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1. 发明申请

US20060213258A1 System useful for holding a sample and in subjecting the sample to chromatographic analysis 有权
标题翻译：用于保存样品和使样品进行色谱分析的系统
公开(公告)号：US20060213258A1
公开(公告)日：2006-09-28
申请号：US11388722
申请日：2006-03-24
申请人： John Hale , Michael Knierman , Kirk Boraas
发明人： John Hale , Michael Knierman , Kirk Boraas
IPC分类号： G01N30/84
CPC分类号： G01N30/24 , G01N30/6065 , G01N30/82 , G01N2035/00237
摘要： A robotic system for handling components during chromatographic analysis of a sample includes a holder for positioning a sample within a separation pathway, the holder including a first opening having an internally tapered shape and a second opening having an externally tapered shape. An interior of the holder, between the first and second openings, defines the separation pathway. A hollow rigid member has an externally tapered shape, and a receiving portion has an internally tapered shape. The holder is positioned between the hollow rigid member and the receiving portion, wherein the externally tapered hollow rigid member engages the internally tapered first opening and the internally tapered receiving portion receives the externally tapered second opening to provide a sealed separation pathway extending from the hollow rigid member to the receiving portion.
摘要翻译：用于在样品的色谱分析过程中处理组分的机器人系统包括用于将样品定位在分离通道内的保持器，所述保持器包括具有内锥形形状的第一开口和具有外锥形形状的第二开口。保持器的内部在第一和第二开口之间限定分离通道。中空的刚性构件具有外锥形形状，并且接收部分具有内锥形形状。保持器定位在中空刚性构件和接收部分之间，其中外锥形中空刚性构件接合内锥形第一开口，并且内锥形接收部分接收外锥形第二开口，以提供从空心刚性延伸的密封分离路径成员到接收部分。

2. 发明申请

US20060167233A1 One-step reduction and alkylation of proteins 审中-公开
公开(公告)号：US20060167233A1
公开(公告)日：2006-07-27
申请号：US11223059
申请日：2005-09-09
申请人： John Hale , Michael Knierman
发明人： John Hale , Michael Knierman
IPC分类号： C07K14/00
CPC分类号： C12N9/2462 , C07K14/00
摘要： The present invention relates generally to the field of analyzing proteins and more specifically to the reduction and alkylation of protein samples during protein analysis. A novel composition and method for reducing and alkylating proteins is disclosed. A novel reagent including a combination of a volatile reducing agent, a volatile alkylating agent, and a volatile solvent is used for a one-step reduction and alkylation of proteins allowing the protein sample to remain in the same container during the reduction and alkylation processes.

3. 发明授权

US07101968B2 One-step reduction and alkylation of proteins 失效
标题翻译：蛋白质的一步还原和烷基化
公开(公告)号：US07101968B2
公开(公告)日：2006-09-05
申请号：US10654062
申请日：2003-09-03
申请人： John Hale , Michael Knierman
发明人： John Hale , Michael Knierman
IPC分类号： C07K1/00
CPC分类号： C12N9/2462 , C07K14/00
摘要： The present invention relates generally to the field of analyzing proteins and more specifically to the reduction and alkylation of protein samples during protein analysis. A novel composition and method for reducing and alkylating proteins is disclosed. A novel reagent including a combination of a volatile reducing agent, a volatile alkylating agent, and a volatile solvent is used for a one-step reduction and alkylation of proteins allowing the protein sample to remain in the same container during the reduction and alkylation processes.
摘要翻译：本发明一般涉及分析蛋白质的领域，更具体地涉及蛋白质分析中蛋白质样品的还原和烷基化。公开了一种用于还原和烷基化蛋白质的新型组合物和方法。包括挥发性还原剂，挥发性烷基化剂和挥发性溶剂的组合的新型试剂用于使蛋白质样品在还原和烷基化方法期间保留在相同容器中的一步还原和烷基化蛋白质。

4. 发明申请

US20050253887A1 Print cartridge ordering system 有权
标题翻译：打印墨盒订购系统
公开(公告)号：US20050253887A1
公开(公告)日：2005-11-17
申请号：US10843785
申请日：2004-05-12
申请人： Henry Garrana , Bay Anthon , John Hale , Gary Lerhaupt , Carol Truman , Jeremy Staadeker
发明人： Henry Garrana , Bay Anthon , John Hale , Gary Lerhaupt , Carol Truman , Jeremy Staadeker
IPC分类号： B41J2/175 , B41J29/393
CPC分类号： B41J29/393 , B41J2/17533 , B41J2/17546
摘要： A method for automatically ordering printer consumables which includes determining when a printer consumable is close to depletion and automatically ordering a replacement to the printer consumable based upon a plurality of criteria. The criteria includes the amount of consecutive time a consumer has been a member of a printer consumable subscription service and the number of printer consumables ordered by a consumer.
摘要翻译：一种用于自动排序打印机耗材的方法，其包括确定打印机耗材何时接近耗尽，并且基于多个标准自动排序替换打印机耗材。标准包括消费者已经是打印机可消费订阅服务的成员的连续时间量以及消费者订购的打印机消耗品的数量。

5. 发明申请

US20080313853A1 HANDLE WITH INSERT 审中-公开
标题翻译：带插件的手柄
公开(公告)号：US20080313853A1
公开(公告)日：2008-12-25
申请号：US11767802
申请日：2007-06-25
申请人： John Hale
发明人： John Hale
IPC分类号： A47B95/02
CPC分类号： A47B95/02 , Y10T16/444 , Y10T29/53
摘要： A handle for an appliance and a method of securing the handle to an appliance includes a handle having a hollow end. The handle further includes an insert having a fastener receiving portion. The insert is placed within the hollow end and secured to the appliance with a fastener.
摘要翻译：用于器具的手柄和将手柄固定到器具的方法包括具有中空端的手柄。手柄还包括具有紧固件接收部分的插入件。将插入件放置在中空端内并用紧固件固定到器具上。

6. 发明申请

US20070024421A1 SECURE UNATTENDED DELIVERY SYSTEM 审中-公开
标题翻译：安全未决交付系统
公开(公告)号：US20070024421A1
公开(公告)日：2007-02-01
申请号：US11530368
申请日：2006-09-08
申请人： John Hale
发明人： John Hale
IPC分类号： B60R25/00
CPC分类号： G07C9/00912 , G07C9/00309 , G07C9/00817 , G07C2009/00825 , G07C2009/0092
摘要： There is disclosed an access system for secure delivery of goods and a secure method for the delivery of such goods. In one embodiment, the access system is accessed by a two-part access code. In another embodiment, the secure storage unit is accessed by the use of an access code in a certain time frame. A central controller preferably controls the delivery technique. The technique is particularly advantageous when used as a method of delivering goods ordered over the Internet. The delivery technique is controlled through a central management system or hub, access to which may be provided through a website. Participating retailers can be accessed directly or through the central management system.
摘要翻译：公开了一种用于货物安全交付的接入系统和用于交付这种货物的安全方法。在一个实施例中，访问系统由两部分访问代码访问。在另一个实施例中，通过在特定时间帧内使用访问代码来访问安全存储单元。中央控制器优选地控制传送技术。当用作通过因特网订购的货物的方法时，该技术是特别有利的。交付技术通过中央管理系统或集线器进行控制，可以通过网站提供访问。参与的零售商可以直接访问或通过中央管理系统访问。

7. 发明申请

US20050070694A1 Antagonistic anti-htnfsf13b human antibodies 有权
标题翻译：拮抗抗htnfsf13b人抗体
公开(公告)号：US20050070694A1
公开(公告)日：2005-03-31
申请号：US10484790
申请日：2002-08-15
申请人： Valentina Gelfanova , John Hale , Kristine Kikly , Rahakrishnan Rathnachalam , Derrick Witcher
发明人： Valentina Gelfanova , John Hale , Kristine Kikly , Rahakrishnan Rathnachalam , Derrick Witcher
IPC分类号： C12N15/09 , A61K39/395 , A61P1/04 , A61P11/06 , A61P15/00 , A61P17/02 , A61P17/06 , A61P19/02 , A61P29/00 , A61P31/04 , A61P35/00 , A61P37/02 , A61P37/08 , C07K16/24 , C07K16/28 , C12P21/08
CPC分类号： C07K16/2875 , A01K2217/05 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/53 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Human monoclonal antibodies that specifically bind to TNFSF13b polypeptides are disclosed. These antibodies have high affinity for hTNFSF13b (e.g., KD=10−8 M or less), a slow off rate for TNFSF13b dissociation (e.g., Koff=10−3 sec−1 or less) and neutralize TNFSF13b activity in vitro and in vivo. The antibodies of the invention are useful in one embodiment for inhibiting TNFSF13b activity in a human subject suffering from a disorder in which hTNFSF13b activity is detrimental. Nucleic acids encoding the antibodies of the present invention, as well as, vectors and host cells for expressing them are also encompassed by the invention.
摘要翻译：公开了特异性结合TNFSF13b多肽的人单克隆抗体。这些抗体对hTNFSF13b具有高亲和力（例如，KD = 10 -8 M或更低），TNFSF13b解离的缓慢速率（例如，Koff = 10 -3 sec -1或更小）并中和TNFSF13b活性体外和体内。本发明的抗体在一个实施方案中可用于在患有hTNFSF13b活性有害的病症的人类受试者中抑制TNFSF13b活性。编码本发明抗体的核酸以及用于表达本发明抗体的载体和宿主细胞也包括在本发明中。

8. 发明申请

US20050017131A1 Aerial delivery system 有权
标题翻译：空中交付系统
公开(公告)号：US20050017131A1
公开(公告)日：2005-01-27
申请号：US10867571
申请日：2004-06-14
申请人： John Hale , Christopher Harris , Daniel Kottman
发明人： John Hale , Christopher Harris , Daniel Kottman
IPC分类号： A62C3/02 , B64D1/16 , B64D1/00
CPC分类号： A62C3/0228 , A62C3/0242 , B64D1/16 , Y10T137/6906
摘要： A method and apparatus for aerial fire suppression utilizing a potable fire retardant chemical dispensing system, readily adaptable, without extensive aircraft modification, to various makes of aircraft, for dispensing current types of forest and range fire fighting chemicals. The aerial delivery system is self contained and reusable. It enables cargo/utility aircraft to carry and dump a load, under control. The aerial delivery system is capable of attachment at the wing box, pressurized delivery from the nozzles, and nozzles directed straight downward.
摘要翻译：一种用于空中灭火的方法和装置，其利用一种易燃的阻燃化学药物分配系统，对于各种飞机制造而言，不需要广泛的飞机改装便可适应，用于分配当前类型的森林和灭火化学品。空中交付系统是独立的和可重用的。它使货物/公用事业飞机能够承受和卸载负载。空中输送系统能够在翼盒附近，来自喷嘴的加压输送和直接向下定向的喷嘴。

9. 发明授权

US5379625A Method and apparatus for upsetting the ends of steel pipe 失效
标题翻译：破坏钢管端部的方法和装置
公开(公告)号：US5379625A
公开(公告)日：1995-01-10
申请号：US139306
申请日：1993-10-20
申请人： John Hale
发明人： John Hale
IPC分类号： B21D41/04 , B21J5/08 , B21K21/12
CPC分类号： B21D41/04 , B21J5/08 , B21K21/12
摘要： A method and apparatus for working one end of a steel pipe by externally upsetting the end in a first die set and sequentially shifting some of the upset internally by pressing in a second die with a reduced diameter mandrel to form a tapered internal shoulder in the pipe upset in only two passes.
摘要翻译：一种用于通过在第一模具组中外端镦锻端部来对钢管的一端进行加工的方法和装置，并且通过在具有减小直径的心轴的第二模具中压制而在内部顺序地移动一些镦锻，以在管中形成锥形内肩只有两次传球令人不安。

10. 发明授权

US09928268B2 System and method for verifying the contents of forms relative to a separate dataset 有权
公开(公告)号：US09928268B2
公开(公告)日：2018-03-27
申请号：US14796292
申请日：2015-07-10
申请人： Mark Besch , John Hale , Randall Broyles
发明人： Mark Besch , John Hale , Randall Broyles
IPC分类号： G06F17/00 , G06F17/30 , G06F17/24
CPC分类号： G06F17/30371 , G06F17/243 , G06F17/30864 , G06F17/30876
摘要： A method is provided for verifying the contents of forms, comprising: receiving a dataset from a client, the dataset associated with a transaction; transmitting the dataset to a document vendor to be entered into and complete a transaction document form; receiving the completed transaction document form from the document vendor; generating a code uniquely associating the completed document with the dataset; printing the code onto the completed document; transmitting the completed document to the client; after the document has been executed, receiving the executed document from the client and separately the current dataset; using the code on the executed document, retrieving the stored transaction dataset; comparing the stored dataset with the dataset separately delivered as the current dataset; identifying all inconsistencies between the two datasets and storing these results as separate data; and transmitting a message to the client with the result of the comparison.

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