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    • 1. 发明授权
    • Medical diagnostic ultrasound-aided drug delivery system and method
    • 医学诊断超声辅助药物输送系统及方法
    • US06475148B1
    • 2002-11-05
    • US09696411
    • 2000-10-25
    • John I. JacksonEdward A. Gardner
    • John I. JacksonEdward A. Gardner
    • A61B812
    • A61B8/481A61B5/0456A61M31/00A61M37/0092
    • A method and system is provided for delivering drugs carried by microspheres. A medical diagnostic ultrasound system destroys microspheres in a specific localized area or at a specific time. A region of interest that is a subset of an imaged area is identified for destroying drug-carrying microspheres. The transmit beamformer is configured to transmit acoustic energy for destroying microspheres within that area while minimizing the destruction of microspheres outside of the region of interest. A multidimensional transducer array may provide focusing in three-dimensions for accurately destroying microspheres in the specific region while minimizing the destruction of microspheres outside that region. A trigger responsive to a heart or breathing cycle may control when microspheres are destroyed, providing delivery of drugs at the most opportune time in the cycle.
    • 提供用于输送由微球携带的药物的方法和系统。 医疗诊断超声系统在特定局部区域或特定时间破坏微球。 鉴定为成像区域的子集的感兴趣区域用于破坏携带药物的微球体。 发射波束形成器被配置为传输用于破坏该区域内的微球的声能,同时最小化感兴趣区域外的微球的破坏。 多维换能器阵列可以提供三维聚焦以精确地破坏特定区域中的微球,同时最小化该区域外的微球的破坏。 响应于心脏或呼吸循环的触发器可以控制微球被破坏时,在循环中最合适的时间提供药物的递送。
    • 2. 发明授权
    • Diagnostic medical ultrasound image and system for contrast agent imaging
    • 诊断医学超声图像和造影剂成像系统
    • US06645147B1
    • 2003-11-11
    • US09200648
    • 1998-11-25
    • John I. JacksonJay S. PluggeEdward A. Gardner
    • John I. JacksonJay S. PluggeEdward A. Gardner
    • A61B800
    • A61B8/12A61B5/0456A61B8/06A61B8/08A61B8/14A61B8/445A61B8/481A61B8/488A61B8/543
    • A method and system for contrast agent imaging with a catheter transducer is provided. The catheter transducer may comprise an intra-vascular, intra-cardiac or other transducer for insertion into or through a small space. The catheter transducer is inserted within the heart or other portion of a patient. Contrast agents, such as micro-spheres, are injected into the patient. Using the catheter transducer, ultrasonic acoustic energy is transmitted, and reflected energy is received. The reflected energy is responsive to the contrast agents. An image processor generates an image of the tissue and contrast agents as a function of the reflected energy. The image provides an indication of perfusion. Alternatively, the ultrasound system calculates perfusion. By generating intra-vascular images or data, interference from other tissues is avoided. Therefore, the perfusion information obtained may have higher resolution. Images with better resolution better assist doctors in medical diagnosis.
    • 提供了一种用导管换能器对比剂成像的方法和系统。 导管换能器可以包括血管内,心脏内或其他换能器,用于插入或通过小空间。 导管换能器插入心脏或患者其他部分内。 对比剂,如微球,注射到患者体内。 使用导管换能器,传输超声波声能,并接收反射能量。 反射能量对造影剂有反应。 图像处理器产生作为反射能量的函数的组织和造影剂的图像。 图像提供灌注指示。 或者,超声系统计算灌注。 通过产生血管内图像或数据,避免了来自其他组织的干扰。 因此,获得的灌注信息可能具有较高的分辨率。 具有更好分辨率的图像更好地帮助医生进行医学诊断。