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1. 发明申请

US20120267389A1 APPARATUS AND METHOD FOR DELIVERING BENEFICIAL LIQUIDS AT A CONSISTENT RATE 审中-公开
标题翻译：用于以一致性递送受益液体的装置和方法
公开(公告)号：US20120267389A1
公开(公告)日：2012-10-25
申请号：US13523015
申请日：2012-06-14
申请人： John Howard Gordon , Ashok V. Joshi , Truman Wold , Sai Bhavaraju
发明人： John Howard Gordon , Ashok V. Joshi , Truman Wold , Sai Bhavaraju
IPC分类号： B67D7/76
CPC分类号： A01M1/2044 , A61L9/12 , C02F1/001 , C02F1/28 , C02F1/44 , C02F1/68 , C02F1/686
摘要： An apparatus for providing controlled delivery of a beneficial agent is disclosed. In one embodiment, such an apparatus includes a water chamber and a filter to produce filtered water by removing impurities from water introduced into the water chamber. A water-transporting membrane transports filtered water from the water chamber to an extraction chamber, thereby expanding the extraction chamber. The extraction chamber contains an osmagent that provides the driving force to pull the filtered water through the water-transporting membrane. As the extraction chamber expands, a dispensing chamber containing a beneficial agent contracts. This causes the beneficial agent to be expelled through a port in communication with the dispensing chamber. A corresponding method is also disclosed.
摘要翻译：公开了一种用于提供有益药物受控输送的装置。在一个实施例中，这种装置包括水室和过滤器，以通过从引入水室的水中除去杂质来产生过滤水。水输送膜将过滤的水从水室输送到提取室，从而使提取室膨胀。提取室包含一个渗透剂，其提供驱动力以将过滤的水拉过水输送膜。当提取室膨胀时，含有有益代理的分配室合同。这使得有益剂通过与分配室连通的端口排出。还公开了相应的方法。

2. 发明授权

US08240260B2 Apparatus for delivering beneficial liquids at steady rate 有权
标题翻译：用于以稳定的速率输送有益液体的装置
公开(公告)号：US08240260B2
公开(公告)日：2012-08-14
申请号：US13281282
申请日：2011-10-25
申请人： John Howard Gordon , Ashok V. Joshi , Truman Wold , Sai Bhavaraju
发明人： John Howard Gordon , Ashok V. Joshi , Truman Wold , Sai Bhavaraju
IPC分类号： A01C23/02
CPC分类号： A01M1/2044 , A61L9/12 , Y10T137/2931
摘要： An apparatus for delivering a beneficial agent is disclosed in one embodiment of the invention as including a water collection chamber. A water-transporting membrane is provided to communicate with the water collection chamber. An extraction chamber receives water through the water-transporting membrane, expanding the extraction chamber. A dispensing chamber, containing a beneficial agent, is configured to contract upon expanding the extraction chamber. This causes the dispensing chamber to expel the beneficial agent through a subterranean delivery channel, such as a rigid hollow spike. In certain embodiments, a rate adjustment mechanism may control the rate that water is received through the water-transporting membrane, thereby controlling the rate the beneficial agent is expelled. The water-transporting membrane has features that repel osmagent from passing through to the water collection chamber. The apparatus features steady rate performance without refreshing the water chamber and low temperature sensitivity.
摘要翻译：在本发明的一个实施例中公开了一种用于递送有益剂的装置，包括水收集室。提供水输送膜以与收集室连通。提取室通过水输送膜接收水，使提取室膨胀。包含有益剂的分配腔被构造成在膨胀提取室时收缩。这使得分配室通过地下输送通道（例如刚性中空尖峰）排出有益剂。在某些实施例中，速率调节机构可以控制通过水输送膜接收水的速率，从而控制有益剂被排出的速率。水输送膜具有排斥渗透到收集室的特征。该设备具有稳定的速率性能，无需刷新水室和低温灵敏度。

3. 发明申请

US20120037242A1 APPARATUS FOR DELIVERING BENEFICIAL LIQUIDS AT STEADY RATE 有权
标题翻译：以稳定的速度递送受益液体的装置
公开(公告)号：US20120037242A1
公开(公告)日：2012-02-16
申请号：US13281282
申请日：2011-10-25
申请人： John Howard Gordon , Ashok V. Joshi , Truman Wold , Sai Bhavaraju
发明人： John Howard Gordon , Ashok V. Joshi , Truman Wold , Sai Bhavaraju
IPC分类号： B67D7/72
CPC分类号： A01M1/2044 , A61L9/12 , Y10T137/2931
摘要： An apparatus for delivering a beneficial agent is disclosed in one embodiment of the invention as including a water collection chamber. A water-transporting membrane is provided to communicate with the water collection chamber. An extraction chamber receives water through the water-transporting membrane, expanding the extraction chamber. A dispensing chamber, containing a beneficial agent, is configured to contract upon expanding the extraction chamber. This causes the dispensing chamber to expel the beneficial agent through a subterranean delivery channel, such as a rigid hollow spike. In certain embodiments, a rate adjustment mechanism may control the rate that water is received through the water-transporting membrane, thereby controlling the rate the beneficial agent is expelled. The water-transporting membrane has features that repel osmagent from passing through to the water collection chamber. The apparatus features steady rate performance without refreshing the water chamber and low temperature sensitivity.
摘要翻译：在本发明的一个实施例中公开了一种用于递送有益剂的装置，包括水收集室。提供水输送膜以与收集室连通。提取室通过水输送膜接收水，使提取室膨胀。包含有益剂的分配腔被构造成在膨胀提取室时收缩。这使得分配室通过地下输送通道（例如刚性中空尖峰）排出有益剂。在某些实施例中，速率调节机构可以控制通过水输送膜接收水的速率，从而控制有益剂被排出的速率。水输送膜具有排斥渗透到收集室的特征。该设备具有稳定的速率性能，无需刷新水室和低温灵敏度。

4. 发明申请

US20100022993A1 APPARATUS AND METHOD FOR DELIVERING BENEFICIAL LIQUIDS AT STEADY RATE 有权
标题翻译：用于以稳定速率递送受益液体的装置和方法
公开(公告)号：US20100022993A1
公开(公告)日：2010-01-28
申请号：US12550050
申请日：2009-08-28
申请人： John Howard Gordon , Ashok V. Joshi , Truman Wold , Sai Bhavaraju
发明人： John Howard Gordon , Ashok V. Joshi , Truman Wold , Sai Bhavaraju
IPC分类号： A61M5/142
CPC分类号： A01M1/2044 , A61L9/12 , Y10T137/2931
摘要： An apparatus for delivering a beneficial agent is disclosed in one embodiment of the invention as including a water collection chamber. A water-transporting membrane is provided to communicate with the water collection chamber. An extraction chamber receives water through the water-transporting membrane, expanding the extraction chamber. A dispensing chamber, containing a beneficial agent, is configured to contract upon expanding the extraction chamber. This causes the dispensing chamber to expel the beneficial agent through a subterranean delivery channel, such as a rigid hollow spike. In certain embodiments, a rate adjustment mechanism may control the rate that water is received through the water-transporting membrane, thereby controlling the rate the beneficial agent is expelled. The water-transporting membrane has features that repel osmagent from passing through to the water collection chamber. The apparatus features steady rate performance without refreshing the water chamber and low temperature sensitivity.
摘要翻译：在本发明的一个实施例中公开了一种用于递送有益剂的装置，包括水收集室。提供水输送膜以与收集室连通。提取室通过水输送膜接收水，使提取室膨胀。包含有益剂的分配腔被构造成在膨胀提取室时收缩。这使得分配室通过地下输送通道（例如刚性中空尖峰）排出有益剂。在某些实施例中，速率调节机构可以控制通过水输送膜接收水的速率，从而控制有益剂被排出的速率。水输送膜具有排斥渗透到收集室的特征。该设备具有稳定的速率性能，无需刷新水室和低温灵敏度。

5. 发明申请

US20120037658A1 METHOD FOR DELIVERING BENEFICIAL LIQUIDS AT STEADY RATE 有权
标题翻译：以稳定速度递送受益液体的方法
公开(公告)号：US20120037658A1
公开(公告)日：2012-02-16
申请号：US13281288
申请日：2011-10-25
申请人： John Howard Gordon , Ashok V. Joshi , Truman Wold , Sai Bhavaraju
发明人： John Howard Gordon , Ashok V. Joshi , Truman Wold , Sai Bhavaraju
IPC分类号： B67D7/16
CPC分类号： A01M1/2044 , A61L9/12 , Y10T137/2931
摘要： A method for delivering a beneficial agent is disclosed in one embodiment of the invention as including a water collection chamber. A water-transporting membrane is provided to communicate with the water collection chamber. An extraction chamber receives water through the water-transporting membrane, expanding the extraction chamber. A dispensing chamber, containing a beneficial agent, is configured to contract upon expanding the extraction chamber. This causes the dispensing chamber to expel the beneficial agent through a subterranean delivery channel, such as a rigid hollow spike. In certain embodiments, a rate adjustment mechanism may control the rate that water is received through the water-transporting membrane, thereby controlling the rate the beneficial agent is expelled. The water-transporting membrane has features that repel osmagent from passing through to the water collection chamber. The method features steady rate performance without refreshing the water chamber and low temperature sensitivity.
摘要翻译：在本发明的一个实施例中公开了一种递送有益剂的方法，包括一个收水室。提供水输送膜以与收集室连通。提取室通过水输送膜接收水，使提取室膨胀。包含有益剂的分配腔被构造成在膨胀提取室时收缩。这使得分配室通过地下输送通道（例如刚性中空尖峰）排出有益剂。在某些实施例中，速率调节机构可以控制通过水输送膜接收水的速率，从而控制有益剂被排出的速率。水输送膜具有排斥渗透到收集室的特征。该方法具有稳定的速率性能，无需刷新水箱和低温灵敏度。

6. 发明授权

US08061280B2 Apparatus and method for delivering beneficial liquids at steady rate 有权
标题翻译：以稳定的速度输送有益液体的装置和方法
公开(公告)号：US08061280B2
公开(公告)日：2011-11-22
申请号：US12550050
申请日：2009-08-28
申请人： John Howard Gordon , Ashok V. Joshi , Truman Wold , Sai Bhavaraju
发明人： John Howard Gordon , Ashok V. Joshi , Truman Wold , Sai Bhavaraju
IPC分类号： A01C23/02
CPC分类号： A01M1/2044 , A61L9/12 , Y10T137/2931
摘要： An apparatus for delivering a beneficial agent is disclosed in one embodiment of the invention as including a water collection chamber. A water-transporting membrane is provided to communicate with the water collection chamber. An extraction chamber receives water through the water-transporting membrane, expanding the extraction chamber. A dispensing chamber, containing a beneficial agent, is configured to contract upon expanding the extraction chamber. This causes the dispensing chamber to expel the beneficial agent through a subterranean delivery channel, such as a rigid hollow spike. In certain embodiments, a rate adjustment mechanism may control the rate that water is received through the water-transporting membrane, thereby controlling the rate the beneficial agent is expelled. The water-transporting membrane has features that repel osmagent from passing through to the water collection chamber. The apparatus features steady rate performance without refreshing the water chamber and low temperature sensitivity.
摘要翻译：在本发明的一个实施例中公开了一种用于递送有益剂的装置，包括水收集室。提供水输送膜以与收集室连通。提取室通过水输送膜接收水，使提取室膨胀。包含有益剂的分配腔被构造成在膨胀提取室时收缩。这使得分配室通过地下输送通道（例如刚性中空尖峰）排出有益剂。在某些实施例中，速率调节机构可以控制通过水输送膜接收水的速率，从而控制有益剂被排出的速率。水输送膜具有排斥渗透到收集室的特征。该设备具有稳定的速率性能，无需刷新水室和低温灵敏度。

7. 发明授权

US08240261B2 Method for delivering beneficial liquids at steady rate 有权
标题翻译：以稳定的速度输送有益液体的方法
公开(公告)号：US08240261B2
公开(公告)日：2012-08-14
申请号：US13281288
申请日：2011-10-25
申请人： John Howard Gordon , Ashok V. Joshi , Truman Wold , Sai Bhavaraju
发明人： John Howard Gordon , Ashok V. Joshi , Truman Wold , Sai Bhavaraju
IPC分类号： A01C23/02
CPC分类号： A01M1/2044 , A61L9/12 , Y10T137/2931
摘要： A method for delivering a beneficial agent is disclosed in one embodiment of the invention as including a water collection chamber. A water-transporting membrane is provided to communicate with the water collection chamber. An extraction chamber receives water through the water-transporting membrane, expanding the extraction chamber. A dispensing chamber, containing a beneficial agent, is configured to contract upon expanding the extraction chamber. This causes the dispensing chamber to expel the beneficial agent through a subterranean delivery channel, such as a rigid hollow spike. In certain embodiments, a rate adjustment mechanism may control the rate that water is received through the water-transporting membrane, thereby controlling the rate the beneficial agent is expelled. The water-transporting membrane has features that repel osmagent from passing through to the water collection chamber. The method features steady rate performance without refreshing the water chamber and low temperature sensitivity.
摘要翻译：在本发明的一个实施例中公开了一种递送有益剂的方法，包括一个收水室。提供水输送膜以与收集室连通。提取室通过水输送膜接收水，使提取室膨胀。包含有益剂的分配腔被构造成在膨胀提取室时收缩。这使得分配室通过地下输送通道（例如刚性中空尖峰）排出有益剂。在某些实施例中，速率调节机构可以控制通过水输送膜接收水的速率，从而控制有益剂被排出的速率。水输送膜具有排斥渗透到收集室的特征。该方法具有稳定的速率性能，无需刷新水箱和低温灵敏度。

8. 发明授权

US07896867B2 Fluid delivery device having an electrochemical pump with an ion-exchange membrane and associated method 有权
标题翻译：流体输送装置具有具有离子交换膜的电化学泵和相关方法
公开(公告)号：US07896867B2
公开(公告)日：2011-03-01
申请号：US11160650
申请日：2005-07-01
申请人： John Howard Gordon , Sai Bhavaraju , Ashok V. Joshi , Lawrence Domenick
发明人： John Howard Gordon , Sai Bhavaraju , Ashok V. Joshi , Lawrence Domenick
IPC分类号： A61K9/22
CPC分类号： A61K9/0004 , A61K9/0024 , A61M5/14276 , A61M5/1452 , A61M5/14526 , A61M2005/14513
摘要： The present invention is directed to an apparatus and method for controllably adjusting a fluid delivery device. The device includes an electrochemical pump capable of transporting a fluid. A displaceable member is positioned between a pump product chamber and a reservoir, wherein the pump product chamber is capable of retaining water generated from the pump. The displaceable member is controllably displaced upon generation of water from the electrochemical pump and the reservoir contains the fluid that is delivered upon displacement of the displaceable member.
摘要翻译：本发明涉及一种用于可控地调节流体输送装置的装置和方法。该装置包括能够输送流体的电化学泵。可移动构件定位在泵产品室和储存器之间，其中泵产品室能够保留从泵产生的水。可移动构件在从电化学泵产生水时可控地移位，并且储存器包含在可移动构件移位时被输送的流体。

9. 发明申请

US20090216204A1 AUTO-REPLENISHING, WOUND-DRESSING APPARATUS AND METHOD 审中-公开
标题翻译：自动再生装置，绕线装置及方法
公开(公告)号：US20090216204A1
公开(公告)日：2009-08-27
申请号：US12341832
申请日：2008-12-22
申请人： Sai Bhavaraju , Troy C. Dayton , John Howard Gordon , Jeremy Heiser , Ashok V. Joshi
发明人： Sai Bhavaraju , Troy C. Dayton , John Howard Gordon , Jeremy Heiser , Ashok V. Joshi
IPC分类号： A61M35/00 , A61F13/00
CPC分类号： A61M35/00 , A61F13/00068 , A61F2013/0017 , A61F2013/00174 , A61F2013/002 , A61F2013/00268 , A61M35/006
摘要： Apparatus and methods to treat skin defects include a pump with reservoirs for a pressurization gas and a fluid, the fluid loaded at a factory and sealed or filled at point of use through a valve, septum, or the like. Upon activation, the pump generates a gas introduced into the gas reservoir, a movable wall of which displaces a movable wall of a fluid source, thus dispensing the fluid into the dressing to spread throughout irrespective of orientation of the dressing, maintaining a transport fluid (e.g. carrier) in the dressing and in contact with a skin defect being treated. Delivery may be periodic, constant, programmatically controlled, or manual. A dressing may maintain intimate contact, a transport fluid, and a controllable concentration of active ingredient against a skin defect.Apparatus and methods to replenish a dressing with a therapeutically effective concentration of a fluid deliver a fluid carrier containing an active ingredient. The fluid may be stored in and delivered from a pump mechanism including reservoirs for a pressurization gas and the fluid, which may be loaded at a factory and sealed or filled at point of use through a valve, septum, or the like. The dressing may have a distribution network, and multiple members, dispensing the fluid into a wick maintaining a transport fluid (e.g. carrier) distributed in the dressing and in contact with a skin defect being treated. Delivery may be periodic, constant, programmatically controlled, or manual to maintain intimate contact, a transport fluid, and a controllable concentration of active ingredient against wounded tissue.
摘要翻译：用于治疗皮肤缺陷的装置和方法包括具有用于加压气体和流体的储存器的泵，流体在工厂加载并通过阀，隔膜等密封或填充在使用点处。在激活时，泵产生引入气体储存器中的气体，其活动壁移动流体源的可移动壁，从而将流体分配到敷料中以遍及敷料的方向，以保持输送流体（例如载体），并与正在治疗的皮肤缺陷接触。交货可以是周期性的，恒定的，程序控制的或手动的。敷料可以保持紧密接触，运输液体和针对皮肤缺陷的可控浓度的活性成分。用治疗有效浓度的流体补充敷料的装置和方法输送含有活性成分的流体载体。流体可以存储在泵机构中并且从泵机构输送，该泵机构包括用于加压气体的储存器和可以在工厂加载并通过阀，隔膜等在使用点处密封或填充的流体。敷料可以具有分配网络和多个部件，将流体分配到芯中，以保持分布在敷料中并与被处理的皮肤缺陷接触的输送流体（例如载体）。输送可以是定期的，恒定的，程序控制的或手动的，以保持紧密接触，运输液体和对受伤组织的可控浓度的活性成分。

10. 发明申请

US20070265586A1 DEVICE AND METHOD FOR WOUND THERAPY 有权
标题翻译：治疗方法的装置和方法
公开(公告)号：US20070265586A1
公开(公告)日：2007-11-15
申请号：US11610458
申请日：2006-12-13
申请人： Ashok V. Joshi , John Howard Gordon , Sai Bhavaraju , Troy C. Dayton , Jeremy Heiser
发明人： Ashok V. Joshi , John Howard Gordon , Sai Bhavaraju , Troy C. Dayton , Jeremy Heiser
IPC分类号： A61M1/00
CPC分类号： A61M1/009 , A61F13/0206 , A61F13/0213 , A61F13/0216 , A61F13/0243 , A61L15/28 , A61L15/425 , A61L15/58 , A61L15/60 , A61M1/0025 , A61M1/0031 , A61M1/0035 , A61M1/0049 , A61M1/0052 , A61M1/0088 , A61M1/0096 , A61M27/00 , A61M2205/13 , A61M2205/15 , A61M2205/7509 , A61M2205/7518
摘要： A wound therapy device is disclosed. The wound therapy device may include a housing for covering at least a portion of a wound and for sealing to a body surface of a patient. The housing may also include a liquid collector for retaining liquid therein and a vacuum connection for coupling to a vacuum source. The vacuum connection may be in gaseous communication with the liquid collector. The vacuum connection may be separated from the liquid collector by a liquid barrier.
摘要翻译：公开了伤口治疗装置。伤口治疗装置可以包括用于覆盖伤口的至少一部分并用于密封到患者身体表面的壳体。壳体还可以包括用于将液体保持在其中的液体收集器和用于耦合到真空源的真空连接。真空连接可以与液体收集器气态连通。真空连接可以通过液体屏障与液体收集器分离。

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