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1. 发明申请

US20080051720A1 Instrument Including Connector For Facilitating Connection Onto A Guide-Wire Without Access To The Ends Of The Guide-Wire And Method Of Use 失效
标题翻译：包括连接器的仪器可以方便连接到导线上，而不需要使用导线的末端和使用方法
公开(公告)号：US20080051720A1
公开(公告)日：2008-02-28
申请号：US11928897
申请日：2007-10-30
申请人： John Nash , Gregory Walters , Douglas Evans , David Szabo , Michael Paris
发明人： John Nash , Gregory Walters , Douglas Evans , David Szabo , Michael Paris
IPC分类号： A61M25/01
CPC分类号： A61M25/0169 , A61M25/09041 , A61M2025/018 , A61M2025/0183
摘要： An attachment tool to facilitate the attachment of one or more catheters or similar elongated instruments to a guide-wire or other elongated guide member, without requiring access to either end of said wire or member. The tool provides repeatable and reliable alignment of components to be attached, while being operated with a single hand. The catheter systems can be used for revascularization or treatment of arteries and lumens within the body, and the associated delivery of therapies therein and can include side attachable and over-the-wire components and/or low profile combination catheters to allow for flush and extraction of debris in small or tortuous anatomic pathways.
摘要翻译：附件工具，以便于将一个或多个导管或类似的细长器械连接到导丝或其它细长导向件，而不需要接近所述线或构件的任一端。该工具在单手操作的同时可提供要连接的组件的可重复且可靠的对齐。导管系统可用于血管重建或治疗体内的动脉和腔，以及其中相关的治疗传递，并且可以包括侧附件和线上组件和/或薄型组合导管，以允许冲洗和提取的碎屑在小或曲折的解剖通路。

2. 发明申请

US20070282303A1 Thrombectomy and soft debris removal device 有权
标题翻译：血栓切除术和软切除装置
公开(公告)号：US20070282303A1
公开(公告)日：2007-12-06
申请号：US11751443
申请日：2007-05-21
申请人： John Nash , Greg Walters , Dennis Sauro , Mark Eberhart , William Fisher , Douglas Evans
发明人： John Nash , Greg Walters , Dennis Sauro , Mark Eberhart , William Fisher , Douglas Evans
IPC分类号： A61M1/00
CPC分类号： A61B17/32037 , A61B17/320783 , A61B2017/00685 , A61B2017/22039 , A61B2017/22067 , A61B2017/22084 , A61M1/0058 , A61M1/0066 , A61M1/101 , A61M25/0068 , A61M25/0069 , A61M25/007 , A61M25/0082 , A61M25/10 , A61M2025/0177 , A61M2025/0183 , A61M2025/1052
摘要： A device suitable for removing material from a living being is provided, featuring an infusate pump, and an aspiration pump, both powered by a motor. The aspiration pump and infusate pump preferably feature a helical pumping mechanism, and operate at a high rate of rotation, thereby ensuring adequate pumping performance and flexibility. Additionally, a narrow crossing profile is maintained, ensuring that the device may reach more tortuous regions of the vasculature. In one embodiment, the system comprises a wire-guided mono-rail catheter with a working head mounted on a flexible portion of the catheter that can laterally displace away from the guide wire to facilitate thrombus removal. The working head may be operated to separate and move away from the guide wire to come within a closer proximity of the obstructive material to more effectively remove it from the vessel.
摘要翻译：提供了一种适用于从活体中去除材料的装置，其特征在于具有输注泵和吸引泵，两者都由马达驱动。抽吸泵和输注泵优选地具有螺旋泵送机构，并且以高转速进行操作，从而确保足够的泵送性能和柔性。另外，保持狭窄的横截面，确保装置可能达到脉管系统的更曲折的区域。在一个实施例中，系统包括导线单轨导管，其具有安装在导管的柔性部分上的工作头，所述工作头能横向移位远离引导线以促进血栓移除。工作头可以被操作以分离并远离引导线进入更靠近阻塞物质的位置，以更有效地将其从容器中移出。

3. 发明授权

US5935147A Hemostatic puncture closure system and method of use 失效
标题翻译：止血穿刺闭合系统及使用方法
公开(公告)号：US5935147A
公开(公告)日：1999-08-10
申请号：US992041
申请日：1997-12-17
申请人： Kenneth Kensey , John Nash , Douglas Evans
发明人： Kenneth Kensey , John Nash , Douglas Evans
IPC分类号： A61B17/12 , A61B17/00 , A61B17/03 , A61B17/04 , A61B19/00 , A61F2/06 , A61M25/00 , A61M37/00 , F16G11/04 , F16G11/10 , A61B17/08
CPC分类号： A61B17/0057 , F16G11/108 , A61B2017/00004 , A61B2017/00637 , A61B2017/00654 , A61B2017/00659 , A61B2017/00672 , A61B2017/00898 , A61B2017/0496 , A61B2090/032 , A61B2090/0811 , A61B90/03 , A61B90/39 , Y10S604/90
摘要： A system, a closure, and method of use for sealing a percutaneous puncture in a blood vessel. The puncture includes an opening in the vessel wall and a tract leading to the opening. The system includes an introducer sheath and associated positioning device, a hemostatic puncture closure, and a deployment instrument. The positioning device enables the introducer sheath to be positioned at a desired position within the vessel. The deployment instrument includes a tubular carrier storing the closure. The closure comprises a rigid, e.g., radio-opaque, anchor, a compressed collagen plug, and a thin filament connecting the two in a pulley-like arrangement. The instrument and introducer are used to introduce the closure into the puncture, with the anchor located within the artery and with the collagen plug within the puncture tract. A locking member is provided to hold the closure in place at its operative position, whereupon hemostasis occurs rapidly, thereby sealling the puncture.
摘要翻译：用于密封血管中的经皮穿刺的系统，闭合件和方法。穿刺包括血管壁中的开口和通向开口的通道。该系统包括引导器护套和相关联的定位装置，止血穿刺闭合器和展开装置。定位装置使引导器护套能够定位在容器内的期望位置。展开仪器包括一个储存封闭件的管状载体。封闭件包括刚性例如不透射线的锚，压缩的胶原塞，以及以滑轮状布置连接两者的细丝。仪器和导引器用于将闭合件引入穿刺中，锚固件位于动脉内并且胶原栓塞在穿刺道内。提供锁定构件以在其操作位置处将闭合件保持在适当位置，从而快速发生止血，从而刺穿穿刺。

4. 发明授权

US06179863B2 Hemostatic puncture closure system and method of use 失效
公开(公告)号：US06179863B2
公开(公告)日：2001-01-30
申请号：US09294154
申请日：1999-04-19
申请人： Kenneth Kensey , John Nash , Douglas Evans
发明人： Kenneth Kensey , John Nash , Douglas Evans
IPC分类号： A61B1708
CPC分类号： A61B17/0057 , A61B90/03 , A61B90/39 , A61B2017/00004 , A61B2017/00637 , A61B2017/00654 , A61B2017/00659 , A61B2017/00672 , A61B2017/00898 , A61B2017/0496 , A61B2090/032 , A61B2090/0811 , F16G11/108 , Y10S604/90
摘要： A system, a closure, and method of use for sealing a percutaneous puncture in a blood vessel. The puncture includes an opening in the vessel wall and a tract leading to the opening. The system includes an introducer sheath and associated positioning device, a hemostatic puncture closure, and a deployment instrument. The positioning device enables the introducer sheath to be positioned at a desired position within the vessel. The deployment instrument includes a tubular carrier storing the closure. The closure comprises a rigid, e.g., radio-opaque, anchor, a compressed collagen plug, and a thin filament connecting the two in a pulley-like arrangement. The instrument and introducer are used to introduce the closure into the puncture, with the anchor located within the artery and with the collagen plug within the puncture tract. A locking member is provided to hold the closure in place at its operative position, whereupon hemostasis occurs rapidly, thereby sealing the puncture.

5. 发明授权

US5676689A Hemostatic puncture closure system including vessel location device and method of use 失效
标题翻译：止血穿刺闭合系统，包括血管位置装置和使用方法
公开(公告)号：US5676689A
公开(公告)日：1997-10-14
申请号：US608428
申请日：1996-02-28
申请人： Kenneth Kensey , John Nash , Douglas Evans
发明人： Kenneth Kensey , John Nash , Douglas Evans
IPC分类号： A61B17/00 , A61B17/04 , A61B17/12 , A61B19/00 , F16G11/04 , F16G11/10
CPC分类号： A61B17/0057 , F16G11/108 , A61B2017/00004 , A61B2017/00637 , A61B2017/00654 , A61B2017/00659 , A61B2017/00672 , A61B2017/0496 , A61B2090/032 , A61B2090/0811 , A61B90/03 , A61B90/39 , Y10S604/90
摘要： A system for sealing a percutaneous puncture in a blood vessel in a living being and method of use thereof. The system includes a hemostatic closure, a blood vessel locator device for determining the position of the blood vessel via the percutaneous puncture, and a deployment instrument for deploying the closure within the puncture to seal the puncture. The vessel locator includes means for enabling blood from the vessel to flow therethrough so that the position of the vessel can be rapidly determined. Once the vessel has been located the deployment instrument, which includes a tubular carrier storing the closure, is extend into the puncture to deploy the closure. The closure basically comprises a radiopaque rigid anchor for location within the blood vessel, a compressed collagen plug for location within the puncture tract leading to the vessel, and a thin filament connecting the two in a pulley-like arrangement. The deployment instrument also includes a tamper which is used to mechanically deform the plug within the tract. Once the closure is positioned hemostasis occurs rapidly, thereby locking the closure in place.
摘要翻译：一种用于密封生物体内的血管中的经皮穿刺的系统及其使用方法。该系统包括止血闭合件，用于通过经皮穿刺确定血管位置的血管定位装置，以及用于在穿刺部内展开封闭物以密封穿刺的展开装置。容器定位器包括用于使来自血管的血液流过其中的装置，使得能够快速确定容器的位置。一旦容器已经定位，包括容纳封闭件的管状载体的展开器械延伸到穿刺部分中以展开闭合件。闭合件基本上包括用于定位在血管内的不透射线的刚性锚固件，用于定位在穿过血管的穿刺道内的压缩胶原塞，以及以滑轮状布置连接两者的细丝。部署仪器还包括用于将管塞内的插头机械地变形的篡改。一旦闭合物被定位，止血就快速发生，从而将闭合件锁定就位。

6. 发明授权

US5222974A Hemostatic puncture closure system and method of use 失效
标题翻译：止血穿刺闭合系统及使用方法
公开(公告)号：US5222974A
公开(公告)日：1993-06-29
申请号：US789704
申请日：1991-11-08
申请人： Kenneth Kensey , John Nash , Douglas Evans
发明人： Kenneth Kensey , John Nash , Douglas Evans
IPC分类号： A61B17/00 , A61B17/04 , A61B17/12 , A61B19/00 , F16G11/04 , F16G11/10
CPC分类号： A61B17/0057 , F16G11/108 , A61B2017/00004 , A61B2017/00654 , A61B2017/00659 , A61B2017/00898 , A61B2017/0496 , A61B2090/032 , A61B2090/0811 , A61B90/03 , A61B90/39
摘要： A system, a closure, and method of sealing a percutaneous puncture in an artery. The system includes a conventional introducer sheath, a hemostatic puncture closure, and an instrument for deploying the closure. The instrument includes a tubular carrier storing the closure. The carrier has a distally located free end to be extended through the puncture and its associated tract. The closure comprises a rigid anchor, a compressed collagen plug, and a thin filament connect the two in a pulley-like arrangement. The carrier is operated to eject the plug through the puncture and to then draw it against the free end of the introducer. The instrument and introducer are then withdrawn together to pull the anchor against the tissue contiguous with the puncture on the inside of the artery. Further withdrawing of the introducer and the instrument draws the plug out of the carrier into the puncture tract, whereupon it moves with respect to the anchor and into engagement with the outside of artery wall contiguous with the puncture to seal the puncture. The carrier also includes a tamper which is used to mechanically deform the plug within the tract. Once positioned the hemostasis occurs rapidly, thereby locking the closure device in place.
摘要翻译：一种在动脉中密封经皮穿刺的系统，闭合件和方法。该系统包括常规的引导器护套，止血穿刺闭合件和用于展开封闭件的器械。仪器包括一个储存封闭件的管状载体。载体具有远端定位的自由端，以延伸通过穿刺及其相关联的管道。封闭件包括刚性锚固件，压缩胶原塞和细丝，以滑轮状布置连接两者。操作载体以通过穿刺将插塞推出，然后将其拉到引导器的自由端。然后将仪器和引导器一起拉出以将锚固件靠在与动脉内侧上的穿刺邻接的组织上。进一步取出导引器和仪器将插塞从载体中抽出到穿刺管中，于是其相对于锚移动并与与穿刺相邻的动脉壁的外侧接合以密封穿刺。载体还包括用于使塞子在管道内机械变形的篡改。一旦定位，止血快速发生，从而将闭合装置锁定就位。

7. 发明申请

US20050245946A1 Surgical connector systems and methods of use 有权
公开(公告)号：US20050245946A1
公开(公告)日：2005-11-03
申请号：US11179456
申请日：2005-07-11
申请人： John Nash , Douglas Evans , David Hoganson
发明人： John Nash , Douglas Evans , David Hoganson
IPC分类号： A61B17/00 , A61B17/06 , A61B17/08 , A61B17/11 , A61B17/12
CPC分类号： A61B17/11 , A61B17/0057 , A61B17/06 , A61B17/12009 , A61B2017/00004 , A61B2017/00243 , A61B2017/1107 , A61B2017/1135
摘要： A system and method of use for effecting the bypass or other anastomosis, connection, or port in a portion of a native blood vessel, duct, lumen or other tubular organ within the body of a living being. The system includes a connector assembly and a deployment instrument for carrying the device to the desired position within the vessel, duct, lumen or tubular organ. The system includes a piercer-dilator instrument to form an opening in the wall of the vessel, duct, lumen or tubular organ into which a connector assembly may be deployed by the deployment instrument. The connector assembly may be at least partially formed of a resorbable material and includes movable members for securing it to the tissue of the vessel, duct, lumen or tubular organ contiguous with the opening. Other components may be included in the device for expediting the procedure, with or without the use of sutures.

8. 发明授权

US5700277A Hemostatic vessel puncture closure with filament lock 失效
标题翻译：止血血管穿刺闭合与灯丝锁
公开(公告)号：US5700277A
公开(公告)日：1997-12-23
申请号：US439895
申请日：1995-05-12
申请人： John Nash , Douglas Evans
发明人： John Nash , Douglas Evans
IPC分类号： A61B17/00
CPC分类号： A61B17/0057 , A61B2017/00654 , A61B2017/00659
摘要： A hemostatic closure for sealing a percutaneous puncture in a blood vessel. The puncture includes a tract leading to it from the skin of the being. The closure comprises a rigid, resorbable material anchor having a reinforcement strip therein, a compressed collagen plug, a thin filament connecting the anchor and the plug in a pulley-like arrangement, and a locking mechanism, The plug is deployed so that the anchor is pulled against the tissue contiguous with the puncture inside the artery and with the plug and the locking member within the puncture tract. Pulling on the filament moves the plug toward the anchor member to a puncture sealing position. The locking mechanism is arranged to be actuated to engage the filament in such a manner that the plug is held in the puncture sealing position. In one embodiment the locking mechanism comprises a compressible disk mounted on the filament. In another embodiment the locking mechanism comprises a notched passageway in the anchor and the filament comprises a portion having plural projections or teeth thereon adapted to slide into the notched passageway in one direction but resistant to sliding in the opposite direction. An optional spacer member may be provided interposed between the plug and the anchor to prevent the plug from entering the opening in the vessel.
摘要翻译：用于密封血管中经皮穿刺的止血闭合件。穿刺包括从皮肤的皮肤导致的穿孔。封闭件包括一个刚性的，可再吸收的材料锚固件，其中具有一个加强条，一个压缩的胶原塞，一个细长的细丝，以一个带轮状布置的方式连接锚固件和塞子，以及一个锁定机构。拉动在与动脉内的穿刺邻接的组织上，并且将塞子和锁定构件拉到穿刺道内。拉动灯丝将插头朝向锚固件移动到穿刺密封位置。锁定机构被布置成致动以使得插头被保持在穿刺密封位置中的方式接合灯丝。在一个实施例中，锁定机构包括安装在灯丝上的可压缩盘。在另一个实施例中，锁定机构包括在锚固件中的切口通道，并且灯丝包括其上具有多个突起或齿的部分，其适于在一个方向上滑入切口通道，但是在相反方向上滑动。可以设置插入插塞和锚固件之间的可选的间隔件，以防止塞子进入容器中的开口。

9. 发明授权

US5312435A Fail predictable, reinforced anchor for hemostatic puncture closure 失效
标题翻译：不可预测的，加固的止血止血止血栓
公开(公告)号：US5312435A
公开(公告)日：1994-05-17
申请号：US64192
申请日：1993-05-17
申请人： John Nash , Douglas Evans
发明人： John Nash , Douglas Evans
IPC分类号： A61B17/00 , A61B17/04 , A61B17/06 , A61F2/06 , A61L31/06 , A61L31/14
CPC分类号： A61L31/148 , A61B17/0057 , A61B17/0401 , A61L31/06 , A61B17/06166 , A61B2017/00004 , A61B2017/0414 , A61B2017/0417 , A61F2/06
摘要： A closure for sealing a percutaneous puncture in an vessel, e.g., an artery, or lumen. The puncture also includes a puncture tract in which a portion of the closure is to be located. The closure comprises an elongated rigid anchor member formed of a resorbable material, a sealing member formed of a resorbable material, e.g., compressed collagen plug, and a thin resorbable material filament, e.g., a suture, connecting the anchor member and the sealing member. The anchor member is located in the interior of the vessel, with the sealing member being located in the puncture tract. An elongated reinforcing filament or ribbon, formed of a resorbable material, is incorporated in the elongated anchor member to prevent any portion of it from breaking away in the event that the anchor is loaded beyond its breaking point.
摘要翻译：用于密封容器例如动脉或内腔中的经皮穿刺的封闭件。穿刺还包括穿孔，其中封闭件的一部分将位于其中。闭合件包括由可再吸收材料形成的细长刚性锚固构件，由可再吸收材料例如压缩的胶原塞形成的密封构件以及连接锚定构件和密封构件的薄的可再吸收材料丝，例如缝合线。锚定构件位于容器的内部，密封构件位于穿刺道中。由可再吸收的材料形成的细长的增强长丝或带被并入细长的锚固构件中，以防止锚固件超过其断裂点的情况下其任何部分脱离。

10. 发明授权

US5306254A Vessel position locating device and method of use 失效
标题翻译：船位定位装置及使用方法
公开(公告)号：US5306254A
公开(公告)日：1994-04-26
申请号：US955095
申请日：1992-10-01
申请人： John Nash , Douglas Evans , John J. Fleischhacker
发明人： John Nash , Douglas Evans , John J. Fleischhacker
IPC分类号： A61B17/00 , A61B5/15 , A61B17/12 , A61M25/06 , A61M5/00
CPC分类号： A61M25/0693 , A61B2017/00672 , A61B5/15003 , A61B5/1535 , A61M2025/0681
摘要： A device for determining the location of the wall of an artery in a living being via a percutaeous incision or puncture. The device comprises an elongated tubular member having a distal end portion, a proximal end portion, and a passageway extending therethrough for receipt of a guide wire. The device is inserted through an introducer sheath having an open distal end into said percutaneous incision or puncture over said guide wire so its distal end portion is located within the artery and its proximal end portion is located outside of the body of the being. The has two liquid entrance ports in its distal end portion and one liquid outlet port in its proximal end portion. The liquid entrance ports and outlet port are in communication with each other through the device's passageway. When the device is positioned within the introducer sheath and the entrance ports are located beyond the open distal end of the introducer sheath and within the artery blood flows into the entrance ports through passageway and out through the outlet port so that it can be observed. The device and introducer sheath are then retracted until the flow of blood out of the outlet port stops, thereby indicating the location of the artery wall.
摘要翻译：一种用于通过经皮切口或穿刺来确定生物体内动脉壁的位置的装置。该装置包括细长的管状构件，其具有远端部分，近端部分和延伸穿过其中的通道以便接收导丝。该装置通过具有开口远端的引导器护套插入所述经皮切口或穿过所述导丝的刺穿，使得其远端部分位于动脉内，并且其近端部分位于存在体的外部。其前端部具有两个液体入口和其近端部分中的一个液体出口。液体入口和出口通过设备的通道彼此连通。当装置定位在引导器护套内并且入口位于引导器护套的开口远端之上并且在动脉内时，血液通过通道流入入口并通过出口流出，从而可以观察到。然后将装置和引导器护套缩回直到从出口流出的血液流动停止，从而指示动脉壁的位置。

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