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1. 发明申请

US20050032790A1 Compounds 审中-公开
标题翻译：化合物
公开(公告)号：US20050032790A1
公开(公告)日：2005-02-10
申请号：US10923010
申请日：2004-08-23
申请人： John Liebeschuetz , Amanda Lyons , Christopher Murray , Andrew Rimmer , Stephen Young , Nicholas Camp , Stuart Jones , Phillip Morgan , William Wylie , Simon Richards , John Masters , Michael Wiley
发明人： John Liebeschuetz , Amanda Lyons , Christopher Murray , Andrew Rimmer , Stephen Young , Nicholas Camp , Stuart Jones , Phillip Morgan , William Wylie , Simon Richards , John Masters , Michael Wiley
IPC分类号： C07C237/36 , C07C255/60 , C07D209/08 , C07D209/30 , C07D209/34 , C07D209/42 , C07D211/26 , C07D211/34 , C07D211/46 , C07D211/60 , C07D213/53 , C07D213/74 , C07D213/82 , C07D215/38 , C07D217/04 , C07D217/06 , C07D231/56 , C07D235/06 , C07D241/24 , C07D277/28 , C07D277/46 , C07D277/64 , C07D277/82 , C07D295/135 , C07D295/185 , C07D317/68 , C07D333/38 , C07D333/68 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D405/14 , C07D413/14 , C07D417/06 , C07D487/04 , A61K31/54 , A61K31/19 , A61K31/40 , A61K31/445 , A61K31/497
CPC分类号： C07D401/14 , C04B35/632 , C07C237/36 , C07C255/60 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2602/42 , C07D209/08 , C07D209/30 , C07D209/34 , C07D209/42 , C07D211/26 , C07D211/34 , C07D211/46 , C07D211/60 , C07D213/53 , C07D213/74 , C07D213/82 , C07D215/38 , C07D217/04 , C07D217/06 , C07D231/56 , C07D235/06 , C07D241/24 , C07D277/28 , C07D277/46 , C07D277/64 , C07D277/82 , C07D295/135 , C07D295/185 , C07D317/68 , C07D333/38 , C07D333/68 , C07D401/06 , C07D401/12 , C07D403/06 , C07D405/14 , C07D413/14 , C07D417/06 , C07D487/04
摘要： Compounds of formula (I) where R2, each X, L, Y, Cy, Lp, D and n are as defined in the specification, are serine protease inhibitors useful as antithrombotic agents.
摘要翻译：其中R2，X，L，Y，Cy，Lp，D和n如说明书中所定义的式（I）化合物是用作抗血栓形成剂的丝氨酸蛋白酶抑制剂。

2. 发明申请

US20070072869A1 CERTAIN GLYCINE DERIVATIVES AS FACTOR Xa INHIBITORS FOR USE IN THE TREATMENT OF THROMBOTIC DISORDERS 失效
标题翻译：某些谷氨酸衍生物作为用于治疗血栓性疾病的因子Xa抑制剂
公开(公告)号：US20070072869A1
公开(公告)日：2007-03-29
申请号：US11456589
申请日：2006-07-11
申请人： Michael Wiley , Daniel Sall , Christopher Murray , Stephen Young , Jolie Bastian
发明人： Michael Wiley , Daniel Sall , Christopher Murray , Stephen Young , Jolie Bastian
IPC分类号： A61K31/496 , A61K31/4545 , C07D403/14
CPC分类号： C07D401/14 , C07D211/26 , C07D211/58 , C07D401/04 , C07D401/12 , C07D409/12 , C07D409/14
摘要： Compounds of formula (I) in which R, R1, R2, n and X1 have the meanings given in the specification are Factor Xa inhibitors useful in the treatment of thrombotic disorders.
摘要翻译：其中R，R 1，R 2，n和X 1具有本说明书中给出的含义的式（I）化合物是因子可用于治疗血栓形成障碍的Xa抑制剂。

3. 发明申请

US20050026928A1 Chemical compounds 失效
标题翻译：化合物
公开(公告)号：US20050026928A1
公开(公告)日：2005-02-03
申请号：US10483264
申请日：2002-07-24
申请人： Michael Wiley , Daniel Sall , John Liebeschuetz
发明人： Michael Wiley , Daniel Sall , John Liebeschuetz
IPC分类号： A61P7/02 , C07D211/26 , C07D211/58 , C07D401/12 , C07D401/14 , C07D409/12 , C07D409/14 , A61K31/496 , A61K31/4545 , C07
CPC分类号： C07D401/12 , C07D211/26 , C07D211/58 , C07D401/14 , C07D409/12 , C07D409/14
摘要： Compounds of formula (I) in which R1, R2 and X4 have the meanings given in the specification are Factor Xa inhibitors useful in the treatment of thrombotic disorders.
摘要翻译：其中R 1，R 2和X 4具有本说明书中给出的含义的式（I）化合物是可用于治疗血栓形成障碍的因子Xa抑制剂。

4. 发明申请

US20050282862A1 Aromatic amides 失效
标题翻译：芳香酰胺
公开(公告)号：US20050282862A1
公开(公告)日：2005-12-22
申请号：US10629817
申请日：2003-07-29
申请人： Douglas Beight , Trelia Craft , Carl Denny , Jeffry Franciskovich , Theodore Goodson , Steven Hall , David Herron , Sajan Joseph , Valentine Klimkowski , Jeffrey Kyle , John Masters , David Mendel , Guy Milot , Marta Pineiro-Nunez , Jason Sawyer , Robert Shuman , Gerald Smith , Anne Tebbe , Jennifer Tinsley , Leonard Weir , James Wikel , Michael Wiley , Ying Yee
发明人： Douglas Beight , Trelia Craft , Carl Denny , Jeffry Franciskovich , Theodore Goodson , Steven Hall , David Herron , Sajan Joseph , Valentine Klimkowski , Jeffrey Kyle , John Masters , David Mendel , Guy Milot , Marta Pineiro-Nunez , Jason Sawyer , Robert Shuman , Gerald Smith , Anne Tebbe , Jennifer Tinsley , Leonard Weir , James Wikel , Michael Wiley , Ying Yee
IPC分类号： A61K31/44 , A61K31/4427 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/5377 , A61P7/02 , A61P9/10 , C07D213/75 , C07D401/12 , C07D401/14 , C07D405/14 , C07D407/14 , C07D409/14 , C07D417/14 , C07D41/02
CPC分类号： C07D213/75 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14
摘要： This application relates to a compound of formula I (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
摘要翻译：本申请涉及如本文所定义的式I化合物（或其药学上可接受的盐），其药物组合物及其作为因子Xa抑制剂的用途，以及其制备方法及其中间体。

5. 发明申请

US20070027185A1 Antithrombotic aromatic ethers 失效
标题翻译：抗血栓芳香醚
公开(公告)号：US20070027185A1
公开(公告)日：2007-02-01
申请号：US10571373
申请日：2004-09-24
申请人： Jeffry Franciskovich , Theodore Goodson , David Herron , Angela Marquart , John Masters , David Mendel , Leander Merritt , Andrew Ratz , Gerald Smith , Michael Wiley , Ying Yee
发明人： Jeffry Franciskovich , Theodore Goodson , David Herron , Angela Marquart , John Masters , David Mendel , Leander Merritt , Andrew Ratz , Gerald Smith , Michael Wiley , Ying Yee
IPC分类号： A61K31/4545 , A61K31/444 , C07D401/02
CPC分类号： C07C49/84 , C04B35/632 , C07C65/05 , C07C65/21 , C07D213/81 , C07D295/155 , C07D317/30 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/12 , C07D409/14 , C07D417/14
摘要： This application relates to a compound of formula I (or a prodrug thereof or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa and/or thrombin, as well as a process for its preparation and intermediates therefor.
摘要翻译：本申请涉及如本文所定义的式I化合物（或其前体药物或其药学上可接受的盐），其药物组合物及其作为因子Xa和/或凝血酶抑制剂的用途，以及作为其制备方法及其中间体。

6. 发明授权

US08553553B1 Quality-of-service marking network configurations 有权
标题翻译：服务质量标记网络配置
公开(公告)号：US08553553B1
公开(公告)日：2013-10-08
申请号：US13410123
申请日：2012-03-01
申请人： Edward Thomas Lingham Hardie , Michael Wiley
发明人： Edward Thomas Lingham Hardie , Michael Wiley
IPC分类号： G01R31/08
CPC分类号： H04L41/0803 , H04L47/2433
摘要： System, method and program product, the system comprising: return network element along a return path for network flows for network sessions for a client; a controller computer; network elements along a forward path for the network flow for network sessions; with the return network element, configured to: receive packets for a return path network flow; determine whether there is an existing ruleset entry for quality-of-service marking packet data combination; sending the packet to the controller computer when the return network element deter mines no existing ruleset entry for the quality-of-service marking packet data combination. The return network element and/or controller computer configured to determine if the source network node is trusted. The controller computer configured to identify one or more network elements in a forward path, and initiate installation of a ruleset entry for the client along the forward path.
摘要翻译：系统，方法和程序产品，所述系统包括：沿着用于客户端的网络会话的网络流的返回路径返回网络元件; 控制器电脑; 沿着网络会话的网络流的前向路径的网络元素; 与返回网络元素配置为：接收返回路径网络流的数据包; 确定是否存在用于服务质量标记分组数据组合的现有规则集条目; 当返回网络元件确定不存在用于服务质量标记分组数据组合的现有规则集条目时，将分组发送到控制器计算机。被配置为确定源网络节点是否被信任的返回网元和/或控制器计算机。控制器计算机被配置为识别前向路径中的一个或多个网络元件，并且启动沿着前向路径为客户端安排规则集条目。

7. 发明申请

US20050096328A1 Certain 1-(D-cycloproplyglycinyl)-4-piperidin-4-yl)piperazine compounds as inhibitors of the serine protease factor xa 失效
标题翻译：某些1-（D-环丙基甘氨酰基）-4-哌啶-4-基）哌嗪化合物作为丝氨酸蛋白酶因子xa的抑制剂
公开(公告)号：US20050096328A1
公开(公告)日：2005-05-05
申请号：US10486138
申请日：2003-03-24
申请人： Michael Wiley , Gary Engel
发明人： Michael Wiley , Gary Engel
IPC分类号： A61K31/496 , A61P7/02 , C07C57/145 , C07C57/15 , C07C235/52 , C07D211/58 , C07D43/04
CPC分类号： C07D211/58 , C07C235/52 , C07C2601/02
摘要： The compounds of formula (I) in which R represents a hydrogen atom or a fluorine atom, or a pharmaceutically acceptable salt thereof are Factor Xa inhibitors useful in the treatment of thrombotic disorders.
摘要翻译：其中R表示氢原子或氟原子的式（I）化合物或其药学上可接受的盐是可用于治疗血栓形成障碍的因子Xa抑制剂。

8. 发明申请

US20050060226A1 Recommending an offering based on inventory data 审中-公开
标题翻译：推荐基于库存数据的产品
公开(公告)号：US20050060226A1
公开(公告)日：2005-03-17
申请号：US10660160
申请日：2003-09-11
申请人： Daniel Heithoff , R. Holcomb , Satheesh Krishnamoorthy , David Nusbaum , Van Sammons , Kurt Thompson , Paul Wertzler , Michael Wiley
发明人： Daniel Heithoff , R. Holcomb , Satheesh Krishnamoorthy , David Nusbaum , Van Sammons , Kurt Thompson , Paul Wertzler , Michael Wiley
IPC分类号： G06Q30/00 , G06F17/60
CPC分类号： G06Q30/02 , G06Q30/0223
摘要： A method, apparatus, system, and signal-bearing medium that in an embodiment recommend an offering to a client based on inventory data received from a client, a condition, and a threshold. The client provides the inventory data, which in various embodiments may be an inventory of hardware and/or software installed at the client and/or an inventory of data that describes performance characteristics and/or a trend of the client. In this way, an offering, such as an offer to provide goods or services, can be targeted to the client based on the specific needs of the client.
摘要翻译：一种方法，装置，系统和信号承载介质，其在一个实施例中基于从客户接收的库存数据，条件和阈值向客户端推荐产品。客户端提供清单数据，其在各种实施例中可以是安装在客户端的硬件和/或软件的清单和/或描述客户端的性能特征和/或趋势的数据的库存。通过这种方式，可以根据客户的具体需求，向客户提供诸如提供商品或服务的产品。

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