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1. 发明授权

US08369936B2 Wearable apparatus for measuring heart-related parameters and deriving human status parameters from sensed physiological and contextual parameters 有权
标题翻译：用于测量心脏相关参数并从感测的生理和语境参数中导出人体状态参数的穿戴式装置
公开(公告)号：US08369936B2
公开(公告)日：2013-02-05
申请号：US12840109
申请日：2010-07-20
申请人： Jonathan Farringdon , John M. Stivoric , Eric Teller , David Andre , Scott Boehmke , James Gasbarro , Gregory Kovacs , Raymond Pelletier , Christopher Kasabach
发明人： Jonathan Farringdon , John M. Stivoric , Eric Teller , David Andre , Scott Boehmke , James Gasbarro , Gregory Kovacs , Raymond Pelletier , Christopher Kasabach
IPC分类号： A61B5/04
CPC分类号： A61B5/0245 , A61B5/0205 , A61B5/02055 , A61B5/021 , A61B5/02125 , A61B5/04012 , A61B5/0408 , A61B5/0428 , A61B5/053 , A61B5/11 , A61B5/4812 , A61B5/6824 , A61B5/721 , A61B5/7267
摘要： A monitor device and associated methodology are disclosed which provide a self contained, relatively small and continuously wearable package for the monitoring of heart related parameters, including ECG. The detection of heart related parameters is predicated on the location of inequipotential signals located within regions of the human body conventionally defined as equivalent for the purpose of detection of heart related electrical activity, such as on single limbs. Amplification, filtering and processing methods and apparatus are described in conjunction with analytical tools for beat detection and display.
摘要翻译：公开了一种监测装置和相关联的方法，其提供用于监测心脏相关参数（包括ECG）的独立的，相对较小且持续可穿戴的包装。心脏相关参数的检测是基于位于人体区域内的等位信号的位置，通常定义为等同于检测心脏相关电活动的目的，例如在单个肢体上。结合用于拍子检测和显示的分析工具描述了放大，滤波和处理方法和装置。

2. 发明申请

US20100286532A1 WEARABLE APPARATUS FOR MEASURING HEART-RELATED PARAMETERS AND DERIVING HUMAN STATUS PARAMETERS FROM SENSED PHYSIOLOGICAL AND CONTEXTUAL PARAMETERS 有权
标题翻译：用于测量与心脏相关的参数和从感觉的生理学和背景参数传播人类状态参数的有用的装置
公开(公告)号：US20100286532A1
公开(公告)日：2010-11-11
申请号：US12840109
申请日：2010-07-20
申请人： Jonathan Farringdon , John M. Stivoric , Eric Teller , David Andre , Scott K. Boehmke , James Gasbarro , Gregory Kovacs , Raymond Pelletier , Christopher Kasabach
发明人： Jonathan Farringdon , John M. Stivoric , Eric Teller , David Andre , Scott K. Boehmke , James Gasbarro , Gregory Kovacs , Raymond Pelletier , Christopher Kasabach
IPC分类号： A61B5/0205 , A61B5/0402
CPC分类号： A61B5/0245 , A61B5/0205 , A61B5/02055 , A61B5/021 , A61B5/02125 , A61B5/04012 , A61B5/0408 , A61B5/0428 , A61B5/053 , A61B5/11 , A61B5/4812 , A61B5/6824 , A61B5/721 , A61B5/7267
摘要： A monitor device and associated methodology are disclosed which provide a self contained, relatively small and continuously wearable package for the monitoring of heart related parameters, including ECG. The detection of heart related parameters is predicated on the location of inequipotential signals located within regions of the human body conventionally defined as equivalent for the purpose of detection of heart related electrical activity, such as on single limbs. Amplification, filtering and processing methods and apparatus are described in conjunction with analytical tools for beat detection and display.
摘要翻译：公开了一种监测装置和相关联的方法，其提供用于监测心脏相关参数（包括ECG）的独立的，相对较小且持续可穿戴的包装。心脏相关参数的检测是基于位于人体区域内的等位信号的位置，通常定义为等同于检测心脏相关电活动的目的，例如在单个肢体上。结合用于拍子检测和显示的分析工具描述了放大，滤波和处理方法和装置。

3. 发明申请

US20120245439A1 METHOD AND APPARATUS FOR DETERMINING CRITICAL CARE PARAMETERS 审中-公开
标题翻译：用于确定关键护理参数的方法和装置
公开(公告)号：US20120245439A1
公开(公告)日：2012-09-27
申请号：US13130282
申请日：2009-11-20
申请人： David Andre , Kevin Ward , Nisang Vyas , Eric Teller , John M. Stivoric , Jonathan Farringdon , Scott K. Boehmke , Christopher Pacione , Raymond Pelletier , Kevin Ross , Scott Safier , Suresh Vishnubhatla , Gregory Kovacs , James Gasbarro , Christopher Kasabach
发明人： David Andre , Kevin Ward , Nisang Vyas , Eric Teller , John M. Stivoric , Jonathan Farringdon , Scott K. Boehmke , Christopher Pacione , Raymond Pelletier , Kevin Ross , Scott Safier , Suresh Vishnubhatla , Gregory Kovacs , James Gasbarro , Christopher Kasabach
IPC分类号： A61B5/00 , A61B5/0402 , A61B5/08 , A61B5/01 , A61B5/053 , A61B5/0488 , A61B5/1455 , A61B5/11 , A61B5/0476 , A61B5/0496 , A61B5/021 , A61B5/103 , A61B5/145 , A61B6/00 , A61B5/085 , A61B5/1468 , A61B5/024
CPC分类号： A61B5/0205 , A61B5/002 , A61B5/0022 , A61B5/412 , A61B5/413 , A61B5/4519 , A61B5/7207 , A61B5/721 , A61B5/7267 , A61N1/37252 , G16H40/67
摘要： A physiological measuring system is disclosed that monitors certain physiological parameters of an individual through the use of a body-mounted sensing apparatus. The apparatus is particularly adapted for continuous wear. The system is also adaptable or applicable to calculating derivations of such parameters. A oxygen debt measuring embodiment is directed predicting an outcome in response to injury and illness. The technique allows for closed-loop resuscitation, early identification of illness and early corrective action.
摘要翻译：公开了一种生理测量系统，其通过使用身体安装的感测装置来监测个体的某些生理参数。该装置特别适用于连续磨损。该系统也适用于或适用于计算这些参数的推导。氧负债测量实施例是针对损伤和疾病预测结果的。该技术允许闭环复苏，早期识别疾病和早期纠正措施。

4. 发明授权

US07502643B2 Method and apparatus for measuring heart related parameters 有权
标题翻译：用于测量心脏相关参数的方法和装置
公开(公告)号：US07502643B2
公开(公告)日：2009-03-10
申请号：US10940889
申请日：2004-09-13
申请人： Jonathan Farringdon , John M. Stivoric , Eric Teller , David Andre , Scott K. Boehmke , James Gasbarro , Gregory Kovacs , Raymond Pelletier , Christopher Kasabach
发明人： Jonathan Farringdon , John M. Stivoric , Eric Teller , David Andre , Scott K. Boehmke , James Gasbarro , Gregory Kovacs , Raymond Pelletier , Christopher Kasabach
IPC分类号： A61B5/04
CPC分类号： A61B5/0245 , A61B5/0205 , A61B5/02055 , A61B5/021 , A61B5/02125 , A61B5/04012 , A61B5/0408 , A61B5/0428 , A61B5/053 , A61B5/11 , A61B5/4812 , A61B5/6824 , A61B5/721 , A61B5/7267
摘要： A monitor device and associated methodology are disclosed which provide a self contained, relatively small and continuously wearable package for the monitoring of heart related parameters, including ECG. The detection of heart related parameters is predicated on the location of inequipotential signals located within regions of the human body conventionally defined as equivalent for the purpose of detection of heart related electrical activity, such as on single limbs. Amplification, filtering and processing methods and apparatus are described in conjunction with analytical tools for beat detection and display.
摘要翻译：公开了一种监测装置和相关联的方法，其提供用于监测心脏相关参数（包括ECG）的独立的，相对较小且持续可穿戴的包装。心脏相关参数的检测是基于位于人体区域内的等位信号的位置，通常定义为等同于检测心脏相关电活动的目的，例如在单个肢体上。结合用于拍子检测和显示的分析工具描述了放大，滤波和处理方法和装置。

5. 发明申请

US20050113703A1 Method and apparatus for measuring heart related parameters 有权
标题翻译：用于测量心脏相关参数的方法和装置
公开(公告)号：US20050113703A1
公开(公告)日：2005-05-26
申请号：US10940889
申请日：2004-09-13
申请人： Jonathan Farringdon , John Stivoric , Eric Teller , David Andre , Scott Boehmke , James Gasbarro , Gregory Kovacs , Raymond Pelletier , Christopher Kasabach
发明人： Jonathan Farringdon , John Stivoric , Eric Teller , David Andre , Scott Boehmke , James Gasbarro , Gregory Kovacs , Raymond Pelletier , Christopher Kasabach
IPC分类号： A61B20060101 , A61B5/04 , A61B5/0402 , A61B5/0428
CPC分类号： A61B5/0245 , A61B5/0205 , A61B5/02055 , A61B5/021 , A61B5/02125 , A61B5/04012 , A61B5/0408 , A61B5/0428 , A61B5/053 , A61B5/11 , A61B5/4812 , A61B5/6824 , A61B5/721 , A61B5/7267
摘要： A monitor device and associated methodology are disclosed which provide a self contained, relatively small and continuously wearable package for the monitoring of heart related parameters, including ECG. The detection of heart related parameters is predicated on the location of inequipotential signals located within regions of the human body conventionally defined as equivalent for the purpose of detection of heart related electrical activity, such as on single limbs. Amplification, filtering and processing methods and apparatus are described in conjunction with analytical tools for beat detection and display.
摘要翻译：公开了一种监测装置和相关联的方法，其提供用于监测心脏相关参数（包括ECG）的独立的，相对较小且持续可穿戴的包装。心脏相关参数的检测是基于位于人体区域内的等位信号的位置，通常定义为等同于检测心脏相关电活动的目的，例如在单个肢体上。结合用于拍子检测和显示的分析工具描述了放大，滤波和处理方法和装置。

6. 发明申请

US20120123232A1 METHOD AND APPARATUS FOR DETERMINING HEART RATE VARIABILITY USING WAVELET TRANSFORMATION 审中-公开
标题翻译：用于使用小波变换来确定心率变化的方法和装置
公开(公告)号：US20120123232A1
公开(公告)日：2012-05-17
申请号：US13140165
申请日：2009-12-16
申请人： Kayvan Najarian , David Andre , Kevin Ward , Nisarg Vyas , Eric Teller , John M. Stivoric , Jonathan Farringdon , Scott K. Boehmke , Gregory Kovacs , James Gabarro , Christopher Kasabach , Soo-Yeon Ji , Abel Al Raoff , Raymond Pelletier
发明人： Kayvan Najarian , David Andre , Kevin Ward , Nisarg Vyas , Eric Teller , John M. Stivoric , Jonathan Farringdon , Scott K. Boehmke , Gregory Kovacs , James Gabarro , Christopher Kasabach , Soo-Yeon Ji , Abel Al Raoff , Raymond Pelletier
IPC分类号： A61B5/0205 , A61B5/08 , A61B5/145 , A61B5/01 , A61B5/053 , A61B5/0488 , A61B6/00 , A61B5/0476 , A61B3/113 , A61B5/107 , A61B5/11 , A61B5/1468 , A61B5/22 , A61B5/021 , A61B5/044
CPC分类号： A61B5/0022 , A61B5/02055 , A61B5/02125 , A61B5/024 , A61B5/02405 , A61B5/0402 , A61B5/0476 , A61B5/0488 , A61B5/0496 , A61B5/053 , A61B5/0816 , A61B5/0833 , A61B5/1116 , A61B5/1118 , A61B5/14532 , A61B5/4872 , A61B5/4875 , A61B5/7203 , A61B5/7267 , G16H40/67
摘要： The present invention relates to advanced signal processing methods including digital wavelet transformation to analyze heart-related electronic signals and extract features that can accurately identify various states of the cardiovascular system. The invention may be utilized to estimate the extent of blood volume loss, distinguish blood volume loss from physiological activities associated with exercise, and predict the presence and extent of cardiovascular disease in general.
摘要翻译：本发明涉及先进的信号处理方法，包括数字小波变换以分析与心脏相关的电子信号，并且提取可准确地识别心血管系统的各种状态的特征。本发明可以用于估计血容量损失的程度，区分血容量损失与运动相关的生理活动，并且一般来说预测心血管疾病的存在和程度。

7. 发明申请

US20120084022A1 Enhanced Microfluidic Electromagnetic Measurements 有权
标题翻译：增强微流控电磁测量
公开(公告)号：US20120084022A1
公开(公告)日：2012-04-05
申请号：US13250605
申请日：2011-09-30
申请人： Laurent Giovangrandi , Antonio J. Ricco , Gregory Kovacs
发明人： Laurent Giovangrandi , Antonio J. Ricco , Gregory Kovacs
IPC分类号： G01F1/58 , G06F19/00
CPC分类号： G01F1/58 , G01F1/584 , G01F1/586 , G01F1/588
摘要： Techniques for enhanced microfluidic impedance spectroscopy include causing a core fluid to flow into a channel between two sheath flows of one or more sheath fluids different from the core fluid. Flow in the channel is laminar. A dielectric constant of a fluid constituting either sheath flow is much less than a dielectric constant of the core fluid. Electrical impedance is measured in the channel between at least a first pair of electrodes. In some embodiments, enhanced optical measurements include causing a core fluid to flow into a channel between two sheath flows of one or more sheath fluids different from the core fluid. An optical index of refraction of a fluid constituting either sheath flow is much less than an optical index of refraction of the core fluid. An optical property is measured in the channel.
摘要翻译：用于增强的微流体阻抗光谱的技术包括使核心流体流入不同于核心流体的一种或多种鞘液的两个鞘流之间的通道中。通道中的流动是层流。构成鞘流的流体的介电常数远小于芯流体的介电常数。在至少第一对电极之间的通道中测量电阻抗。在一些实施例中，增强的光学测量包括使芯流体流入不同于芯流体的一种或多种护套流体的两个鞘流之间的通道中。构成鞘流的流体的光学折射率远小于芯流体的光学折射率。在通道中测量光学性质。

8. 发明申请

US20070208232A1 Physiologic monitoring initialization systems and methods 审中-公开
标题翻译：生理监测初始化系统和方法
公开(公告)号：US20070208232A1
公开(公告)日：2007-09-06
申请号：US11367155
申请日：2006-03-03
申请人： Gregory Kovacs
发明人： Gregory Kovacs
IPC分类号： A61B5/00 , A61B5/04 , A61B5/08 , A61B5/103
CPC分类号： A61B5/02055 , A61B5/0402 , A61B5/04325 , A61B5/053 , A61B5/085 , A61B5/1116 , A61B5/1118 , A61B5/14551 , A61B5/4866 , A61B5/6831 , A61B2562/0219
摘要： According to one aspect, physiologic monitor and/or firmware piracy are reduced by initializing physiologic monitors in the field, e.g. in medical facilities or user homes, upon verifying user authorization. A physiologic monitor may include sensors such as electrocardiogram (ECG) electrodes, accelerometers, respiratory and/or fluid load impedance electrodes, and a temperature sensor. The monitor may be connected to an initialization console, which activates and configures the monitor by transferring an authorization code, firmware, a set of enabled sensors and sampling rates, a set of customized voice messages, and other parameters, and/or by programming a programmable logic array. The initialization console may be a computer situated in a doctor's office or user's home, programmed with initialization and analysis software, and capable of connecting to an authorization server at a time of use. Physiologic monitoring and configuration/authorization data may be stored in a removable digital memory capable of use with multiple disposable monitors.
摘要翻译：根据一个方面，通过初始化现场的生理监视器来减少生理监视和/或固件盗版，例如。在医疗设施或用户家庭中，在验证用户授权时。生理监视器可以包括诸如心电图（ECG）电极，加速度计，呼吸和/或流体负载阻抗电极的传感器以及温度传感器。显示器可以连接到初始化控制台，其通过传送授权码，固件，一组启用的传感器和采样率，一组定制的语音消息和其他参数来激活和配置监视器，和/或通过编程可编程逻辑阵列。初始化控制台可以是位于医生办公室或用户家中的计算机，用初始化和分析软件编程，并且能够在使用时连接到授权服务器。生理监测和配置/授权数据可以存储在能够与多个一次性监视器一起使用的可移动数字存储器中。

9. 发明申请

US20050282149A1 Closed-loop electrical stimulation system for cell cultures 失效
标题翻译：用于细胞培养的闭环电刺激系统
公开(公告)号：US20050282149A1
公开(公告)日：2005-12-22
申请号：US11137721
申请日：2005-05-24
申请人： Gregory Kovacs , R. Whittington
发明人： Gregory Kovacs , R. Whittington
IPC分类号： C12Q1/00 , G01N33/487
CPC分类号： G01N33/4836
摘要： The present invention provides a sensitive system for measuring the physiological response of an in-vitro cell culture to an environmental parameter. An electrical property of the cell culture is measured as a control signal, and a parameter of a stimulus is adjusted in real time to maintain the control signal at a specified value as the environment of the cell culture is altered, for example, pharmacologically. Artifact reduction and real-time control methods are two key aspects of preferred embodiments of the invention, and enable highly accurate determination of pulse parameters which elicit a desired response. Both aspects must be highly robust to the natural variations inherent in a biological system. This system is beneficial for studying the effects of environmental alterations because extremely small changes in the physiological response can be measured over time, revealing the magnitude and time-dependence of the impact of these alterations on the cell culture.
摘要翻译：本发明提供了一种用于测量体外细胞培养物对环境参数的生理反应的敏感系统。测量细胞培养物的电性质作为对照信号，并且例如在药理学上改变细胞培养物的环境时，实时调整刺激参数以将控制信号维持在规定值。人造物减少和实时控制方法是本发明的优选实施例的两个关键方面，并且能够高精度地确定引起期望响应的脉冲参数。这两个方面对于生物系统中固有的自然变异必须是高度鲁棒的。该系统有利于研究环境变化的影响，因为可以随时间测量生理反应的极小变化，揭示这些改变对细胞培养的影响的程度和时间依赖性。

10. 发明授权

US5006050A High accuracy disposable cassette infusion pump 失效
标题翻译：高精度一次性盒式输液泵
公开(公告)号：US5006050A
公开(公告)日：1991-04-09
申请号：US283107
申请日：1988-12-09
申请人： James E. Cooke , Philip Barkan , Gregory Kovacs
发明人： James E. Cooke , Philip Barkan , Gregory Kovacs
IPC分类号： A61M5/142 , F04B43/04 , F04B49/00
CPC分类号： F04B49/005 , A61M5/14224 , F04B43/04 , A61M2205/6072
摘要： An infusion pump for delivery of drugs to a patient includes a unit in which the pump mechanism is situated and a cassette through which the drugs to be delivered to the patient are pumped. The cassette includes a path for the fluid to flow from a drug vial to an outlet port. Disposed along the path are recesses for an inlet valve, a pressurization region, and an outlet valve. The cassette is sealed by an elastomeric layer to maintain the drugs to be delivered in a contaminant-free condition. The pump includes an inlet valve which has a contour matching the recess of the inlet port, and an outlet valve matching the recess of the outlet port. By biasing the inlet and outlet valves against the recesses, a pumping chamber is created. A piston in the unit pressurizes the pumping chamber to open the outlet valve and permit fluid to escape. By appropriate timing of the operation of the inlet valve and the piston, a continuous stream of fluid is delivered by the pump to the patient.
摘要翻译：用于将药物递送到患者的输液泵包括其中泵机构所在的单元和用于泵送待递送给患者的药物的盒。所述盒包括用于流体从药瓶流向出口的路径。沿着路径布置的是用于入口阀，加压区域和出口阀的凹槽。该盒由弹性体层密封，以使药物在无污染的条件下被输送。泵包括入口阀，其具有与入口端口的凹部匹配的轮廓，以及与出口的凹部匹配的出口阀。通过将入口和出口阀偏置抵靠凹槽，产生泵送室。该单元中的活塞对泵送室加压以打开出口阀并允许流体逸出。通过入口阀和活塞的适当操作时间，连续的流体流被泵输送到病人身上。

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