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    • 5. 发明申请
    • Method of detecting or diagnosing of a neurodegenerative disease or condition
    • 检测或诊断神经变性疾病或病症的方法
    • US20060141541A1
    • 2006-06-29
    • US11359489
    • 2006-02-23
    • John McIntyre
    • John McIntyre
    • G01N33/567G01N33/53
    • G01N33/92G01N33/564G01N33/6854G01N33/6896G01N2800/28G01N2800/2814G01N2800/2821G01N2800/2835G01N2800/285
    • A neurodegenerative disease or condition is diagnosed in a subject by obtaining a sample of cerebral spinal fluid from the subject and assaying the sample by an assay method that detects the presence of at least one antiphospholipid autoantibody in the sample, wherein an elevated level of at least one antiphospholipid autoantibody in the sample of cerebral spinal fluid correlates with a neurodegenerative disease or condition in the subject. The neurodegenerative disease or condition may also be diagnosed by assaying a sample of cerebral spinal fluid to detect nitrosylated antibodies, wherein an elevated level of nitrosylated antibodies correlates with a neurodegenerative disease or condition in said subject. A neurodegenerative disease or condition is also detected or diagnosed by assaying a first sample of cerebral spinal fluid from the subject to determine a level of at least one autoantibody having a selected specificity, treating a second sample of cerebral spinal fluid with an oxidizing agent and assaying the oxidized second sample to determine a level the at least autoantibody having the selected specificity, and comparing the level of the at least one autoantibody in the first sample with the level of the at least one autoantibody in the oxidized second sample, wherein a lack of increase in the level of the at least one autoantibody in the oxidized second sample as compared to the level of the at least one autoantibody in the first sample correlates with a neurodegenerative disease or condition in said subject.
    • 通过从受试者获得脑脊液的样品并通过检测样品中至少一种抗磷脂自身抗体的存在的测定方法来测定样品,在受试者中诊断神经变性疾病或病症,其中升高的水平至少 脑脊髓液样品中的一种抗磷脂自身抗体与受试者的神经变性疾病或病症相关。 神经变性疾病或病症也可以通过测定脑脊髓液样品来检测亚硝酰化抗体来诊断,其中升高水平的亚硝基化抗体与所述受试者的神经变性疾病或病症相关。 还通过测定来自受试者的第一脑脊液样品来确定至少一种具有选定特异性的自身抗体的水平,用氧化剂处理脑脊髓液的第二样品和测定法来检测或诊断神经变性疾病或病症 氧化的第二样品以确定具有所选特异性的至少自身抗体的水平,并将第一样品中的至少一种自身抗体的水平与氧化的第二样品中的至少一种自身抗体的水平进行比较,其中缺乏 与第一样品中的至少一种自身抗体的水平相比,氧化的第二样品中的至少一种自身抗体的水平的增加与所述受试者的神经变性疾病或病症相关。
    • 6. 发明授权
    • Electromagnetic analysis of concrete tensioning wires
    • 混凝土电缆的电磁分析
    • US06791318B2
    • 2004-09-14
    • US10221998
    • 2003-01-07
    • Peter O. PaulsonJohn McIntyreKevin Mitchell
    • Peter O. PaulsonJohn McIntyreKevin Mitchell
    • G01N2782
    • G01N27/82G01N27/902G01N33/383
    • Discloses methods to perform magnetic testing of tensioning elements in a pre-stressed concrete cylinder, such as a pipe or water reservoir and testing apparatus. The apparatus includes magnetic flux production means and detector means disposed proximal to a surface of the cylinder in a plane in common with the magnetic flux production means that is orthogonal to an axis of the cylinder. The apparatus operates over a range of low frequency signals, for example, between 20 and 300 hertz or a pulse. Output of the inspection apparatus includes a signal and distance plot showing the results of testing a cylinder at one or more frequencies. In accordance with another method of analysis, a characteristic of the phase of the output over distance is plotted, including the phase or representations of the in-phase or quadrature components of the received signal in relation to the driving signal.
    • 公开了对预应力混凝土圆柱体(例如管道或储水器和测试装置)中的张紧元件进行磁性测试的方法。 该装置包括磁通量产生装置和检测装置,该装置在与与气缸的轴线正交的磁通量产生装置共同的平面内设置在气缸表面附近。 该装置在一些范围的低频信号上工作,例如在20和300赫兹或脉冲之间。 检查装置的输出包括示出以一个或多个频率测试圆筒的结果的信号和距离图。 根据另一种分析方法,绘制出距离输出相位的特征,包括相对于驱动信号的接收信号的同相或正交分量的相位或表示。