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1. 发明申请

US20060014759A1 Methods for the use of inhibitors of cytosolic phospholipase A2 有权
标题翻译：使用细胞溶质磷脂酶A2抑制剂的方法
公开(公告)号：US20060014759A1
公开(公告)日：2006-01-19
申请号：US11140390
申请日：2005-05-27
申请人： John McKew , Steven Tam , Katherine Lee , Lihren Chen , Paresh Thakker , Fuk-Wah Sum , Mark Behnke , Baihua Hu , James Clark , Wei Li , Valerie Clerin , Suzana Marusic , Kevin Pong
发明人： John McKew , Steven Tam , Katherine Lee , Lihren Chen , Paresh Thakker , Fuk-Wah Sum , Mark Behnke , Baihua Hu , James Clark , Wei Li , Valerie Clerin , Suzana Marusic , Kevin Pong
IPC分类号： A61K31/505 , C07D239/02
CPC分类号： A61K31/505 , C07D209/14 , C07D209/16 , C07D209/20 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/08 , C07D491/10
摘要： This invention provides methods for the use of substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms thereof. The invention provides methods for the use of the compounds as inhibitors of the activity of various phospholipase enzymes, particularly phospholipase A2 enzymes, and for the medical treatment, prevention and inhibition diseases and disorders including asthma, stroke, atherosclerosis, multiple sclerosis, Parkinson's disease, arthritic disorders, rheumatic disorders, central nervous system damage resulting from stroke, central nervous system damage resulting from ischemia, central nervous system damage resulting from trauma, inflammation caused or potentiated by prostaglandins, inflammation caused or potentiated by leukotrienes, inflammation caused or potentiated by platelet activation factor, pain caused or potentiated by prostaglandins, pain caused or potentiated by leukotrienes, and pain caused or potentiated by platelet activation factor.
摘要翻译：本发明提供了使用通式的取代的吲哚化合物及其药学上可接受的盐形式的方法。本发明提供了使用化合物作为各种磷脂酶，特别是磷脂酶2酶的活性抑制剂的方法，以及用于治疗，预防和抑制疾病和病症的方法，包括哮喘，中风，动脉粥样硬化，多发性硬化，帕金森病，关节炎疾病，风湿病，由中风引起的中枢神经系统损伤，由缺血引起的中枢神经系统损伤，由创伤引起的中枢神经系统损伤，由前列腺素引起或增强的炎症，由...引起或增强的炎症白细胞三烯，血小板活化因子引起或增强的炎症，前列腺素引起或加剧的疼痛，白细胞三烯引起或增强的疼痛，以及血小板激活因子引起或增强的疼痛。

2. 发明申请

US20070004719A1 Inhibitors of cytosolic phospholipase A2 有权
标题翻译：胞浆磷脂酶A2抑制剂
公开(公告)号：US20070004719A1
公开(公告)日：2007-01-04
申请号：US11442199
申请日：2006-05-26
申请人： John McKew , Katherine Lee , Lihren Chen , Richard Vargas , James Clark , Cara Williams , Valerie Clerin , Suzan Marusic , Kevin Pong
发明人： John McKew , Katherine Lee , Lihren Chen , Richard Vargas , James Clark , Cara Williams , Valerie Clerin , Suzan Marusic , Kevin Pong
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/405 , C07D413/02 , C07D403/02 , C07D209/18
CPC分类号： C07D209/14 , C07D209/18
摘要： This invention provides chemical inhibitors of the activity of various phospholipase enzymes, particularly cytosolic phospholipase A2 enzymes (cPLA2), more particularly including inhibitors of cytosolic phospholipase A2 alpha enzymes (cPLA2α). In some embodiments, the inhibitors have the Formula I: wherein the constituent variables are as defined herein.
摘要翻译：本发明提供了各种磷脂酶，特别是胞质磷脂酶A 2 N 2酶（cPLA 2 N）的活性的化学抑制剂，更具体地包括胞质磷脂酶A 2的抑制剂 α酶（cPLA2α）。在一些实施方案中，抑制剂具有式I：其中组成变量如本文所定义。

3. 发明授权

US11232310B2 Apparatus and method for detecting, classifying and tracking road users on frames of video data 有权
公开(公告)号：US11232310B2
公开(公告)日：2022-01-25
申请号：US16535547
申请日：2019-08-08
申请人： Sohail Zangenehpour , Luis Miranda-Moreno , Chiasen Chung , James Clark , Liqiang Ding
发明人： Sohail Zangenehpour , Luis Miranda-Moreno , Chiasen Chung , James Clark , Liqiang Ding
IPC分类号： G06K9/00 , G06T7/246 , G06T7/223 , G06T7/285 , G06T7/277
摘要： An apparatus and a method for detecting, classifying and tracking road users on frames of video data are provided. An object detection unit identifies an object in a frame of the video data. A pre-filtering unit determines whether the identifier associated to an object corresponds to another identifier associated to the same object in the same frame of the video data when the identifiers overlap. A tracking unit matches the identified object to a corresponding object in another frame of the video data, such that a path of the sequence of matched objects is tracked throughout the frames of the video data. A scenario unit determines a safety indicator that is a function of the risk indicators indicating interactions between road users.

4. 发明授权

US08799278B2 Data augmentation based on second-phase metadata 有权
标题翻译：基于二阶段元数据的数据扩充
公开(公告)号：US08799278B2
公开(公告)日：2014-08-05
申请号：US13632829
申请日：2012-10-01
申请人： Harry Blount , Travis Shanahan , James Clark , Dana Guido
发明人： Harry Blount , Travis Shanahan , James Clark , Dana Guido
IPC分类号： G06F17/30
CPC分类号： G06F17/30882
摘要： A data augmentation machine may form all or part of a data augmentation system that is configured to augment data. The data augmentation machine may be configured (e.g., by one or more software modules) to access data (e.g., by crawling one or more public or private networks), extract metadata based on the data (e.g., from the data and its source), create a link to additional data (e.g., based on the extracted metadata), and augment the extracted metadata (e.g., by storing augmented metadata with the extracted metadata). Such augmented metadata may be presented (e.g., within a user interface), published publicly (e.g., on a webpage), published privately (e.g., in a report available only to premium subscribers of a data augmentation service), or any suitable combination thereof.
摘要翻译：数据增加机器可以形成被配置为增加数据的数据增强系统的全部或部分。数据增强机器可以被配置（例如，通过一个或多个软件模块）来访问数据（例如，通过爬行一个或多个公共或专用网络），基于数据（例如，从数据及其来源）提取元数据，创建到附加数据的链接（例如，基于所提取的元数据），并且增加提取的元数据（例如，通过使用所提取的元数据存储增强的元数据）。或者其任何合适的组合，可公开（例如，在仅可用于数据增强服务的高级用户的报告中）公开（例如，在网页上）发布这样的增强元数据（例如，在用户界面内）。

5. 发明授权

US08162584B2 Method and apparatus for semiconductor wafer alignment 有权
标题翻译：用于半导体晶片对准的方法和装置
公开(公告)号：US08162584B2
公开(公告)日：2012-04-24
申请号：US11508551
申请日：2006-08-23
申请人： David J. Michael , James Clark , Gang Liu
发明人： David J. Michael , James Clark , Gang Liu
IPC分类号： G06K9/00 , H01L21/677
CPC分类号： H01L21/681 , G06T7/73
摘要： The invention provides, in some aspects, a wafer alignment system comprising an image acquisition device, an illumination source, a rotatable wafer platform, and an image processor that includes functionality for mapping coordinates in an image of an article (such as a wafer) on the platform to a “world” frame of reference at each of a plurality of angles of rotation of the platform.
摘要翻译：本发明在一些方面提供了一种晶片对准系统，其包括图像获取装置，照明源，可旋转晶片平台和图像处理器，该图像处理器包括用于将物品（例如晶片）的图像中的坐标映射到平台在平台的多个旋转角度的每一个处以“世界”参照系。

6. 发明申请

US20080051778A1 APPARATUS FOR SECURING A SENSOR TO A SURGICAL INSTRUMENT FOR USE IN COMPUTER GUIDED ORTHOPAEDIC SURGERY 审中-公开
标题翻译：用于将传感器固定在手术仪器上用于计算机指导性手术的装置
公开(公告)号：US20080051778A1
公开(公告)日：2008-02-28
申请号：US11928867
申请日：2007-10-30
申请人： Gabriel Surma , Troy Martin , James Clark , Jack Bryant
发明人： Gabriel Surma , Troy Martin , James Clark , Jack Bryant
IPC分类号： A61B17/56 , F16D1/06
CPC分类号： A61B90/39 , A61B2090/3983 , Y10T403/18
摘要： A self-centering coupling device is provided for coupling a sensor array to a surgical instrument for use in computer guided surgery. The self-centering coupling device includes a sensor support having a stem and sensor support arms coupled to the stem to support the sensors of the sensor array. The self-centering coupling device is received within a recess formed in the surgical instrument.
摘要翻译：提供了一种自动对中耦合装置，用于将传感器阵列耦合到用于计算机引导手术的外科器械。自定心联接装置包括传感器支架，传感器支架具有连接到杆的杆和传感器支撑臂，以支撑传感器阵列的传感器。自对中联接装置被容纳在形成在外科器械中的凹部内。

7. 发明申请

US20080040144A1 TRANSPORT LOGISTICS SYSTEMS AND METHODS 审中-公开
标题翻译：运输物流系统和方法
公开(公告)号：US20080040144A1
公开(公告)日：2008-02-14
申请号：US11873969
申请日：2007-10-17
申请人： Glenn RIGGS , John Kivela , Robert Shellman , Joseph Rocky , Stanley Bainor , Ralph Brechter , Douglas Clark , James Clark , Jon Clow , Amy Daley , Larry Hu , Louis Indelicato , William Lohan , Michael Naughton , Peter Nelson , Alan Shollenberger , M. Willett , Doug Johnston , Donald Mueller , Michael Michaud , Robert Phaneuf , Joseph Bainor
发明人： Glenn RIGGS , John Kivela , Robert Shellman , Joseph Rocky , Stanley Bainor , Ralph Brechter , Douglas Clark , James Clark , Jon Clow , Amy Daley , Larry Hu , Louis Indelicato , William Lohan , Michael Naughton , Peter Nelson , Alan Shollenberger , M. Willett , Doug Johnston , Donald Mueller , Michael Michaud , Robert Phaneuf , Joseph Bainor
IPC分类号： G06Q30/00
CPC分类号： G06Q10/08 , G06Q10/0631 , G06Q10/06316 , G06Q10/06375 , G06Q10/0639 , G06Q10/083 , G06Q10/0833 , G06Q10/0834 , G06Q10/087 , G06Q20/40 , G06Q30/00 , G06Q30/0201 , G06Q50/188
摘要： A logistics system manages the shipments of goods supplied from a plurality of different shippers by a plurality of carriers. It has a variety of modules integrated with each other to perform various functionalities. For example, it may have a purchasing module evaluating proposals by shippers for respective shipments of goods and awarding contracts for the shipments to the plurality of carriers. It may have an optimization module analyzing the proposals and informing the purchasing module if an opportunity exists for at least some of the shipments to be consolidated, in which case at least one contract awarded by the purchasing module is for a consolidated group of the shipments. It may have a contract administration module maintaining information relating to the status of proposals received and contracts awarded by the purchasing module. It may have a scheduling module scheduling shipments according to the awarded contracts. It may also have a shipment management module tracking the status of shipments awarded by the purchasing module and scheduled by said scheduling module. It may further have a financial module authorizing payments according to the status of shipments tracked by the shipment management module are passed between first and second asynchronous clock domains.
摘要翻译：物流系统管理由多个承运人从多个不同托运人提供的货物的运输。它具有各种模块相互集成以执行各种功能。例如，它可能有一个采购模块来评估托运人对各货物运输的提案，并向多个承运人发运货物合同。可能有一个优化模块来分析提案，并通知采购模块是否存在至少一些货物合并的机会，在这种情况下，采购模块授予的至少一个合同是针对合并的出货组合。它可能有一个合同管理模块来维护有关收到的提案的状态和购买模块授予的合同的信息。可能有一个调度模块根据授予的合同安排出货。还可以具有跟踪由购买模块授予并由所述调度模块调度的货物状态的装运管理模块。还可以有一个财务模块根据货物管理模块跟踪的运输状态来授权付款，在第一和第二异步时钟域之间传递。

8. 发明申请

US20070240441A1 Automated ice vending machine and method of vending ice 有权
标题翻译：自动冰自动售货机和自动售冰方法
公开(公告)号：US20070240441A1
公开(公告)日：2007-10-18
申请号：US11634557
申请日：2006-12-06
申请人： Robert Hobson , James Clark , Warren Johnston
发明人： Robert Hobson , James Clark , Warren Johnston
IPC分类号： F25C1/00
CPC分类号： F25C5/187 , B65B43/36 , F25C1/00 , F25C5/00 , G07F17/0071
摘要： The present invention is an automated ice vending machine for delivering ice to consumers. The machine of the present invention includes an insulated enclosure, an ice manufacturing apparatus, a cooling unit, an ice inventory storage bin, an ice agitating device, an incline ice transport device, and a bagger assembly. The present invention also includes a method of vending ice to a consumer.
摘要翻译：本发明是用于向消费者输送冰的自动化冰自动售货机。本发明的机器包括绝缘外壳，制冰装置，冷却单元，冰库存储箱，冰搅拌装置，倾斜冰运输装置和袋装组件。本发明还包括向消费者销售冰的方法。

9. 发明申请

US20070237191A1 Devices for high power, high-repetition rate, broadly tunable coherent radiation, and its applications 审中-公开
标题翻译：高功率，高重复率，广泛可调谐相干辐射的器件及其应用
公开(公告)号：US20070237191A1
公开(公告)日：2007-10-11
申请号：US11700366
申请日：2007-01-30
申请人： James Kafka , James Clark , David Spence
发明人： James Kafka , James Clark , David Spence
IPC分类号： H01S3/10
CPC分类号： H01S3/2308 , G02F2001/392
摘要： The present application is directed to various embodiments of laser systems which include a laser oscillator and a pump source configured to produce coherent light at high repetition rates and with short pulse durations, wherein the output from the laser oscillator is then amplified in a laser amplifier, which includes a pump source, the output from the laser amplifier has increased average and peak power, but preserves the short pulse duration and high repetition rate of the laser oscillator.
摘要翻译：本申请涉及激光系统的各种实施例，其包括激光振荡器和被配置为以高重复率和短脉冲持续时间产生相干光的泵浦源，其中激光振荡器的输出然后在激光放大器中被放大，其包括泵浦源，激光放大器的输出具有增加的平均和峰值功率，但保持激光振荡器的短脉冲持续时间和高重复率。

10. 发明申请

US20070131502A1 Cam actuated drum brake 有权
公开(公告)号：US20070131502A1
公开(公告)日：2007-06-14
申请号：US11657801
申请日：2007-01-25
申请人： James Clark , Dominic Licavoli , James Sheets , Ralph Larson
发明人： James Clark , Dominic Licavoli , James Sheets , Ralph Larson
IPC分类号： F16D51/00
CPC分类号： F16D65/09 , F16D65/08 , F16D65/22 , F16D2125/30 , Y10T74/2101
摘要： A cam for a brake is provided that allows for greater brake shoe travel and thicker brake linings while providing the same or greater mechanical force as compared to conventional cams. One or more lobes of the cam include multiple portions having varying profiles in axial cross-section. The variation in the cam profiles results in a cam in which the outermost ends or tips of the lobes are longer than in conventional cams yet retain the same mechanical strength.

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