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    • 1. 发明申请
    • TUNABLE MICROSTRIP TRANSMISSION PATH IN A HARD DISK DRIVE
    • 硬盘驱动器中的微处理器传输路径
    • US20110149443A1
    • 2011-06-23
    • US12646612
    • 2009-12-23
    • John T. CONTRERASLuiz Franca-NetoStephen Williams
    • John T. CONTRERASLuiz Franca-NetoStephen Williams
    • G11B5/48H01R43/00
    • G11B5/486G11B5/484Y10T29/49169
    • A disk pack, comprising at least one hard disk, is rotatably mounted to a housing. The disk pack defines an axis of rotation and a radial direction relative to the axis. At least one actuator mounted to the housing is coupled with a suspension and is movable relative to the disk pack. A slider, comprising a slider body and a head configured to read data from and write data to at least one hard disk, is coupled with the suspension. A first suspension electrical interconnect is configured to electrically couple a first signal conducting pathway with the slider and with a first non-terminated signal pathway. A second suspension electrical interconnect is configured to electrically couple a second signal conducting pathway with the slider and with a second non-terminated signal pathway. The length of the second non-terminated signal pathway is selected to achieve a desired impedance level.
    • 包括至少一个硬盘的盘组件可旋转地安装到壳体。 磁盘盒定义了一个旋转轴线和一个相对于轴线的径向方向。 安装到壳体的至少一个致动器与悬架联接并且可相对于盘组件移动。 包括滑块体和被配置为从至少一个硬盘读取数据并将数据写入至少一个硬盘的磁头的滑块与该悬架联接。 第一悬挂电互连被配置为将第一信号传导路径与滑块电耦合并具有第一非终端信号路径。 第二悬挂电互连被配置为将第二信号传导路径与滑块电连接,并且具有第二非终止信号路径。 选择第二非终止信号路径的长度以实现期望的阻抗水平。
    • 2. 发明授权
    • Tunable microstrip signal transmission path in a hard disk drive
    • 可调式微带信号传输路径在硬盘驱动器
    • US08305712B2
    • 2012-11-06
    • US12646612
    • 2009-12-23
    • John T. ContrerasLuiz Franca-NetoStephen Williams
    • John T. ContrerasLuiz Franca-NetoStephen Williams
    • G11B5/55
    • G11B5/486G11B5/484Y10T29/49169
    • A disk pack, comprising at least one hard disk, is rotatably mounted to a housing. The disk pack defines an axis of rotation and a radial direction relative to the axis. At least one actuator mounted to the housing is coupled with a suspension and is movable relative to the disk pack. A slider, comprising a slider body and a head configured to read data from and write data to at least one hard disk, is coupled with the suspension. A first suspension electrical interconnect is configured to electrically couple a first signal conducting pathway with the slider and with a first non-terminated signal pathway. A second suspension electrical interconnect is configured to electrically couple a second signal conducting pathway with the slider and with a second non-terminated signal pathway. The length of the second non-terminated signal pathway is selected to achieve a desired impedance level.
    • 包括至少一个硬盘的盘组件可旋转地安装到壳体。 磁盘盒定义了一个旋转轴线和一个相对于轴线的径向方向。 安装到壳体的至少一个致动器与悬架联接并且可相对于盘组件移动。 包括滑块体和被配置为从至少一个硬盘读取数据并将数据写入至少一个硬盘的磁头的滑块与该悬架联接。 第一悬挂电互连被配置为将第一信号传导路径与滑块电耦合并具有第一非终端信号路径。 第二悬挂电互连被配置为将第二信号传导路径与滑块电连接,并且具有第二非终止信号路径。 选择第二非终止信号路径的长度以实现期望的阻抗水平。
    • 4. 发明授权
    • Method of stiffening a rib
    • 加强筋的方法
    • US08523111B2
    • 2013-09-03
    • US12737549
    • 2009-07-20
    • Stephen Williams
    • Stephen Williams
    • B64C1/00
    • B64C3/187B64F5/10Y10T29/49622
    • A method of stiffening a rib (19, 20) during the assembly of an aircraft wing is described. A stiffener panel (40, 41) is attached to a face of the rib (19, 20). The rib is aligned with one or more wing components with the stiffener panel (40, 41) attached. An assembly operation such as drilling (16) is performed with the rib aligned and the stiffener panel attached. The stiffener panel (40, 41) is removed from the rib after the assembly operation. The stiffener panel has a resilient external sealing ring which is mounted on a face of the panel and forms an external perimeter of a vacuum cavity; and at least one resilient internal sealing ring which is mounted on the panel (20, 21) within the perimeter defined by the external sealing ring and forms an internal perimeter of the vacuum cavity. The stiffener can be attached to the rib by a vacuum clamping force, the vacuum being sealed by the external and internal sealing rings. The internal sealing ring(s) seal any holes which are present in the rib. The stiffener (40, 41) can support the rib (20, 21) during alignment to give it the required flatness.
    • 描述了在飞行器机翼的组装期间加强肋(19,20)的方法。 加强板(40,41)附接到肋(19,20)的表面。 肋与一个或多个机翼部件对准,并且加强板(40,41)连接在一起。 执行诸如钻孔(16)的组装操作,其中肋对准并且加强板连接。 在组装操作之后,加强板(40,41)从肋上移除。 加强板具有弹性的外部密封环,其安装在面板的表面上并形成真空腔的外周; 以及至少一个弹性内部密封环,其安装在由外部密封环限定的周边内的面板(20,21)上并形成真空腔的内部周边。 加强件可以通过真空夹紧力连接到肋上,真空由外部和内部密封环密封。 内密封环密封肋中存在的任何孔。 加强件(40,41)可以在对准期间支撑肋(20,21),以使其成为所需的平整度。
    • 6. 发明申请
    • AIRCRAFT WIRING INSTALLATION
    • 飞机接线安装
    • US20090209129A1
    • 2009-08-20
    • US12293461
    • 2007-03-21
    • Stephen Williams
    • Stephen Williams
    • H01R13/66
    • H01R13/73H01R13/533H02G3/22
    • An aircraft wiring installation connecting a set of fuel side wires in an aircraft fuel tank to a set of airside wires outside the fuel tank, the installation comprising: a connector box having a fuel side wall (22) and an airside wall (21); one or more connectors (40, 43) carried by the fuel side wall (22) which connect the fuel side wires to the airside wires; a fairing (6) partially covering the airside wall (21); and one or more holes (30) in the airside wall through which the airside wires pass from the connector box into the fairing (6).
    • 一种将飞机燃料箱中的一组燃料侧电线连接到燃料箱外部的一组空气侧电线的飞行器接线装置,该装置包括:具有燃料侧壁(22)和空气侧壁(21)的连接器盒; 一个或多个由燃料侧壁(22)承载的连接器(40,43),其将燃料侧电线连接到空气侧电线; 部分覆盖空气侧壁(21)的整流罩(6); 和空气侧壁中的一个或多个孔(30),空气侧线通过该孔从连接器盒穿过整流罩(6)。
    • 7. 发明申请
    • Artificial proteins with reduced immunogenicity
    • 具有降低免疫原性的人造蛋白
    • US20070269435A1
    • 2007-11-22
    • US11716878
    • 2007-03-12
    • Stephen GilliesFrancis CarrJones TimGraham CarterAnila HamiltonStephen WilliamsMarian HanlonJohn WatkinsMatthew BakerJeffrey Way
    • Stephen GilliesFrancis CarrJones TimGraham CarterAnila HamiltonStephen WilliamsMarian HanlonJohn WatkinsMatthew BakerJeffrey Way
    • A61K39/395A61P35/00C07H21/00C12P21/08
    • C07K16/30C07K16/28C07K16/2863C07K2317/24C07K2317/34C07K2319/00C07K2319/30
    • The invention relates to artificial modified proteins, preferably fusion proteins, having a reduced immunogenicity compared to the parent non-modified molecule when exposed to a species in vivo. The invention relates, above all, to novel immunoglobulin fusion proteins which essentially consist of an immunoglobulin molecule or a fragment thereof covalently fused via its C-terminus to the N-terminus of a biologically active non-immunoglobulin molecule, preferably a polypeptide or protein or a biologically active fragment thereof. In a specific embodiment, the invention relates to fusion proteins consisting of an Fc portion of an antibody which is fused as mentioned to the non-immunological target molecule which elicits biological or pharmacological efficacy. The molecules of the invention have amino acid sequences which are altered in one or more amino acid residue positions but have in principal the same biological activity as compared with the non-altered molecules. The changes are made in regions of the molecules which are identified as T-cell epitopes, which contribute to an immune reaction in a living host. Thus, the invention also relates to a novel method of making such fusion proteins by identifying said epitopes comprising calculation of T-cell epitope values for MHC Class II molecule binding sites in a peptide by computer-aided methods.
    • 本发明涉及人体修饰蛋白,优选融合蛋白,当与体内物种暴露时,与亲本非修饰分子相比具有降低的免疫原性。 本发明首先涉及新的免疫球蛋白融合蛋白,其基本上由通过其C-末端与生物活性非免疫球蛋白分子(优选多肽或蛋白质)的N末端共价融合的免疫球蛋白分子或其片段组成,或 其生物活性片段。 在一个具体的实施方案中,本发明涉及由抗体的Fc部分组成的融合蛋白,所述Fc部分如提及的非免疫靶标分子融合而引起生物学或药理学功效。 本发明的分子具有氨基酸序列,其在一个或多个氨基酸残基位置被改变,但与未改变的分子相比具有相同的生物学活性。 在被鉴定为T细胞表位的分子的区域中进行改变,其有助于在宿主中的免疫反应。 因此,本发明还涉及通过鉴定所述表位来制备此类融合蛋白的新方法,包括通过计算机辅助方法计算肽中MHC II类分子结合位点的T细胞表位值。
    • 8. 发明授权
    • Communication terminal having a predictive editor application
    • 具有预测编辑器应用的通信终端
    • US07155683B1
    • 2006-12-26
    • US09507945
    • 2000-02-22
    • Stephen Williams
    • Stephen Williams
    • G06F3/00
    • G06F3/0237H04M1/274558H04M1/72552H04M2001/274541H04M2250/70
    • A communication terminal having a display; a keypad having a plurality of keys associated with several letters each; a processor for controlling the display in accordance with the operation of the keypad; a selectable predictive editor program for generating an output containing words matching a received string of ambiguous key strokes, the predictive editor program has a number of associated vocabularies including at least one language dependent dictionary and at least one dictionary receiving user defined inputs. An editor application is controlled by the processor which communicates with said predictive editor programs for generating matching words based on an ambiguous string of key strokes. A second memory of the communication terminal for storing user inputted data. The processor automatically searches the second memory for words and copies these words into the dictionary for receiving user defined inputs associated with said predictive editor program.
    • 具有显示器的通信终端; 键盘,其具有与多个字母相关联的多个键; 处理器,用于根据键盘的操作来控制显示; 一种可选择的预测编辑器程序,用于生成包含与所接收的不明确的关键笔划串匹配的单词的输出,所述预测编辑器程序具有包括至少一个取决于语言的字典和至少一个接收用户定义的输入的字典的相关词汇的数量。 编辑器应用程序由处理器控制,该处理器与所述预测编辑器程序进行通信,用于基于不确定的键击串来产生匹配词。 用于存储用户输入数据的通信终端的第二存储器。 处理器自动搜索第二存储器中的字,并将这些字复制到字典中,以接收与所述预测编辑器程序相关联的用户定义的输入。