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1. 发明授权

US5663183A N-(3-Aminopropyl)-N-phenyl-5,6,7,8-tetrahydronaphthalene-2-carboxamide derivatives, their preparation and their therapeutic use 失效
标题翻译： N-（3-氨基丙基）-N-苯基-5,6,7,8-四氢萘-2-甲酰胺衍生物，其制备及其治疗用途
公开(公告)号：US5663183A
公开(公告)日：1997-09-02
申请号：US653233
申请日：1996-05-24
申请人： Jonathan Frost , Pascal George , Patrick Pasau , Regine Bartsch , Corinne Rousselle , Paul Howard Williams , Jean Claude Muller
发明人： Jonathan Frost , Pascal George , Patrick Pasau , Regine Bartsch , Corinne Rousselle , Paul Howard Williams , Jean Claude Muller
IPC分类号： A61K31/165 , A61K31/38 , A61K31/395 , A61K31/40 , A61K31/403 , A61K31/4035 , A61K31/435 , A61K31/47 , A61K31/472 , A61K31/55 , A61P3/00 , A61P3/14 , A61P9/00 , A61P9/08 , A61P9/10 , A61P25/00 , A61P25/28 , A61P37/00 , C07C233/11 , C07C233/78 , C07C233/80 , C07C233/88 , C07D209/44 , C07D217/04 , C07D217/24 , C07D223/16 , C07D233/16 , C07D471/04 , C07D495/04 , C07D513/04 , C07D217/00
CPC分类号： C07D223/16 , C07C233/78 , C07C233/88 , C07D209/44 , C07D217/04 , C07D471/04 , C07D495/04 , C07C2102/08 , C07C2102/10
摘要： Compounds of the formula: ##STR1## in which R.sub.1 represents a hydrogen or halogen atom or a methyl or C.sub.1 -C.sub.4 alkoxy group, R'.sub.1 represents a hydrogen or halogen atom, R".sub.1 represents a hydrogen atom or a methoxy group, R.sub.3 represents a C.sub.1 -C.sub.3 alkyl group, R.sub.4 represents a 2,3-dihydro-1H-inden-2-yl, 2,3-dihydro-1H-inden-1-yl or 1,2,3,4-tetrahydronaphthalen-1-yl group, or R.sub.3 and R.sub.4 together form, with the adjacent nitrogen atom, a 1,2,3,4-tetrahydroisoquinol-2-yl, 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinol-2-yl, 5,8-dimethoxy-1,2,3,4-tetrahydroisoquinol-2-yl, 1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indol-2-yl, 1,2,3,4-tetrahydro-9H-pyrido[4,3-b]indol-3-yl, 4,5,6,7-tetrahydrothieno[2,3-c]pyrid-6-yl, 2,3-dihydro-1H-isoindol-2-yl or 2,3,4,5-tetra-hydro-1H-3-benzazepin-3-yl, group are useful in the treatment of cerebral disorders.
摘要翻译：下式的化合物：其中R 1表示氢或卤素原子或甲基或C 1 -C 4烷氧基，R 1表示氢或卤素原子，R“1表示氢原子或甲氧基，R 3表示C 1 -C 3烷基，R 4表示2,3-二氢-1H-茚-2-基，2,3-二氢-1H-茚-1-基或1,2,3,4 四氢萘-1-基或R3和R4一起与相邻的氮原子一起形成1,2,3,4-四氢异喹啉-2-基，6,7-二甲氧基-1,2,3,4-四氢萘-1-基，四氢异喹啉-2-基，5,8-二甲氧基-1,2,3,4-四氢异喹啉-2-基，1,2,3,4-四氢-9H-吡啶并[3,4-b] -1,2,3,4-四氢-9H-吡啶并[4,3-b]吲哚-3-基，4,5,6,7-四氢噻吩并[2,3-c]吡啶-6-基， 2,3-二氢-1H-异吲哚-2-基或2,3,4,5-四氢-1H-3-苯并氮杂-3-基可用于治疗脑部疾病。

2. 发明授权

US5550125A 3-(2-aminomethyl)-4-[3-trifluoromethyl)benzoyl]-3-4 dihydro-2h-1,4-benzoxazine derivatives and their therapeutic application 失效
标题翻译： 3-（2-氨基甲基）-4- [3-三氟甲基]苯甲酰基] -3- [4-三氟甲基]苯并恶嗪衍生物及其治疗应用
公开(公告)号：US5550125A
公开(公告)日：1996-08-27
申请号：US382589
申请日：1995-02-02
申请人： Pascal George , Jonathan Frost , Patrick Pasau , Corinne Rousselle , R egine Bartsch , Paul Howard Williams , Jean Claude Muller
发明人： Pascal George , Jonathan Frost , Patrick Pasau , Corinne Rousselle , R egine Bartsch , Paul Howard Williams , Jean Claude Muller
IPC分类号： C07D265/26 , A61K31/38 , A61K31/395 , A61K31/435 , A61K31/535 , A61K31/538 , A61P9/10 , A61P25/00 , A61P25/28 , A61P27/02 , C07D265/36 , C07D413/06 , C07D471/04 , C07D495/04
CPC分类号： C07D413/06 , C07D265/36 , C07D471/04 , C07D495/04
摘要： Compounds of the general formula (I) ##STR1## wherein R.sub.1 represents a hydrogen, fluorine or chlorine atom or a methyl, C.sub.1 -C.sub.3 alkoxy or nitro group; R.sub.3 represents a hydrogen atom or a C.sub.1 -C.sub.3 alkyl group; R.sub.4 represents a 2,3-dihydro-1H-inden-2-yl, 2,3-dihydro-1H-inden-1-yl or 1,2,3,4-tetrahydronaphthalen-1-yl group; or alternatively R.sub.3 and R.sub.4 complete, with the nitrogen atom to which they are attached, a 1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indol-2-yl, 1,2,3,4-tetrahydro-9H-pyrido[4,3-b]indol-3-yl, 4,5,6,7-tetrahydrothieno[2,3-c]pyrid-6-yl, 4,5,6,7-tetrahydrothieno[3,2-c]pyrid-6-yl or 2,3-dihydro-1H-isoindol-2-yl group; are useful for the treatment and prevention of cerebral disorders.
摘要翻译：通式（I）的化合物其中R 1表示氢，氟或氯原子或甲基，C 1 -C 3烷氧基或硝基; R3表示氢原子或C1-C3烷基; R 4表示2,3-二氢-1H-茚-2-基，2,3-二氢-1H-茚-1-基或1,2,3,4-四氢萘-1-基; 或者R3和R4与它们所连接的氮原子一起形成1,2,3,4-四氢-9H-吡啶并[3,4-b]吲哚-2-基， 4,3-b]吲哚-3-基，4,5,6,7-四氢噻吩并[2,3-c]吡啶-6-基，4,5,6,7-四氢-9H-吡啶并[4,3-b] 四氢噻吩并[3,2-c]吡啶-6-基或2,3-二氢-1H-异吲哚-2-基; 可用于治疗和预防脑部疾病。

3. 发明授权

US5373023A Tetrahydronaphtalene derivatives, their preparation and pharmaceutical compositions containing them 失效
标题翻译：四氢萘衍生物，它们的制备和含有它们的药物组合物
公开(公告)号：US5373023A
公开(公告)日：1994-12-13
申请号：US101764
申请日：1993-08-04
申请人： Paul Howard Williams , Christian Hoornaert , Jean Claude Muller
发明人： Paul Howard Williams , Christian Hoornaert , Jean Claude Muller
IPC分类号： A61K31/165 , A61P3/00 , A61P9/10 , A61P25/28 , C07C231/14 , C07C233/66 , C07C233/75 , C07C233/78 , C07C233/88 , C07C253/30 , C07C255/60 , C07D213/38 , C07D319/18 , C07C53/06 , C07C55/07 , C07C233/65
CPC分类号： C07D319/18 , C07C233/66 , C07C233/75 , C07C233/78 , C07C233/88 , C07C255/60 , C07D213/38
摘要： The invention provides compounds which are tetrahydronaphthalene derivatives of the formula (I) ##STR1## wherein R.sub.1 represents a halogen atom, a cyano group, a nitro group, an unbranched (C.sub.1 -C.sub.6) alkoxy group, a (C.sub.1 -C.sub.6 cycloalkyl) (C.sub.1 -C.sub.2 alkoxy) group or an aryl (C.sub.1 -C.sub.2 alkoxy) group,R.sub.2 represents a (C.sub.1 -C.sub.4) alkyl group, an aryl group optionally substituted with at least one methoxy group, a pyridyl group or a benzodioxanyl group,R.sub.3 represents a hydrogen atom or a (C.sub.1 -C.sub.2) alkyl group, and n=0 to 3, or are addition salts with pharmaceutically acceptable acids. The compounds of the invention have anti-ischaemic activity.
摘要翻译：本发明提供化合物，其为式（I）的四氢萘衍生物其中R 1表示卤素原子，氰基，硝基，无支链（C1-C6）烷氧基，（C1-C6）烷氧基环烷基）（C1-C2烷氧基）或芳基（C1-C2烷氧基）基，R2表示（C1-C4）烷基，任选被至少一个甲氧基，吡啶基或苯并二恶烷基取代的芳基，R3表示氢原子或（C1-C2）烷基，n = 0〜3，或与药学上可接受的酸形成的加成盐。本发明的化合物具有抗缺血活性。

4. 发明授权

US5457112A 3-(6-quinolylmethyl)-4H-imidazol-4-one derivatives, their preparation and their application in therapy 失效
标题翻译： 3-（6-喹啉基甲基）-4H-咪唑-4-酮衍生物，其制备及其在治疗中的应用
公开(公告)号：US5457112A
公开(公告)日：1995-10-10
申请号：US165648
申请日：1993-12-13
申请人： Gerard Cremer , Jean Claude Muller
发明人： Gerard Cremer , Jean Claude Muller
IPC分类号： C07D401/14 , C07D215/04 , A61K31/47
CPC分类号： C07D401/14
摘要： 3-(6-Quinolylmethyl)-4H-imidazol-4-one derivatives corresponding to the formula (I): ##STR1## in which R.sub.1 represents an unbranched or branched (C.sub.2 -C.sub.5) alkyl group,R.sub.2 and R.sub.3 represent, each independently of one another, either a hydrogen atom, or an unbranched or branched (C.sub.1 -C.sub.5)alkyl group, or a (CH.sub.2).sub.n -aryl group where n=0 to 3, or R.sub.2 and R.sub.3 with the imidazole ring can form a spirocyclo(C.sub.3 -C.sub.8)alkyl group,as well as their addition salts with pharmaceutically acceptable acids and bases.
摘要翻译：对应于式（I）的3-（6-喹啉基甲基）-4H-咪唑-4-酮衍生物：其中R 1表示无支链或支链（C2-C5）烷基，R2和R3表示（C 1 -C 5）烷基或其中n = 0至3的（CH 2）n - 芳基或具有咪唑环的R 2和R 3可彼此独立地为氢原子，形成螺环（C 3 -C 8）烷基，以及它们与药学上可接受的酸和碱的加成盐。

5. 发明授权

US4501282A Combine harvester crop in-feed conveyor 失效
标题翻译：联合收割机作物进料输送机
公开(公告)号：US4501282A
公开(公告)日：1985-02-26
申请号：US403743
申请日：1982-08-02
申请人： Jean Claude Muller , James B. McNaught
发明人： Jean Claude Muller , James B. McNaught
IPC分类号： A01F12/10
CPC分类号： A01F12/10
摘要： A combine harvester of the type having a crop elevator 9, 10, 11 that feeds crop upwards across a crop floor 11 to a crop threshing mechanism comprising a threshing cylinder 1 located adjacent a concave threshing grate 13 and driven to thresh crop fed tangentially between the cylinder and grating, a crop conveyor 14 in the form of a roller or continuous band conveyor being located along the leading edge of the grate 13 with respect to the crop feed direction so that crop passes over it to the cylinder and grating and a changeable speed drive mechanism being provided to drive the conveyor 14 and allow its speed to be changed, thereby to control the speed of crop flow. The crop elevator 9, 10, 11 is supported to pivot about the axis of the cylinder 1 to raise and lower a crop collecting table 2 carried at the bottom of the elevator, the conveyor 14 being located between the upper end of the elevator floor 11 and the leading edge of the grate 13 so as to form a substantially continuous crop flow path with said floor and grate. The grate 13 and conveyor 14 are mounted so as to pivot with the elevator 11 about the axis of the cylinder 1. A crop guide flap 15 is provided adjacent the conveyor 14 to vary the angle at which the crop is fed to the cylinder 1.
摘要翻译： PCT No.PCT / GB81 / 00258 Sec。 371日期1982年8月2日 102（e）日期1982年8月2日PCT提交1981年11月25日PCT公布。公开号WO82 / 01805 日期：1982年6月10日。一种具有作物升降机9,10,11的联合收割机，其将作物向上穿过作物地板11向作物打谷机构进料，该作物脱粒机构包括位于邻近脱粒炉排13并驱动的脱粒筒1 为了切割在圆筒和格栅之间切割的作物，以辊子或连续带式输送器形式的作物输送机14相对于作物进给方向沿着格栅13的前缘定位，使得作物通过其到达气缸和光栅以及可变速驱动机构，用于驱动输送机14并允许其速度改变，从而控制作物流速。作物升降机9,10,11被支撑以围绕气缸1的轴线枢转以升高和降低在电梯底部承载的作物收集台2，传送器14位于升降机地板11的上端和格栅13的前缘，以便与所述地板和格栅形成基本上连续的作物流动路径。格栅13和输送机14安装成与电梯11围绕气缸1的轴线枢转。在输送机14附近设置作物引导翼片15，以改变作物向气缸1供给的角度。

6. 发明授权

US5543526A 1-amino-4-(1H-imidazole)- aminobutaneboronic acid derivatives, their preparation and use as synthetic intermediates 失效
标题翻译： 1-氨基-4-（1H-咪唑） - 氨基丁烷硼酸衍生物，其制备和用作合成中间体
公开(公告)号：US5543526A
公开(公告)日：1996-08-06
申请号：US419923
申请日：1995-04-11
申请人： Sergio Mallart , Gilbert Lassalle , Thomas Andrew Purcell , Jean Claude Muller
发明人： Sergio Mallart , Gilbert Lassalle , Thomas Andrew Purcell , Jean Claude Muller
IPC分类号： C07F5/02 , C07K5/06 , C07F5/04 , C10M1/10 , C10M1/54
CPC分类号： C07K5/06191 , C07F5/025
摘要： A compound of formula (I) ##STR1## in which R.sub.3 and R.sub.4 together represent the residue of a dihydroxy compound, andR.sub.5 represents a hydrogen atom or a (C.sub.1 -C.sub.4) alkyl group, or a salt thereof, and its use as a synthetic intermediate.
摘要翻译：式（I）化合物其中R 3和R 4一起代表二羟基化合物的残基，R 5表示氢原子或（C 1 -C 4）烷基或其盐，并且其用作合成中间体。

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