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1. 发明授权

US5677445A Polycyclic complexing agents 失效
标题翻译：多环络合剂
公开(公告)号：US5677445A
公开(公告)日：1997-10-14
申请号：US573377
申请日：1995-12-15
申请人： John L. Toner , David A. Hilborn , Bruce J. Murray , Timothy Z. Hossain
发明人： John L. Toner , David A. Hilborn , Bruce J. Murray , Timothy Z. Hossain
IPC分类号： A61K47/48 , A61K49/00 , A61K51/00 , A61K51/10 , C07D213/38 , C07D213/53 , C07D213/61 , C07D213/74 , C07D213/77 , C07D401/14 , C07D403/10 , C07D471/04 , C07D471/14 , C07D471/18 , C07D487/22 , G01N33/534 , C07D487/16 , C07D498/16 , C07D513/16
CPC分类号： C07D213/53 , A61K47/48169 , A61K47/48707 , A61K51/1054 , A61K51/1063 , A61K51/1093 , C07D213/61 , C07D213/77 , C07D471/04
摘要： A compound of formula ##STR1## where the two R.sup.2 groups, taken together, represent the atoms necessary to complete a macrocyclic ring structure containing at least one heteroatom coordinating site and at least one alkylene group forming part of the ring structure; R.sup.3 represents hydrogen, alkyl, alkoxy, alkylthio, alkylamino, alkylformamido, aryl, aryloxy, heterocyclyl or a protein reactive group; and R.sup.4 represents hydrogen or a protein reactive group, provided that at least one of the R.sup.4 groups is a protein reactive group, and salts, complexes and protein conjugates thereof.
摘要翻译：其中两个R 2基团一起表示完成含有至少一个杂原子配位位点和至少一个形成环结构部分的亚烷基的大环环结构所必需的原子的化合物 R 3表示氢，烷基，烷氧基，烷硫基，烷基氨基，烷基酰氨基，芳基，芳氧基，杂环基或蛋白质反应性基团; 并且R 4表示氢或蛋白质反应性基团，条件是至少一个R 4基团是蛋白质反应性基团，以及其盐，复合物和蛋白质缀合物。

2. 发明授权

US5523402A Tripyridyl macrocyclic compounds 失效
标题翻译：三吡啶基大环化合物
公开(公告)号：US5523402A
公开(公告)日：1996-06-04
申请号：US287381
申请日：1994-08-08
申请人： John L. Toner , David A. Hilborn , Bruce J. Murray , Timothy Z. Hossain
发明人： John L. Toner , David A. Hilborn , Bruce J. Murray , Timothy Z. Hossain
IPC分类号： A61K47/48 , A61K49/00 , A61K51/00 , A61K51/10 , C07D213/38 , C07D213/53 , C07D213/61 , C07D213/74 , C07D213/77 , C07D401/14 , C07D403/10 , C07D471/04 , C07D471/14 , C07D471/18 , C07D487/22 , G01N33/534 , C07D259/00
CPC分类号： C07D213/53 , A61K47/48169 , A61K47/48707 , A61K51/1054 , A61K51/1063 , A61K51/1093 , C07D213/61 , C07D213/77 , C07D471/04
摘要： Tripyridyl macrocyclic compounds that are employed in the production of a complexing agent for use in targeting radioactive immunoreagents with the following formula are disclosed: ##STR1## wherein R.sup.1 represents hydrogen, alkyl, alkoxy, alkylthio, alkylamino, alkylformamido, aryl, aryloxy, heterocyclyl or a protein reactive group;the two R.sup.2 groups, taken together, represent a bridging group serving to complete a macrocyclic ring, the bridging group containing at least one heteroatom and at least one alkylene group which form part of the resulting macrocyclic ring;R.sup.3 represents hydrogen, alkyl, alkoxy, alkylthio, alkylamino, alkylformamido, aryl, aryloxy, heterocyclyl, or a protein reactive group;R.sup.5 represents alkyl or alkoxy; andR.sup.6 represents a protein reactive group.
摘要翻译：公开了用于制备用于靶向具有下式的放射性免疫试剂的络合剂的三吡啶基大环化合物：其中R 1表示氢，烷基，烷氧基，烷硫基，烷基氨基，烷基酰氨基，芳基，芳氧基，杂环基或蛋白质反应性基团; 两个R2基团一起表示用于完成大环的桥连基团，桥连基团含有至少一个杂原子和至少一个形成所得大环的一部分的亚烷基; R3代表氢，烷基，烷氧基，烷硫基，烷基氨基，烷基酰氨基，芳基，芳氧基，杂环基或蛋白质反应性基团; R5代表烷基或烷氧基; R6表示蛋白质反应性基团。

3. 发明授权

US5707603A Pyridine complexing agents and targeting immunoreagents useful in therapeutic and diagnostic compositions 失效
标题翻译：吡啶络合剂和靶向免疫反应剂可用于治疗和诊断组合物
公开(公告)号：US5707603A
公开(公告)日：1998-01-13
申请号：US375276
申请日：1995-01-19
申请人： John L. Toner , David A. Hilborn , Bruce J. Murray , Timothy Z. Hossain , Robert A. Snow , Ashis K. Saha , Richard Philion , Clyde W. Shearman , Chandra Shah
发明人： John L. Toner , David A. Hilborn , Bruce J. Murray , Timothy Z. Hossain , Robert A. Snow , Ashis K. Saha , Richard Philion , Clyde W. Shearman , Chandra Shah
IPC分类号： A61K47/48 , A61K49/00 , A61K51/00 , A61K51/10 , C07D213/38 , C07D213/53 , C07D213/61 , C07D213/74 , C07D213/77 , C07D401/14 , C07D403/10 , C07D471/04 , C07D471/14 , C07D471/18 , C07D487/22 , G01N33/534 , A61K51/04 , C07D213/22 , C07F13/00
CPC分类号： C07D213/53 , A61K47/48169 , A61K47/48707 , A61K51/1054 , A61K51/1063 , A61K51/1093 , C07D213/61 , C07D213/77 , C07D471/04
摘要： The invention provides targeting radioactive immunoreagents comprising a metal radionuclide ion, a complexing agent having structure A-I, as defined in the specification, and an immunoreactive group covalently bonded to the complexing agent. The present invention also provides novel complexing agents having the structure A-I, as defined in the specification. The targeting radioactive immunoreagents are particularly useful in therapeutic and diagnostic imaging compositions and methods.
摘要翻译：本发明提供靶向的放射免疫试剂，其包含金属放射性核素离子，如说明书中所定义的具有结构A-1的络合剂和共价键合到络合剂上的免疫反应性基团。本发明还提供具有本说明书中定义的结构A-1的新型络合剂。靶向放射免疫试剂在治疗和诊断成像组合物和方法中特别有用。

4. 发明授权

US5367080A Complexing agents and targeting radioactive immunoreagents useful in therapeutic and diagnostic imaging compositions and methods 失效
标题翻译：复合剂和靶向用于治疗和诊断成像组合物和方法的放射免疫试剂
公开(公告)号：US5367080A
公开(公告)日：1994-11-22
申请号：US784333
申请日：1991-10-29
申请人： John L. Toner , David A. Hilborn , Bruce J. Murray , Timothy Z. Hossain
发明人： John L. Toner , David A. Hilborn , Bruce J. Murray , Timothy Z. Hossain
IPC分类号： A61K47/48 , A61K49/00 , A61K51/00 , A61K51/10 , C07D213/38 , C07D213/53 , C07D213/61 , C07D213/74 , C07D213/77 , C07D401/14 , C07D403/10 , C07D471/04 , C07D471/14 , C07D471/18 , C07D487/22 , G01N33/534 , C07D213/22
CPC分类号： C07D213/53 , A61K47/48169 , A61K47/48707 , A61K51/1054 , A61K51/1063 , A61K51/1093 , C07D213/61 , C07D213/77 , C07D471/04
摘要： A targeting radioactive immunoreagent comprising a compound having the structure ##STR1##
摘要翻译：靶向放射免疫试剂，其包含具有结构的化合物

5. 发明授权

US4795712A Calcium complexing dyes and their use in analytical compositions, elements and methods 失效
标题翻译：钙络合染料及其在分析组合物，元素和方法中的应用
公开(公告)号：US4795712A
公开(公告)日：1989-01-03
申请号：US37303
申请日：1987-04-10
申请人： John L. Toner , Bruce J. Murray , Bruce E. Babb , Michael W. Sundberg
发明人： John L. Toner , Bruce J. Murray , Bruce E. Babb , Michael W. Sundberg
IPC分类号： C09B23/14 , C09B29/36 , C09B57/00 , C09B57/06 , C09B57/10 , C09B69/00 , G01N33/84 , G01N31/22
CPC分类号： C09B23/145 , C09B29/36 , C09B57/06 , C09B57/10 , C09B69/00 , G01N33/84 , G01N2800/04
摘要： Novel chromogenic derivatives of 1,2-bis-(o-aminoaryloxy)ethane-N,N,N',N'-tetraacetic acid are useful for the determination of calcium ions in both solution and dry assays. These compounds comprise a dye moiety which is directly conjugated to the acetic acid substituted-nitrogen atom and which enables the compounds to exhibit maximum absorbance at a wavelength generally greater than 400 nm before complexation. When the compounds are complexed with calcium ions, the absorbance shifts to a shorter wavelength.

6. 发明授权

US08257724B2 Delivery of highly lipophilic agents via medical devices 有权
标题翻译：通过医疗器械递送高度亲脂性的药剂
公开(公告)号：US08257724B2
公开(公告)日：2012-09-04
申请号：US11386469
申请日：2006-03-22
申请人： Keith R. Cromack , John L. Toner , Sandra E. Burke , Richard W. Krasula , Lewis B. Schwartz
发明人： Keith R. Cromack , John L. Toner , Sandra E. Burke , Richard W. Krasula , Lewis B. Schwartz
IPC分类号： A61F2/00
CPC分类号： A61L31/10 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/16 , A61L2300/00 , A61L2300/22 , A61L2300/416 , A61L2300/45
摘要： An apparatus and system for delivering a lipophilic agent associated with a medical device including: a medical device, a first lipophilic agent capable of penetrating a body lumen, wherein the transfer coefficients of the first lipophilic agent is by an amount that is statistically significant of at least approximately 5,000, wherein the first lipophilic agent is associated with the medical device, wherein the first lipophilic agent/medical device is placed adjacent to said body lumen, and wherein a therapeutically effective amount of the first lipophilic agent is delivered to a desired area within a subject. Furthermore, the invention relates to a method for improving patency in a subject involving placement of a medical device in a body lumen for treating and/or preventing adjacent diseases or maintaining patency of the body lumen.
摘要翻译：一种用于递送与医疗装置相关联的亲脂剂的装置和系统，包括：医疗装置，能够穿透体腔的第一亲脂性试剂，其中第一亲脂性试剂的转移系数为统计学上显着的至少约5,000，其中所述第一亲脂性试剂与所述医疗装置相关联，其中所述第一亲脂性试剂/医疗装置放置在所述体腔附近，并且其中治疗有效量的所述第一亲脂性试剂被递送至课程。此外，本发明涉及一种用于提高受试者通畅的方法，包括将医疗装置放置在体腔中，用于治疗和/或预防相邻疾病或维持体腔通畅。

7. 发明申请

US20100030183A1 Method of treating vascular disease at a bifurcated vessel using a coated balloon 审中-公开
标题翻译：使用涂覆气球在分叉血管处理血管疾病的方法
公开(公告)号：US20100030183A1
公开(公告)日：2010-02-04
申请号：US12371426
申请日：2009-02-13
申请人： John L. Toner , Sandra E. Burke , Keith R. Cromack , Randolf Von Oepen
发明人： John L. Toner , Sandra E. Burke , Keith R. Cromack , Randolf Von Oepen
IPC分类号： A61M31/00 , A61M29/00
CPC分类号： A61M25/104 , A61F2/958 , A61F2250/0067 , A61F2310/0097 , A61K31/4745 , A61K45/06 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61M25/10 , A61M2025/105 , A61M2025/1088
摘要： Disclosed is a method for delivery of at least one therapeutic agent from an angioplasty balloon for treating vascular disease at a bifurcated vessel. The invention also relates to the method of loading the beneficial agents onto the balloon and the device, as well as the method of delivery of the agents from separate surfaces. The invention also relates to a method of loading multiple beneficial agents onto the balloon surfaces
摘要翻译：公开了一种用于从血管成形术球囊递送至少一种治疗剂以在分叉血管处理血管疾病的方法。本发明还涉及将有益试剂装载到球囊和装置上的方法以及将试剂从分开的表面递送的方法。本发明还涉及一种将多种有益剂装载到球囊表面上的方法

8. 发明申请

US20090216317A1 Delivery of Highly Lipophilic Agents Via Medical Devices 审中-公开
标题翻译：通过医疗器械交付高亲脂性药物
公开(公告)号：US20090216317A1
公开(公告)日：2009-08-27
申请号：US11886815
申请日：2006-03-22
申请人： Keith R. Cromack , John L. Toner , Sandra E. Burke , Richard W. Krasula , Lewis B. Schwartz
发明人： Keith R. Cromack , John L. Toner , Sandra E. Burke , Richard W. Krasula , Lewis B. Schwartz
IPC分类号： A61F2/82 , A61K31/436 , A61K31/7088 , A61K39/395 , A61K38/00 , A61K31/727 , A61K31/352 , A61K38/14 , A61K31/405 , A61K31/565 , A61K31/568 , A61K31/337 , A61K31/519 , A61K38/13 , A61K31/4745 , A61K31/573
CPC分类号： A61L31/10 , A61F2/04 , A61F2/82 , A61F2002/044 , A61F2002/047 , A61F2250/0067 , A61L31/16 , A61L2300/00 , A61L2300/216 , A61L2300/222 , A61L2300/606
摘要： An apparatus and system for delivering a lipophilic agent associated with a medical device including: a medical device, a first lipophilic agent capable of penetrating a body lumen, wherein the transfer coefficients of the first lipophilic agent is by an amount that is statistically significant of at least approximately 5,000, wherein the first lipophilic agent is associated with the medical device, wherein the first lipophilic agent/medical device is placed adjacent to said body lumen, and wherein a therapeutically effective amount of the first lipophilic agent is delivered to a desired area within a subject. Furthermore, the invention relates to a method for improving patency in a subject involving placement of a medical device in a body lumen for treating and/or preventing adjacent diseases or maintaining patency of the body lumen.
摘要翻译：一种用于递送与医疗装置相关联的亲脂剂的装置和系统，包括：医疗装置，能够穿透体腔的第一亲脂性试剂，其中第一亲脂性试剂的转移系数为统计学上显着的至少约5,000，其中所述第一亲脂性试剂与所述医疗装置相关联，其中所述第一亲脂性试剂/医疗装置放置在所述体腔附近，并且其中治疗有效量的所述第一亲脂性试剂被递送至课程。此外，本发明涉及一种用于提高受试者通畅的方法，包括将医疗装置放置在体腔中，用于治疗和/或预防相邻疾病或维持体腔通畅。

9. 发明申请

US20090162413A1 COMPOSITIONS AND METHODS OF ADMINISTERING RAPAMYCIN ANALOGS WITH PACLITAXEL USING MEDICAL DEVICES 审中-公开
标题翻译：使用医疗器械管理吡虫啉类似物的组合物和方法
公开(公告)号：US20090162413A1
公开(公告)日：2009-06-25
申请号：US12090253
申请日：2006-10-12
申请人： Sandra E. Burke , Keith R. Cromack , Matthew Mack , John L. Toner
发明人： Sandra E. Burke , Keith R. Cromack , Matthew Mack , John L. Toner
IPC分类号： A61K9/00 , A61K31/337 , A61K31/395 , A61K31/56 , A61P7/02
CPC分类号： C07D498/18 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/254 , A61L2300/40 , A61L2300/41 , A61L2300/416 , A61L2300/42 , A61L2300/43 , A61L2300/45 , A61L2300/606
摘要： Systems and compositions comprising paclitaxel and a second drug, such as rapamycin, analogs, derivatives, salts and esters thereof are disclosed, as well as methods of delivery wherein the drugs have effects that complement each other. Medical devices comprising supporting structures capable of including or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient can contain one or more therapeutic agents or substances, with the carrier preferably including a coating on the surface thereof, and the coating including the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. These compositions and systems can be used in combination with other drugs, including anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these and other drugs.
摘要翻译：公开了包含紫杉醇和第二药物如雷帕霉素，类似物，衍生物，盐和酯的系统和组合物，以及其中药物具有互补作用的递送方法。包含能够包含或支持药学上可接受的载体或赋形剂的支持结构的医疗装置，所述载体或赋形剂可以含有一种或多种治疗剂或物质，所述载体优选在其表面上包括涂层，所述包衣包括治疗物质，例如药物。适用于本发明的医疗装置的支撑结构包括冠状支架，外周支架，导管，动静脉移植物，旁路移植物和用于脉管系统中的药物递送球囊。这些组合物和系统可以与其它药物组合使用，包括抗增殖剂，抗血小板剂，抗炎剂，抗血栓形成剂，细胞毒性药物，抑制细胞因子或趋化因子结合的药物，细胞去分化抑制剂，抗脂血症药，基质金属蛋白酶抑制剂，细胞抑制药物或这些和其他药物的组合。

10. 发明授权

US5932188A Therapeutic and diagnostic imaging compositions and methods 失效
标题翻译：治疗和诊断成像组合物和方法
公开(公告)号：US5932188A
公开(公告)日：1999-08-03
申请号：US963125
申请日：1997-10-28
申请人： Robert A. Snow , David L. Ladd , John L. Toner
发明人： Robert A. Snow , David L. Ladd , John L. Toner
IPC分类号： A61K47/48 , A61K49/00 , A61K51/00 , A61K51/04 , C08G65/34 , C08G65/48 , C08G69/40 , A61B5/055 , C07F5/00
CPC分类号： A61K47/48215 , A61K47/48192 , A61K47/48207 , A61K51/0497 , A61K2123/00
摘要： This invention provides therapeutic and diagnostic imaging compositions and methods featuring a polymer comprising units containing a poly(alkylene oxide) moiety linked to the residue of a chelating agent, said polymer having a cytotoxic agent associated therewith.
摘要翻译：本发明提供治疗和诊断成像组合物和方法，其特征在于包含含有与螯合剂残基连接的聚（环氧烷）部分的单元的聚合物，所述聚合物具有与其相关的细胞毒性剂。

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