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1. 发明授权

US07857976B2 Hemofiltration system and method based on monitored patient parameters, supervisory control of hemofiltration, and adaptive control of pumps for hemofiltration 有权
标题翻译：基于监测患者参数的血液滤过系统和方法，血液滤过的监督控制和血液滤过的泵的适应性控制
公开(公告)号：US07857976B2
公开(公告)日：2010-12-28
申请号：US12581599
申请日：2009-10-19
申请人： John J. Bissler , Marios M. Polycarpou , Nat Hemasilpin , Efrain O. Morales
发明人： John J. Bissler , Marios M. Polycarpou , Nat Hemasilpin , Efrain O. Morales
IPC分类号： B01D61/22
CPC分类号： G05B13/0275 , A61M1/16 , A61M1/1603 , A61M1/1605 , A61M1/1611 , A61M1/1615 , A61M1/1643 , A61M1/1647 , A61M1/34 , A61M1/341 , A61M1/3413 , A61M1/342 , A61M1/3434 , A61M1/3437 , A61M1/3441 , A61M1/3451 , A61M1/3496 , A61M1/3607 , A61M1/3639 , A61M2205/3331 , A61M2205/3334 , A61M2205/3344 , A61M2205/3393 , A61M2205/50 , Y10S210/929
摘要： A multipurpose hemofiltration system and method are disclosed for the removal of fluid and/or soluble waste from the blood of a patient. The system continuously monitors the flow rates of drained fluid, blood, and infusate. When necessary, the pumping rates of the infusate, drained fluid and blood are adjusted to remove a preselected amount of fluid from the blood in a preselected time period. A supervisory controller can monitor patient parameters, such as heart rate and blood pressure, and adjust the pumping rates accordingly. The supervisory controller uses fuzzy logic to make expert decisions, based upon a set of supervisory rules, to control each pumping rate to achieve a desired flow rate and to respond to fault conditions. An adaptive controller corrects temporal variations in the flow rate based upon an adaptive law and a control law.
摘要翻译：公开了用于从患者的血液中去除流体和/或可溶性废物的多用途血液滤过系统和方法。系统连续监测排出的液体，血液和灌注液的流量。必要时，调节输注液，排出的液体和血液的泵送速率，以在预选的时间段内从血液中除去预选量的流体。监督控制器可以监测患者的参数，如心率和血压，并相应地调整泵送速率。监督控制器使用模糊逻辑来基于一组监督规则做出专家决定，以控制每个泵送速率以实现期望的流量并响应故障状况。自适应控制器基于自适应法和控制律来校正流量的时间变化。

2. 发明申请

US20100038317A1 HEMOFILTRATION SYSTEM AND METHOD BASED ON MONITORED PATIENT PARAMETERS, SUPERVISORY CONTROL OF HEMOFILTRATION, AND ADAPTIVE CONTROL OF PUMPS FOR HEMOFILTRATION 有权
标题翻译：基于监测患者参数的血液透析系统和方法，血液透析的监督控制和用于血液透析的泵的自适应控制
公开(公告)号：US20100038317A1
公开(公告)日：2010-02-18
申请号：US12581599
申请日：2009-10-19
申请人： John J. Bissler , Marios M. Polycarpou , Nat Hemasilpin , Efrain O. Morales
发明人： John J. Bissler , Marios M. Polycarpou , Nat Hemasilpin , Efrain O. Morales
IPC分类号： B01D61/22
CPC分类号： G05B13/0275 , A61M1/16 , A61M1/1603 , A61M1/1605 , A61M1/1611 , A61M1/1615 , A61M1/1643 , A61M1/1647 , A61M1/34 , A61M1/341 , A61M1/3413 , A61M1/342 , A61M1/3434 , A61M1/3437 , A61M1/3441 , A61M1/3451 , A61M1/3496 , A61M1/3607 , A61M1/3639 , A61M2205/3331 , A61M2205/3334 , A61M2205/3344 , A61M2205/3393 , A61M2205/50 , Y10S210/929
摘要： A multipurpose hemofiltration system and method are disclosed for the removal of fluid and/or soluble waste from the blood of a patient. The system continuously monitors the flow rates of drained fluid, blood, and infusate. When necessary, the pumping rates of the infusate, drained fluid and blood are adjusted to remove a preselected amount of fluid from the blood in a preselected time period. A supervisory controller can monitor patient parameters, such as heart rate and blood pressure, and adjust the pumping rates accordingly. The supervisory controller uses fuzzy logic to make expert decisions, based upon a set of supervisory rules, to control each pumping rate to achieve a desired flow rate and to respond to fault conditions. An adaptive controller corrects temporal variations in the flow rate based upon an adaptive law and a control law.
摘要翻译：公开了用于从患者的血液中去除流体和/或可溶性废物的多用途血液滤过系统和方法。系统连续监测排出的液体，血液和灌注液的流量。必要时，调节输注液，排出的液体和血液的泵送速率，以在预选的时间段内从血液中除去预选量的流体。监督控制器可以监测患者的参数，如心率和血压，并相应地调整泵送速率。监督控制器使用模糊逻辑来基于一组监督规则做出专家决定，以控制每个泵送速率以实现期望的流量并响应故障状况。自适应控制器基于自适应法和控制律来校正流量的时间变化。

3. 发明授权

US06780322B1 Hemofiltration system 失效
标题翻译：血液滤过系统
公开(公告)号：US06780322B1
公开(公告)日：2004-08-24
申请号：US10030011
申请日：2002-06-11
申请人： John J. Bissler , Marios M. Polycarpou , Nat Hemasilpin , Efrain O. Morales
发明人： John J. Bissler , Marios M. Polycarpou , Nat Hemasilpin , Efrain O. Morales
IPC分类号： B01D6122
CPC分类号： G05B13/0275 , A61M1/16 , A61M1/1603 , A61M1/1605 , A61M1/1611 , A61M1/1615 , A61M1/1643 , A61M1/1647 , A61M1/34 , A61M1/341 , A61M1/3413 , A61M1/342 , A61M1/3434 , A61M1/3437 , A61M1/3441 , A61M1/3451 , A61M1/3496 , A61M1/3607 , A61M1/3639 , A61M2205/3331 , A61M2205/3334 , A61M2205/3344 , A61M2205/3393 , A61M2205/50 , Y10S210/929
摘要： A multipurpose hemofiltration system (10) and method are disclosed for the removal of fluid and/or soluble waste from the blood of a patient. The system (10) continuously monitors the flow rates of drained fluid, blood, and infusate. When necessary, the pumping rates of the infusate, drained fluid and blood are adjusted to remove a preselected amount of fluid from the blood in a preselected time period. A supervisory controller (160) can monitor patient parameters, such as heart rate (120) and blood pressure (130), and adjust the pumping rates accordingly. The supervisory controller (160) uses fuzzy logic to make expert decisions, based upon a set of supervisory rules, to control each pumping rate to achieve a desired flow rate and to respond to fault conditions. An adaptive controller (162) corrects temporal variations in the flow rate based upon an adaptive law and a control law.
摘要翻译：公开了用于从患者的血液中除去流体和/或可溶性废物的多用途血液滤过系统（10）和方法。系统（10）连续监测排出的流体，血液和灌注液的流量。必要时，调节输注液，排出的液体和血液的泵送速率，以在预选的时间段内从血液中除去预选量的流体。监督控制器（160）可以监测诸如心率（120）和血压（130）的患者参数，并相应地调节泵送速率。监督控制器（160）使用模糊逻辑基于一组监督规则来做出专家决定，以控制每个泵送速率以实现期望的流速并对故障状况做出响应。自适应控制器（162）基于自适应规律和控制律来校正流量的时间变化。

4. 发明授权

US07785463B2 Extracorporeal renal replacement modeling system 有权
标题翻译：体外肾脏替代建模系统
公开(公告)号：US07785463B2
公开(公告)日：2010-08-31
申请号：US11378051
申请日：2006-03-17
申请人： John J. Bissler , Nat Hemasilpin , Marios M. Polycarpou
发明人： John J. Bissler , Nat Hemasilpin , Marios M. Polycarpou
IPC分类号： B01D61/32 , B01D61/22 , A61M1/14
CPC分类号： A61M1/16 , A61M1/1613 , A61M1/3609 , A61M1/3639 , A61M2205/3331 , A61M2205/3351 , A61M2205/3355 , A61M2205/3365 , A61M2205/3379 , A61M2205/3584 , A61M2205/50 , A61M2205/52 , A61M2205/707 , A61M2230/207 , G06F19/00
摘要： A system, program product and method continuously optimize an ultrafiltration rate during an extracorporeal renal replacement process by modeling physiological and actual rate data. The system maps the sensed, physiological data to a mathematical model to assess the data in terms of the ultrafiltration rate. The model provides parameters used to predict where the treatment is headed based on current conditions. The system processes the parameters in terms of preset criteria to generate the optimized ultrafiltration rate. Where the system is networked, communication of the data may be accomplished using remote and online communication techniques.
摘要翻译：系统，程序产品和方法通过对生理和实际速率数据进行建模，在体外肾脏替代过程中不断优化超滤速率。系统将感测的生理数据映射到数学模型，以根据超滤速率评估数据。该模型提供了用于根据当前条件预测治疗前进的参数。系统根据预设标准处理参数以产生优化的超滤率。在系统联网的情况下，可以使用远程和在线通信技术来实现数据的通信。

5. 发明授权

US5344568A Hemofiltration system and method 失效
标题翻译：血液滤过系统及方法
公开(公告)号：US5344568A
公开(公告)日：1994-09-06
申请号：US62928
申请日：1993-05-17
申请人： Yuli Kitaevich , Nat Hemasilpin , J. Gabriel Marchevsky , John J. Bissler , George Benzing, III , Paul T. McEnery
发明人： Yuli Kitaevich , Nat Hemasilpin , J. Gabriel Marchevsky , John J. Bissler , George Benzing, III , Paul T. McEnery
IPC分类号： A61M1/16 , A61M1/34 , B01D61/100
CPC分类号： A61M1/16 , A61M1/1643 , A61M1/34 , A61M1/3427 , A61M1/3451 , A61M2205/3393 , Y10S210/929
摘要： A multipurpose hemofiltration system and method are disclosed for the removal of fluid and/or soluble waste from the blood of a patient. The system and method are equally applicable to adult, pediatric and neonatal patients. The system continuously monitors the weight of infusate in a first reservoir and drained fluid in a second reservoir and compares those weights to corresponding predetermined computed weights. When necessary, the pumping rates of the infusate, drained fluid and blood are adjusted in order to achieve a preselected amount of fluid removal from the patient's blood in a preselected time period. Application of this system and method provide repeatable and highly precise results.
摘要翻译：公开了用于从患者的血液中去除流体和/或可溶性废物的多用途血液滤过系统和方法。该系统和方法同样适用于成人，儿科和新生儿患者。该系统连续地监测第一储存器中的输注物的重量和第二储存器中排出的流体，并将这些权重与相应的预定计算权重进行比较。必要时调节输液，排出的液体和血液的泵送速率，以便在预选的时间段内实现从患者血液中预先选择的流体去除量。该系统和方法的应用提供了可重复和高精度的结果。

6. 发明授权

US5211849A Hemofiltration system and method 失效
标题翻译： HEMOFILTRATION系统和方法
公开(公告)号：US5211849A
公开(公告)日：1993-05-18
申请号：US775183
申请日：1991-10-11
申请人： Yuli Kitaevich , Nat Hemasilpin , J. Gabriel Marchevsky , John J. Bissler , George Benzing, III , Paul T. McEnery
发明人： Yuli Kitaevich , Nat Hemasilpin , J. Gabriel Marchevsky , John J. Bissler , George Benzing, III , Paul T. McEnery
IPC分类号： A61M1/16 , A61M1/34
CPC分类号： A61M1/16 , A61M1/1643 , A61M1/34 , A61M1/3427 , A61M1/3451 , A61M2205/3393 , Y10S210/929
摘要： A multipurpose hemofiltration system and method are disclosed for the removal of fluid and/or soluble waste from the blood of a patient. The system and method are equally applicable to adult, pediatric and neonatal patients. The system continuously monitors the weight of infusate in a first reservoir and drained fluid in a second reservoir and compares those weights to corresponding predetermined computed weights. When necessary, the pumping rates of the infusate, drained fluid and blood are adjusted in order to achieve a preselected amount of fluid removal from the patient's blood in a preselected time period. Application of this system and method provide repeatable and highly precise results.
摘要翻译：公开了用于从患者的血液中去除流体和/或可溶性废物的多用途血液滤过系统和方法。该系统和方法同样适用于成人，儿科和新生儿患者。该系统连续地监测第一储存器中的输注物的重量和第二储存器中排出的流体，并将这些权重与相应的预定计算权重进行比较。必要时调节输液，排出的液体和血液的泵送速率，以便在预选的时间段内实现从患者血液中预先选择的流体去除量。该系统和方法的应用提供了可重复和高精度的结果。

7. 发明授权

US06471872B2 Hemofiltration system and method based on monitored patient parameters 失效
标题翻译：基于监测患者参数的血液滤过系统及方法
公开(公告)号：US06471872B2
公开(公告)日：2002-10-29
申请号：US08814160
申请日：1997-03-10
申请人： Yuli Kitaevich , Nat Hemasilpin , J. Gabriel Marchevsky , John J. Bissler , George Benzing, III , Paul T. McEnery
发明人： Yuli Kitaevich , Nat Hemasilpin , J. Gabriel Marchevsky , John J. Bissler , George Benzing, III , Paul T. McEnery
IPC分类号： A61M134
CPC分类号： A61M1/34 , A61M1/16 , A61M1/1611 , A61M1/1643 , A61M1/341 , A61M1/3427 , A61M1/3451 , A61M1/3607 , A61M2205/15 , A61M2205/18 , A61M2205/3331 , A61M2205/3344 , A61M2205/3393 , A61M2205/50 , A61M2205/52 , A61M2230/205 , Y10S210/929
摘要： A multipurpose hemofiltration system and method are disclosed for the removal of fluid and/or soluble waste from the blood of a patient. The system and method are equally applicable to adult, pediatric and neonatal patients. In one embodiment, the system continuously monitors the weight of infusate in a first reservoir and drained fluid in a second reservoir and compares those weights to corresponding predetermined computed weights. When necessary, the pumping rates of the infusate, drained fluid and blood are adjusted in order to achieve a preselected amount of fluid removal from the patient's blood in a preselected time period. Application of this system and method provide repeatable and highly precise results. Alternatively, predetermined patient parameters can be monitored and the adjustment of pumping rates may be responsive to these monitored parameters. Suitable patient parameters are arterial pressure, central venous pressure, pulmonary arterial pressure, mean arterial pressure, capillary wedge pressure, systemic vascular resistance, cardiac output, mixed venous O2 saturation, arterial O2 saturation, blood pressure, heart rate, patient weight, and hematocrit.
摘要翻译：公开了用于从患者的血液中去除流体和/或可溶性废物的多用途血液滤过系统和方法。该系统和方法同样适用于成人，儿科和新生儿患者。在一个实施例中，系统连续监测第一储存器中的输注物的重量和第二储存器中的排出的流体，并将这些权重与相应的预定计算权重进行比较。必要时调节输液，排出的液体和血液的泵送速率，以便在预选的时间段内实现从患者血液中预先选择的流体去除量。该系统和方法的应用提供了可重复和高精度的结果。或者，可以监测预定的患者参数，并且泵送速率的调整可以响应于这些监视的参数。合适的患者参数是动脉压，中心静脉压，肺动脉压，平均动脉压，毛细血管楔压，全身血管阻力，心输出量，混合静脉血氧饱和度，动脉血氧饱和度，血压，心率，患者体重和血细胞比容。

8. 发明授权

US06200485B1 Hemofiltration system and method 失效
标题翻译：血液滤过系统及方法
公开(公告)号：US06200485B1
公开(公告)日：2001-03-13
申请号：US09262437
申请日：1999-03-04
申请人： Yuli Kitaevich , Nat Hemasilpin , J. Gabriel Marchevsky , John J. Bissler , George Benzing, III , Paul T. McEnery
发明人： Yuli Kitaevich , Nat Hemasilpin , J. Gabriel Marchevsky , John J. Bissler , George Benzing, III , Paul T. McEnery
IPC分类号： A61M134
CPC分类号： A61M1/34 , A61M1/16 , A61M1/1611 , A61M1/1643 , A61M1/341 , A61M1/3427 , A61M1/3451 , A61M1/3607 , A61M2205/15 , A61M2205/18 , A61M2205/3331 , A61M2205/3344 , A61M2205/3393 , A61M2205/50 , A61M2205/52 , A61M2230/205 , Y10S210/929
摘要： A multipurpose hemofiltration system and method are disclosed for the removal of fluid and/or soluble waste from the blood of a patient. The system and method are equally applicable to adult, pediatric and neonatal patients. In one embodiment, the system continuously monitors the weight of infusate in a first reservoir and drained fluid in a second reservoir and compares those weights to corresponding predetermined computed weights. When necessary, the pumping rates of the infusate, drained fluid and blood are adjusted in order to achieve a preselected amount of fluid removal from the patient's blood in a preselected time period. Application of this system and method provide repeatable and highly precise results. Alternatively, predetermined patient parameters can be monitored and the adjustment of pumping rates may be responsive to these monitored parameters. Suitable patient parameters are arterial pressure, central venous pressure, pulmonary arterial pressure, mean arterial pressure, capillary wedge pressure, systemic vascular resistance, cardiac output, mixed venous O2 saturation, arterial O2 saturation, blood pressure, heart rate, patient weight, and hematocrit.
摘要翻译：公开了用于从患者的血液中去除流体和/或可溶性废物的多用途血液滤过系统和方法。该系统和方法同样适用于成人，儿科和新生儿患者。在一个实施例中，系统连续监测第一储存器中的输注物的重量和第二储存器中的排出的流体，并将这些权重与相应的预定计算权重进行比较。必要时调节输液，排出的液体和血液的泵送速率，以便在预选的时间段内实现从患者血液中预先选择的流体去除量。该系统和方法的应用提供了可重复和高精度的结果。或者，可以监测预定的患者参数，并且泵送速率的调整可以响应于这些监视的参数。合适的患者参数是动脉压，中心静脉压，肺动脉压，平均动脉压，毛细血管楔压，全身血管阻力，心输出量，混合静脉血氧饱和度，动脉血氧饱和度，血压，心率，患者体重和血细胞比容。

9. 发明申请

US20050126961A1 Hemofiltration system and method based on monitored patient parameters, supervisory control of hemofiltration, and adaptive control of pumps for hemofiltration 审中-公开
标题翻译：基于监测患者参数的血液滤过系统和方法，血液滤过的监督控制和血液滤过的泵的适应性控制
公开(公告)号：US20050126961A1
公开(公告)日：2005-06-16
申请号：US10864209
申请日：2004-06-09
申请人： John Bissler , Marios Polycarpou , Nat Hemasilpin , Efrain Morales
发明人： John Bissler , Marios Polycarpou , Nat Hemasilpin , Efrain Morales
IPC分类号： A61M1/14 , A61M1/16 , A61M1/34 , B01D61/14 , B01D61/22 , B01D61/32 , G05B13/02
CPC分类号： G05B13/0275 , A61M1/16 , A61M1/1603 , A61M1/1605 , A61M1/1611 , A61M1/1615 , A61M1/1643 , A61M1/1647 , A61M1/34 , A61M1/341 , A61M1/3413 , A61M1/342 , A61M1/3434 , A61M1/3437 , A61M1/3441 , A61M1/3451 , A61M1/3496 , A61M1/3607 , A61M1/3639 , A61M2205/3331 , A61M2205/3334 , A61M2205/3344 , A61M2205/3393 , A61M2205/50 , Y10S210/929
摘要： A multipurpose hemofiltration system and method are disclosed for the removal of fluid and/or soluble waste from the blood of a patient. The system continuously monitors the flow rates of drained fluid, blood, and infusate. When necessary, the pumping rates of the infusate, drained fluid and blood are adjusted to remove a preselected amount of fluid from the blood in a preselected time period. A supervisory controller can monitor patient parameters, such as heart rate and blood pressure, and adjust the pumping rates accordingly. The supervisory controller uses fuzzy logic to make expert decisions, based upon a set of supervisory rules, to control each pumping rate to achieve a desired flow rate and to respond to fault conditions. An adaptive controller corrects temporal variations in the flow rate based upon an adaptive law and a control law.
摘要翻译：公开了用于从患者的血液中去除流体和/或可溶性废物的多用途血液滤过系统和方法。系统连续监测排出的液体，血液和灌注液的流量。必要时，调节输注液，排出的液体和血液的泵送速率，以在预选的时间段内从血液中除去预选量的流体。监督控制器可以监测患者的参数，如心率和血压，并相应地调整泵送速率。监督控制器使用模糊逻辑来基于一组监督规则做出专家决定，以控制每个泵送速率以实现期望的流量并响应故障状况。自适应控制器基于自适应法和控制律来校正流量的时间变化。

10. 发明申请

US20070215545A1 Extracorporeal renal replacement modeling system 有权
标题翻译：体外肾脏替代建模系统
公开(公告)号：US20070215545A1
公开(公告)日：2007-09-20
申请号：US11378051
申请日：2006-03-17
申请人： John Bissler , Nat Hemasilpin , Marios Polycarpou
发明人： John Bissler , Nat Hemasilpin , Marios Polycarpou
IPC分类号： B01D61/32
CPC分类号： A61M1/16 , A61M1/1613 , A61M1/3609 , A61M1/3639 , A61M2205/3331 , A61M2205/3351 , A61M2205/3355 , A61M2205/3365 , A61M2205/3379 , A61M2205/3584 , A61M2205/50 , A61M2205/52 , A61M2205/707 , A61M2230/207 , G06F19/00
摘要： A system, program product and method continuously optimize an ultrafiltration rate during an extracorporeal renal replacement process by modeling physiological and actual rate data. The system maps the sensed, physiological data to a mathematical model to assess the data in terms of the ultrafiltration rate. The model provides parameters used to predict where the treatment is headed based on current conditions. The system processes the parameters in terms of preset criteria to generate the optimized ultrafiltration rate. Where the system is networked, communication of the data may be accomplished using remote and online communication techniques.
摘要翻译：系统，程序产品和方法通过对生理和实际速率数据进行建模，在体外肾脏替代过程中不断优化超滤速率。系统将感测的生理数据映射到数学模型，以根据超滤速率评估数据。该模型提供了用于根据当前条件预测治疗前进的参数。系统根据预设标准处理参数以产生优化的超滤率。在系统联网的情况下，可以使用远程和在线通信技术来实现数据的通信。

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