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1. 发明申请

US20070104780A1 Formulation comprising a drug of low water solubility and method of use thereof 审中-公开
标题翻译：包含低水溶性药物的制剂及其使用方法
公开(公告)号：US20070104780A1
公开(公告)日：2007-05-10
申请号：US11552344
申请日：2006-10-24
申请人： John Lipari , Didier Lefebvre , Tzuchi Ju , Kennan Marsh , Geoff Zhang , Jayanthy Jayanth , Chetan Pujara , Howard Cheskin , Vitomir Vucenovic , Ping Tong
发明人： John Lipari , Didier Lefebvre , Tzuchi Ju , Kennan Marsh , Geoff Zhang , Jayanthy Jayanth , Chetan Pujara , Howard Cheskin , Vitomir Vucenovic , Ping Tong
IPC分类号： A61K31/506 , A61K31/501 , A61K31/497 , A61K31/4439 , A61K31/425 , A61K31/42 , A61K31/416 , A61K9/64
CPC分类号： A61K9/10 , A61K9/0056 , A61K9/0095 , A61K9/107 , A61K9/48 , A61K31/416 , A61K31/42 , A61K31/423 , A61K31/425 , A61K31/428 , A61K31/4439 , A61K31/47 , A61K31/497 , A61K31/501 , A61K31/503 , A61K31/506 , A61K31/517 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/24 , A61K47/44
摘要： A pharmaceutical composition comprises a drug-carrier system having a small-molecule drug of low water solubility, e.g. N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N′-(2-fluoro-5-methylphenyl)urea (ABT-869), and (+)-1-(5-tert-butyl-1-yl)-3-(1H-indazol-4-yl)-urea (ABT-102), in solution in a substantially non-aqueous carrier that comprises at least one phospholipid and a pharmaceutically acceptable solubilizing agent. The drug-carrier system, when mixed with an aqueous phase, typically forms a non-gelling, substantially non-transparent liquid dispersion. The composition is suitable for administration by a suitable route, e.g. orally, to a subject in need thereof.
摘要翻译：药物组合物包含具有低水溶性的小分子药物的药物 - 载体体系，例如。 N- [4-（3-氨基-1H-吲唑-4-基）苯基] -N' - （2-氟-5-甲基苯基）脲（ABT-869）和（+） - - 叔丁基-1-基）-3-（1H-吲唑-4-基） - 脲（ABT-102）在基本上非水性载体中的溶液中，其包含至少一种磷脂和药学上可接受的增溶剂。当与水相混合时，药物载体体系通常形成非凝胶化的基本不透明的液体分散体。该组合物适合通过合适途径施用，例如口服，给有需要的受试者。

2. 发明申请

US20050191324A1 Flavoring systems for pharmaceutical compositions and methods of making such compositions 审中-公开
标题翻译：用于药物组合物的调味剂系统和制备这种组合物的方法
公开(公告)号：US20050191324A1
公开(公告)日：2005-09-01
申请号：US11118733
申请日：2005-04-29
申请人： Laman Alani , Donald Gauwitz , Dilip Kaul , John Lipari , Soumojeet Ghosh , Kennan Marsh , Richard Whelan , Vanik Petrossian
发明人： Laman Alani , Donald Gauwitz , Dilip Kaul , John Lipari , Soumojeet Ghosh , Kennan Marsh , Richard Whelan , Vanik Petrossian
IPC分类号： A61K9/00 , A61K31/7056
CPC分类号： A61K47/46 , A61K9/0095 , A61K47/02 , A61K47/12
摘要： A flavoring system for a liquid pharmaceutical composition and pharmaceutical compositions containing such flavoring systems are disclosed. Flavoring systems of the invention include at least one sweetening agent, at least two flavored ingredients, and at least one flavor modifier selected from the group consisting of citric acid, sodium citrate, sodium chloride, and mixtures thereof. At least two of the flavored ingredients are selected from the group consisting of a vanilla flavored ingredient, a peppermint flavored ingredient, a menthol flavored ingredient, a cotton candy flavored ingredient, and mixtures thereof. The one or more sweetening agents comprise glycerin, monoammonium glycyrrhizinate, saccharin sodium, acesulfame potassium, high fructose corn syrup, and/or mixtures thereof. Pharmaceutical compositions of the invention include a flavoring system of the invention, a solvent system, and at least one pharmaceutically active agent, such as lopinavir or derivatives thereof, ritonavir or derivatives thereof, or mixtures thereof. Methods for making such liquid pharmaceutical compositions are also disclosed.
摘要翻译：公开了一种用于液体药物组合物的调味体系和含有这种调味体系的药物组合物。本发明的调味系统包括至少一种甜味剂，至少两种调味成分和至少一种选自柠檬酸，柠檬酸钠，氯化钠及其混合物的调味剂。至少两种调味成分选自香草调味成分，薄荷调味成分，薄荷醇风味成分，棉花糖调味成分及其混合物。一种或多种甜味剂包括甘油，甘草酸单铵盐，糖精钠，乙酰磺胺酸钾，高果糖玉米糖浆和/或其混合物。本发明的药物组合物包括本发明的调味剂体系，溶剂体系和至少一种药物活性剂，例如洛匹那韦或其衍生物，利托那韦或其衍生物，或其混合物。还公开了制备这种液体药物组合物的方法。

3. 发明授权

US06458818B1 Pharmaceutical composition 有权
标题翻译：药物组成
公开(公告)号：US06458818B1
公开(公告)日：2002-10-01
申请号：US09347077
申请日：1999-07-02
申请人： John Lipari , Laman A. Al-Razzak , Soumojeet Ghosh , Rong Gao , Dilip Kaul
发明人： John Lipari , Laman A. Al-Razzak , Soumojeet Ghosh , Rong Gao , Dilip Kaul
IPC分类号： A61K31425
CPC分类号： A61K31/427 , A61K9/4858
摘要： A liquid pharmaceutical composition providing improved oral bioavailability is disclosed for compounds which are inhibitors of HIV protease. In particular, the composition comprises a solution in a pharmaceutically acceptable organic solvent of (a) the HIV protease inhibitor and, optionally, (b) a surfactant. The composition can optionally be encapsulated in either hard gelatin capsules or soft elastic capsules (SEC).
摘要翻译：对于作为HIV蛋白酶抑制剂的化合物，公开了提供改善的口服生物利用度的液体药物组合物。特别地，组合物包含（a）HIV蛋白酶抑制剂和任选的（b）表面活性剂的药学上可接受的有机溶剂中的溶液。组合物可以任选地包封在硬明胶胶囊或软弹性胶囊（SEC）中。

4. 发明授权

US06521651B1 Pharmaceutical composition 有权
公开(公告)号：US06521651B1
公开(公告)日：2003-02-18
申请号：US09393872
申请日：1999-09-10
申请人： John Lipari , Laman A. Al-Razzak , Soumojeet Ghosh , Rong Gao , Dilip Kaul
发明人： John Lipari , Laman A. Al-Razzak , Soumojeet Ghosh , Rong Gao , Dilip Kaul
IPC分类号： A61K31425
CPC分类号： A61K31/427 , A61K9/4858
摘要： A liquid pharmaceutical composition providing improved oral bioavailability is disclosed for compounds which are inhibitors of HIV protease. In particular, the composition comprises a solution in a pharmaceutically acceptable organic solvent of (a) the HIV protease inhibitor and, optionally, (b) a surfactant. The composition can optionally be encapsulated in either hard gelatin capsules or soft elastic capsules (SEC).

5. 发明申请

US20050112191A1 Novel formulations comprising lipid-regulating agents 审中-公开
标题翻译：包含脂质调节剂的新型制剂
公开(公告)号：US20050112191A1
公开(公告)日：2005-05-26
申请号：US10993239
申请日：2004-11-19
申请人： John Lipari , Dawn Raymond , Tom Reiland , Yeshwant Sanzgiri
发明人： John Lipari , Dawn Raymond , Tom Reiland , Yeshwant Sanzgiri
IPC分类号： A61K9/107 , A61K36/47 , A61K47/14 , A61K9/48 , A61K31/192 , A61K35/78
CPC分类号： A61K47/14 , A61K9/107
摘要： The present invention is directed to a formulation comprising a lipid-regulating agent dissolved in at least one monoglyceride as the primary solvent medium for said agent. One or more emulsifiers may be added to the formulation.
摘要翻译：本发明涉及包含溶解在至少一种单酸甘油酯作为所述药剂的主要溶剂介质的脂质调节剂的制剂。可以向制剂中加入一种或多种乳化剂。

6. 发明授权

US06232333B1 Pharmaceutical composition 失效
标题翻译：药物组成
公开(公告)号：US06232333B1
公开(公告)日：2001-05-15
申请号：US08966495
申请日：1997-11-07
申请人： John Lipari , Laman A. Al-Razzak , Soumojeet Ghosh , Rong Gao , Dilip Kaul
发明人： John Lipari , Laman A. Al-Razzak , Soumojeet Ghosh , Rong Gao , Dilip Kaul
IPC分类号： A61K31425
CPC分类号： A61K31/427 , A61K9/4858
摘要： A liquid pharmaceutical composition providing improved oral bioavailability is disclosed for compounds which are inhibitors of HIV protease. In particular, the composition comprises a solution in a pharmaceutically acceptable organic solvent of (a) the HIV protease inhibitor and, optionally, (b) a surfactant. The composition can optionally be encapsulated in either hard gelatin capsules or soft elastic capsules (SEC).
摘要翻译：对于作为HIV蛋白酶抑制剂的化合物，公开了提供改善的口服生物利用度的液体药物组合物。特别地，组合物包含（a）HIV蛋白酶抑制剂和任选的（b）表面活性剂的药学上可接受的有机溶剂中的溶液。组合物可以任选地包封在硬明胶胶囊或软弹性胶囊（SEC）中。

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