04R1/1033 , H04R5/033
摘要： A miniature audio earphone includes a pair of audio earphones, an electrical connector adapted for making a selectively detachable physical and electrical connection to a source of stereo audio signals, a generally Y-shaped electrical lead assembly having a bifurcated upper portion and an adjoining lower portion, whose lower end is coupled to the connector. The upper portion has a pair of branch leads each of which is coupled to a respective one of said earphones. A plurality of exteriorly disposed mechanical shielding elements at least partially surrounds an underlying portion of at least one of said branch leads to resist damage to the lead assembly due to abrasion, crushing, kinking and cutting without unduly impairing the flexibility of the assembly or causing it to have an unattractive appearance. A tensile stress-relief line is also provided for resisting damage to the upper portion of the assembly due to tension.
摘要翻译：一个微型音频耳机包括一对音频耳机，一个电连接器，适于与一个立体声音频信号源进行有选择地可拆卸的物理和电气连接，一个大体为Y形的电线组件，其具有分叉的上部和相邻的下部，其下端连接到连接器。上部具有一对分支引线，每个分支引线联接到相应的一个所述耳机。多个外部设置的机械屏蔽元件至少部分地围绕至少一个所述分支引线的下部部分，以抵抗由于磨损，破碎，扭结和切割而导致的引线组件的损坏，而不会不适当地损害组件的柔性或引起它具有不吸引人的外观。还提供拉伸应力消除线，用于抵抗由于张力而对组件的上部的损坏。

9. 发明授权

US08883428B2 Methods to determine atherosclerosis regression, plaque stabilization and cardiovascular risk 有权
标题翻译：确定动脉粥样硬化消退，斑块稳定和心血管风险的方法
公开(公告)号：US08883428B2
公开(公告)日：2014-11-11
申请号：US13262597
申请日：2010-04-02
申请人： Joseph L. Witztum , Sotirios Tsimikas , Elizabeth Miller
发明人： Joseph L. Witztum , Sotirios Tsimikas , Elizabeth Miller
IPC分类号： G01N33/53 , G01N33/68 , G01N33/92 , C07K16/18
CPC分类号： C07K16/18 , G01N33/6893 , G01N33/92 , G01N2405/00 , G01N2800/323 , G01N2800/52
摘要： Provided herein are compositions and methods for examining the progression, regression or risk of individuals at risk for developing coronary artery disease (CAD).
摘要翻译：本文提供了用于检查发展成冠状动脉疾病（CAD）风险的个体的进展，回归或风险的组合物和方法。

10. 发明授权

US08311260B2 Miniature stereo audio earphones 失效
标题翻译：微型立体声音频耳机
公开(公告)号：US08311260B2
公开(公告)日：2012-11-13
申请号：US12051197
申请日：2008-03-19
申请人： Elizabeth Miller
发明人： Elizabeth Miller
IPC分类号： H04M3/00
CPC分类号： H04R1/1033 , H04R5/033
摘要： A miniature audio earphone includes a pair of audio earphones, an electrical connector adapted for making a selectively detachable physical and electrical connection to a source of stereo audio signals, a generally Y-shaped electrical lead assembly having a bifurcated upper portion and an adjoining lower portion, whose lower end is coupled to the connector. The upper portion has a pair of branch leads each of which is coupled to a respective one of said earphones. A plurality of exteriorly disposed mechanical shielding elements at least partially surrounds an underlying portion of at least one of said branch leads to resist damage to the lead assembly due to abrasion, crushing, kinking and cutting without unduly impairing the flexibility of the assembly or causing it to have an unattractive appearance. A tensile stress-relief line is also provided for resisting damage to the upper portion of the assembly due to tension.
摘要翻译：一个微型音频耳机包括一对音频耳机，一个电连接器，适于与一个立体声音频信号源进行有选择地可拆卸的物理和电气连接，一个大体为Y形的电线组件，其具有分叉的上部和相邻的下部，其下端连接到连接器。上部具有一对分支引线，每个分支引线联接到相应的一个所述耳机。多个外部设置的机械屏蔽元件至少部分地围绕至少一个所述分支引线的下部部分，以抵抗由于磨损，破碎，扭结和切割而导致的引线组件的损坏，而不会不适当地损害组件的柔性或引起它具有不吸引人的外观。还提供拉伸应力消除线，用于抵抗由于张力而对组件的上部的损坏。

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