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1. 发明授权

US07214659B2 Reduction of the electrocardiographic QT interval 有权
标题翻译：降低心电图QT间期
公开(公告)号：US07214659B2
公开(公告)日：2007-05-08
申请号：US10380301
申请日：2001-09-12
申请人： John Wahren , Bo-Lennart Johansson , Joseph Bianchine
发明人： John Wahren , Bo-Lennart Johansson , Joseph Bianchine
IPC分类号： A61K38/00
CPC分类号： A61K38/28
摘要： The present invention relates to the use of proinsulin C-peptide or a variant, derivative or fragment thereof in the manufacture of a medicament for reducing the OTc interval and the use of proinsulin C-peptide or a variant, derivative or fragment thereof in the manufacture of a medicament for reducing the risk of sudden death or ‘dead in bed’ syndrome; particularly in patients suffering from IDDM.
摘要翻译：本发明涉及胰岛素原C肽或其变体，衍生物或片段在制备用于减少OTc间期的药物中的用途，以及在制造中使用胰岛素原C肽或其变体，衍生物或片段用于降低猝死或“死于床”综合征的风险的药物; 特别是患有IDDM的患者。

2. 发明授权

US06610649B2 Insulin C-peptides 失效
标题翻译：胰岛素C肽
公开(公告)号：US06610649B2
公开(公告)日：2003-08-26
申请号：US09269439
申请日：1999-07-08
申请人： John Wahren , Bo-Lennart Johansson , Hans Jörnvall
发明人： John Wahren , Bo-Lennart Johansson , Hans Jörnvall
IPC分类号： A61K3816
CPC分类号： C07K14/62 , A61K38/00
摘要： The invention features peptides that are fragments of the human insulin C-peptide, which peptides include the sequence ELGGGPGAG or a fragment thereof, or the sequence EGSLQ or a fragment thereof. The peptides have the ability to stimulate Na+K+ATPase activity. Also provided are biomimetic organic compounds exhibiting activation of Na+K+ATPase activity and/or cellular binding to renal tubule cells and fibroblasts. Such peptides and compounds are useful in combating diabetes and diabetic complications, or for stimulating Na+K+ATPase activity.
摘要翻译：本发明具有作为人胰岛素C肽的片段的肽，该肽包括序列ELGGGPGAG或其片段，或序列EGSLQ或其片段。肽具有刺激Na + K + ATP酶活性的能力。还提供了表现出Na + K + ATP酶活性和/或细胞与肾小管细胞和成纤维细胞结合的活化的仿生有机化合物。这样的肽和化合物可用于治疗糖尿病和糖尿病并发症，或用于刺激Na + K + ATP酶活性。

3. 发明授权

US08895710B2 Chromatography ligand 有权
标题翻译：色谱配体
公开(公告)号：US08895710B2
公开(公告)日：2014-11-25
申请号：US12984132
申请日：2011-01-04
申请人： Carina Engstrand , Annika Forss , Gunnar Glad , Bo-Lennart Johansson , Hans J. Johansson , Jean-Luc Maloisel
发明人： Carina Engstrand , Annika Forss , Gunnar Glad , Bo-Lennart Johansson , Hans J. Johansson , Jean-Luc Maloisel
IPC分类号： C07K1/14 , B01D15/36 , B01D15/38 , B01J20/286 , B01J41/20 , B01J20/32 , B01D15/32 , C07K16/06 , C07K1/36
CPC分类号： B01D15/3828 , B01D15/327 , B01D15/363 , B01D15/3804 , B01D15/3809 , B01D15/3847 , B01J20/286 , B01J20/3253 , B01J20/3285 , B01J41/20 , C07K1/165 , C07K1/36 , C07K16/00 , C07K16/065
摘要： The present invention relates to a chromatography ligand defined by the following formula R1—R2—N(R3)—R4—R5 wherein R1 is a substituted or non-substituted phenyl group; R2 is a hydrocarbon chain comprising 0-4 carbon atoms; R3 is a hydrocarbon chain comprising 1-3 carbon atoms; R4 is a hydrocarbon chain comprising 1-5 carbon atoms; and R5 is OH or H. The invention also comprises a separation matrix, comprising the described ligands coupled to a porous support, such as particles or a membrane. The ligand and matrix according to the invention is useful for purification of biomolecules or organic compounds, such as proteins, polypeptides, DNA etc. An advantageous use according to the invention is the purification of antibodies.
摘要翻译：本发明涉及由下式R1-R2-N（R3）-R4-R5定义的色谱配体，其中R1是取代或未取代的苯基; R2是包含0-4个碳原子的烃链; R3是包含1-3个碳原子的烃链; R4是包含1-5个碳原子的烃链; 并且R 5是OH或H.本发明还包括分离基质，其包含与多孔载体如颗粒或膜耦合的所述配体。根据本发明的配体和基质可用于纯化生物分子或有机化合物，例如蛋白质，多肽，DNA等。根据本发明的有利用途是抗体的纯化。

4. 发明申请

US20130244229A1 BUFFERING COMPOSITIONS ENCLOSED IN A SIZE EXCLUSION MATRIX 审中-公开
标题翻译：缓冲组合物在一个尺寸排除矩阵中
公开(公告)号：US20130244229A1
公开(公告)日：2013-09-19
申请号：US13990765
申请日：2011-11-29
申请人： Jan Bergstrom , Bo-Lennart Johansson
发明人： Jan Bergstrom , Bo-Lennart Johansson
IPC分类号： G01N1/28
CPC分类号： G01N1/28 , B01J20/28009 , B01J20/286 , B01J20/3208 , B01J20/3217 , B01J20/327 , B01J20/3274 , B01J20/3285 , B01J20/3293 , Y10T436/2525
摘要： The present invention relates to a buffering composition, more closely a composition comprising porous matrix-enclosed buffering agent(s) giving a stabilisation of pH when applied in for example aqueous environment.The composition comprises buffering agent(s) enclosed in a first porous matrix with an impenetrability corresponding to a fractionation range for globular proteins and peptides of
摘要翻译：本发明涉及一种缓冲组合物，更接近地包含当在例如水性环境中施用时提供pH稳定化的多孔基质封闭的缓冲剂的组合物。组合物包含封闭在第一多孔基质中的缓冲剂，其不透性对应于球状蛋白和肽的分数范围<10000g / mol，优选<5000g / mol，更优选<700g / mol。

5. 发明申请

US20110155668A1 SEPARATION MEDIUM FOR CHROMATOGRAPHY OF VARIOUS BIOMOLECULES 审中-公开
标题翻译：分离介质用于各种生物分子的色谱分析
公开(公告)号：US20110155668A1
公开(公告)日：2011-06-30
申请号：US13002878
申请日：2009-06-04
申请人： Gunnar Glad , Bo-Lennart Johansson , Jean-Luc Maloisel , Nils Norrman
发明人： Gunnar Glad , Bo-Lennart Johansson , Jean-Luc Maloisel , Nils Norrman
IPC分类号： B01D15/36 , B01J20/22 , B01J20/26 , B01J20/24
CPC分类号： B01D15/3828 , B01D15/166 , B01D15/36 , B01J20/28092 , B01J20/285 , B01J20/286 , B01J20/3242 , B01J20/3293 , C07K1/16 , C07K1/22 , C07K16/00
摘要： The present invention relates to a separation medium, comprising an inner core of a porous material provided with charged ligands, and an outer lid comprising a porous material provided with charged ligands, wherein the charge of the ligands in the inner core is opposite that of the charge of the ligands in the lid. The present invention also relates to a method for biomolecule separation comprising applying a sample to the above separation medium, wherein large molecules are prevented from entering the medium by charge repulsion from the medium and small molecules are captured in the inner core.
摘要翻译：本发明涉及一种分离介质，其包括具有带电配位体的多孔材料的内核和包含带有带电配位体的多孔材料的外盖，其中内芯中配体的电荷与盖中配体的电荷。本发明还涉及一种用于生物分子分离的方法，包括将样品施加到上述分离介质中，其中通过从介质的电荷排斥来防止大分子进入介质，并且小分子被捕获在内核中。

6. 发明申请

US20100009867A1 MULTI-MODAL ION EXCHANGE CHROMATOGRAPHY RESINS 失效
标题翻译：多模式离子交换色谱树脂
公开(公告)号：US20100009867A1
公开(公告)日：2010-01-14
申请号：US12517570
申请日：2008-01-10
申请人： Enrique Carredano , Bo-Lennart Johansson , Jean-Luc Maloisel
发明人： Enrique Carredano , Bo-Lennart Johansson , Jean-Luc Maloisel
IPC分类号： C40B30/04 , C40B50/14 , C40B40/14
CPC分类号： C40B30/04 , B01D15/1885 , B01D15/361 , B01D15/362 , B01D15/363 , B01D15/3847 , B01J20/3285 , B01J39/26 , B01J41/20 , B01J2220/54 , C40B40/14 , C40B50/00 , G01N30/466 , G01N30/96
摘要： The present invention relates to a method of preparing a library of resins which are useful in chromatography, which method comprises creating a diversity of multi-modal ion exchange resins; and providing the diversity in a parallel system in which each resin is presented separated from the other resin(s).
摘要翻译：本发明涉及一种制备可用于色谱法的树脂文件库的方法，该方法包括产生多种多模式离子交换树脂; 并且在与其它树脂分离出每种树脂的并行系统中提供多样性。

7. 发明申请

US20070196858A1 Separation Matrix And Method Of Purification 有权
标题翻译：分离矩阵和纯化方法
公开(公告)号：US20070196858A1
公开(公告)日：2007-08-23
申请号：US11570530
申请日：2005-06-22
申请人： Gunnar Glad , Bo-Lennart Johansson , Jean-Luc Maloisel , Nils Norrman
发明人： Gunnar Glad , Bo-Lennart Johansson , Jean-Luc Maloisel , Nils Norrman
IPC分类号： G01N33/53 , C08G63/91 , C07K16/18
CPC分类号： B01J20/3212 , B01D15/426 , B01J20/286 , B01J20/289 , B01J20/3219 , B01J20/3251
摘要： The present invention relates to a separation matrix comprised of a porous support to which ligands have been immobilised, wherein said ligands comprise at least one sulphonamide and the R group of the sulphonyl comprises an aromatic group. The nitrogen of the sulphonamide may be a secondary or tertiary amine. The invention also relates to a chromatography column that contains the described separation matrix, as well as to a method of isolating immunoglobulin-like compounds by adsorption to the separation matrix.
摘要翻译：本发明涉及由已经固定有配体的多孔载体组成的分离基质，其中所述配体包含至少一个磺酰胺，并且磺酰基的R基包括芳族基团。磺酰胺的氮可以是仲胺或叔胺。本发明还涉及含有所述分离基质的色谱柱，以及通过吸附到分离基质上分离免疫球蛋白样化合物的方法。

8. 发明申请

US20070151928A1 Purification of immunoglobulins 审中-公开
标题翻译：免疫球蛋白的纯化
公开(公告)号：US20070151928A1
公开(公告)日：2007-07-05
申请号：US10584714
申请日：2004-12-21
申请人： Grunnar Glad , Bo-Lennart Johansson , Jean-Luc Maloisel , Nils Norrman
发明人： Grunnar Glad , Bo-Lennart Johansson , Jean-Luc Maloisel , Nils Norrman
IPC分类号： B01D15/08
CPC分类号： B01J20/262 , B01J20/267 , B01J20/28019 , B01J20/28023 , B01J20/28033 , B01J20/28042 , B01J20/286 , B01J20/289 , B01J20/3092 , B01J20/3208 , B01J20/3212 , B01J20/3219 , B01J20/3246 , B01J20/3248 , B01J20/3251 , B01J20/3255 , B01J20/3272 , B01J20/3285 , B01J2220/54 , B01J2220/58 , C07K16/065 , Y10T428/249963
摘要： The present invention relates to a separation matrix comprised of a porous support to which ligands have been immobilised, wherein said ligands comprise at least one aliphatic sulphonamide. The nitrogen of the sulphonamide may be a secondary or tertiary amine. The invention also relates to a chromatography column that contains the described separation matrix, as well as to a method of isolating immunoglobulin-like compounds by adsorption to a separation matrix that comprises aliphatic sulphonamide ligands.
摘要翻译：本发明涉及由已经固定有配体的多孔载体组成的分离基质，其中所述配体包含至少一种脂族磺酰胺。磺酰胺的氮可以是仲胺或叔胺。本发明还涉及含有所述分离基质的色谱柱，以及通过吸附到包含脂族磺酰胺配体的分离基质上分离免疫球蛋白样化合物的方法。

9. 发明授权

US07214321B2 Adsorption method and ligands 有权
标题翻译：吸附法和配体
公开(公告)号：US07214321B2
公开(公告)日：2007-05-08
申请号：US10312054
申请日：2001-07-16
申请人： Makonnen Belew , Bo-Lennart Johansson , Jean-Luc Maloisel
发明人： Makonnen Belew , Bo-Lennart Johansson , Jean-Luc Maloisel
IPC分类号： B01D15/04
CPC分类号： B01J20/3285 , B01J39/04 , B01J39/18
摘要： The invention relates to a method for removing a positively charged substance from an aqueous liquid (I) by contacting the liquid with a cation-exchanger (1), possibly followed by a subsequent desorption of said substance. The cation-exchanger is selected to be capable of (a) binding to said substance by cation-exchange in an aqueous liquid reference (II) at an ionic strength corresponding to 0.3 M NaCl and (b) permitting a break through capacity for said substance 3200%, such as 3300% or 3500%, of the break-through capacity of said substance for a reference cation-exchanger (2) containing sulphopropyl groups —CH2CH2CH2SO2O—. The cation exchange ligands have an at least bimodal function by comprising a cation exchanging group and a separate hydrogen-bonding atom. The invention also relates to a method for testing the appropriateness of a cation-exchanger for removing a substance from a liquid and novel cation exchangers.
摘要翻译：本发明涉及通过使液体与阳离子交换剂（1）接触，从而可以随后随后解吸所述物质从水性液体（I）中除去带正电荷的物质的方法。阳离子交换剂被选择为能够（a）在水性液体参考物（II）中以对应于0.3M NaCl的离子强度的阳离子交换结合所述物质，和（b）允许所述物质的破裂能力例如300％或3％以上500％以上的所述物质用于参考阳离子交换器的穿透能力的200％（2）含有磺基丙基-CH 2 CH 2 CH 2 SO 2 O-。阳离子交换配体通过包含阳离子交换基团和单独的氢键原子具有至少双峰功能。本发明还涉及一种用于测试用于从液体和新型阳离子交换剂中除去物质的阳离子交换器的适当性的方法。

10. 发明授权

US10562007B2 Separation matrix 有权
公开(公告)号：US10562007B2
公开(公告)日：2020-02-18
申请号：US12667873
申请日：2008-07-22
申请人： Andreas Axen , Jan Bergstrom , Gunnar Glad , Bo-Lennart Johansson , Nils Norrman
发明人： Andreas Axen , Jan Bergstrom , Gunnar Glad , Bo-Lennart Johansson , Nils Norrman
IPC分类号： B01D15/36 , B01J20/289 , B01J20/32
摘要： The present invention relates to a separation matrix, which comprises a support; extenders coupled to an outer part of said support; and ligands coupled to said extenders, wherein the part of the support to which the extenders are coupled constitutes less than 50% of the volume of the separation matrix. The invention also embraces a method of preparing such a separation matrix, as well as a process wherein the separation media is used.

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