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1. 发明申请

US20050282908A1 Substituted aminopropoxyaryl derivatives useful as agonists for LXR 审中-公开
标题翻译：可用作LXR激动剂的取代的氨基丙氧基芳基衍生物
公开(公告)号：US20050282908A1
公开(公告)日：2005-12-22
申请号：US11154852
申请日：2005-06-16
申请人： Jon Collins , Adam Fivush , Patrick Maloney , Eugene Stewart , Timothy Willson
发明人： Jon Collins , Adam Fivush , Patrick Maloney , Eugene Stewart , Timothy Willson
IPC分类号： C07D233/64 , A61K31/165 , A61K31/192 , A61K31/216 , A61K31/277 , A61K31/341 , A61K31/343 , A61K31/351 , A61K31/357 , A61K31/36 , A61K31/381 , A61K31/40 , A61K31/4045 , A61K31/415 , A61K31/417 , A61K31/4184 , A61K31/42 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4409 , A61K31/4468 , A61K31/513 , A61K45/00 , A61P3/06 , A61P9/00 , A61P9/10 , A61P43/00 , C07C217/22 , C07C217/58 , C07C235/34 , C07C235/46 , C07C255/58 , C07C317/32 , C07C323/32 , C07D207/09 , C07D209/14 , C07D211/58 , C07D213/36 , C07D213/38 , C07D213/74 , C07D213/78 , C07D213/82 , C07D231/16 , C07D233/54 , C07D235/10 , C07D235/14 , C07D235/16 , C07D235/26 , C07D239/52 , C07D261/08 , C07D277/28 , C07D307/52 , C07D307/79 , C07D307/81 , C07D309/20 , C07D317/58 , C07D317/62 , C07D317/64 , C07D319/18 , C07D333/20 , C07C233/62
CPC分类号： C07D213/82 , C07C217/22 , C07C217/58 , C07C235/34 , C07C235/46 , C07C2601/02 , C07C2601/14 , C07C2601/16 , C07C2602/42 , C07D207/09 , C07D209/14 , C07D211/58 , C07D213/38 , C07D231/16 , C07D233/64 , C07D235/14 , C07D235/16 , C07D239/52 , C07D261/08 , C07D277/28 , C07D307/52 , C07D307/79 , C07D307/81 , C07D309/20 , C07D317/58 , C07D317/62 , C07D317/64 , C07D319/18 , C07D333/20
摘要： The invention relates to a compound of formula (I), wherein all variables are as defined herein, and pharmaceutically acceptable salts or solvates thereof. The compounds of formula (I) are useful as LXR agonists.
摘要翻译：本发明涉及式（I）化合物，其中所有变量如本文所定义，及其药学上可接受的盐或溶剂化物。式（I）化合物可用作LXR激动剂。

2. 发明申请

US20060258725A1 Farnesoid x receptor agonists 失效
标题翻译：法呢糖x受体激动剂
公开(公告)号：US20060258725A1
公开(公告)日：2006-11-16
申请号：US10535228
申请日：2003-11-12
申请人： Sharon Boggs , Jon Collins , Stephen Hyatt , Patrick Maloney
发明人： Sharon Boggs , Jon Collins , Stephen Hyatt , Patrick Maloney
IPC分类号： A61K31/42 , C07D261/06
CPC分类号： C07D261/08 , C07D413/12 , C07D417/12
摘要： The invention relates to a compound of formula (I): wherein all variables are as defined herein and to pharmaceutical compositions, methods of using, and processes for preparing the same.
摘要翻译：本发明涉及式（I）化合物：其中所有变量如本文所定义，以及药物组合物，使用方法及其制备方法。

3. 发明授权

US5175791A Fragrance diffuser having stepped power levels 失效
标题翻译：具有步进功率水平的FRAGRANCE DIFFUSER
公开(公告)号：US5175791A
公开(公告)日：1992-12-29
申请号：US598421
申请日：1990-10-16
申请人： Kenneth J. Muderlak , Patrick Maloney , Tsung-Ying Hsieh
发明人： Kenneth J. Muderlak , Patrick Maloney , Tsung-Ying Hsieh
IPC分类号： A61L9/03 , H05B1/02
CPC分类号： H05B1/0225 , A61L9/03 , Y10S261/89
摘要： A fragrance diffuser (100) comprises a housing defining a chamber (116) for holding a fragrance-emitting block (110), a heating element (112) located within the housing, a timing and indicating circuit board (114) to signal when the predicted life of the fragrance emitting block has expired, a power supply connection plug (134) for providing electrical power to the heating element and the timing and indicating board, and a keying system (234, 236, 238) incorporated in the chamber (116) and on the fragrance-emitting blocks (110). The blocks are encoded or keyed to indicate that they possess particular predefined characteristics, such that only blocks having those characteristics may be inserted. The diffuser is constructed with a downwardly-projecting housing extension (132) for the power supply connection to allow the use of an adjacent electric power outlet when the diffuser is properly installed. The diffuser also includes an indicator LED (156) to indicate when a timing interval, corresponding to the life of a fragrance block inserted therein, has expired, wherein the timing interval is reset by a switch (182) only at the request of a user. Various circuit embodiments are disclosed for increasing the power applied to the heating element over time, since the aroma strength of a fragrance block decreases over time.
摘要翻译：香味扩散器（100）包括壳体，其限定用于保持香料发射块（110）的腔室（116），位于壳体内的加热元件（112），定时和指示电路板（114）香味发射块的预期寿命已经过期，用于向加热元件和定时和指示板提供电力的电源连接插头（134）以及结合在腔室（116）中的键控系统（234,236,238））和在香料发射块（110）上。块被编码或键入以指示它们具有特定的预定义特性，使得只有具有这些特征的块可以被插入。扩散器构造有用于电源连接的向下突出的壳体延伸部（132），以在扩散器正确安装时允许使用相邻的电力出口。扩散器还包括指示器LED（156），用于指示与插入其中的香料块的寿命相对应的定时间隔是否已经期满，其中仅通过用户的请求，定时间隔由开关（182）重置。公开了各种电路实施例，用于随时间增加施加到加热元件的功率，因为香料块的香气强度随时间而减小。

4. 发明申请

US20060173681A1 Semi-covert emergency transmitter 审中-公开
标题翻译：半隐式应急发射机
公开(公告)号：US20060173681A1
公开(公告)日：2006-08-03
申请号：US11047935
申请日：2005-02-01
申请人： F. Koch , Patrick Maloney , Jon Ciemiewicz
发明人： F. Koch , Patrick Maloney , Jon Ciemiewicz
IPC分类号： G10L17/00
CPC分类号： G10L17/00
摘要： A semi-covert emergency transmission device and methodology for soldiers and other such personnel requiring pick-up or rescue is disclosed. The device has a flashlight mode and a transmit mode. In flashlight mode, an LED is turned on to provide an illumination source that can be used in numerous applications. In transmit mode, the device uses the same LED to transmit a coded message that includes information relevant to the user. The coded message can be preprogrammed and stored in the device, or translated in real-time. The transmit mode is further configured so as to confirm that the intended user is the one requesting the transmission of the coded message. The light emitted from the LED can be seen for up to a mile or so away by friendly forces or other potential rescuers.
摘要翻译：披露了一个半秘密的应急传输装置和方法，为士兵和其他需要接载或救援的人员提供了方法。该设备具有手电筒模式和发送模式。在手电筒模式下，LED被打开以提供可用于许多应用的照明源。在发送模式下，设备使用相同的LED来发送包含与用户相关的信息的编码消息。编码的消息可以被预编程并存储在设备中，或者被实时地翻译。进一步配置发送模式，以确认预期用户是请求发送编码消息的用户。从LED发出的光可以通过友军或其他潜在的救援人员看到一英里以上的距离。

5. 发明授权

US5111477A Fragrance diffuser 失效
标题翻译：香味散发器
公开(公告)号：US5111477A
公开(公告)日：1992-05-05
申请号：US521981
申请日：1990-05-07
申请人： Ken Muderlak , Patrick Maloney
发明人： Ken Muderlak , Patrick Maloney
IPC分类号： A61L9/03 , H05B1/02
CPC分类号： H05B1/0225 , A61L9/03
摘要： A fragrance diffuser (100) comprises a housing defining a chamber (116) for holding a fragrance-emitting block (110), a heating element (112) located within the housing, a timing and indicating circuit board (114) to signal when the predicted life of the fragrance emitting block has expired, a power supply connection plug (134) for providing electrical power to the heating element and the timing and indicating board, and a keying system (234, 236, 238) incorporated in the chamber (116) and on the fragrance-emitting blocks (110). The blocks are encoded or keyed to indicate that they possess particular predefined characteristics, such that only blocks having those characteristics may be inserted. The diffuser is constructed with a downwardly-projecting housing extension (132) for the power supply connection to allow the use of an adjacent electric power outlet when the diffuser is properly installed. The diffuser also includes an indicator LED (156) to indicate when a timing interval, corresponding to the life of a fragrance block inserted therein, has expired, wherein the timing interval is reset by a switch (182) only at the request of a user.
摘要翻译：香味扩散器（100）包括壳体，其限定用于保持香料发射块（110）的腔室（116），位于壳体内的加热元件（112），定时和指示电路板（114）香味发射块的预期寿命已经过期，用于向加热元件和定时和指示板提供电力的电源连接插头（134）以及结合在腔室（116）中的键控系统（234,236,238））和在香料发射块（110）上。块被编码或键入以指示它们具有特定的预定义特性，使得只有具有这些特征的块可以被插入。扩散器构造有用于电源连接的向下突出的壳体延伸部（132），以在扩散器正确安装时允许使用相邻的电力出口。扩散器还包括指示器LED（156），用于指示与插入其中的香料块的寿命相对应的定时间隔是否已经期满，其中仅通过用户的请求，定时间隔由开关（182）重置。

6. 发明申请

US20090325276A1 INTEGRATED MICROFLUIDIC ASSAY DEVICES AND METHODS 审中-公开
标题翻译：综合微流感测定装置及方法
公开(公告)号：US20090325276A1
公开(公告)日：2009-12-31
申请号：US12411020
申请日：2009-03-25
申请人： C. Frederick Battrell , John Gerdes , Wayne L. Breidford , Jason Capodanno , Stephen Mordue , John Clemmens , Denise Maxine Hoekstra , Christy A. Lancaster , John R. Williford , Patrick Maloney , Joan Haab
发明人： C. Frederick Battrell , John Gerdes , Wayne L. Breidford , Jason Capodanno , Stephen Mordue , John Clemmens , Denise Maxine Hoekstra , Christy A. Lancaster , John R. Williford , Patrick Maloney , Joan Haab
IPC分类号： C12M1/00
CPC分类号： G01N33/5302 , B01F11/0071 , B01F13/0059 , B01L3/502715 , B01L7/52 , B01L2300/0636 , B01L2300/069 , B01L2300/0816 , B01L2300/0864 , B01L2400/0481 , B01L2400/0487 , B01L2400/0638 , Y02A50/58
摘要： Combinations of microfluidic diagnostic testing modules for simultaneous evaluations of serological and molecular biological targets are provided, and include panel testing for both antibodies (or antigens) and nucleic acid targets in one single-use device. These improvements are directed to evaluating the overall progress and activity of a pathogenic process in real time, at the point of care, not merely the presence or absence of a particular diagnostic marker, which can often be incomplete or misleading.
摘要翻译：提供了用于同时评估血清学和分子生物学靶标的微流体诊断测试模块的组合，并且包括在一次性使用的装置中对抗体（或抗原）和核酸靶标进行面板测试。这些改进旨在评估致病过程的总体进展和活动，而不仅仅是特定诊断标记的存在或不存在，这通常是不完整的或具有误导性的。

7. 发明授权

US06317047B1 Firefighter's safety device 有权
标题翻译：消防员的安全装置
公开(公告)号：US06317047B1
公开(公告)日：2001-11-13
申请号：US09561543
申请日：2000-04-28
申请人： Michael Stein , Patrick Maloney
发明人： Michael Stein , Patrick Maloney
IPC分类号： G08B2300
CPC分类号： A62B99/00 , G08B7/06
摘要： A fire fighter's safety device, comprising a hollow body having a sidewall, a top end and a bottom end and an arm connected to the body and extending parallel to the sidewall. There is a light source disposed at one of the top and bottom ends and an audible signal disposed within the body. There is a heat sensor connected to the body for sensing the temperature in the surrounding area, and a power source disposed with the hollow body and connected to the light source, audible signal and heat sensor. The device keeps a door open when the arm is inserted between a door and a door frame to rest on a door hinge and the audible signal and light indicate the exit during a fire.
摘要翻译：一种消防员的安全装置，包括具有侧壁，顶端和底端的中空主体和连接到主体并平行于侧壁延伸的臂。存在设置在顶端和底端之一处的光源和设置在身体内的可听信号。连接有身体的热传感器用于感测周围的温度，以及设置有中空体并连接到光源，可听信号和热传感器的电源。当手臂插入门和门框之间时，该装置保持门打开，以便搁置在门铰链上，并且可听见的信号和灯在火灾期间指示出口。

8. 发明申请

US20060180830A1 Resonant cavity enhanced multi-quantum well light modulator and detector 有权
标题翻译：谐振腔增强型多量子阱光调制器和检测器
公开(公告)号：US20060180830A1
公开(公告)日：2006-08-17
申请号：US11060191
申请日：2005-02-17
申请人： Kambiz Alavi , Joseph Pellegrino , Patrick Maloney , F. Koch
发明人： Kambiz Alavi , Joseph Pellegrino , Patrick Maloney , F. Koch
IPC分类号： H01L31/109
CPC分类号： H01L31/035236 , B82Y20/00 , G02F1/017 , G02F1/01708 , G02F2001/213 , G02F2202/102 , G02F2203/15 , H01L31/03046 , Y02E10/544
摘要： Multi-quantum well (MQW) spatial light modulator devices are disclosed that are capable of achieving reasonable quantum efficiencies and high contrast ratios in order to close an optical communication link by resolving the logical on or off state. The device both modulates and detects light through the use of the quantum well design and resonant cavity enhancement. Based on the materials (e.g., InGaAs/InAlAs) and their band structures, this device can be configured to communicate in the eye-safe wavelength range (e.g., 1550±20 nm). The device can be fabricated using standard photolithographic processes such as molecular beam epitaxy (MBE) and inductively coupled plasma (ICP) reactive ion etching (RIE).
摘要翻译：公开了能够实现合理的量子效率和高对比度的多量子阱（MQW）空间光调制器装置，以通过解决逻辑开启或关闭状态来闭合光通信链路。该器件通过使用量子阱设计和谐振腔增强来调制和检测光。基于材料（例如，InGaAs / InAlAs）及其带结构，该器件可以被配置为在眼睛安全的波长范围（例如1550±20nm）内进行通信。可以使用诸如分子束外延（MBE）和电感耦合等离子体（ICP）反应离子蚀刻（RIE）的标准光刻工艺来制造器件。

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