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1. 发明申请

US20060088942A1 Measuring nitric oxide in blood gases and treatments based thereon 审中-公开
标题翻译：测量血液中的一氧化氮及其处理
公开(公告)号：US20060088942A1
公开(公告)日：2006-04-27
申请号：US10516250
申请日：2003-05-27
申请人： Jonathan Stamler , Timothy McMahon
发明人： Jonathan Stamler , Timothy McMahon
IPC分类号： G01N33/50
CPC分类号： G01N33/84 , G01N33/4925
摘要： Nitric oxide is measured in blood as a marker of tissue blood flow and oxygenation. Where nitric oxide is measured to be below physiological or to be below average, in a patient having a disease associated with oxygen delivery deficiency, nitric oxide is infused alone or with nitrite. Where nitric oxide is measured to be normal, nitrite is infused. The storage time of whole blood or red blood cells is increased and the vasodilator response of outdated or NO depleted whole blood and red blood cells are increased by treatment with nitric oxide and/or nitrite. A patient in need of a transfusion is transfused with whole blood or red blood cells treated to increase vasodilator response therein.
摘要翻译：在血液中测量一氧化氮作为组织血流和氧合的标志物。当一氧化氮被测量为低于生理或低于平均值时，在具有与氧输送缺陷相关的疾病的患者中，一氧化氮单独或与亚硝酸盐注入。当一氧化氮测量正常时，输入亚硝酸盐。全血或红细胞的储存时间增加，通过用一氧化氮和/或亚硝酸盐处理可以增加过期或NO耗尽的全血和红细胞的血管扩张反应。需要输血的患者输入全血或红细胞，以增加血管扩张反应。

2. 发明申请

US20080107637A1 Use of an agent that restores tissue perfusion and oxygenation 有权
公开(公告)号：US20080107637A1
公开(公告)日：2008-05-08
申请号：US12006842
申请日：2008-01-07
申请人： Mark Dewhirst , Jonathan Stamler , Timothy McMahon , Pierre Sonveaux
发明人： Mark Dewhirst , Jonathan Stamler , Timothy McMahon , Pierre Sonveaux
IPC分类号： A61K35/18 , A61K38/16 , A61K33/00 , A61P43/00 , A61K31/04
CPC分类号： A61K38/1709 , A61K31/21 , A61K33/00 , A61K35/18 , A61K38/00 , A61K38/42 , A61K45/06 , A61K47/08 , A61K47/16 , A61K47/6445 , A61K2300/00
摘要： The presently disclosed subject matter provides methods for increasing perfusion in hypoxic regions of tissues in subjects. Also provided are methods for treating diseases and/or disorders associated with hypoxia in subjects, methods for increasing sensitivity of tumors to radiation and/or chemotherapy treatments, methods for delaying tumor growth in subjects, and methods for inhibiting tumor blood vessel growth in subjects. In some embodiments, the presently disclosed methods involve administering to subjects in need thereof a first composition selected from the group consisting of a nitrosylated hemoglobin and an agent that induces nitrosylation of endogenous hemoglobin in the subject and a second composition comprising a hyperoxic gas. In some embodiments, the presently disclosed methods also include treating a tumor with radiation therapy, chemotherapy, photodynamic therapy, immunotherapy, or combinations thereof. Also provided are inhalable gases that can be employed in the presently disclosed methods.

3. 发明申请

US20080113901A1 Use of an agent that restores tissue perfusion and oxygenation 有权
标题翻译：使用恢复组织灌注和氧合的药物
公开(公告)号：US20080113901A1
公开(公告)日：2008-05-15
申请号：US12006849
申请日：2008-01-07
申请人： Mark Dewhirst , Jonathan Stamler , Timothy McMahon , Pierre Sonveaux
发明人： Mark Dewhirst , Jonathan Stamler , Timothy McMahon , Pierre Sonveaux
IPC分类号： A61K38/42 , A61P35/00
CPC分类号： A61K38/1709 , A61K31/21 , A61K33/00 , A61K35/18 , A61K38/00 , A61K38/42 , A61K45/06 , A61K47/08 , A61K47/16 , A61K47/6445 , A61K2300/00
摘要： The presently disclosed subject matter provides methods for increasing perfusion in hypoxic regions of tissues in subjects. Also provided are methods for treating diseases and/or disorders associated with hypoxia in subjects, methods for increasing sensitivity of tumors to radiation and/or chemotherapy treatments, methods for delaying tumor growth in subjects, and methods for inhibiting tumor blood vessel growth in subjects. In some embodiments, the presently disclosed methods involve administering to subjects in need thereof a first composition selected from the group consisting of a nitrosylated hemoglobin and an agent that induces nitrosylation of endogenous hemoglobin in the subject and a second composition comprising a hyperoxic gas. In some embodiments, the presently disclosed methods also include treating a tumor with radiation therapy, chemotherapy, photodynamic therapy, immunotherapy, or combinations thereof. Also provided are inhalable gases that can be employed in the presently disclosed methods.
摘要翻译：目前公开的主题提供了在受试者的组织的缺氧区域中增加灌注的方法。还提供了用于治疗受试者与缺氧相关的疾病和/或病症的方法，用于增加肿瘤对放射和/或化疗治疗的敏感性的方法，用于延迟受试者的肿瘤生长的方法，以及用于抑制受试者的肿瘤血管生长的方法。在一些实施方案中，本发明公开的方法包括向有需要的受试者施用选自亚硝基化血红蛋白和诱导受试者内源性血红蛋白亚硝基化的试剂的第一组合物和包含高氧气体的第二组合物。在一些实施方案中，本发明公开的方法还包括用放射治疗，化疗，光动力疗法，免疫治疗或其组合治疗肿瘤。还提供了可在本公开的方法中使用的可吸入气体。

4. 发明申请

US20060276374A1 Use of an agent that restores tissue perfusion and oxygenation 有权
公开(公告)号：US20060276374A1
公开(公告)日：2006-12-07
申请号：US11404494
申请日：2006-04-13
申请人： Mark Dewhirst , Jonathan Stamler , Timothy McMahon , Pierre Sonveaux
发明人： Mark Dewhirst , Jonathan Stamler , Timothy McMahon , Pierre Sonveaux
IPC分类号： A61K38/42 , A61K31/21
CPC分类号： A61K38/1709 , A61K31/21 , A61K33/00 , A61K35/18 , A61K38/00 , A61K38/42 , A61K45/06 , A61K47/08 , A61K47/16 , A61K47/6445 , A61K2300/00
摘要： The presently disclosed subject matter provides methods for increasing perfusion in hypoxic regions of tissues in subjects. Also provided are methods for treating diseases and/or disorders associated with hypoxia in subjects, methods for increasing sensitivity of tumors to radiation and/or chemotherapy treatments, methods for delaying tumor growth in subjects, and methods for inhibiting tumor blood vessel growth in subjects. In some embodiments, the presently disclosed methods involve administering to subjects in need thereof a first composition selected from the group consisting of a nitrosylated hemoglobin and an agent that induces nitrosylation of endogenous hemoglobin in the subject and a second composition comprising a hyperoxic gas. In some embodiments, the presently disclosed methods also include treating a tumor with radiation therapy, chemotherapy, photodynamic therapy, immunotherapy, or combinations thereof. Also provided are inhalable gases that can be employed in the presently disclosed methods.

5. 发明申请

US20060024283A1 Red blood cells loaded with S-nitrosothiol and uses therefor 有权
标题翻译：装有S-亚硝基硫醇的红细胞并用于此
公开(公告)号：US20060024283A1
公开(公告)日：2006-02-02
申请号：US11179349
申请日：2005-07-12
申请人： Jonathan Stamler , Joseph Bonaventura , John Pawloski , Timothy McMahon
发明人： Jonathan Stamler , Joseph Bonaventura , John Pawloski , Timothy McMahon
IPC分类号： C12Q1/68 , A61K35/18
CPC分类号： A61K31/00 , A61K31/04 , A61K31/095 , A61K31/195 , A61K33/00 , A61K38/1816 , A61K47/54 , A61K47/6445 , A61K47/6901 , C07K14/00 , G01N21/631 , G01N21/76 , G01N33/721
摘要： Red blood cells can be loaded with low molecular weight nitrosylating agents, such as S-nitrosothiols, to act as a delivery system for NO+ groups to tissues. Loaded red blood cells can be used in methods of therapy for conditions which are characterized by abnormal O2 metabolism of tissues, oxygen-related toxicity, abnormal vascular tone, abnormal red blood cell adhesion, or abnormal O2 delivery by red blood cells. Such treatment of red blood cells can be extended to in vivo therapies, with the object to achieve an increase in the ratio of red blood cell S-nitrosothiol to hemoglobin.
摘要翻译：红细胞可以装载低分子量亚硝酰化剂，如S-亚硝基硫醇，作为组织的NO + +组的递送系统。加载的红细胞可以用于治疗方法，其特征在于组织的异常O 2代谢，氧相关毒性，异常血管紧张度，异常红细胞粘附或异常的O < 通过红细胞递送SUB> 2 。红细胞的这种治疗可以延伸到体内治疗，其目的是实现红细胞S-亚硝基硫醇与血红蛋白的比例的增加。

6. 发明申请

US20060120568A1 System and method for tracking individuals 审中-公开
标题翻译：跟踪个人的系统和方法
公开(公告)号：US20060120568A1
公开(公告)日：2006-06-08
申请号：US11005531
申请日：2004-12-06
申请人： Patrick McConville , Orlando Rodriguez , Timothy McMahon , Lawrence Mandell , Philip Connell
发明人： Patrick McConville , Orlando Rodriguez , Timothy McMahon , Lawrence Mandell , Philip Connell
IPC分类号： G06K9/00
CPC分类号： G07C9/00158 , G07C9/00111
摘要： In one general aspect, biometric information and location information associated with the biometric information are received. An individual is identified based, at least in part, on the biometric information. The individual is verified to be at a predetermined location and a predetermined time based, at least in part, on the location information.
摘要翻译：在一个一般方面，接收与生物特征信息相关联的生物信息和位置信息。至少部分地基于生物特征信息识别个体。至少部分地基于位置信息，将个体验证为处于预定位置和预定时间。

7. 发明授权

US08686890B2 Customizable remote control device 有权
标题翻译：可定制遥控设备
公开(公告)号：US08686890B2
公开(公告)日：2014-04-01
申请号：US12127550
申请日：2008-05-27
申请人： Seale Moorer , William K. Virgin , Timothy McMahon
发明人： Seale Moorer , William K. Virgin , Timothy McMahon
IPC分类号： G08C19/12 , H04L17/02 , H04N5/44 , G06F15/16 , G06F15/173
CPC分类号： H01H9/0235 , H01H2221/07 , H01H2231/032 , H04N21/42206 , H04N21/42225 , H04N21/42226 , H04N21/43615 , H04N2005/4407 , H04N2005/4416
摘要： A remote controller for controlling a remote unit includes a stationary button assigned to a first function of the remote unit, and a first flexible button assigned to a second function of the remote unit and configured to be addable to or removable from the remote controller. The remote controller may further include a base, a membrane layer mountable on the base, the membrane layer including the stationary button and a first flexible button base, a first flexible button cap mountable on the first flexible button base to form the first flexible button, and a first face mountable on the membrane layer and having a first opening pattern exposing the stationary button and the first flexible button.
摘要翻译：用于控制远程单元的遥控器包括分配给远程单元的第一功能的固定按钮和分配给远程单元的第二功能的第一灵活按钮，并且被配置为可以从遥控器添加或移除。遥控器还可以包括底座，可安装在基座上的膜层，包括固定按钮的膜层和第一柔性按钮底座，可安装在第一柔性按钮底座上以形成第一柔性按钮的第一柔性按钮帽，以及可安装在膜层上并具有暴露固定按钮和第一柔性按钮的第一开口图案的第一面。

8. 发明授权

US07962130B2 Portable device for convergence and automation solution 有权
标题翻译：用于融合和自动化解决方案的便携式设备
公开(公告)号：US07962130B2
公开(公告)日：2011-06-14
申请号：US11937889
申请日：2007-11-09
申请人： Seale Moorer , Eric Eichensehr , Kyle Virgin , Timothy McMahon
发明人： Seale Moorer , Eric Eichensehr , Kyle Virgin , Timothy McMahon
IPC分类号： H04M3/00
CPC分类号： H04L12/2838 , H04L12/2814 , H04L12/282 , H04L67/16
摘要： A convergence and automation system (CAS) includes an internet-protocol (IP) based network implemented with a web service for devices (WSD) protocol, devices connected to the network, each configured to perform at least one service, a server implemented with the WSD protocol, connected to the network and configured to control the devices to converge and automate the services thereof, and a portable device implemented with the WSD protocol, connected to the network and configured to control the devices and perform the services. The server is implemented with Windows Sideshow to collect information necessary for controlling the devices and provides the collected information to the portable device.
摘要翻译：汇聚和自动化系统（CAS）包括基于互联网协议（IP）的网络，其中实现了用于设备的Web服务（WSD）协议，连接到网络的设备，每个被配置为执行至少一个服务的设备， WSD协议，连接到网络并被配置为控制设备收敛和自动化其服务;以及使用WSD协议实现的便携式设备，连接到网络并且被配置为控制设备并执行服务。服务器通过Windows Sideshow实现，用于收集控制设备所需的信息，并将收集的信息提供给便携式设备。

9. 发明申请

US20090027252A1 CUSTOMIZABLE REMOTE CONTROL DEVICE 有权
标题翻译：可定制远程控制设备
公开(公告)号：US20090027252A1
公开(公告)日：2009-01-29
申请号：US12127550
申请日：2008-05-27
申请人： Seale Moorer , William K. Virgin , Timothy McMahon
发明人： Seale Moorer , William K. Virgin , Timothy McMahon
IPC分类号： H04L17/00
CPC分类号： H01H9/0235 , H01H2221/07 , H01H2231/032 , H04N21/42206 , H04N21/42225 , H04N21/42226 , H04N21/43615 , H04N2005/4407 , H04N2005/4416
摘要： A remote controller for controlling a remote unit includes a stationary button assigned to a first function of the remote unit, and a first flexible button assigned to a second function of the remote unit and configured to be addable to or removable from the remote controller. The remote controller may further include a base, a membrane layer mountable on the base, the membrane layer including the stationary button and a first flexible button base, a first flexible button cap mountable on the first flexible button base to form the first flexible button, and a first face mountable on the membrane layer and having a first opening pattern exposing the stationary button and the first flexible button.
摘要翻译：用于控制远程单元的遥控器包括分配给远程单元的第一功能的固定按钮和分配给远程单元的第二功能的第一灵活按钮，并且被配置为可以从遥控器添加或移除。遥控器还可以包括底座，可安装在基座上的膜层，包括固定按钮的膜层和第一柔性按钮底座，可安装在第一柔性按钮底座上以形成第一柔性按钮的第一柔性按钮帽，以及可安装在膜层上并具有暴露固定按钮和第一柔性按钮的第一开口图案的第一面。

10. 发明申请

US20080154398A1 PORTABLE DEVICE FOR CONVERGENCE AND AUTOMATION SOLUTION 有权
标题翻译：便携式设备的综合和自动化解决方案
公开(公告)号：US20080154398A1
公开(公告)日：2008-06-26
申请号：US11937889
申请日：2007-11-09
申请人： Seale Moorer , Eric Eichensehr , Kyle Virgin , Timothy McMahon
发明人： Seale Moorer , Eric Eichensehr , Kyle Virgin , Timothy McMahon
IPC分类号： G06F17/00
CPC分类号： H04L12/2838 , H04L12/2814 , H04L12/282 , H04L67/16
摘要： A convergence and automation system (CAS) includes an internet-protocol (IP) based network implemented with a web service for devices (WSD) protocol, devices connected to the network, each configured to perform at least one service, a server implemented with the WSD protocol, connected to the network and configured to control the devices to converge and automate the services thereof, and a portable device implemented with the WSD protocol, connected to the network and configured to control the devices and perform the services. The server is implemented with Windows Sideshow to collect information necessary for controlling the devices and provides the collected information to the portable device.
摘要翻译：汇聚和自动化系统（CAS）包括基于互联网协议（IP）的网络，其中实现了用于设备的Web服务（WSD）协议，连接到网络的设备，每个被配置为执行至少一个服务的设备， WSD协议，连接到网络并被配置为控制设备收敛和自动化其服务;以及使用WSD协议实现的便携式设备，连接到网络并且被配置为控制设备并执行服务。服务器通过Windows Sideshow实现，用于收集控制设备所需的信息，并将收集的信息提供给便携式设备。

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