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1. 发明授权

US06503240B1 Vial access adapter 有权
标题翻译：样品瓶接口适配器
公开(公告)号：US06503240B1
公开(公告)日：2003-01-07
申请号：US09665090
申请日：2000-09-20
申请人： John J. Niedospial, Jr. , Jacqueline M. Kline , Michael N. Eakins , Ernest Balestracci
发明人： John J. Niedospial, Jr. , Jacqueline M. Kline , Michael N. Eakins , Ernest Balestracci
IPC分类号： A61B1900
CPC分类号： A61J1/2096 , A61J1/1406 , A61J1/201 , A61J1/2044 , A61J1/2075 , A61J1/2082 , A61J1/2089
摘要： A vial access adapter for withdrawal of a medical fluid contained in a vial which includes a vial access adapter body having a circular top wall with a plurality of vent holes, a circular second wall spaced from the top wall, and a cylindrical side wall which walls define a chamber for holding an anti-bacterial filter. A first spike centrally located in the vial access adapter body extends through the top wall, chamber, and bottom wall, with one end extending above the top wall terminating in a threaded luer connector, while the other end terminates in a sharp point. A flow channel extends through the first spike designed for withdrawal of the medical fluid from the vial. A second spike positioned parallel to the first spike and is integral with the first spike extends from the second wall, one end of which extends into the chamber, and the other end terminates in a sharp point co-joined with the sharp point of the first spike. A flow channel extends through the second spike designed for air flow from the chamber into the vial. An elastomeric membrane positioned within the threaded luer connector seals the opening in the vial access adapter. Preferably the elastomeric membrane is of M-shaped configuration capable of flexing under pressure and of re-sealing itself after being pierced by a luer connector or a syringe equipped with a luer connector.
摘要翻译：用于取出容纳在小瓶中的医用流体的小瓶接入适配器，其包括具有多个通气孔的圆形顶壁的小瓶接入适配器主体，与顶壁间隔开的圆形第二壁，以及圆柱形侧壁，定义一个用于容纳抗菌过滤器的室。中心位于小瓶接入适配器主体中的第一个尖峰延伸穿过顶壁，室和底壁，一端延伸到顶壁上方终止于螺纹鲁尔连接器，而另一端终止于尖锐点。流动通道延伸穿过设计用于从小瓶中取出医用流体的第一尖峰。平行于第一尖钉定位并且与第一尖钉成一体的第二尖峰从第二壁延伸，其一端延伸到腔室中，另一端终止于与第一尖钉尖锐点共同连接的尖锐点穗。流动通道延伸穿过设计用于从腔室进入小瓶的气流的第二尖峰。定位在螺纹鲁尔连接器内的弹性体膜密封小瓶接入适配器中的开口。优选地，弹性体膜是M形构造，其能够在被鲁尔连接器或装有鲁尔连接器的注射器刺穿之后能够在压力下弯曲并且自身重新密封。

2. 发明授权

US06846303B2 Tamper evident syringe barrel 失效
标题翻译：篡改明显的注射器筒
公开(公告)号：US06846303B2
公开(公告)日：2005-01-25
申请号：US10774852
申请日：2004-02-09
申请人： Michael N. Eakins , Ernest Balestracci , Ernst Schramm , John J. Niedospial Jr.
发明人： Michael N. Eakins , Ernest Balestracci , Ernst Schramm , John J. Niedospial Jr.
IPC分类号： A61M5/00 , A61M5/31 , A61M5/32 , A61M5/50
CPC分类号： A61M5/3202 , A61M5/3134 , A61M5/5086 , A61M2005/3118 , A61M2005/312
摘要： A prefilled syringe of cartridge barrel having a tamper evident closure. Tamper evidence is provided by: a frangible tip seal which is integral with the tapered tip of the barrel; a frangible tip cap covering the tip, the tip seal and a portion of the distal end of the barrel; and an overwrap covering the frangible tip cap and the distal end of the barrel sealed to the distal end of the barrel by a tamper evident seal. The tapered tip is optionally equipped with a luer collar to receive an external luer connector. Alternatively, the tapered tip can be provided with a bore therethrough which can be closed with an elastomeric plug and the external connector can be a tubing conduit.
摘要翻译：具有防拆封闭的暗盒筒的预充式注射器。篡改证据由以下提供：与桶的锥形尖端成一体的易碎顶端密封; 覆盖所述尖端，所述尖端密封件和所述筒体的远端的一部分的易碎顶端帽; 以及通过显窃启密封件覆盖易碎的尖端盖和筒的远端的外包装，其密封到筒的远端。锥形尖端可选地配备有鲁尔接头以接收外部鲁尔连接器。或者，锥形尖端可以设置有穿过其中的孔，其可以用弹性塞子封闭，并且外部连接器可以是管道导管。

3. 发明授权

US06726652B2 Tamper evident syringe barrel 失效
标题翻译：篡改明显的注射器筒
公开(公告)号：US06726652B2
公开(公告)日：2004-04-27
申请号：US10265986
申请日：2002-10-07
申请人： Michael N. Eakins , Ernest Balestracci , Ernst Schramm , John J. Niedospial, Jr.
发明人： Michael N. Eakins , Ernest Balestracci , Ernst Schramm , John J. Niedospial, Jr.
IPC分类号： A61M500
CPC分类号： A61M5/3202 , A61M5/3134 , A61M5/5086 , A61M2005/3118 , A61M2005/312
摘要： A prefilled syringe of cartridge barrel having a tamper evident closure. Tamper evidence is provided by: a frangible tip seal which is integral with the tapered tip of the barrel; a frangible tip cap covering the tip, the tip seal and a portion of the distal end of the barrel; and an overwrap covering the frangible tip cap and the distal end of the barrel sealed to the distal end of the barrel by a tamper evident seal. The tapered tip is optionally equipped with a luer collar to receive an external luer connector. Alternatively, the tapered tip can be provided with a bore therethrough which can be closed with an elastomeric plug and the external connector can be a tubing conduit.
摘要翻译：具有防拆封闭的暗盒筒的预充式注射器。篡改证据由以下提供：与桶的锥形尖端成一体的易碎顶端密封; 覆盖所述尖端，所述尖端密封件和所述筒体的远端的一部分的易碎顶端帽; 以及通过显窃启密封件覆盖易碎的尖端盖和筒的远端的外包装，其密封到筒的远端。锥形尖端可选地配备有鲁尔接头以接收外部鲁尔连接器。或者，锥形尖端可以设置有穿过其中的孔，其可以用弹性塞子封闭，并且外部连接器可以是管道导管。

4. 发明授权

US06942643B2 Tamper evident syringe barrel 失效
公开(公告)号：US06942643B2
公开(公告)日：2005-09-13
申请号：US11008723
申请日：2004-12-09
申请人： Michael N. Eakins , Ernest Balestracci , Ernst Schramm , John J. Niedospial, Jr.
发明人： Michael N. Eakins , Ernest Balestracci , Ernst Schramm , John J. Niedospial, Jr.
IPC分类号： A61M5/00 , A61M5/31 , A61M5/32 , A61M5/50
CPC分类号： A61M5/3202 , A61M5/3134 , A61M5/5086 , A61M2005/3118 , A61M2005/312
摘要： A prefilled syringe of cartridge barrel having a tamper evident closure. Tamper evidence is provided by: a frangible tip seal which is integral with the tapered tip of the barrel; a frangible tip cap covering the tip, the tip seal and a portion of the distal end of the barrel; and an overwrap covering the frangible tip cap and the distal end of the barrel sealed to the distal end of the barrel by a tamper evident seal. The tapered tip is optionally equipped with a luer collar to receive an external luer connector. Alternatively, the tapered tip can be provided with a bore therethrough which can be closed with an elastomeric plug and the external connector can be a tubing conduit.

5. 发明授权

US06485460B2 Tamper evident syringe barrel 失效
标题翻译：篡改明显的注射器筒
公开(公告)号：US06485460B2
公开(公告)日：2002-11-26
申请号：US09759565
申请日：2001-01-12
申请人： Michael N. Eakins , Ernest Balestracci , Ernst Schramm , John J. Niedospial, Jr.
发明人： Michael N. Eakins , Ernest Balestracci , Ernst Schramm , John J. Niedospial, Jr.
IPC分类号： A61M500
CPC分类号： A61M5/3202 , A61M5/3134 , A61M5/5086 , A61M2005/3118 , A61M2005/312
摘要： A prefilled syringe of cartridge barrel having a tamper evident closure. Tamper evidence is provided by: a frangible tip seal which is integral with the tapered tip of the barrel; a frangible tip cap covering the tip, the tip seal and a portion of the distal end of the barrel; and an overwrap covering the frangible tip cap and the distal end of the barrel sealed to the distal end of the barrel by a tamper evident seal. The tapered tip is optionally equipped with a luer collar to receive an external luer connector. Alternatively, the tapered tip can be provided with a bore therethrough which can be closed with an elastomeric plug and the external connector can be a tubing conduit.
摘要翻译：具有防拆封闭的暗盒筒的预充式注射器。篡改证据由以下提供：与桶的锥形尖端成一体的易碎顶端密封; 覆盖所述尖端，所述尖端密封件和所述筒体的远端的一部分的易碎顶端帽; 以及通过显窃启密封件覆盖易碎的尖端盖和筒的远端的外包装，其密封到筒的远端。锥形尖端可选地配备有鲁尔接头以接收外部鲁尔连接器。或者，锥形尖端可以设置有穿过其中的孔，其可以用弹性塞子封闭，并且外部连接器可以是管道导管。

6. 发明授权

US6142978A Self-aligning plunger rod 失效
标题翻译：自调心柱塞杆
公开(公告)号：US6142978A
公开(公告)日：2000-11-07
申请号：US527334
申请日：2000-03-17
申请人： John J. Niedospial, Jr. , Ernest Balestracci
发明人： John J. Niedospial, Jr. , Ernest Balestracci
IPC分类号： A61M5/315
CPC分类号： A61M5/31511 , A61M5/31515
摘要： A self-aligning reinforced plunger rod and a non-elastomeric plastic plunger insert assembly for use with an elastomeric plunger in a cartridge or syringe barrel, the plunger rod having a first, second, third and fourth sides, a distal end with an end disc, a proximal end with a thumb rest, and a plunger rod tip integral with the end disc and having a neck portion and a ball portion for engagement with a cavity in the non-elastomeric plastic plunger insert. Connecting the end disc and thumb rest there are: four longitudinal radially extending rectangular vanes spaced about 90.degree. from each other; on the first side of the plunger rod a first pair of longitudinal radially extending reinforcing vanes, and a second pair of longitudinal radially extending reinforcing vanes; on the third side opposite to the first side of the plunger rod, a first pair of longitudinal radially extending reinforcing vanes, and a second pair of longitudinal radially extending reinforcing vanes; each of the first pair and each of the second pair of longitudinal radially extending reinforcing vanes on the first side of the plunger rod and each of the first pair and each of the second pair of the longitudinal radially extending reinforcing vanes on the third side of the plunger rod forms an obtuse triangle with one of the longitudinal radially extending reinforcing vanes; on the second side of the plunger rod, a first pair of longitudinal radially extending reinforcing vanes forms a two-dimensional hourglass-shaped surface, and on the fourth side of the plunger rod, a second pair of longitudinal radially extending reinforcing vanes forms a two-dimensional hourglass-shaped surface. The non-elastomeric plastic plunger insert contains a cavity defined by its inside surface to receive the plunger rod tip. The combination directs the force exerted on the plunger rod in an axial direction.
摘要翻译：自对准增强柱塞杆和用于与筒或注射器筒中的弹性柱塞一起使用的非弹性塑料柱塞插入组件，所述柱塞杆具有第一，第二，第三和第四侧，远端具有端盘具有拇指托的近端和与端盘一体的柱塞杆末端，并且具有颈部和用于与非弹性塑料柱塞插入件中的空腔接合的球部分。连接端盘和拇指托具有：彼此间隔约90度的四个纵向径向延伸的矩形叶片; 在所述柱塞杆的第一侧上具有第一对纵向径向延伸的加强叶片和第二对纵向径向延伸的加强翼片; 在与所述柱塞杆的第一侧相对的第三侧上具有第一对纵向径向延伸的加强叶片和第二对纵向径向延伸的加强叶片; 在柱塞杆的第一侧上的第一对和第二对纵向径向延伸的加强叶片中的每一个以及第一对和第二对纵向径向延伸的加强叶片中的每一个在第三侧上柱塞杆与纵向径向延伸的加强翼之一形成钝角三角形; 在柱塞杆的第二侧上，第一对纵向径向延伸的加强叶片形成二维沙漏形表面，并且在柱塞杆的第四侧，第二对纵向径向延伸的加强叶片形成两个三维沙漏形表面。非弹性塑料柱塞插入件包含由其内表面限定以容纳柱塞杆末端的空腔。该组合指示沿轴向施加在柱塞杆上的力。

7. 发明授权

US06206859B1 Self-aligning plunger rod 有权
公开(公告)号：US06206859B1
公开(公告)日：2001-03-27
申请号：US09546342
申请日：2000-04-10
申请人： John J. Niedospial, Jr. , Ernest Balestracci
发明人： John J. Niedospial, Jr. , Ernest Balestracci
IPC分类号： A61M5315
CPC分类号： A61M5/31511 , A61M5/31515
摘要： A self-aligning reinforced plunger rod and a non-elastomeric plastic plunger insert assembly for use with an elastomeric plunger in a cartridge or syringe barrel, the plunger rod having a first, second, third and fourth sides, a distal end with an end disc, a proximal end with a thumb rest, a central reinforcing disc at the midpoint between the end disc and the thumb rest, and a plunger rod tip integral with the end disc and having a neck portion and a ball portion for engagement with a cavity in the non-elastomeric plastic plunger insert. Connecting the end disc and thumb rest there are: four longitudinal radially extending rectangular vanes spaced about 90° from each other; on the first side of the plunger rod a first pair of longitudinal radially extending reinforcing vanes, and a second pair of longitudinal radially extending reinforcing vanes; on the third side opposite to the first side of the plunger rod, a first pair of longitudinal radially extending reinforcing vanes, and a second pair of longitudinal radially extending reinforcing vanes; each of the first pair and each of the second pair of longitudinal radially extending reinforcing vanes on the first side of the plunger rod and each of the first pair and each of the second pair of the longitudinal radially extending reinforcing vanes on the third side of the plunger rod forms an obtuse triangle with one of the longitudinal radially extending reinforcing vanes; on the second side of the plunger rod, a first pair of longitudinal radially extending reinforcing vanes forms a two-dimensional hourglass-shape surface, and on the fourth side of the plunger rod, a second pair of longitudinal radially extending reinforcing vanes forms a two-dimensional hourglass-shape surface. The non-elastomeric plastic plunger insert contains a cavity defined by its inside surface to receive the plunger rod tip. The combination directs the force exerted on the plunger rod in an axial direction.

8. 发明授权

US06193688B1 Tamper evident protector cap for pre-filled syringe barrels 有权
标题翻译：用于预装注射器筒的防篡改保护帽
公开(公告)号：US06193688B1
公开(公告)日：2001-02-27
申请号：US09617900
申请日：2000-07-17
申请人： Ernest Balestracci , John J. Niedospial, Jr.
发明人： Ernest Balestracci , John J. Niedospial, Jr.
IPC分类号： A61M500
CPC分类号： A61M5/3134 , A61M5/5086 , A61M2005/3104 , A61M2005/3106
摘要： A tamper evident protector cap for a pre-filled syringe or cartridge barrel stoppered by an elastomeric closure. The protector cap securely retains the elastomeric closure during in-line processing, handling and shipment. The protector cap includes frangible brackets which on tampering break away from the protector cap evidencing that product integrity might have been jeopardized and the product should not be used.
摘要翻译：用于预填充注射器或药筒的防篡改保护帽，由弹性封闭件塞住。在线处理，处理和装运期间，保护盖牢固地保持弹性体封闭。保护帽包括易碎托架，篡改从保护盖上脱离，证明产品完整性可能受到威胁，不得使用产品。

9. 发明授权

US08273008B2 Shielding assemblies for infusion systems 有权
公开(公告)号：US08273008B2
公开(公告)日：2012-09-25
申请号：US12137356
申请日：2008-06-11
申请人： Charles R. Quirico , Ernest Balestracci , Daniel Darst , Eric J. Krause , Vishal N. Lokhande , Jacob S. Childs , Peter B. Madson , Daniel V. Clements
发明人： Charles R. Quirico , Ernest Balestracci , Daniel Darst , Eric J. Krause , Vishal N. Lokhande , Jacob S. Childs , Peter B. Madson , Daniel V. Clements
IPC分类号： A61N5/00
摘要： A shielding assembly for an infusion system includes a plurality of compartments and a door for each compartment, and provides a radioactive radiation barrier for the compartments. One of the compartments contains a radioisotope generator of the infusion system and another of the compartments may contain a waste bottle of the infusion system. An opening into each of the generator and waste bottle compartments may be oriented upward, and the opening into the latter may be at a higher elevation than the opening into the former, for example, to facilitate independent removal and replacement of each. A door of at least one of the compartments, other than the generator compartment, when closed, may prevent the door of the generator compartment from being opened. A cabinet structure for the infusion system may enclose the shielding assembly and secure the generator.

10. 发明授权

US08216181B2 Apparatus and methods for support of a membrane filter in a medical infusion system 有权
标题翻译：用于在医用输液系统中支撑膜过滤器的装置和方法
公开(公告)号：US08216181B2
公开(公告)日：2012-07-10
申请号：US12273899
申请日：2008-11-19
申请人： Ernest Balestracci
发明人： Ernest Balestracci
IPC分类号： A61M31/00
CPC分类号： A61M5/14 , A61M5/1415 , A61M5/165 , A61M5/38 , A61M39/284 , Y10T29/49947
摘要： A removable clamp, for supporting a membrane filter in a medical infusion system, includes connected and opposing walls. A locking feature, which may be connected to an end of one of the walls, engages and disengages a terminal end of the other wall. The filter may be inserted between the opposing walls of the clamp, and an inner surface of each of the opposing walls may be secured against corresponding major surfaces of the inserted filter, by only pressing at least one of the opposing walls of the clamp toward the other of the opposing walls.
摘要翻译：用于在医用输液系统中支撑膜过滤器的可移除夹具包括连接和相对的壁。可以连接到一个壁的端部的锁定特征使另一个壁的终端接合和分离。过滤器可以插入在夹具的相对壁之间，并且每个相对壁的内表面可以通过仅将夹具的相对壁中的至少一个压向所述夹具的至少一个朝向其他对面的墙壁。

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