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1. 发明授权

US06190657B1 Vectors for the diagnosis and treatment of solid tumors including melanoma 失效
标题翻译：用于诊断和治疗实体瘤包括黑素瘤的载体
公开(公告)号：US06190657B1
公开(公告)日：2001-02-20
申请号：US08658034
申请日：1996-06-04
申请人： John M. Pawelek , David Bermudes , Kenneth Brooks Low
发明人： John M. Pawelek , David Bermudes , Kenneth Brooks Low
IPC分类号： A01N6300
CPC分类号： A61K48/00 , C12N1/00 , C12N15/87 , G01N33/574
摘要： The present invention is directed to the isolation and use of super-infective, tumor-specific vectors that are strains of parasites including, but not limited to bacteria, fungi and protists. In certain embodiments the parasites include, but are not limited to, the bacterium Salmonella spp., such as Salmonella typhimurium, the bacterium Mycobacterium avium and the protozoan Leishmania amazonensis. In other embodiments, the present invention is concerned with the isolation of super-infective, tumor-specific, suicide gene-containing strains of parasites for use in treatment of solid tumors.
摘要翻译：本发明涉及分离和使用作为寄生虫菌株的超感染性肿瘤特异性载体，包括但不限于细菌，真菌和原生生物。在某些实施方案中，寄生虫包括但不限于细菌沙门氏菌属，例如鼠伤寒沙门氏菌，鸟分枝杆菌和原生动物亚利桑尼亚人。在其它实施方案中，本发明涉及用于治疗实体瘤的超感染性，肿瘤特异性，含自杀基因的寄生虫菌株的分离。

2. 发明授权

US06685935B1 Vectors for the diagnosis and treatment of solid tumors including melanoma 有权
标题翻译：用于诊断和治疗实体瘤包括黑素瘤的载体
公开(公告)号：US06685935B1
公开(公告)日：2004-02-03
申请号：US09358052
申请日：1999-07-21
申请人： John M. Pawelek , David Bermudes , Kenneth Brooks Low
发明人： John M. Pawelek , David Bermudes , Kenneth Brooks Low
IPC分类号： A01N6300
CPC分类号： A61K48/00 , C12N1/00 , C12N15/87 , G01N33/574
摘要： The present invention is directed to the isolation and use of super-infective, tumor-specific vectors that are strains of parasites including, but not limited to bacteria, fungi and protists. In certain embodiments the parasites include, but are not limited to, the bacterium Salmonella spp., such as Salmonella typhimurium, the bacterium Mycobacterium avium and the protozoan Leishmania amazonensis. In other embodiments, the present invention is concerned with the isolation of super-infective, tumor-specific, suicide gene-containing strains of parasites for use in treatment of solid tumors.
摘要翻译：本发明涉及分离和使用作为寄生虫菌株的超感染性肿瘤特异性载体，包括但不限于细菌，真菌和原生生物。在某些实施方案中，寄生虫包括但不限于细菌沙门氏菌属，例如鼠伤寒沙门氏菌，鸟分枝杆菌和原生动物亚利桑尼亚利什曼原虫。在其它实施方案中，本发明涉及用于治疗实体瘤的超感染性，肿瘤特异性，含自杀基因的寄生虫菌株的分离。

3. 发明授权

US5744125A Cosmetic melanins 失效
标题翻译：化妆品黑色素
公开(公告)号：US5744125A
公开(公告)日：1998-04-28
申请号：US392589
申请日：1995-02-23
申请人： John M. Pawelek , James T. Platt
发明人： John M. Pawelek , James T. Platt
IPC分类号： A61K8/72 , A01N43/38 , A01N47/28 , A61K8/00 , A61K8/02 , A61K8/40 , A61K8/81 , A61K31/12 , A61K31/175 , A61K31/195 , A61K31/198 , A61K31/20 , A61K31/70 , A61K31/785 , A61K47/30 , A61P17/00 , A61P43/00 , A61Q5/00 , A61Q5/06 , A61Q17/04 , A61Q19/00 , A61Q19/04 , C07D209/04 , C08G61/00 , C08G61/02 , C08G63/06 , C08G65/38 , C08G83/00 , C12P1/00 , G01N33/00 , A61K7/44 , A61K7/42
CPC分类号： A61Q19/04 , A61K8/72 , A61Q17/04 , A61Q5/065
摘要： Disclosed are cosmetic melanins of different colors produced by procedures involving oxidative polymerization of monomeric precursors of melanin and/or co-monomers that enhance substantivity or adherence of the melanins to the skin and hair. Also disclosed are methods for preparing cosmetic melanins and methods for using these compositions topically to produce a natural-appearing tan and to prevent damage to skin caused by UV exposure.
摘要翻译：公开了通过涉及黑色素和/或共聚单体的单体前体的氧化聚合的程序产生的不同颜色的化妆品黑色素，其增强黑色素对皮肤和头发的亲和性或粘附。还公开了用于制备美容黑色素的方法以及使用这些组合物局部地产生天然出现的褐色和防止由UV暴露引起的对皮肤的损伤的方法。

4. 发明授权

US5225435A Soluble melanin 失效
标题翻译：可溶性黑色素
公开(公告)号：US5225435A
公开(公告)日：1993-07-06
申请号：US674489
申请日：1991-03-25
申请人： John M. Pawelek , Seth J. Orlow
发明人： John M. Pawelek , Seth J. Orlow
IPC分类号： A23L1/275 , A61K8/72 , A61K31/785 , A61Q17/04 , C09B69/10 , C12P17/00 , C12P17/10
CPC分类号： C12P17/00 , A23L5/43 , A23L5/47 , A61K31/785 , A61K8/72 , A61Q17/04 , C09B69/104 , C12P17/10
摘要： A melanin that is soluble in an aqueous solution at a pH of at least 5 to 9 at a temperature of 0 to 100.degree. C. The melanin is further characterized by being capable of being filtered through at least a 0.45 micron size filter. Still further, the melanin is characterized by having a molecular weight of greater than 10,000 kilodaltons. The melanin is useful for providing a naturally-appearing tan to mammalian skin and hair. Such melanin can be produced by combining dopachrome and 5,6-dihydroxyindole (or allowing dopachrome to spontaneously form 5,6-dihydroxyindole) and an appropriate enzyme or by combining 5,6-dihydroxyindole and 5,6-dihydroxyindole-2-carboxylic acid or by incubating 5,6-dihydroxyindole-2-carboxylic acid alone. The melanin is also useful for providing a sun-screen to mammalian skin and hair, to treat post-inflammatory hypo- and hyperpigmentation, to tint glass and plastic, to protect industrial materials against ultraviolet damage, and as a coloring agent in foodstuffs such as coffee, tea, soda, whiskey and liquors.
摘要翻译：在0至100℃的温度下，在至少5至9的pH下可溶于水溶液的黑色素。黑色素的进一步特征在于能够通过至少0.45微米尺寸的过滤器过滤。此外，黑色素的特征在于具有大于10,000千道尔顿的分子量。黑色素可用于向哺乳动物皮肤和头发提供天然存在的棕褐色。这种黑色素可以通过组合多巴色胺和5,6-二羟基吲哚（或允许多巴色素自发形成5,6-二羟基吲哚）和合适的酶或通过将5,6-二羟基吲哚和5,6-二羟基吲哚-2-羧酸或通过单独孵育5,6-二羟基吲哚-2-羧酸。黑色素还可用于向哺乳动物皮肤和头发提供防晒剂，以治疗炎症后期和色素沉着过度，使玻璃和塑料变色，以保护工业材料免受紫外线损伤，以及作为食品中的着色剂，例如咖啡，茶，苏打水，威士忌和烈酒。

5. 发明授权

US5216116A Soluble melanin 失效
标题翻译：可溶性麦芽糖
公开(公告)号：US5216116A
公开(公告)日：1993-06-01
申请号：US525944
申请日：1990-05-18
申请人： John M. Pawelek
发明人： John M. Pawelek
IPC分类号： A61K8/72 , A61K31/405 , A61Q17/04 , A61Q19/04 , C08G63/685 , C12P17/00 , C12P17/10 , C08G63/06
CPC分类号： A61Q17/04 , A61K8/72 , A61Q19/04 , C08G63/6852 , C12P17/00 , C12P17/10
摘要： A melanin that is soluble in an aqueous solution at a pH of at least 5 to 9 at a temperature of 0.degree. to 100.degree. C. The melanin is further characterized by being capable of being filtered through at least a 0.45 micron size filter. Still further, the melanin is characterized by having a molecular weight of greater than 10,000 kilodaltons. The melanin is useful for providing a naturally-appearing tan to mammalian skin and hair. The melanin is also useful for providing a sun-screen to mammalian skin and hair.
摘要翻译：在0至100℃的温度下，可溶于pH至少为5至9的水溶液的黑色素。黑色素的进一步特征在于能够通过至少0.45微米尺寸的过滤器过滤。此外，黑色素的特征在于具有大于10,000千道尔顿的分子量。黑色素可用于向哺乳动物皮肤和头发提供天然存在的棕褐色。黑色素也可用于向哺乳动物的皮肤和头发提供防晒霜。

6. 发明授权

US5126125A Decreasing the melanin content in mammalian skin and hair using 5,6-dihydroxindole derivatives 失效
标题翻译：使用5,6-二羟基吲哚衍生物降低哺乳动物皮肤和头发中的黑色素含量
公开(公告)号：US5126125A
公开(公告)日：1992-06-30
申请号：US417987
申请日：1989-10-06
申请人： John M. Pawelek
发明人： John M. Pawelek
IPC分类号： A61K8/49 , A61K8/55 , A61K8/58 , A61K31/40 , A61K31/675 , A61K31/695 , A61Q5/08 , A61Q19/02 , C07D209/08 , C07F7/18 , C07F9/572 , C07F9/6574
CPC分类号： A61K8/492 , A61K31/40 , A61K31/675 , A61K31/695 , A61K8/55 , A61K8/585 , A61Q19/02 , A61Q5/08 , C07D209/08 , C07F7/1856 , C07F7/188 , C07F9/5728 , C07F9/65742 , Y10S424/03 , Y10S514/844 , Y10S514/88
摘要： A method of decreasing the melanin content in mammalian skin and hair by administering to a mammal a composition comprising an effective amount of one or more derivatives of 5,6-dihydroxyindole, the derivatives having one or more substituents which are capable of being removed enzymatically, in admixture with a pharmaceutically acceptable carrier, the amount being 0.5% to 20% wt/wt based on the composition.
摘要翻译：一种通过向哺乳动物施用包含有效量的一种或多种5,6-二羟基吲哚衍生物的组合物来降低哺乳动物皮肤和毛发中的黑色素含量的方法，所述衍生物具有一个或多个能够被酶促除去的取代基，与药学上可接受的载体的混合物，其量为基于组合物的0.5％至20％wt / wt。

7. 发明授权

US5523077A Composition and method for whitening skin 失效
标题翻译：美白皮肤的成分和方法
公开(公告)号：US5523077A
公开(公告)日：1996-06-04
申请号：US104968
申请日：1993-08-10
申请人： John M. Pawelek , Jean L. Bolognia , Michael P. Osber , Stefano A. Sodi
发明人： John M. Pawelek , Jean L. Bolognia , Michael P. Osber , Stefano A. Sodi
IPC分类号： A61K8/34 , A61K8/44 , A61K8/46 , A61Q19/02 , A61K7/42 , A61K7/48
CPC分类号： A61K8/44 , A61K8/347 , A61K8/46 , A61Q19/02
摘要： A skin-whitening and suntan-inhibiting composition comprising (a) a compound which depletes glutathione, and (b) hydroquinone or an alkyl or aralkyl ether of hydroquinone.
摘要翻译：一种皮肤美白和防晒组合物，其包含（a）消耗谷胱甘肽的化合物和（b）氢醌或氢醌的烷基或芳烷基醚。

8. 发明授权

US4695449A Composition and method for treatment of melanomas 失效
标题翻译：治疗黑素瘤的组合物和方法
公开(公告)号：US4695449A
公开(公告)日：1987-09-22
申请号：US480402
申请日：1983-03-30
申请人： John M. Pawelek
发明人： John M. Pawelek
IPC分类号： A61K31/66 , A61K31/665 , A61K49/00 , A61K43/00
CPC分类号： A61K31/665 , A61K31/66
摘要： A composition and method for the treatment of melanomas in human beings wherein the composition comprises at least one O-phosphorylated derivative of 3-(3,4-dihydroxy)phenylalanine.
摘要翻译：用于治疗人类黑素瘤的组合物和方法，其中所述组合物包含3-（3,4-二羟基）苯丙氨酸的至少一种O-磷酸化衍生物。

9. 发明授权

US5618519A Soluble melanin 失效
标题翻译：可溶性黑色素
公开(公告)号：US5618519A
公开(公告)日：1997-04-08
申请号：US16348
申请日：1993-02-11
申请人： John M. Pawelek , Seth J. Orlow
发明人： John M. Pawelek , Seth J. Orlow
IPC分类号： A23L1/275 , A61K8/72 , A61K31/785 , A61Q17/04 , C09B69/10 , C12P17/00 , C12P17/10 , A61K7/42 , A61K7/40 , A61K9/06
CPC分类号： A61K8/72 , A23L5/43 , A23L5/47 , A61K31/785 , A61Q17/04 , C09B69/104 , C12P17/00 , C12P17/10 , Y10S514/937 , Y10S514/938 , Y10S514/939 , Y10S514/969
摘要： A melanin that is soluble in an aqueous solution at a pH of at least 5 to 9 at a temperature of 0.degree. to 100.degree. C. The melanin is further characterized by being capable of being filtered through at least a 0.45 micron size filter. Still further, the melanin is characterized by having a molecular weight of greater than 10,000 kilodaltons. The melanin is useful for providing a naturally-appearing tan to mammalian skin and hair. Such melanin can be produced by combining dopachrome and 5,6-dihydroxyindole (or allowing dopachrome to spontaneously form 5,6-dihydroxyindole) and an appropriate enzyme or by combining 5,6-dihydroxyindole and 5,6-dihydroxyindole-2-carboxylic acid or by incubating 5,6-dihydroxyindole-2-carboxylic acid alone. The melanin is also useful for providing a sun-screen to mammalian skin and hair.
摘要翻译：在0至100℃的温度下，可溶于pH至少为5至9的水溶液的黑色素。黑色素的进一步特征在于能够通过至少0.45微米尺寸的过滤器过滤。此外，黑色素的特征在于具有大于10,000千道尔顿的分子量。黑色素可用于向哺乳动物皮肤和头发提供天然存在的棕褐色。这种黑色素可以通过组合多巴色胺和5,6-二羟基吲哚（或允许多巴色素自发形成5,6-二羟基吲哚）和合适的酶或通过将5,6-二羟基吲哚和5,6-二羟基吲哚-2-羧酸或通过单独孵育5,6-二羟基吲哚-2-羧酸。黑色素也可用于向哺乳动物的皮肤和头发提供防晒霜。

10. 发明授权

US5218079A Soluble melanin 失效
标题翻译：可溶性黑色素
公开(公告)号：US5218079A
公开(公告)日：1993-06-08
申请号：US603111
申请日：1990-10-25
申请人： John M. Pawelek , Seth J. Orlow
发明人： John M. Pawelek , Seth J. Orlow
IPC分类号： A23L1/275 , A61K8/72 , A61K31/785 , A61Q17/04 , C09B69/10 , C12P17/00 , C12P17/10
CPC分类号： A61K8/72 , A23L5/43 , A23L5/47 , A61K31/785 , A61Q17/04 , C09B69/104 , C12P17/00 , C12P17/10 , Y10S514/937 , Y10S514/938 , Y10S514/939 , Y10S514/969
摘要： A melanin that is soluble in an aqueous solution at a pH of at least 5 to 9 at a temperature of 0.degree. to 100.degree. C. The melanin is further characterized by being capable of being filtered through at least a 0.45 micron size filter. Still further, the melanin is characterized by having a molecular weight of greater than 10,000 kilodaltons. The melanin is useful for providing a naturally-appearing tan to mammalian skin and hair. Such melanin can be produced by combining dopachrome and 5,6-dihydroxyindole (or allowing dopachrome to spontaneously form 5,6-dihydroxyindole) and an appropriate enzyme or by combining 5,6-dihydroxyindole and 5,6-dihydroxyindole-2-carboxylic acid or by incubating 5,6-dihydroxyindole-2-carboxylic acid alone. The melanin is also useful for providing a sun-screen to mammalian skin and hair.
摘要翻译：在0至100℃的温度下，可溶于pH至少为5至9的水溶液中的黑色素。黑色素的特征还在于能够通过至少0.45微米尺寸的过滤器过滤。此外，黑色素的特征在于具有大于10,000千道尔顿的分子量。黑色素可用于向哺乳动物皮肤和头发提供天然存在的棕褐色。这种黑色素可以通过组合多巴色胺和5,6-二羟基吲哚（或允许多巴色素自发形成5,6-二羟基吲哚）和合适的酶或通过将5,6-二羟基吲哚和5,6-二羟基吲哚-2-羧酸或通过单独孵育5,6-二羟基吲哚-2-羧酸。黑色素也可用于向哺乳动物的皮肤和头发提供防晒霜。

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