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1. 发明授权

US07766840B2 Method and system for heart failure status evaluation based on a disordered breathing index 有权
标题翻译：基于无序呼吸指数的心衰状态评估方法和系统
公开(公告)号：US07766840B2
公开(公告)日：2010-08-03
申请号：US11291525
申请日：2005-12-01
申请人： Jonathan Kwok , Marina Brockway , Kent Lee , Quan Ni , Yachuan Pu , Jeffrey Stahmann , Yi Zhang , Jesse Hartley
发明人： Jonathan Kwok , Marina Brockway , Kent Lee , Quan Ni , Yachuan Pu , Jeffrey Stahmann , Yi Zhang , Jesse Hartley
IPC分类号： A61B5/08 , A61B5/02
CPC分类号： A61B5/091 , A61B5/0031 , A61B5/0809 , A61B5/0816 , A61B5/113 , A61B5/4818 , A61N1/3627 , A61N1/36521 , A61N1/36535
摘要： An evaluation of heart failure status is provided based on a disordered breathing index. Patient respiration is sensed and a respiration signal is generated. Disordered breathing episodes are detected based on the respiration signal. A disordered breathing index is determined based on the disordered breathing episodes. The disordered breathing index is trended and used to evaluate heart failure status. The disordered breathing index may be combined with additional information and/or may take into account patient activity, posture, sleep stage, or other patient information.
摘要翻译：基于无序呼吸指数提供心力衰竭状态评估。感测患者呼吸并产生呼吸信号。基于呼吸信号检测到无序呼吸事件。基于无序呼吸发作确定无序呼吸指数。无序呼吸指数趋向并用于评估心力衰竭状态。无序呼吸指数可以与附加信息组合和/或可以考虑患者活动，姿势，睡眠阶段或其他患者信息。

2. 发明申请

US20100298733A1 Method and System for Heart Failure Status Evaluation Based on a Disordered Breathing Index 有权
标题翻译：基于无序呼吸指数的心力衰竭状态评估方法与系统
公开(公告)号：US20100298733A1
公开(公告)日：2010-11-25
申请号：US12847698
申请日：2010-07-30
申请人： Jonathan Kwok , Marina Brockway , Kent Lee , Quan Ni , Yachuan Pu , Jeffrey Stahmann , Yi Zhang , Jesse Hartley
发明人： Jonathan Kwok , Marina Brockway , Kent Lee , Quan Ni , Yachuan Pu , Jeffrey Stahmann , Yi Zhang , Jesse Hartley
IPC分类号： A61B5/08
CPC分类号： A61B5/091 , A61B5/0031 , A61B5/0809 , A61B5/0816 , A61B5/113 , A61B5/4818 , A61N1/3627 , A61N1/36521 , A61N1/36535
摘要： An evaluation of heart failure status is provided based on a disordered breathing index. Patient respiration is sensed and a respiration signal is generated. Disordered breathing episodes are detected based on the respiration signal. A disordered breathing index is determined based on the disordered breathing episodes. The disordered breathing index is trended and used to evaluate heart failure status. The disordered breathing index may be combined with additional information and/or may take into account patient activity, posture, sleep stage, or other patient information.
摘要翻译：基于无序呼吸指数提供心力衰竭状态评估。感测患者呼吸并产生呼吸信号。基于呼吸信号检测到无序呼吸事件。基于无序呼吸发作确定无序呼吸指数。无序呼吸指数趋向并用于评估心力衰竭状态。无序呼吸指数可以与附加信息组合和/或可以考虑患者活动，姿势，睡眠阶段或其他患者信息。

3. 发明申请

US20070129643A1 Method and system for heart failure status evaluation based on a disordered breathing index 有权
标题翻译：基于无序呼吸指数的心衰状态评估方法和系统
公开(公告)号：US20070129643A1
公开(公告)日：2007-06-07
申请号：US11291525
申请日：2005-12-01
申请人： Jonathan Kwok , Marina Brockway , Kent Lee , Quan Ni , Yachuan Pu , Jeffrey Stahmann , Yi Zhang , Jesse Hartley
发明人： Jonathan Kwok , Marina Brockway , Kent Lee , Quan Ni , Yachuan Pu , Jeffrey Stahmann , Yi Zhang , Jesse Hartley
IPC分类号： A61B5/08 , A61B5/02
CPC分类号： A61B5/091 , A61B5/0031 , A61B5/0809 , A61B5/0816 , A61B5/113 , A61B5/4818 , A61N1/3627 , A61N1/36521 , A61N1/36535
摘要： An evaluation of heart failure status is provided based on a disordered breathing index. Patient respiration is sensed and a respiration signal is generated. Disordered breathing episodes are detected based on the respiration signal. A disordered breathing index is determined based on the disordered breathing episodes. The disordered breathing index is trended and used to evaluate heart failure status. The disordered breathing index may be combined with additional information and/or may take into account patient activity, posture, sleep stage, or other patient information.
摘要翻译：基于无序呼吸指数提供心力衰竭状态评估。感测患者呼吸并产生呼吸信号。基于呼吸信号检测到无序呼吸事件。基于无序呼吸发作确定无序呼吸指数。无序呼吸指数趋向并用于评估心力衰竭状态。无序呼吸指数可以与附加信息组合和/或可以考虑患者活动，姿势，睡眠阶段或其他患者信息。

4. 发明授权

US08696589B2 Method and system for heart failure status evaluation based on a disordered breathing index 有权
标题翻译：基于无序呼吸指数的心衰状态评估方法和系统
公开(公告)号：US08696589B2
公开(公告)日：2014-04-15
申请号：US12847698
申请日：2010-07-30
申请人： Jonathan T. Kwok , Marina Brockway , Kent Lee , Quan Ni , Yachuan Pu , Jeffrey E. Stahmann , Yi Zhang , Jesse W. Hartley
发明人： Jonathan T. Kwok , Marina Brockway , Kent Lee , Quan Ni , Yachuan Pu , Jeffrey E. Stahmann , Yi Zhang , Jesse W. Hartley
IPC分类号： A61B5/08
CPC分类号： A61B5/091 , A61B5/0031 , A61B5/0809 , A61B5/0816 , A61B5/113 , A61B5/4818 , A61N1/3627 , A61N1/36521 , A61N1/36535
摘要： An evaluation of heart failure status is provided based on a disordered breathing index. Patient respiration is sensed and a respiration signal is generated. Disordered breathing episodes are detected based on the respiration signal. A disordered breathing index is determined based on the disordered breathing episodes. The disordered breathing index is trended and used to evaluate heart failure status. The disordered breathing index may be combined with additional information and/or may take into account patient activity, posture, sleep stage, or other patient information.
摘要翻译：基于无序呼吸指数提供心力衰竭状态评估。感测患者呼吸并产生呼吸信号。基于呼吸信号检测到无序呼吸事件。基于无序呼吸发作确定无序呼吸指数。无序呼吸指数趋向并用于评估心力衰竭状态。无序呼吸指数可以与附加信息组合和/或可以考虑患者活动，姿势，睡眠阶段或其他患者信息。

5. 发明申请

US20120283527A1 RESPIRATION MONITORING FOR HEART FAILURE USING IMPLANTABLE DEVICE 失效
标题翻译：使用可移植设备进行心脏衰竭的呼吸监测
公开(公告)号：US20120283527A1
公开(公告)日：2012-11-08
申请号：US13553098
申请日：2012-07-19
申请人： Yachuan Pu , Kent Lee , Jonathan Kwok , Quan Ni
发明人： Yachuan Pu , Kent Lee , Jonathan Kwok , Quan Ni
IPC分类号： A61B5/0205 , A61B5/11 , A61B5/08
CPC分类号： A61B5/0816 , A61B5/0031 , A61B5/0452 , A61B5/4818 , A61N1/3627 , A61N1/36521
摘要： An implantable respiration monitor can be used to detect disordered breathing or periodic breathing events that can be categorized, such as according to one or more of sleep, exercise, and resting awake states. The categorized frequency of such events can be compared to independently specifiable thresholds, such as to trigger an alert or responsive therapy, or to display one or more trends. The information can also be combined with detection of one or more other congestive heart failure (CHF) symptoms to generate a CHF status indicator or to trigger an alarm or responsive therapy or to display one or more trends. The alert can notify the patient or a caregiver, such as via remote monitoring. The sleep state information can be further categorized according to central sleep apnea (CSA) or obstructive sleep apnea (OSA) events.
摘要翻译：可植入式呼吸监测器可用于检测可分类的无序呼吸或定期呼吸事件，例如根据睡眠，运动和休眠状态中的一种或多种。这些事件的分类频率可以与独立指定的阈值进行比较，例如触发警报或响应治疗，或显示一个或多个趋势。该信息还可以与一种或多种其他充血性心力衰竭（CHF）症状的检测相结合，以产生CHF状态指示器或触发警报或反应性治疗或显示一种或多种趋势。该警报可以通过远程监视来通知病人或看护者。睡眠状态信息可以根据中枢性睡眠呼吸暂停（CSA）或阻塞性睡眠呼吸暂停（OSA）事件进一步分类。

6. 发明授权

US08551010B2 Respiration monitoring for heart failure using implantable device 失效
标题翻译：使用可植入装置进行心力衰竭呼吸监测
公开(公告)号：US08551010B2
公开(公告)日：2013-10-08
申请号：US13553098
申请日：2012-07-19
申请人： Yachuan Pu , Kent Lee , Jonathan Kwok , Quan Ni
发明人： Yachuan Pu , Kent Lee , Jonathan Kwok , Quan Ni
IPC分类号： A61B5/08
CPC分类号： A61B5/0816 , A61B5/0031 , A61B5/0452 , A61B5/4818 , A61N1/3627 , A61N1/36521
摘要： An implantable respiration monitor can be used to detect disordered breathing or periodic breathing events that can be categorized, such as according to one or more of sleep, exercise, and resting awake states. The categorized frequency of such events can be compared to independently specifiable thresholds, such as to trigger an alert or responsive therapy, or to display one or more trends. The information can also be combined with detection of one or more other congestive heart failure (CHF) symptoms to generate a CHF status indicator or to trigger an alarm or responsive therapy or to display one or more trends. The alert can notify the patient or a caregiver, such as via remote monitoring. The sleep state information can be further categorized according to central sleep apnea (CSA) or obstructive sleep apnea (OSA) events.
摘要翻译：可植入式呼吸监测器可用于检测可分类的无序呼吸或定期呼吸事件，例如根据睡眠，运动和休眠状态中的一种或多种。这些事件的分类频率可以与独立指定的阈值进行比较，例如触发警报或响应治疗，或显示一个或多个趋势。该信息还可以与一种或多种其他充血性心力衰竭（CHF）症状的检测相结合，以产生CHF状态指示器或触发警报或反应性治疗或显示一种或多种趋势。该警报可以通过远程监视来通知病人或看护者。睡眠状态信息可以根据中枢性睡眠呼吸暂停（CSA）或阻塞性睡眠呼吸暂停（OSA）事件进一步分类。

7. 发明授权

US08226570B2 Respiration monitoring for heart failure using implantable device 有权
标题翻译：使用可植入装置进行心力衰竭呼吸监测
公开(公告)号：US08226570B2
公开(公告)日：2012-07-24
申请号：US11463076
申请日：2006-08-08
申请人： Yachuan Pu , Kent Lee , Jonathan Kwok , Quan Ni
发明人： Yachuan Pu , Kent Lee , Jonathan Kwok , Quan Ni
IPC分类号： A61B5/08
CPC分类号： A61B5/0816 , A61B5/0031 , A61B5/0452 , A61B5/4818 , A61N1/3627 , A61N1/36521
摘要： An implantable respiration monitor can be used to detect disordered breathing or periodic breathing events that can be categorized, such as according to one or more of sleep, exercise, and resting awake states. The categorized frequency of such events can be compared to independently specifiable thresholds, such as to trigger an alert or responsive therapy, or to display one or more trends. The information can also be combined with detection of one or more other congestive heart failure (CHF) symptoms to generate a CHF status indicator or to trigger an alarm or responsive therapy or to display one or more trends. The alert can notify the patient or a caregiver, such as via remote monitoring. The sleep state information can be further categorized according to central sleep apnea (CSA) or obstructive sleep apnea (OSA) events.
摘要翻译：可植入式呼吸监测器可用于检测可分类的无序呼吸或定期呼吸事件，例如根据睡眠，运动和休眠状态中的一种或多种。这些事件的分类频率可以与独立指定的阈值进行比较，例如触发警报或响应治疗，或显示一个或多个趋势。该信息还可以与一种或多种其他充血性心力衰竭（CHF）症状的检测相结合，以产生CHF状态指示器或触发警报或反应性治疗或显示一种或多种趋势。该警报可以通过远程监视来通知病人或看护者。睡眠状态信息可以根据中枢性睡眠呼吸暂停（CSA）或阻塞性睡眠呼吸暂停（OSA）事件进一步分类。

8. 发明申请

US20080039730A1 RESPIRATION MONITORING FOR HEART FAILURE USING IMPLANTABLE DEVICE 有权
标题翻译：使用可移植设备进行心脏衰竭的呼吸监测
公开(公告)号：US20080039730A1
公开(公告)日：2008-02-14
申请号：US11463076
申请日：2006-08-08
申请人： Yachuan Pu , Kent Lee , Jonathan Kwok , Quan Ni
发明人： Yachuan Pu , Kent Lee , Jonathan Kwok , Quan Ni
IPC分类号： A61B5/02 , A61B5/08
CPC分类号： A61B5/0816 , A61B5/0031 , A61B5/0452 , A61B5/4818 , A61N1/3627 , A61N1/36521
摘要： An implantable respiration monitor can be used to detect disordered breathing or periodic breathing events that can be categorized, such as according to one or more of sleep, exercise, and resting awake states. The categorized frequency of such events can be compared to independently specifiable thresholds, such as to trigger an alert or responsive therapy, or to display one or more trends. The information can also be combined with detection of one or more other congestive heart failure (CHF) symptoms to generate a CHF status indicator or to trigger an alarm or responsive therapy or to display one or more trends. The alert can notify the patient or a caregiver, such as via remote monitoring. The sleep state information can be further categorized according to central sleep apnea (CSA) or obstructive sleep apnea (OSA) events.
摘要翻译：可植入式呼吸监测器可用于检测可分类的无序呼吸或定期呼吸事件，例如根据睡眠，运动和休眠状态中的一种或多种。这些事件的分类频率可以与独立指定的阈值进行比较，例如触发警报或响应治疗，或显示一个或多个趋势。该信息还可以与一种或多种其他充血性心力衰竭（CHF）症状的检测相结合，以产生CHF状态指示器或触发警报或反应性治疗或显示一种或多种趋势。该警报可以通过远程监视来通知病人或看护者。睡眠状态信息可以根据中枢性睡眠呼吸暂停（CSA）或阻塞性睡眠呼吸暂停（OSA）事件进一步分类。

9. 发明申请

US20110319959A1 SYSTEM FOR NEURAL CONTROL OF RESPIRATION 有权
标题翻译：神经控制系统
公开(公告)号：US20110319959A1
公开(公告)日：2011-12-29
申请号：US13229211
申请日：2011-09-09
申请人： Anthony Caparso , Imad Libbus , M. Jason Brooke , Kent Lee , Jonathan Kwok , Yachuan Pu
发明人： Anthony Caparso , Imad Libbus , M. Jason Brooke , Kent Lee , Jonathan Kwok , Yachuan Pu
IPC分类号： A61N1/36
CPC分类号： A61N1/3601 , A61N1/36114
摘要： A system, device and method for neural control of respiration are provided. One aspect of this disclosure relates to an implantable medical device for sensing and controlling respiration during incidence of central respiratory diseases. According to various embodiments, the device includes a sensing circuit to receive sensed signals representative of an incidence of a central respiratory disease. The device also includes a neural stimulator adapted to generate neural stimulation signals, and a controller to communicate with the sensing circuit and to control the neural stimulator to stimulate a desired neural target in response to the detection of the incidence of a central respiratory disease. In an embodiment, the device includes a plurality of sensors which are adapted to monitor physiological parameters to detect the incidence of a central respiratory disease and to send signals to the sensing circuit. Other aspects and embodiments are provided herein.
摘要翻译：提供了一种用于呼吸神经控制的系统，装置和方法。本公开的一个方面涉及用于在中枢呼吸系统疾病发作期间感测和控制呼吸的可植入医疗装置。根据各种实施例，该装置包括感测电路，用于接收代表中枢呼吸系统疾病发生率的感测信号。该装置还包括适于产生神经刺激信号的神经刺激器，以及响应于检测到中枢性呼吸系统疾病发生率而控制器与感测电路通信并控制神经刺激器以刺激所需神经靶标。在一个实施例中，该装置包括多个传感器，其适于监测生理参数以检测中枢性呼吸系统疾病的发生并向感测电路发送信号。本文提供了其它方面和实施例。

10. 发明授权

US08050765B2 Method and apparatus for controlling neural stimulation during disordered breathing 有权
标题翻译：在无序呼吸期间控制神经刺激的方法和装置
公开(公告)号：US08050765B2
公开(公告)日：2011-11-01
申请号：US11468603
申请日：2006-08-30
申请人： Kent Lee , Imad Libbus , Anthony V. Caparso , Jonathan Kwok , Yachuan Pu , Paul A. Haefner , Kristofer J. James
发明人： Kent Lee , Imad Libbus , Anthony V. Caparso , Jonathan Kwok , Yachuan Pu , Paul A. Haefner , Kristofer J. James
IPC分类号： A61N1/08
CPC分类号： A61N1/36135 , A61B5/0215 , A61B5/08 , A61B5/0816 , A61B5/4035 , A61B5/4818 , A61N1/3601
摘要： A neural stimulation system controls the delivery of neural stimulation using a respiratory signal as a therapy feedback input. The respiratory signal is used to increase the effectiveness of the neural stimulation, such as vagal nerve stimulation, while decreasing potentially adverse side effects in respiratory functions. In one embodiment, the neural stimulation system detects apnea and, in response, adjusts the delivery of the neural stimulation pulses and/or delivers a respiratory therapy treating the detected apnea.
摘要翻译：神经刺激系统使用呼吸信号作为治疗反馈输入来控制神经刺激的传递。呼吸信号用于增加神经刺激的有效性，例如迷走神经刺激，同时减少呼吸功能的潜在不利副作用。在一个实施例中，神经刺激系统检测呼吸暂停，并且作为响应调整神经刺激脉冲的传递和/或递送治疗所检测的呼吸暂停的呼吸治疗。

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