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    • 4. 发明授权
    • Rhodococcus erythropolis strain
    • 红球菌红细菌菌株
    • US08119389B2
    • 2012-02-21
    • US12506596
    • 2009-07-21
    • Nigel Ian BowersPaul M. SkoneznyGregory L. SteinThomas FranceschiniShu-Jen ChiangWendy L. AndersonLi YouZizhuo Xing
    • Nigel Ian BowersPaul M. SkoneznyGregory L. SteinThomas FranceschiniShu-Jen ChiangWendy L. AndersonLi YouZizhuo Xing
    • C12N1/20
    • C12R1/01C12P13/001
    • The present invention relates to a process for preparing (2R,3S)-1-halo-2-hydroxy-3-(protected)amino-4-substituted butane comprising contacting a mutagenized Rhodococcus erythropolis having ATCC deposit no. PTA-6648 with (3S)-1-halo-2-oxo-3-(protected)amino-4-substituted butane substrate. The present invention also relates to a process comprising mixing (2R,3S)-1-halo-2-hydroxy-3-(protected)amino-4-substituted butane with at least one base in the presence of at least one solvent to produce a reaction mixture containing (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane. The present invention further relates to a process comprising crystallizing the (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane out of the reaction mixture by concurrently adding water and the reaction mixture together. The present invention is also directed to a mutagenized Rhodococcus erythropolis having ATCC deposit no. PTA-6648.
    • 本发明涉及制备(2R,3S)-1-卤代-2-羟基-3-(被保护的)氨基-4-取代的丁烷的方法,包括将具有ATCC保藏号的诱变的红球菌红景天 (3S)-1-卤代-2-氧代-3-(保护的)氨基-4-取代的丁烷底物的PTA-6648。 本发明还涉及一种方法,其包括在至少一种溶剂的存在下将(2R,3S)-1-卤代-2-羟基-3-(保护的)氨基-4-取代的丁烷与至少一个碱混合以产生 含有(2R,3S)-1,2-环氧-3-(保护)氨基-4-取代丁烷的反应混合物。 本发明还涉及通过将水和反应混合物同时加入,使(2R,3S)-1,2-环氧-3-(被保护的)氨基-4-取代丁烷从反应混合物中结晶出来的方法。 本发明还涉及具有ATCC保藏号的诱变的红球菌红球菌。 PTA-6648。