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1. 发明授权

US5306284A Surgical instrument 失效
标题翻译：手术器械
公开(公告)号：US5306284A
公开(公告)日：1994-04-26
申请号：US838532
申请日：1992-02-19
申请人： John M. Agee , Francis King , Kimberly A. Romanko , Lawrence A. Flor , Thomas A. Turgeon , William A. Mittelstadt
发明人： John M. Agee , Francis King , Kimberly A. Romanko , Lawrence A. Flor , Thomas A. Turgeon , William A. Mittelstadt
IPC分类号： A61B17/32
CPC分类号： A61B17/320036
摘要： Surgical instruments are disclosed for manipulating selected tissue in a body cavity under visual inspection. The preferred instrument includes a probe in which a blade is positioned, wherein the probe includes a lateral aperture near its distal end. The blade can be extended outwardly from the probe along a path which is essentially perpendicular to the longitudinal axis of the probe. After the blade has been extended it can be used to effectively divide tissue. An optical system can be received in the probe for viewing through the lateral aperture in the probe.
摘要翻译：公开了用于在视觉检查下操纵体腔中的选定组织的手术器械。优选的仪器包括其中定位刀片的探针，其中探针包括在其远端附近的侧向孔。刀片可以沿着基本上垂直于探针的纵向轴线的路径从探头向外延伸。刀片延伸后，可用于有效分割组织。光学系统可以被接收在探头中，以便通过探针中的侧向孔观察。

2. 发明授权

US5613976A Instrument for mesh cutting of the flexor retinaculum 失效
标题翻译：屈肌视网膜切割仪
公开(公告)号：US5613976A
公开(公告)日：1997-03-25
申请号：US366038
申请日：1994-12-29
申请人： John M. Agee , Francis King
发明人： John M. Agee , Francis King
IPC分类号： A61B17/3211 , A61B17/32 , A61B17/04
CPC分类号： A61B17/320036
摘要： Apparatus and method are described for selective cutting of the transverse carpal ligament of a patient. The instrument includes spaced-apart teeth which are supported on a first arm and a press member which is carried by a second arm. The teeth are prevented from contacting tissue when the first arm is inserted into, or retracted from, the carpal tunnel. After insertion of the first arm into the carpal tunnel, the teeth are exposed to the transverse carpal ligament and the first and second arms are moved towards each other to force the teeth into the transverse carpal ligament to perforate the ligament and enable it to elongate.
摘要翻译：描述了用于选择性切割患者的横腕腕韧带的装置和方法。仪器包括支撑在第一臂上的间隔开的齿和由第二臂携带的按压构件。当第一臂插入腕管或从腕管回缩时，防止牙齿接触组织。在将第一臂插入腕管之后，牙齿暴露于横腕腕韧带，第一和第二臂彼此相对移动，以迫使牙齿进入横腕腕韧带以穿透韧带并使其伸长。

3. 发明授权

US4963147A Surgical instrument 失效
标题翻译：手术器械
公开(公告)号：US4963147A
公开(公告)日：1990-10-16
申请号：US380624
申请日：1989-07-14
申请人： John M. Agee , Francis King
发明人： John M. Agee , Francis King
IPC分类号： A61B17/32
CPC分类号： A61B17/320036
摘要： Disclosed is an improved surgical method for inspecting and manipulating selected tissue in a body cavity, while minimizing the risk of injury to surrounding tissue, and a surgical instrument therefor.
摘要翻译：公开了一种改进的外科手术方法，用于检查和操纵体腔中的选定组织，同时最小化对周围组织的损伤的风险，以及用于其的手术器械。

4. 发明授权

US5387223A Instrument for mesh cutting of the flexor retinaculum 失效
标题翻译：屈肌视网膜切割仪
公开(公告)号：US5387223A
公开(公告)日：1995-02-07
申请号：US126257
申请日：1993-09-24
申请人： John M. Agee , Francis King
发明人： John M. Agee , Francis King
IPC分类号： A61B17/3211 , A61B17/32
CPC分类号： A61B17/320036
摘要： Apparatus and method are described for selective cutting of the transverse carpal ligament of a patient. The instrument includes spaced-apart teeth which are supported on a first arm and a press member which is carried by a second arm. The teeth are prevented from contacting tissue when the first arm is inserted into, or retracted from, the carpal tunnel. After insertion of the first arm into the carpal tunnel, the teeth are exposed to the transverse carpal ligament and the first and second arms are moved towards each other to force the teeth into the transverse carpal ligament to perforate the ligament and enable it to elongate.
摘要翻译：描述了用于选择性切割患者的横腕腕韧带的装置和方法。仪器包括支撑在第一臂上的间隔开的齿和由第二臂携带的按压构件。当第一臂插入腕管或从腕管回缩时，防止牙齿接触组织。在将第一臂插入腕管之后，牙齿暴露于横腕腕韧带，第一和第二臂彼此相对移动，以迫使牙齿进入横腕腕韧带以穿透韧带并使其伸长。

5. 发明授权

US5089000A Surgical method and instrument therefor 失效
标题翻译：手术方法及其手段
公开(公告)号：US5089000A
公开(公告)日：1992-02-18
申请号：US569835
申请日：1990-08-20
申请人： John M. Agee , Francis King
发明人： John M. Agee , Francis King
IPC分类号： A61B17/32
CPC分类号： A61B17/320036
摘要： Disclosed is an improved surgical method for inspecting and manipulating selected tissue in a body cavity, while minimizing the risk of injury to surrounding tissue, and a surgical instrument therefor.
摘要翻译：公开了一种用于检查和操纵体腔中的选定组织的改进的外科方法，同时最小化对周围组织的损伤风险，以及用于其的手术器械。

6. 发明授权

US4962770A Surgical method 失效
标题翻译：手术方式
公开(公告)号：US4962770A
公开(公告)日：1990-10-16
申请号：US380816
申请日：1989-07-14
申请人： John M. Agee , Francis King
发明人： John M. Agee , Francis King
IPC分类号： A61B17/32
CPC分类号： A61B17/320036
摘要： Disclosed is an improved surgical method for inspecting and manipulating selected tissue in a body cavity, while minimizing the risk of injury to surrounding tissue, and a surgical instrument therefor.
摘要翻译：公开了一种改进的外科手术方法，用于检查和操纵体腔中的选定组织，同时最小化对周围组织的损伤的风险，以及用于其的手术器械。

7. 发明申请

US20060094702A1 5-HT4 receptor antagonists 审中-公开
公开(公告)号：US20060094702A1
公开(公告)日：2006-05-04
申请号：US11304110
申请日：2005-12-15
申请人： Francis King , Laramie Gaster , Keith Mulholland
发明人： Francis King , Laramie Gaster , Keith Mulholland
IPC分类号： A61K31/554 , A61K31/553 , A61K31/5415 , A61K31/538 , A61K31/4745 , C07D417/02 , C07D413/02 , C07D455/02
CPC分类号： C07D401/06
摘要： Compounds of formula (I) and pharmaceutically acceptable salts thereof, and the use of a compound of formula (I) or a pharmaceutically acceptable salt thereof: X—CO—CH2-Z wherein X is a monocyclic or polycyclic aromatic group, Z is of sub-formula (h), (j) or (k): wherein n1 is 1, 2, 3 or 4; n2 is 0, 1, 2, 3 or 4; n3is 2, 3, 4 or 5; q is 0, 1, 2 or 3; p is 0, 1 or 2; m is 0, 1 or 2; R5 is hydrogen, C1-2 alkyl, aralkyl or R5 is (CH2)z-R10 wherein z is 2 or 3 and R10 is selected from cyano, hydroxyl, C1-6 alkoxy, phenoxy, C(O)C1-6 alkyl, COC6H5, —CONR11R12, NR11COR12, SO2NR11R12 or NR11SO2R12 wherein R11 and R12 are hydrogen or C1-6 alkyl; or R5 is straight or branched chain alkylene of chain length 1-6 carbon atoms terminally substituted by aryl, 3 to 8 membered cycloalkyl, 3 to 8 membered heterocyclyl, 5 or 6 membered monocyclic heteroaryl or 9 or 10 membered fused bicyclic heteroaryl linked through carbon, C2-7 alkoxycarbonyl, or secondary or tertiary hydroxy substituted C1-6 alkyl; ; and R6, R7 and R8 are independently hydrogen or C1-6 alkyl; and R9 is hydrogen or C1-10alkyl; and their use as pharmaceuticals in the treatment of gastrointestinal disorders, cardiovascular disorders and CNS disorders.

8. 发明申请

US20050270942A1 Optical disk tracking servo circuit enabled to compensate for non-continuous track segments or prolonged defect 失效
标题翻译：光盘跟踪伺服电路能够补偿非连续轨道段或延长缺陷
公开(公告)号：US20050270942A1
公开(公告)日：2005-12-08
申请号：US10887985
申请日：2004-07-09
申请人： Francis King , Jeffrey Liu
发明人： Francis King , Jeffrey Liu
IPC分类号： G11B7/00 , G11B7/09 , G11B19/04 , G11B20/18
CPC分类号： G11B20/18 , G11B7/0948 , G11B19/04
摘要： The invention pertains to an improvement for a tracking and focusing servo and defect management circuit that controls the tracking and focusing of an optical head on an optical media in an apparatus for reproducing a data, sound or image recorded on the optical media. The invention characterizes by the provision of a circuit for managing modulation of an RF signal from the optical pickup head caused when the optical pickup head encounters a non-continuous track in segment arrangement or a very long extended defect such as a extended flaw in the disc resulted discontinuous track segment thereon, and an adjusting circuit which manages the loop gain of the tracking servo circuit per the track arrangement of defect detection and a tracking profile, whereby the responsiveness of the optical pickup head is improved and track skipping prevented or recovered.
摘要翻译：本发明涉及跟踪和聚焦伺服和缺陷管理电路的改进，其控制在用于再现记录在光学介质上的数据，声音或图像的装置中的光学介质上的光学头的跟踪和聚焦。本发明的特征在于提供一种用于管理来自光学拾取头的RF信号的调制的电路，当光学拾取头在片段布置中遇到不连续的轨道或非常长的扩展缺陷（例如盘中的延长缺陷）时在其上形成不连续的轨道段，以及调整电路，其管理每个缺陷检测的轨道布置跟踪轮廓的跟踪伺服电路的环路增益，从而提高光学拾取头的响应性并防止或恢复轨迹跳跃。

9. 发明申请

US20070006973A1 Cutting element for sealing machine 有权
标题翻译：封口机切割元件
公开(公告)号：US20070006973A1
公开(公告)日：2007-01-11
申请号：US11176759
申请日：2005-07-07
申请人： Francis King , Jonathan Van , Mitchell Smith , Kenneth Chrisman
发明人： Francis King , Jonathan Van , Mitchell Smith , Kenneth Chrisman
IPC分类号： B32B38/04 , B32B37/04
CPC分类号： B26D1/025 , B26D1/0006 , B26D7/10 , B26D7/2628 , B26D2001/006 , B29C65/18 , B29C65/305 , B29C65/7439 , B29C65/7873 , B29C66/1122 , B29C66/133 , B29C66/4312 , B29C66/4322 , B29C66/73921 , B29C66/80 , B29C66/8122 , B29C66/81261 , B29C66/8167 , B29C66/8182 , B29C66/81821 , B29C66/8242 , B29C66/8246 , B29C66/83221 , B29C66/83423 , B29C66/836 , B29C66/849 , B29C66/91212 , B29C66/91231 , B29C66/91421 , B29C66/91431 , B29C66/9161 , B29C66/961 , B65B9/073 , B65B51/18 , B65B61/005 , Y10T156/1054 , Y10T156/108 , Y10T156/1084 , Y10T156/1313 , B29K2905/02
摘要： The present invention describes a blade assembly for use with side-sealing and lap-sealing machines, which are used to seal thermoplastic film. Briefly, the cutting element is oval in shape, and has its entire outer edge profiled. This provides four distinct cutting surfaces, depending on the mounting orientation of the cutting element in the machine. This cutting element is held against a heating block, and its temperature is continuously monitored by a temperature sensor. The sensor is spring-loaded to insure solid contact with the cutting element, and thus, accurate temperature measurements. This entire assembly is then encased in insulation. Additionally, the cutting element is mounted on an adjustable platform, which permits vertical adjustments relative to the film. Thus, the specific portion of the cutting element which actually engages the film can be adjusted to improve the cutting quality or further extend the useful life of the cutting element.
摘要翻译：本发明描述了用于密封热塑性薄膜的侧密封和搭接机的叶片组件。简而言之，切割元件是椭圆形的，并且其整个外边缘成型。这提供了四个不同的切割表面，这取决于切割元件在机器中的安装方向。该切割元件被保持在加热块上，并且其温度由温度传感器连续监测。传感器是弹簧加载的，以确保与切割元件的固体接触，从而实现精确的温度测量。然后将整个组件封装在绝缘体中。此外，切割元件安装在可调平台上，其允许相对于胶片的垂直调节。因此，可以调节实际接合薄膜的切割元件的特定部分，以提高切割质量或进一步延长切割元件的使用寿命。

10. 发明申请

US20050176759A1 7-sulfonyl-3-benzazepine derivatives as modulators of the dopamine receptor and their use for the treatment cns disorders 审中-公开
标题翻译： 7-磺酰基-3-苯并吖庚因衍生物作为多巴胺受体的调节剂及其用于治疗cns病症的用途
公开(公告)号：US20050176759A1
公开(公告)日：2005-08-11
申请号：US10499776
申请日：2002-12-20
申请人： Mahmood Ahmed , Steven Bromidge , Ian Forbes , Andrew Gribble , Christopher Johnson , Francis King , Andrew Lightfoot , Gregor Macdonald , Stephen Moss , Mervyn Thompson , David Witty
发明人： Mahmood Ahmed , Steven Bromidge , Ian Forbes , Andrew Gribble , Christopher Johnson , Francis King , Andrew Lightfoot , Gregor Macdonald , Stephen Moss , Mervyn Thompson , David Witty
IPC分类号： C07D223/14 , A61K31/55 , A61P1/08 , A61P3/04 , A61P15/00 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , C07D223/16 , C07D401/12 , C07D403/12 , A61K31/47 , A61K31/4035
CPC分类号： C07D223/16 , C07D401/12 , C07D403/12
摘要： Invented are non-peptide TPO mimetics. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.
摘要翻译：发明的是非肽TPO模拟物。还发明了一种在有需要的哺乳动物（包括人）中治疗血小板减少症的方法，其包括向所述哺乳动物施用有效量的选择的羟基-1-偶氮苯衍生物。

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