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1. 发明申请

US20110085970A1 ANTI-B7H4 MONOCLONAL ANTIBODY-DRUG CONJUGATE AND METHODS OF USE 审中-公开
标题翻译：抗B7H4单克隆抗体药物联合使用方法
公开(公告)号：US20110085970A1
公开(公告)日：2011-04-14
申请号：US12745677
申请日：2008-11-26
申请人： Jonathan A. Terrett , Josephine M. Cardarelli , Chetana Rao-Naik , Bingliang Chen , David J. King
发明人： Jonathan A. Terrett , Josephine M. Cardarelli , Chetana Rao-Naik , Bingliang Chen , David J. King
IPC分类号： A61K51/10 , C07K16/00 , A61K39/395 , A61P35/00
CPC分类号： A61K47/6851 , A61K47/6817 , A61K47/6825
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to B7H4 with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided, immunoconjugates, including antibody-drug conjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for treating cancer.
摘要翻译：本公开提供分离的单克隆抗体，特别是以高亲和力特异性结合B7H4的人单克隆抗体。还提供了编码本公开的抗体的核酸分子，表达载体，宿主细胞和用于表达本公开的抗体的方法，还提供免疫缀合物，包括抗体 - 药物偶联物，双特异性分子和包含本公开的抗体的药物组合物。本公开还提供了治疗癌症的方法。

2. 发明申请

US20110020329A1 CONJUGATES OF ANTI-RG-1 ANTIBODIES 审中-公开
标题翻译：抗RG-1抗体的结合
公开(公告)号：US20110020329A1
公开(公告)日：2011-01-27
申请号：US12745337
申请日：2008-11-26
申请人： David J. King , Jonathan A. Terrett , Sanjeev Gangwar , Josephine M. Cardarelli , Chetana Rao-Naik , Chin Pan
发明人： David J. King , Jonathan A. Terrett , Sanjeev Gangwar , Josephine M. Cardarelli , Chetana Rao-Naik , Chin Pan
IPC分类号： A61K39/395 , C07K16/18 , C12N5/09 , A61P35/00
CPC分类号： A61K47/6869 , A61K47/6809
摘要： Anti-RG-1 antibodies, antibody fragments, or antibody mimetics conjugated to partner molecules, such as drugs, radioisotopes, and cytotoxins, wherein the partner molecule exerts its effect regardless of whether the RG-1 bound conjugate is internalized within a targeted cell, are useful for treating cancers.
摘要翻译：抗RG-1抗体，抗体片段或偶联于配偶体分子（例如药物，放射性同位素和细胞毒素）的抗体模拟物，其中配偶体分子发挥其作用，而不管RG-1结合的缀合物是否内化在靶细胞内，可用于治疗癌症。

3. 发明授权

US07619070B2 Humanized antibodies to interferon alpha receptor-1 (IFNAR-1) 有权
标题翻译：干扰素α受体-1（IFNAR-1）的人源化抗体
公开(公告)号：US07619070B2
公开(公告)日：2009-11-17
申请号：US10831459
申请日：2004-04-23
申请人： Josephine M. Cardarelli , Tseng-Hui Timothy Chen , David J. King , Christopher R. Bebbington , Sarah Lee Pogue , Francis J. Carr , Stephen Williams
发明人： Josephine M. Cardarelli , Tseng-Hui Timothy Chen , David J. King , Christopher R. Bebbington , Sarah Lee Pogue , Francis J. Carr , Stephen Williams
IPC分类号： C12P21/08
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/70 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： Humanized monoclonal antibodies which bind to IFNAR-1, and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the humanized antibodies and therapeutic and diagnostic methods for using the humanized antibodies.
摘要翻译：公开了结合IFNAR-1的人源化单克隆抗体以及相关的基于抗体的组合物和分子。还公开了包含人源化抗体和使用人源化抗体的治疗和诊断方法的药物组合物。

4. 发明申请

US20080247944A1 Irta-2 Antibodies and Their Uses 审中-公开
标题翻译： Irta-2抗体及其用途
公开(公告)号：US20080247944A1
公开(公告)日：2008-10-09
申请号：US11794606
申请日：2006-01-12
申请人： Robert Graziano , David J. King , Mohan Srinivasan , Josephine M. Cardarelli , Haichun Huang
发明人： Robert Graziano , David J. King , Mohan Srinivasan , Josephine M. Cardarelli , Haichun Huang
IPC分类号： A61K51/00 , C07K16/18 , C12N15/00 , C12P21/04 , A61P43/00 , C12N5/06 , A61K39/395
CPC分类号： C07K16/283 , C07K2317/21 , C07K2317/92 , C07K2319/30
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to IRTA-2 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting IRTA-2, as well as methods for treating various B cell malignancies, including non-Hodgkin's lymphoma.
摘要翻译：本发明提供以高亲和力特异性结合IRTA-2的分离的单克隆抗体，特别是人单克隆抗体。还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。本发明还提供了用于检测IRTA-2的方法，以及用于治疗各种B细胞恶性肿瘤（包括非霍奇金淋巴瘤）的方法。

5. 发明授权

US08025882B2 Interferon alpha antibodies and their uses 有权
标题翻译：干扰素α抗体及其用途
公开(公告)号：US08025882B2
公开(公告)日：2011-09-27
申请号：US12551250
申请日：2009-08-31
申请人： Alison J. Witte , Denise Williams , Josephine M. Cardarelli , David J. King , David B. Passmore
发明人： Alison J. Witte , Denise Williams , Josephine M. Cardarelli , David J. King , David B. Passmore
IPC分类号： A61K39/395
CPC分类号： C07K16/249 , A61K51/1021 , A61K2039/505 , C07K16/24 , C07K2317/21 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/74 , C07K2317/76
摘要： The present invention provides isolated anti-interferon alpha monoclonal antibodies, particularly human monoclonal antibodies, that inhibit the biological activity of multiple interferon (IFN) alpha subtypes but do not substantially inhibit the biological activity of IFN alpha 21 or the biological activity of either IFN beta or IFN omega. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting the biological activity of IFN alpha using the antibodies of the invention, as well as methods of treating disease or disorders mediated by IFN alpha, such as autoimmune diseases, transplant rejection and graft versus host disease, by administering the antibodies of the invention.
摘要翻译：本发明提供分离的抗干扰素α单克隆抗体，特别是人单克隆抗体，其抑制多种干扰素（IFN）α亚型的生物学活性，但基本上不抑制IFNα21的生物活性或IFNβ的生物学活性或IFNγ。还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。本发明还提供了使用本发明的抗体抑制IFNα的生物学活性的方法，以及通过施用本发明的抗体来治疗由IFNα介导的疾病或病症的方法，例如自身免疫疾病，移植排斥反应和移植物抗宿主病本发明的抗体。

6. 发明申请

US20110123440A1 Altered Antibody FC Regions and Uses Thereof 审中-公开
标题翻译：改变抗体FC区域及其用途
公开(公告)号：US20110123440A1
公开(公告)日：2011-05-26
申请号：US11887481
申请日：2006-03-28
申请人： Genevieve Hansen , Gerald Neslund , Amelia Black , Josephine M. Cardarelli , Srinivasan Mohan , David J. King
发明人： Genevieve Hansen , Gerald Neslund , Amelia Black , Josephine M. Cardarelli , Srinivasan Mohan , David J. King
IPC分类号： A61K51/10 , C07K16/00 , A61K39/395 , C12P21/00 , A61P35/00
CPC分类号： C07K14/70535 , C07K16/00 , C07K16/2878 , C07K2317/52 , C07K2317/732 , C07K2317/92 , C07K2319/02 , C07K2319/21
摘要： The present invention relates to altered antibody Fc regions and uses thereof.
摘要翻译：本发明涉及改变的抗体Fc区及其用途。

7. 发明授权

US5328154A Multi-tiered system of leveller units 失效
标题翻译：整平机单元的多层系统
公开(公告)号：US5328154A
公开(公告)日：1994-07-12
申请号：US947220
申请日：1992-09-18
申请人： Warren J. Blatz , David J. King , Gordon G. Wilson
发明人： Warren J. Blatz , David J. King , Gordon G. Wilson
IPC分类号： B66F7/24 , E02C3/00
CPC分类号： B66F7/243
摘要： A multi-tiered system of leveller units for the levelling of recreational vehicles. The leveller units each comprise a planar body, with upper and lower surfaces circumscribed by edges. The body of each unit bears a plurality of pins upwardly extending from spaced locations in the upper surface and has a plurality of pin-engaging pockets formed in the lower surface to matably receive corresponding pins of other similar units. The pins are of slightly smaller size than the corresponding pockets so that when the pins of one unit are associated with the pockets of another, there is provided a loose engagement therebetween. The body may be formed of a discontinuous webbing providing light-weight strength and support to the units to support the large loads placed thereupon.
摘要翻译：用于整修娱乐车辆的整平机的多层次系统。整平器单元各自包括平面主体，上表面和下表面被边缘包围。每个单元的主体具有从上表面中的间隔位置向上延伸的多个销，并且具有形成在下表面中的多个销接合凹坑，以可以适当地接收其它类似单元的相应销。销的尺寸比相应的袋稍小，使得当一个单元的销与另一个的袋相关联时，在它们之间提供松散的接合。主体可以由不连续的织带形成，为单元提供轻量级的强度和支撑，以支撑放置在其上的大负载。

8. 发明授权

US07498302B2 Disulfide prodrugs and linkers and stabilizers useful therefor 有权
标题翻译：用于此的二硫化物前体药物和接头和稳定剂
公开(公告)号：US07498302B2
公开(公告)日：2009-03-03
申请号：US11133970
申请日：2005-05-20
申请人： Howard P. Ng , Zhi-Hong Li , Danny P. C. McGee , Oliver L. Saunders , Guoxian Wu , David J. King , Valeri Martichonok , Sharon Elaine Boyd , Thomas J. Lobl
发明人： Howard P. Ng , Zhi-Hong Li , Danny P. C. McGee , Oliver L. Saunders , Guoxian Wu , David J. King , Valeri Martichonok , Sharon Elaine Boyd , Thomas J. Lobl
IPC分类号： A61K38/00 , C07D487/00
CPC分类号： C07D405/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D405/12 , C07D405/14 , C07D487/04 , C07D487/10 , C07F7/1804 , C07F9/6561
摘要： The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.
摘要翻译：本发明提供了作为有效的细胞毒素的杜卡霉素的类似物。还提供了在体内被切割的肽基和二硫键接头。连接体可用于形成本发明的细胞毒素的前药和缀合物以及其它诊断和治疗部分。本发明提供了杜卡霉素类似物与本发明的连接臂的前药和缀合物。

9. 发明授权

US5458315A Multi-tiered system of leveller units 失效
标题翻译：整平机单元的多层系统
公开(公告)号：US5458315A
公开(公告)日：1995-10-17
申请号：US187762
申请日：1994-01-27
申请人： Warren J. Blatz , David J. King , Gordon G. Wilson
发明人： Warren J. Blatz , David J. King , Gordon G. Wilson
IPC分类号： B66F7/24 , E02C3/00
CPC分类号： B66F7/243
摘要： A multi-tiered system of leveller units for the levelling of recreational vehicles. The leveller units each comprise a planar body, with upper and lower surfaces circumscribed by edges. The body of each unit bears a plurality of pins upwardly extending from spaced locations in the upper surface and has a plurality of pin-engaging pockets formed in the lower surface to matably receive corresponding pins of other similar units. The pins are of slightly smaller size than the corresponding pockets so that when the pins of one unit are associated with the pockets of another, there is provided a loose engagement therebetween. The body may be formed of a discontinuous webbing providing light-weight strength and support to the units to support the large loads placed thereupon.
摘要翻译：用于整修娱乐车辆的整平机的多层次系统。整平器单元各自包括平面主体，上表面和下表面被边缘包围。每个单元的主体具有从上表面中的间隔位置向上延伸的多个销，并且具有形成在下表面中的多个销接合凹坑，以可以适当地接收其它类似单元的相应销。销的尺寸比相应的袋稍小，使得当一个单元的销与另一个的袋相关联时，在它们之间提供松散的接合。主体可以由不连续的织带形成，为单元提供轻量级的强度和支撑，以支撑放置在其上的大负载。

10. 发明申请

US20110244609A1 METHOD OF FORMING CURRENT-INJECTING/TUNNELING LIGHT-EMITTING DEVICE 有权
标题翻译：形成电流注入/隧道发光装置的方法
公开(公告)号：US20110244609A1
公开(公告)日：2011-10-06
申请号：US12956640
申请日：2010-11-30
申请人： Robbie J. Jorgenson , David J. King
发明人： Robbie J. Jorgenson , David J. King
IPC分类号： H01L33/60 , H01L21/20
CPC分类号： H01L33/105 , H01L33/04 , H01L33/06 , H01L33/405 , Y10T29/5313
摘要： An apparatus and method for making same. Some embodiments include a light-emitting device having a light-emitting active region; a tunneling-barrier (TB) structure facing adjacent the active region; a TB grown-epitaxial-metal-mirror (TB-GEMM) structure facing adjacent the TB structure, wherein the TB-GEMM structure includes at least one metal is substantially lattice matched to the active region; and a conductivity-type III-nitride crystal structure adjacent facing the active region opposite the TB structure. In some embodiments, the active region includes an MQW structure. In some embodiments, the TB-GEMM includes an alloy composition such that metal current injectors have a Fermi energy potential substantially equal to the sub-band minimum energy potential of the MQW. Some embodiments further include a second mirror (optionally a GEMM) to form an optical cavity between the second mirror and the TB-GEMM structure. In some embodiments, at least one of the GEMM is deposited on, and lattice matched to, a substrate.
摘要翻译：一种用于制造它的装置和方法。一些实施例包括具有发光有源区的发光器件; 面向邻近有源区的隧道势垒（TB）结构; 面向TB结构的TB生长外延金属镜（TB-GEMM）结构，其中TB-GEMM结构包括至少一种金属与活性区基本上晶格匹配; 以及与TB结构相对的有源区域相邻的导电型III族氮化物晶体结构。在一些实施例中，活动区域包括MQW结构。在一些实施方案中，TB-GEMM包括合金组合物，使得金属电流注入器具有基本上等于MQW的子带最小能量势的费米能量势。一些实施例还包括在第二反射镜和TB-GEMM结构之间形成光腔的第二反射镜（可选地为GEMM）。在一些实施例中，GEMM中的至少一个沉积在衬底上，并且与衬底晶格匹配。

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