会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 10. 发明申请
    • PROCESS FOR REDUCTIVE AMINATION OF ALIPHATIC CYANOALDEHYDES TO ALIPHATIC DIAMINES
    • 脂肪族二胺的还原胺化方法
    • US20120116124A1
    • 2012-05-10
    • US13383596
    • 2010-07-30
    • Erich J. MolitorErich J. MolitorDaniel A. HickmanShawn D. FeistDavid C. MolzahnStacie SanthanyAbraham d. Schuitman
    • Erich J. MolitorErich J. MolitorDaniel A. HickmanShawn D. FeistDavid C. MolzahnStacie SanthanyAbraham d. Schuitman
    • C07C209/48C07C211/18
    • C07C209/48C07C2601/14C07C211/18
    • The instant invention provides a process for reductive amination of aliphatic cyanoaldehydes to aliphatic diamines, and aliphatic diamines produced via such method. The process for reductive amination of aliphatic cyanoaldehydes to aliphatic diamines comprises the steps of: (1) providing a mixture of one or more cycloaliphatic cyanoaldehydes, optionally water, and optionally one or more solvents, wherein said one or more cycloaliphatic cyanoaldehydes are selected from the group consisting of 1,3-cyanocyclohexane carboxaldehyde, 1,4-cyanocyclohexane carboxaldehyde, mixtures thereof, and combinations thereof; (2) contacting said mixture with a metal carbonate based solid bed or a weak base anion exchange resin bed at a temperature in the range of 15 to 40° C. for a period of at least 1 minute or more, for example 5 minutes or more; (3) thereby treating said mixture, wherein said treated mixture has a pH in the range of 6 to 9; (4) feeding said treated mixture, hydrogen, and ammonia into a continuous reductive amination reactor system; (6) contacting said treated mixture, hydrogen, and ammonia with each other in the presence of one or more heterogeneous metal based catalyst systems at a temperature in the range of from 80° C. to about 160° C. and a pressure in the range of from 700 to 3500 psig; (7) thereby producing one or more cycloaliphatic diamines, wherein said one or more cycloaliphatic diamines are diamines selected from the group consisting of 1,3-bis(aminomethyl)cyclohexane, 1,4-bis(aminomethyl)cyclohexane, combinations thereof, and mixtures thereof.
    • 本发明提供了脂肪族氰醛还原胺化成脂肪族二胺的方法,以及通过这种方法制备的脂肪族二胺。 将脂族氰醛还原胺化成脂族二胺的方法包括以下步骤:(1)提供一种或多种脂环族氰醛,任选的水和任选的一种或多种溶剂的混合物,其中所述一种或多种脂环族氰醛选自 由1,3-氰基环己烷甲醛,1,4-氰基环己烷甲醛,其混合物及其组合组成的组; (2)使所述混合物与金属碳酸盐基固体床或弱碱性阴离子交换树脂床在15至40℃的温度下接触至少1分钟或更长的时间,例如5分钟,或 更多; (3),从而处理所述混合物,其中所述处理的混合物的pH在6至9的范围内; (4)将所述处理的混合物,氢气和氨进料到连续还原胺化反应器系统中; (6)在一种或多种非均相金属基催化剂体系的存在下,在80℃至约160℃的温度范围内使所述经处理的混合物,氢气和氨彼此接触,并且在 范围从700至3500psig; (7),从而产生一种或多种脂环族二胺,其中所述一种或多种脂环族二胺是选自1,3-双(氨基甲基)环己烷,1,4-双(氨基甲基)环己烷及其组合的二胺和 其混合物。