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1. 发明授权

US08124729B2 Splice variants of human G-protein coupled receptor HGPRBMY29 (HGPRMBY29SV2) 有权
标题翻译：人G蛋白偶联受体HGPRBMY29（HGPRBMY29SV2）的剪接变体
公开(公告)号：US08124729B2
公开(公告)日：2012-02-28
申请号：US11891240
申请日：2007-08-09
申请人： John N. Feder , Chandra S. Ramanathan , Gabriel A. Mintier , David K. Bol , Donald R. Hawken
发明人： John N. Feder , Chandra S. Ramanathan , Gabriel A. Mintier , David K. Bol , Donald R. Hawken
IPC分类号： C07K1/00 , C07K14/00 , C07K17/00 , C12P21/06 , C12N1/20 , C12N15/74
CPC分类号： A61K49/0008 , A61K38/00 , C07K14/705 , C07K16/2863 , C07K2317/21 , C07K2317/622 , Y10S435/975
摘要： The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY28, HGPRBMY29, HGPRBMY29v1, and HGPRBMY29v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供编码HGPRBMY28和HGPRBMY29多肽的新型多核苷酸，其片段及其同源物。本发明还提供编码HGPRBMY29多肽，HGPRBMY29v1和HGPRBMY29v2的剪接变体的多核苷酸。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新型HGPRBMY28，HGPRBMY29，HGPRBMY29v1和HGPRBMY29v2多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

2. 发明申请

US20080213918A1 Polynucleotides encoding two novel human G-protein coupled receptors, HGPRBMY28 and HGPRBMY29, and splice variants thereof 审中-公开
公开(公告)号：US20080213918A1
公开(公告)日：2008-09-04
申请号：US11891836
申请日：2007-08-13
申请人： John N. Feder , Chandra S. Ramanathan , Gabriel A. Mintier , David Bol , Donald R. Hawken
发明人： John N. Feder , Chandra S. Ramanathan , Gabriel A. Mintier , David Bol , Donald R. Hawken
IPC分类号： G01N33/566 , C07K16/18
CPC分类号： A61K49/0008 , A61K38/00 , C07K14/705 , C07K16/2863 , C07K2317/21 , C07K2317/622 , Y10S435/975
摘要： The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY28, HGPRBMY29, HGPRBMY29v1, and HGPRBMY29v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

3. 发明申请

US20120010385A1 SPLICE VARIANTS OF HUMAN G-PROTEIN COUPLED RECEPTOR HGPRBMY29 (HGPRMBY29SV2) 有权
标题翻译：人G蛋白偶联受体HGPRBMY29（HGPRBMY29SV2）的差异变体
公开(公告)号：US20120010385A1
公开(公告)日：2012-01-12
申请号：US11891240
申请日：2007-08-09
申请人： John N. Feder , Chandra S. Ramanathan , Gabriel A. Mintier , David Bol , Donald R. Hawken
发明人： John N. Feder , Chandra S. Ramanathan , Gabriel A. Mintier , David Bol , Donald R. Hawken
IPC分类号： C07K14/00 , C07H21/04
CPC分类号： A61K49/0008 , A61K38/00 , C07K14/705 , C07K16/2863 , C07K2317/21 , C07K2317/622 , Y10S435/975
摘要： The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY28, HGPRBMY29, HGPRBMY29v1, and HGPRBMY29v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供编码HGPRBMY28和HGPRBMY29多肽的新型多核苷酸，其片段及其同源物。本发明还提供编码HGPRBMY29多肽，HGPRBMY29v1和HGPRBMY29v2的剪接变体的多核苷酸。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新型HGPRBMY28，HGPRBMY29，HGPRBMY29v1和HGPRBMY29v2多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

4. 发明授权

US07049096B2 Polynucleotides encoding a novel human G-protein coupled receptor splice variant HGPRBMY29sv1 有权
标题翻译：编码新型人G蛋白偶联受体剪接变体HGPRBMY29sv1的多核苷酸
公开(公告)号：US07049096B2
公开(公告)日：2006-05-23
申请号：US10120604
申请日：2002-04-11
申请人： John N. Feder , Chandra S. Ramanathan , Gabriel A. Mintier , David Bol , Donald R. Hawken
发明人： John N. Feder , Chandra S. Ramanathan , Gabriel A. Mintier , David Bol , Donald R. Hawken
IPC分类号： C12P21/06 , C12N1/20 , C12N15/00 , C12N15/74 , C07H21/04
CPC分类号： A61K49/0008 , A61K38/00 , C07K14/705 , C07K16/2863 , C07K2317/21 , C07K2317/622 , Y10S435/975
摘要： The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY28, HGPRBMY29, HGPRBMY29v1, and HGPRBMY29v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供编码HGPRBMY28和HGPRBMY29多肽的新型多核苷酸，其片段及其同源物。本发明还提供编码HGPRBMY29多肽，HGPRBMY29v1和HGPRBMY29v2的剪接变体的多核苷酸。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新型HGPRBMY28，HGPRBMY29，HGPRBMY29v1和HGPRBMY29v2多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

5. 发明授权

US07635758B2 Antibodies directed to G-protein coupled receptor HGPRBMY29sv1 有权
标题翻译：针对G蛋白偶联受体HGPRBMY29sv1的抗体
公开(公告)号：US07635758B2
公开(公告)日：2009-12-22
申请号：US11890963
申请日：2007-08-08
申请人： John N. Feder , Chandra S. Ramanathan , Gabriel A. Mintier , David K. Bol
发明人： John N. Feder , Chandra S. Ramanathan , Gabriel A. Mintier , David K. Bol
IPC分类号： C07K16/00 , C12P21/08
CPC分类号： A61K49/0008 , A61K38/00 , C07K14/705 , C07K16/2863 , C07K2317/21 , C07K2317/622 , Y10S435/975
摘要： The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing these polypeptides. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing these polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY28, HGPRBMY29, HGPRBMY29v1, and HGPRBMY29v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供编码HGPRBMY28和HGPRBMY29多肽的新型多核苷酸，其片段及其同源物。本发明还提供编码HGPRBMY29多肽，HGPRBMY29v1和HGPRBMY29v2的剪接变体的多核苷酸。还提供了载体，宿主细胞，抗体以及用于产生这些多肽的重组和合成方法。还提供了载体，宿主细胞，抗体以及用于产生这些多肽的重组和合成方法。本发明还涉及将这些新型HGPRBMY28，HGPRBMY29，HGPRBMY29v1和HGPRBMY29v2多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

6. 发明授权

US07304141B2 Human leucine-rich repeat containing protein expressed predominately in bone marrow, HLRRBM1 有权
标题翻译：人类含有亮氨酸的重复含有蛋白质主要在骨髓HLRRBM1中表达
公开(公告)号：US07304141B2
公开(公告)日：2007-12-04
申请号：US11107572
申请日：2005-04-15
申请人： John N. Feder , Chandra S. Ramanathan , Gabriel A. Mintier , David Bol
发明人： John N. Feder , Chandra S. Ramanathan , Gabriel A. Mintier , David Bol
IPC分类号： C07K14/47 , C12N15/12 , C12N5/20 , C12P21/02
CPC分类号： C07K16/18 , A61K38/00 , A61K2039/53 , C07K14/47
摘要： The present invention provides novel polynucleotides encoding HLRRBM1 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HLRRBM1 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly immune diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供了编码HLRRBM1多肽的新型多核苷酸，其片段及其同源物。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新型HLRRBM1多肽应用于诊断，治疗和/或预防与这些多肽，特别是免疫疾病和/或病症相关的各种疾病和/或病症的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

7. 发明授权

US07183379B2 Human leucine-rich repeat containing protein expressed predominately in small intestine, HLRRSI1 有权
标题翻译：人类富含亮氨酸的重复含有蛋白主要表达于小肠，HLRRSI1
公开(公告)号：US07183379B2
公开(公告)日：2007-02-27
申请号：US10882761
申请日：2004-07-01
申请人： John N. Feder , Chandra S. Ramanathan , Gabriel A. Mintier
发明人： John N. Feder , Chandra S. Ramanathan , Gabriel A. Mintier
IPC分类号： C07K1/00
CPC分类号： G01N33/5008 , A61K38/00 , C07K14/705 , C12Q1/6883 , G01N33/5011 , G01N33/502 , G01N33/5044 , G01N33/505 , G01N33/5052 , G01N33/5058 , G01N33/5064 , G01N33/5076 , G01N33/5091 , G01N33/68 , G01N33/6842
摘要： The present invention provides novel polynucleotides encoding HLRRSI1 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HLRRSI1 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly gastrointestinal diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供了编码HLRRSI1多肽的新型多核苷酸，其片段及其同源物。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新型HLRRSI1多肽应用于诊断，治疗和/或预防与这些多肽，特别是胃肠道疾病和/或病症有关的各种疾病和/或病症的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

8. 发明授权

US06858407B2 Human leucine-rich repeat containing protein expressed predominately in small intestine, HLRRSI1 有权
标题翻译：人类富含亮氨酸的重复含有蛋白主要表达于小肠，HLRRSI1
公开(公告)号：US06858407B2
公开(公告)日：2005-02-22
申请号：US10029347
申请日：2001-12-20
申请人： John N. Feder , Chandra S. Ramanathan , Gabriel A. Mintier
发明人： John N. Feder , Chandra S. Ramanathan , Gabriel A. Mintier
IPC分类号： A61K38/00 , A61K39/395 , A61K48/00 , A61P1/00 , A61P9/04 , A61P9/10 , A61P31/18 , A61P35/00 , A61P37/00 , A61P43/00 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/02 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/68 , G01N33/68 , C12P21/06 , C07H21/04
CPC分类号： G01N33/5008 , A61K38/00 , C07K14/705 , C12Q1/6883 , G01N33/5011 , G01N33/502 , G01N33/5044 , G01N33/505 , G01N33/5052 , G01N33/5058 , G01N33/5064 , G01N33/5076 , G01N33/5091 , G01N33/68 , G01N33/6842
摘要： The present invention provides novel polynucleotides encoding HLRRSI1 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HLRRSI1 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly gastrointestinal diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供了编码HLRRSI1多肽的新型多核苷酸，其片段及其同源物。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新型HLRRSI1多肽应用于诊断，治疗和/或预防与这些多肽，特别是胃肠道疾病和/或病症有关的各种疾病和/或病症的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

9. 发明授权

US07276354B2 Polynucleotides encoding a novel human G-protein coupled receptor splice variant, HGPRBMY29SV2 有权
标题翻译：编码新型人G蛋白偶联受体剪接变体的多核苷酸HGPRBMY29SV2
公开(公告)号：US07276354B2
公开(公告)日：2007-10-02
申请号：US11071761
申请日：2005-03-03
申请人： John N. Feder , Chandra S. Ramanathan , Gabriel A. Mintier , David Bol
发明人： John N. Feder , Chandra S. Ramanathan , Gabriel A. Mintier , David Bol
IPC分类号： C12P21/06 , C07H21/04 , C12N15/74 , C12N1/20
CPC分类号： A61K49/0008 , A61K38/00 , C07K14/705 , C07K16/2863 , C07K2317/21 , C07K2317/622 , Y10S435/975
摘要： The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing these polypeptides. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing these polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY28, HGPRBMY29, HGPRBMY29v1, and HGPRBMY29v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供编码HGPRBMY28和HGPRBMY29多肽的新型多核苷酸，其片段及其同源物。本发明还提供编码HGPRBMY29多肽，HGPRBMY29v1和HGPRBMY29v2的剪接变体的多核苷酸。还提供了载体，宿主细胞，抗体以及用于产生这些多肽的重组和合成方法。还提供了载体，宿主细胞，抗体以及用于产生这些多肽的重组和合成方法。本发明还涉及将这些新型HGPRBMY28，HGPRBMY29，HGPRBMY29v1和HGPRBMY29v2多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

10. 发明授权

US07348149B2 Methods of diagnosing Parkinson's disease by measuring expression level of RNA encoding human protein HLLRCR-1 有权
标题翻译：通过测量编码人类蛋白质HLLRCR-1的RNA的表达水平来诊断帕金森病的方法
公开(公告)号：US07348149B2
公开(公告)日：2008-03-25
申请号：US11511141
申请日：2006-08-28
申请人： John N. Feder , Chandra S. Ramanathan , Gabriel A. Mintier
发明人： John N. Feder , Chandra S. Ramanathan , Gabriel A. Mintier
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C07K14/47 , A61K38/00 , C12Q1/6886 , C12Q2600/158
摘要： The present invention provides novel polynucleotides encoding HLLRCR-1 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HLLRCR-1 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly nervous system diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供了编码HLLRCR-1多肽的新型多核苷酸，其片段及其同源物。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新型HLLRCR-1多肽应用于诊断，治疗和/或预防与这些多肽，特别是神经系统疾病和/或病症相关的各种疾病和/或病症的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

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