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1. 发明授权

US5792094A Method of delivering cardioplegic fluid to a patient's heart 失效
标题翻译：将心脏停跳液输送到患者心脏的方法
公开(公告)号：US5792094A
公开(公告)日：1998-08-11
申请号：US535676
申请日：1995-09-28
申请人： John H. Stevens , Wesley D. Sterman , Hanson S. Gifford, III , Philip C. Evard , Timothy R. Machold
发明人： John H. Stevens , Wesley D. Sterman , Hanson S. Gifford, III , Philip C. Evard , Timothy R. Machold
IPC分类号： A61B17/00 , A61B17/28 , A61B17/32 , A61F2/24 , A61F2/958 , A61M1/36 , A61M25/00 , A61M25/01 , A61M25/06 , A61M29/02 , A61M37/00
CPC分类号： A61F2/2427 , A61B17/29 , A61F2/2433 , A61M1/3653 , A61M1/3659 , A61M25/0041 , A61M25/0147 , A61M25/0152 , A61M25/0662 , A61M25/10 , A61B17/320016 , A61B2017/00243 , A61B2018/00232 , A61B2018/00261 , A61F2/2436 , A61M2025/0031 , A61M2025/0078 , A61M2025/015 , A61M2025/0161 , A61M2025/028 , A61M2025/1047 , A61M2025/1052 , A61M2025/1077 , A61M2025/1095 , A61M2205/11 , A61M2205/366 , A61M2210/125 , A61M2210/127 , A61M25/0032 , A61M25/0125 , A61M25/1002
摘要： A system for accessing a patient's cardiac anatomy which includes an endovascular aortic partitioning device that separates the coronary arteries and the heart from the rest of the patient's arterial system. The endovascular device for partitioning a patient's ascending aorta comprises a flexible shaft having a distal end, a proximal end, and a fist inner lumen therebetween with an opening at the distal end. The shaft may have a preshaped distal portion with a curvature generally corresponding to the curvature of the patient's aortic arch. An expandable means, e.g. a balloon, is disposed near the distal end of the shaft proximal to the opening in the first inner lumen for occluding the ascending aorta so as to block substantially all blood flow therethrough for a plurality of cardiac cycles, while the patient is supported by cardiopulmonary bypass. The endovascular aortic partitioning device may be coupled to an arterial bypass cannula for delivering oxygenated blood to the patient's arterial system. The heart muscle or myocardium is paralyzed by the retrograde delivery of a cardioplegic fluid to the myocardium through patient's coronary sinus and coronary veins, or by antegrade delivery of cardioplegic fluid through a lumen in the endovascular aortic partitioning device to infuse cardioplegic fluid into the coronary arteries. The pulmonary trunk may be vented by withdrawing liquid from the trunk through an inner lumen of an elongated catheter. The cardiac accessing system is particularly suitable for removing the aortic valve and replacing the removed valve with a prosthetic valve.
摘要翻译：一种用于访问患者心脏解剖结构的系统，其包括将冠状动脉和心脏与患者动脉系统的其余部分分离的血管内主动脉分配装置。用于分隔患者升主动脉的血管内装置包括具有远端，近端和其中的第一内腔的柔性轴，在其前端具有开口。轴可以具有预先形成的远端部分，其曲率通常对应于患者主动脉弓的曲率。可膨胀装置，例如靠近靠近第一内腔中的开口的轴的远端附近的气囊，用于闭塞升主动脉，以便阻止基本上所有的血液通过其进行多个心动周期，同时患者由体外循环。血管内主动脉分配装置可以联接到动脉旁路套管，用于将氧合血液输送到患者的动脉系统。通过患者的冠状窦和冠状静脉逆行递送心脏停搏液到心肌，或者通过血管内主动脉分配装置的内腔顺序递送心脏停跳液，将心肌或心肌瘫痪，将心脏停搏液注入冠状动脉。可以通过从细长的导管的内腔中抽出液体来排出肺动脉干。心脏存取系统特别适用于去除主动脉瓣并用假体瓣替换去除的瓣膜。

2. 发明授权

US5885238A System for cardiac procedures 失效
标题翻译：心脏手术系统
公开(公告)号：US5885238A
公开(公告)日：1999-03-23
申请号：US453426
申请日：1995-05-30
申请人： John H. Stevens , Philip C. Evard , Timothy R. Machold
发明人： John H. Stevens , Philip C. Evard , Timothy R. Machold
IPC分类号： A61B17/00 , A61B17/28 , A61B17/32 , A61F2/24 , A61F2/958 , A61M1/36 , A61M25/00 , A61M25/01 , A61M25/06 , A61M29/02 , A61M37/00 , A61M29/00
CPC分类号： A61F2/2427 , A61B17/29 , A61F2/2433 , A61M1/3653 , A61M1/3659 , A61M25/0041 , A61M25/0147 , A61M25/0152 , A61M25/0662 , A61M25/10 , A61B17/320016 , A61B2017/00243 , A61B2018/00232 , A61B2018/00261 , A61F2/2436 , A61M2025/0031 , A61M2025/0078 , A61M2025/015 , A61M2025/0161 , A61M2025/028 , A61M2025/1047 , A61M2025/1052 , A61M2025/1077 , A61M2025/1095 , A61M2205/11 , A61M2205/366 , A61M2210/125 , A61M2210/127 , A61M25/0032 , A61M25/0125 , A61M25/1002
摘要： A system for accessing a patient's cardiac anatomy which includes an endovascular aortic partitioning device that separates the coronary arteries and the heart from the rest of the patient's arterial system. The endovascular device for partitioning a patient's ascending aorta comprises a flexible shaft having a distal end, a proximal end, and a first inner lumen therebetween with an opening at the distal end. The shaft may have a preshaped distal portion with a curvature generally corresponding to the curvature of the patient's aortic arch. An expandable means, e.g. a balloon, is disposed near the distal end of the shaft proximal to the opening in the first inner lumen for occluding the ascending aorta so as to block substantially all blood flow therethrough for a plurality of cardiac cycles, while the patient is supported by cardiopulmonary bypass. The endovascular aortic partitioning device may be coupled to an arterial bypass cannula for delivering oxygenated blood to the patient's arterial system. The heart muscle or myocardium is paralyzed by the retrograde delivery of a cardioplegic fluid to the myocardium through patient's coronary sinus and coronary veins, or by antegrade delivery of cardioplegic fluid through a lumen in the endovascular aortic partitioning device to infuse cardioplegic fluid into the coronary arteries. The pulmonary trunk may be vented by withdrawing liquid from the trunk through an inner lumen of an elongated catheter. The cardiac accessing system is particularly suitable for removing the aortic valve and replacing the removed valve with a prosthetic valve.
摘要翻译：一种用于访问患者心脏解剖结构的系统，其包括将冠状动脉和心脏与患者动脉系统的其余部分分离的血管内主动脉分配装置。用于分隔患者升主动脉的血管内装置包括具有远端，近端和其间的第一内腔的柔性轴，在远端具有开口。轴可以具有预先形成的远端部分，其曲率通常对应于患者主动脉弓的曲率。可膨胀装置，例如靠近靠近第一内腔中的开口的轴的远端附近的气囊，用于闭塞升主动脉，以便阻止基本上所有的血液通过其进行多个心动周期，同时患者由体外循环。血管内主动脉分配装置可以联接到动脉旁路套管，用于将氧合血液输送到患者的动脉系统。通过患者的冠状窦和冠状静脉逆行递送心脏停搏液到心肌，或者通过血管内主动脉分配装置的内腔顺序递送心脏停跳液，将心肌或心肌瘫痪，将心脏停搏液注入冠状动脉。可以通过从细长的导管的内腔中抽出液体来排出肺动脉干。心脏存取系统特别适用于去除主动脉瓣并用假体瓣替换去除的瓣膜。

3. 发明授权

US5584803A System for cardiac procedures 失效
公开(公告)号：US5584803A
公开(公告)日：1996-12-17
申请号：US282192
申请日：1994-07-28
申请人： John H. Stevens , Philip C. Evard , Timothy R. Machold
发明人： John H. Stevens , Philip C. Evard , Timothy R. Machold
IPC分类号： A61B17/00 , A61B17/28 , A61B17/32 , A61F2/24 , A61F2/958 , A61M1/36 , A61M25/00 , A61M25/01 , A61M25/06 , A61M29/02 , A61M37/00 , A61M29/00
CPC分类号： A61F2/2427 , A61B17/29 , A61F2/2433 , A61M1/3653 , A61M1/3659 , A61M25/0041 , A61M25/0147 , A61M25/0152 , A61M25/0662 , A61M25/10 , A61B17/320016 , A61B2017/00243 , A61B2018/00232 , A61B2018/00261 , A61F2/2436 , A61M2025/0031 , A61M2025/0078 , A61M2025/015 , A61M2025/0161 , A61M2025/028 , A61M2025/1047 , A61M2025/1052 , A61M2025/1077 , A61M2025/1095 , A61M2205/11 , A61M2205/366 , A61M2210/125 , A61M2210/127 , A61M25/0032 , A61M25/0125 , A61M25/1002
摘要： A system for accessing a patient's cardiac anatomy which includes an endovascular aortic partitioning device that separates the coronary arteries and the heart from the rest of the patient's arterial system. The endovascular device for partitioning a patient's ascending aorta comprises a flexible shaft having a distal end, a proximal end, and a first inner lumen therebetween with an opening at the distal end. The shaft may have a preshaped distal portion with a curvature generally corresponding to the curvature of the patient's aortic arch. An expandable means, e.g. a balloon, is disposed near the distal end of the shaft proximal to the opening in the first inner lumen for occluding the ascending aorta so as to block substantially all blood flow therethrough for a plurality of cardiac cycles, while the patient is supported by cardiopulmonary bypass. The endovascular aortic partitioning device may be coupled to an arterial bypass cannula for delivering oxygenated blood to the patient's arterial system. The heart muscle or myocardium is paralyzed by the retrograde delivery of a cardioplegic fluid to the myocardium through patient's coronary sinus and coronary veins, or by antegrade delivery of cardioplegic fluid through a lumen in the endovascular aortic partitioning device to infuse cardioplegic fluid into the coronary arteries. The pulmonary trunk may be vented by withdrawing liquid from the trunk through an inner lumen of an elongated catheter. The cardiac accessing system is particularly suitable for removing the aortic valve and replacing the removed valve with a prosthetic valve.

4. 发明授权

US5536251A Thoracoscopic devices and methods for arresting the heart 失效
公开(公告)号：US5536251A
公开(公告)日：1996-07-16
申请号：US415273
申请日：1995-04-03
申请人： Philip C. Evard , Timothy R. MacHold , Hanson S. Gifford, III , Alex T. Roth , Wesley D. Sterman , Lawrence C. Siegel
发明人： Philip C. Evard , Timothy R. MacHold , Hanson S. Gifford, III , Alex T. Roth , Wesley D. Sterman , Lawrence C. Siegel
IPC分类号： A61B1/00 , A61B17/00 , A61B17/02 , A61B17/04 , A61B17/06 , A61B17/064 , A61B17/068 , A61B17/12 , A61B17/122 , A61B17/128 , A61B17/28 , A61B17/30 , A61B17/34 , A61B18/14 , A61B19/00 , A61F2/24 , A61F2/958 , A61M1/00 , A61M25/00 , A61M25/01 , A61M11/00
CPC分类号： A61B17/0218 , A61B17/00234 , A61B17/0469 , A61B17/06061 , A61B17/12013 , A61B17/122 , A61B17/1227 , A61B17/1285 , A61B18/1442 , A61B18/1492 , A61B90/50 , A61F2/2427 , A61M25/01 , A61M39/0247 , A61B17/0057 , A61B17/0467 , A61B17/064 , A61B17/068 , A61B17/29 , A61B17/2909 , A61B17/295 , A61B17/30 , A61B17/34 , A61B17/3403 , A61B2017/00243 , A61B2017/00247 , A61B2017/00353 , A61B2017/00544 , A61B2017/00637 , A61B2017/00663 , A61B2017/0243 , A61B2017/047 , A61B2017/0472 , A61B2017/0474 , A61B2017/0475 , A61B2017/2905 , A61B2017/2933 , A61B2017/2943 , A61B2017/2945 , A61B2017/2946 , A61B2017/306 , A61B2017/3405 , A61B2017/3427 , A61B2017/3445 , A61B2017/3492 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00291 , A61B2018/00363 , A61B2018/00392 , A61B2018/00577 , A61B2018/1432 , A61B2090/064 , A61M2025/0003 , A61M2025/0089 , A61M2025/028 , A61M2039/0279 , A61M2202/047 , A61M2205/3344 , A61M2205/3355 , A61M2205/366 , A61M2210/127 , A61M25/1011 , Y10S128/26
摘要： The invention provides devices and methods for thoracoscopically arresting the heart and establishing cardiopulmonary bypass, thus facilitating a variety of less-invasive surgical procedures on and within the heart and great vessels of the thorax. In one embodiment, the invention provides a thoracoscopic system for arresting a patient's heart including a clamp configured for introduction into the patient's thoracic cavity through a percutaneous intercostal penetration in the patient's chest. The clamp is positionable about the patient's ascending aorta between the coronary arteries and the brachiocephalic artery. The clamp is coupled to the distal end of an elongated handle means for manipulating the clamp from a location outside of the patient's thoracic cavity. A means for actuating the clamp is coupled to the proximal end of the handle means. When actuated, the clamp blocks blood flow through the ascending aorta. A delivery cannula may be used to deliver cardioplegic fluid into the ascending aorta upstream from the clamp to arrest cardiac function.

5. 发明授权

US5425705A Thoracoscopic devices and methods for arresting the heart 失效
标题翻译：胸腔镜装置和止血方法
公开(公告)号：US5425705A
公开(公告)日：1995-06-20
申请号：US173899
申请日：1993-12-27
申请人： Philip C. Evard , Timothy R. Machold , Hanson S. Gifford, III , Alex T. Roth , Wesley D. Sterman , Lawrence C. Siegel , Jeffry J. Grainger
发明人： Philip C. Evard , Timothy R. Machold , Hanson S. Gifford, III , Alex T. Roth , Wesley D. Sterman , Lawrence C. Siegel , Jeffry J. Grainger
IPC分类号： A61B1/00 , A61B17/00 , A61B17/02 , A61B17/04 , A61B17/06 , A61B17/064 , A61B17/068 , A61B17/12 , A61B17/122 , A61B17/128 , A61B17/28 , A61B17/30 , A61B17/34 , A61B18/14 , A61B19/00 , A61F2/24 , A61F2/958 , A61M1/00 , A61M25/00 , A61M25/01
CPC分类号： A61B17/0218 , A61B17/00234 , A61B17/0469 , A61B17/06061 , A61B17/12013 , A61B17/122 , A61B17/1227 , A61B17/1285 , A61B18/1442 , A61B18/1492 , A61B90/50 , A61F2/2427 , A61M25/01 , A61M39/0247 , A61B17/0057 , A61B17/0467 , A61B17/064 , A61B17/068 , A61B17/29 , A61B17/2909 , A61B17/295 , A61B17/30 , A61B17/34 , A61B17/3403 , A61B2017/00243 , A61B2017/00247 , A61B2017/00353 , A61B2017/00544 , A61B2017/00637 , A61B2017/00663 , A61B2017/0243 , A61B2017/047 , A61B2017/0472 , A61B2017/0474 , A61B2017/0475 , A61B2017/2905 , A61B2017/2933 , A61B2017/2943 , A61B2017/2945 , A61B2017/2946 , A61B2017/306 , A61B2017/3405 , A61B2017/3427 , A61B2017/3445 , A61B2017/3492 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00291 , A61B2018/00363 , A61B2018/00392 , A61B2018/00577 , A61B2018/1432 , A61B2090/064 , A61M2025/0003 , A61M2025/0089 , A61M2025/028 , A61M2039/0279 , A61M2202/047 , A61M2205/3344 , A61M2205/3355 , A61M2205/366 , A61M2210/127 , A61M25/1011 , Y10S128/26
摘要： The invention provides devices and methods for thoracoscopically arresting the heart and establishing cardiopulmonary bypass, thus facilitating a variety of less-invasive surgical procedures on and within the heart and great vessels of the thorax. In one embodiment, the invention provides a thoracoscopic system for arresting a patient's heart including a clamp configured for introduction into the patient's thoracic cavity through a percutaneous intercostal penetration in the patient's chest. The clamp is positionable about the patient's ascending aorta between the coronary arteries and the brachiocephalic artery. The clamp is coupled to the distal end of an elongated handle means for manipulating the clamp from a location outside of the patient's thoracic cavity. A means for actuating the clamp is coupled to the proximal end of the handle means. When actuated, the clamp blocks blood flow through the ascending aorta. A delivery cannula may be used to deliver cardioplegic fluid into the ascending aorta upstream from the clamp to arrest cardiac function.
摘要翻译：本发明提供了用于胸腔镜阻塞心脏并建立心肺旁路的装置和方法，从而促进在胸部和/或胸部的心脏和大血管内部和内部的多种较小侵入性的外科手术。在一个实施例中，本发明提供了一种用于阻止患者心脏的胸腔镜系统，包括构造成通过患者胸部经皮肋间穿透引入患者胸腔的夹具。夹具可以围绕冠状动脉和头臂动脉之间的患者升主动脉定位。夹具联接到细长手柄的远端，用于从患者胸腔外部的位置操纵夹具。用于致动夹具的装置联接到手柄装置的近端。当启动时，夹具阻止血流通过升主动脉。输送插管可用于将心脏停搏液输送到夹钳上游的升主动脉以阻止心脏功能。

6. 发明授权

US07303571B2 Methods and apparatus for blocking flow through blood vessels 有权
标题翻译：阻止流经血管的方法和装置
公开(公告)号：US07303571B2
公开(公告)日：2007-12-04
申请号：US10651824
申请日：2003-08-29
申请人： Joshua Makower , J. C. Flaherty , Timothy R. Machold , Jason B. Whitt , Philip C. Evard , Patrick E. Macaulay , John T. Garibotto , Marc Jensen
发明人： Joshua Makower , J. C. Flaherty , Timothy R. Machold , Jason B. Whitt , Philip C. Evard , Patrick E. Macaulay , John T. Garibotto , Marc Jensen
IPC分类号： A61B17/34
CPC分类号： A61B1/3137 , A61B17/00234 , A61B17/00491 , A61B17/0643 , A61B17/11 , A61B17/12022 , A61B17/12045 , A61B17/12109 , A61B17/12131 , A61B17/12136 , A61B17/12159 , A61B17/12172 , A61B17/12186 , A61B17/1219 , A61B17/3417 , A61B17/3496 , A61B18/00 , A61B18/1445 , A61B18/1477 , A61B18/1492 , A61B18/24 , A61B90/361 , A61B90/40 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/00504 , A61B2017/0641 , A61B2017/0647 , A61B2017/0649 , A61B2017/1107 , A61B2017/1139 , A61B2017/1205 , A61B2017/12127 , A61B2017/22038 , A61B2017/22077 , A61B2017/306 , A61B2017/347 , A61B2017/3488 , A61B2018/00392 , A61B2018/00404 , A61B2018/00869 , A61B2018/1425 , A61B2018/1475 , A61B2090/378 , A61B2090/3925 , A61B2090/3929 , A61B2090/3958 , A61F2/07 , A61F2/2493 , A61F2/90 , A61F2/95 , A61F2002/075 , A61F2002/30079 , A61F2002/8486 , A61F2210/009 , A61M2025/0076 , A61M2025/0096 , A61M2025/1052
摘要： Methods and apparatus for occluding blood flow within a blood vessel. In a first series of embodiments, the present invention comprises a plurality of embolic devices deployable through the lumen of a conventional catheter such that when deployed, said embolic devices remain resident and occlude blood flow at a specific site within the lumen of the blood vessel. Such embolic devices comprise either mechanical embolic devices that become embedded within or compress against the lumen of the vessel or chemical vaso-occlusive agents that seal off blood flow at a given site. A second embodiment of the present invention comprises utilization of a vacuum/cauterizing device capable of sucking in the lumen of the vessel about the device to maintain the vessel in a closed condition where there is then applied a sufficient amount of energy to cause the tissue collapsed about the device to denature into a closure. In a third series of embodiments, the present invention comprises the combination of an embolization facilitator coupled with the application of an energy force to form an intraluminal closure at a specified site within a vessel.
摘要翻译：阻塞血管内血流的方法和装置。在第一系列实施例中，本发明包括可以通过常规导管的内腔部署的多个栓塞装置，使得当展开时，所述栓塞装置保持驻留并阻塞在血管腔内的特定部位处的血流。这种栓塞装置包括机械栓塞装置，其嵌入或压缩容器的内腔或封闭给定部位的血流的化学血管闭塞剂。本发明的第二个实施方案包括使用能够吸收容器内腔的设备的真空/烧灼装置，以将容器保持在闭合状态，在那里然后施加足够量的能量以使组织折叠关于器件变性成闭合。在第三系列实施方案中，本发明包括栓塞促进剂与施加能量力的组合，以在血管内的指定部位形成腔内闭合。

7. 发明授权

US06638293B1 Methods and apparatus for blocking flow through blood vessels 有权
标题翻译：阻止流经血管的方法和装置
公开(公告)号：US06638293B1
公开(公告)日：2003-10-28
申请号：US09117516
申请日：1999-01-21
申请人： Joshua Makower , J. Christopher Flaherty , Timothy R. Machold , Jason B. Whitt , Philip C. Evard , Patrick E. Macaulay , John T. Garibotto , Marc Jensen
发明人： Joshua Makower , J. Christopher Flaherty , Timothy R. Machold , Jason B. Whitt , Philip C. Evard , Patrick E. Macaulay , John T. Garibotto , Marc Jensen
IPC分类号： A61M2900
CPC分类号： A61B1/3137 , A61B17/00234 , A61B17/00491 , A61B17/0643 , A61B17/11 , A61B17/12022 , A61B17/12045 , A61B17/12109 , A61B17/12131 , A61B17/12136 , A61B17/12159 , A61B17/12172 , A61B17/12186 , A61B17/1219 , A61B17/3417 , A61B17/3496 , A61B18/00 , A61B18/1445 , A61B18/1477 , A61B18/1492 , A61B18/24 , A61B90/361 , A61B90/40 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/00504 , A61B2017/0641 , A61B2017/0647 , A61B2017/0649 , A61B2017/1107 , A61B2017/1139 , A61B2017/1205 , A61B2017/12127 , A61B2017/22038 , A61B2017/22077 , A61B2017/306 , A61B2017/347 , A61B2017/3488 , A61B2018/00392 , A61B2018/00404 , A61B2018/00869 , A61B2018/1425 , A61B2018/1475 , A61B2090/378 , A61B2090/3925 , A61B2090/3929 , A61B2090/3958 , A61F2/07 , A61F2/2493 , A61F2/90 , A61F2/95 , A61F2002/075 , A61F2002/30079 , A61F2002/8486 , A61F2210/009 , A61M2025/0076 , A61M2025/0096 , A61M2025/1052
摘要： This invention is methods and apparatus for occluding blood flow within a blood vessel (22). In a first series of embodiments, the present invention comprises a plurality of embolic devices (16) deployable through the lumen (12) of a conventional catheter (10) such that when deployed, said embolic devices (16) remain resident and occlude blood flow at a specific site within the lumen of the blood vessel (22). Such embolic devices (16) comprise either mechanical embolic devices that become embedded within or compress against the lumen of the vessel or chemical vaso occlusive agents that seal off blood flow at a given site. A second embodiment of the present invention comprises utilization of a vacuum/cauterizing device capable of sucking in the lumen of the vessel about the device to maintain the vessel in a closed condition where there is then applied a sufficient amount of energy to cause the tissue collapsed about the device to denature into a closure. In a third series of embodiments, the present invention comprises the combination of an embolization facilitator coupled with the application of an energy force to form an intraluminal closure at a specified site within a vessel.
摘要翻译：本发明是用于阻塞血管内血流的方法和装置（22）。在第一系列实施例中，本发明包括可以通过常规导管（10）的内腔（12）展开的多个栓塞装置（16），使得当展开时，所述栓塞装置（16）保持驻留并阻塞血流在血管（22）的内腔内的特定部位。这种栓塞装置（16）包括机械栓塞装置，其嵌入或压缩在容器的内腔或封闭给定部位的血液流动的化学血管闭塞剂。本发明的第二个实施方案包括使用能够吸收容器内腔的设备的真空/烧灼装置，以将容器保持在闭合状态，在那里然后施加足够量的能量以使组织折叠关于器件变性成闭合。在第三系列实施方案中，本发明包括栓塞促进剂与施加能量力的组合，以在血管内的指定部位形成腔内闭合。

8. 发明授权

US5176661A Composite vascular catheter 失效
标题翻译：复合血管导管
公开(公告)号：US5176661A
公开(公告)日：1993-01-05
申请号：US776726
申请日：1991-10-15
申请人： Philip C. Evard , Timothy R. Machold , Bojana Spahic
发明人： Philip C. Evard , Timothy R. Machold , Bojana Spahic
IPC分类号： A61M25/00 , A61M29/02
CPC分类号： A61M25/104 , A61M25/0053
摘要： An improved vascular catheter having a tubular member of composite structure with a tubular substrate and a resin-impregnated fibrous covering extending over a substantial part of the length thereof. The tubular substrate which is longitudinally flexible but relatively inextendible, is preferably polyimide tubing with a lubricious coating on the inner surface thereof defining an inner lumen. The fibrous covering is preferably epoxy-impregnated aramid or polyester (Dacron) multi-filament fibers. The strands are is snugly wrapped around the tubular substrate and then impregnated with a suitable resin. One or more of the strands in the distal portion are at an angle with respect to the longitudinal axis of the tubular substrate between about 20.degree. and about 45.degree. greater than the angle of one or more strands in the proximal portion. Individual strand wraps in the distal portion are at an angle of about 60.degree. to about 85.degree. and strand wraps in such as the proximal portion are at an angle of about 30.degree. to about 60.degree.. The composite tubular member is preferably utilized in balloon dilatation catheters used in angioplasty procedures.
摘要翻译：一种改进的血管导管，其具有复合结构的管状构件，其具有管状基底和在其长度的大部分上延伸的树脂浸渍的纤维覆盖物。纵向柔性但相对可延伸的管状基底优选为聚酰亚胺管，其内表面上具有限定内腔的润滑涂层。纤维覆盖物优选为环氧树脂浸渍的芳族聚酰胺或聚酯（涤纶）复丝纤维。股线被紧密地缠绕在管状基底上，然后用合适的树脂浸渍。远侧部分中的一条或多条股线相对于管状基材的纵向轴线处于与近端部分中的一条或多条股线的角度大约20度至大约45度之间的一角度。远侧部分的单股股卷绕约60度至约85度的角度，并且诸如近端部分的股线卷绕成大约30度至大约60度的角度。复合管状构件优选用于血管成形术中使用的球囊扩张导管中。

9. 发明授权

US06616675B1 Methods and apparatus for connecting openings formed in adjacent blood vessels or other anatomical structures 有权
标题翻译：用于连接相邻血管或其他解剖结构中形成的开口的方法和装置
公开(公告)号：US06616675B1
公开(公告)日：2003-09-09
申请号：US09117520
申请日：1999-03-17
申请人： Philip C. Evard , Joshua Makower , J. C. Flaherty , Timothy R. Machold , Jason B. Whitt , Patrick E. Macaulay , John T. Garibotto , Alex T. Roth
发明人： Philip C. Evard , Joshua Makower , J. C. Flaherty , Timothy R. Machold , Jason B. Whitt , Patrick E. Macaulay , John T. Garibotto , Alex T. Roth
IPC分类号： A61B1708
CPC分类号： A61B1/3137 , A61B17/00234 , A61B17/00491 , A61B17/0643 , A61B17/11 , A61B18/00 , A61B18/1445 , A61B18/1477 , A61B18/1492 , A61B18/24 , A61B90/361 , A61B90/40 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/00504 , A61B2017/0641 , A61B2017/0647 , A61B2017/0649 , A61B2017/1107 , A61B2017/1139 , A61B2017/22038 , A61B2017/22077 , A61B2018/00392 , A61B2018/00404 , A61B2018/00869 , A61B2018/1425 , A61B2018/1475 , A61B2090/378 , A61B2090/3925 , A61B2090/3929 , A61B2090/3958 , A61F2/07 , A61F2/2493 , A61F2/90 , A61F2/95 , A61F2/958 , A61F2002/30079 , A61F2002/8486 , A61F2210/009 , A61F2230/001 , A61M2025/0076 , A61M2025/0096 , A61M2025/1052
摘要： Anastomotic connectors and apparatus for forming and/or maintaining connections between openings formed in anatomical structures, such as blood vessels. The apparatus is initially deployed in a first configuration which is sufficiently compact to be delivered through the lumen of a catheter or cannula. Thereafter, the device is expanded to a second configuration whereby it engages the anatomical structures and forms or maintains the desired connection between openings in the anatomical structures.
摘要翻译：用于在解剖结构（例如血管）中形成的开口之间形成和/或维持连接的吻合连接器和装置。该装置最初部署在第一配置中，该构型足够紧凑以便通过导管或套管的内腔输送。此后，该装置被扩展成第二构型，由此其与解剖结构接合并且在解剖结构中的开口之间形成或维持期望的连接。

10. 发明授权

US4981478A Composite vascular catheter 失效
标题翻译：复合血管导管
公开(公告)号：US4981478A
公开(公告)日：1991-01-01
申请号：US241047
申请日：1988-09-06
申请人： Philip C. Evard , Timothy R. Machold , Bojana Spahic
发明人： Philip C. Evard , Timothy R. Machold , Bojana Spahic
IPC分类号： A61L29/00 , A61M25/00
CPC分类号： A61M25/0053 , A61M25/005
摘要： An improved vascular catheter having a tubular member of composite structure with a tubular substrate and a resin-impregnated fibrous covering extending over a substantial part of the length thereof. The tubular substrate which is longitudinally flexible but relatively inextendible, is preferably polyimide tubing with a lubricious coating on the inner surface thereof defining an inner lumen. The fibrous covering is preferably epoxy-impregnated aramid or polyester (Dacron) multi-filament fibers. The strands are is snugly wrapped about the tubular substrate and then impregnated with a suitable resin. One or more of the strands in the distal portion are at an angle with respect to the longitudinal axis of the tubular substrate between about 20.degree. and about 45.degree. greater than the angle of one or more strands in the proximal portion. Individual strand wraps in the distal portion are at an angle of about 60.degree. to about 85.degree. and strand wraps in such as the proximal portion are at an angle of about 30.degree. to about 60.degree.. The composite tubular member is preferably utilized in balloon dilatation catheters used in angioplasty procedures.

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