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1. 发明申请

US20050272770A1 Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase 审中-公开
公开(公告)号：US20050272770A1
公开(公告)日：2005-12-08
申请号：US11118090
申请日：2005-04-29
申请人： John Griffin , William Mydlowec , Guido Lanza , Jessen Yu
发明人： John Griffin , William Mydlowec , Guido Lanza , Jessen Yu
IPC分类号： A61K31/445
CPC分类号： A61K31/445 , Y02A50/409
摘要： The present invention provides compositions of matter, kits and methods for their use in the treatment of MAP kinase-related conditions and/or HMG-CoA reductase-related conditions. In particular, the invention provides compositions for treating inflammatory and/or cardiovascular conditions in an animal subject by inhibiting p38α MAP kinase and/or HMG-CoA reductase, as well as providing formulations and modes of administering such compositions. The invention further provides methods for the rational design of inhibitors of MAP kinase, HMG-CoA reductase, or both for use in the practice of the present invention.

2. 发明申请

US20050278124A1 Methods for molecular property modeling using virtual data 审中-公开
标题翻译：使用虚拟数据进行分子特性建模的方法
公开(公告)号：US20050278124A1
公开(公告)日：2005-12-15
申请号：US11074587
申请日：2005-03-08
申请人： Nigel Duffy , Guido Lanza , Jessen Yu , William Mydlowec
发明人： Nigel Duffy , Guido Lanza , Jessen Yu , William Mydlowec
IPC分类号： G01N33/48 , G01N33/50 , G01N33/68 , G06F19/00
CPC分类号： G01N33/6803 , G16C20/30 , G16C20/70
摘要： Embodiments of the invention provide methods, systems, and articles of manufacture for modeling molecular properties based on information obtained from sources other than direct empirical measurements of the properties. Embodiments of the invention use “virtual data” related to molecular properties to train a molecular properties model. Virtual data about a molecule may include real-valued data (e.g. measurement values falling along a continuous range) or a positive or negative assertion about whether a molecule exhibits a property of interest. Virtual data may be generated using a variety of techniques and may be further characterized by confidence in the accuracy of the virtual data. In addition to virtual data, embodiments of the invention may use “virtual molecules” paired with “virtual data” to train a molecular properties model. The virtual molecules may themselves be generated in a variety of ways.
摘要翻译：本发明的实施方案提供了基于从属性的直接经验测量以外的源获得的信息来建模分子性质的方法，系统和制品。本发明的实施方案使用与分子性质相关的“虚拟数据”来训练分子性质模型。关于分子的虚拟数据可以包括实数数据（例如沿着连续范围落下的测量值）或关于分子是否表现出感兴趣的性质的正或负的断言。可以使用各种技术生成虚拟数据，并且可以进一步表征为对虚拟数据的准确性的置信度。除了虚拟数据之外，本发明的实施例可以使用与“虚拟数据”配对的“虚拟分子”来训练分子性质模型。虚拟分子本身可以以各种方式产生。

3. 发明申请

US20090227602A1 COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE 审中-公开
标题翻译：用于抑制激素和/或HMG-COA还原的组合物和治疗
公开(公告)号：US20090227602A1
公开(公告)日：2009-09-10
申请号：US12090434
申请日：2006-10-30
申请人： John Griffin , Guido Lanza , Jessen Yu
发明人： John Griffin , Guido Lanza , Jessen Yu
IPC分类号： A61K31/4439 , C07D401/14 , A61P37/06
CPC分类号： C07D405/14 , C07D401/04 , C07D403/04
摘要： The present invention provides compositions of matter, kits and methods for their use in the treatment of MAP kinase-related conditions and/or HMG-CoA reductase-related conditions. In particular, the invention provides compositions for treating inflammatory and/or cardiovascular conditions in an animal subject by inhibiting p38αMAP kinase and/or HMG-CoA reductase, as well as providing formulations and modes of administering such compositions. The invention further provides methods for the rational design of inhibitors of MAP kinase, HMG-CoA reductase, or both for use in the practice of the present invention.
摘要翻译：本发明提供了用于治疗MAP激酶相关病症和/或HMG-CoA还原酶相关病症的物质，试剂盒和方法的组合物。特别地，本发明提供了通过抑制p38alphaMAP激酶和/或HMG-CoA还原酶来治疗动物受试者的炎性和/或心血管病症的组合物，以及提供施用这种组合物的制剂和模式。本发明还提供了用于实施本发明的MAP激酶，HMG-CoA还原酶抑制剂或两者的合理设计的方法。

4. 发明申请

US20060084695A1 Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase 审中-公开
标题翻译：用于抑制激酶和/或HMG-CoA还原酶的组合物和治疗
公开(公告)号：US20060084695A1
公开(公告)日：2006-04-20
申请号：US11262521
申请日：2005-10-28
申请人： John Griffin , Guido Lanza , Jessen Yu
发明人： John Griffin , Guido Lanza , Jessen Yu
IPC分类号： A61K31/405 , A61K31/4025 , A61K31/366
CPC分类号： A61K31/366 , A61K31/4025 , A61K31/405 , Y02A50/409 , A61K2300/00
摘要： The present invention provides compositions of matter, kits and methods for their use in the treatment of MAP kinase-related conditions and/or HMG-CoA reductase-related conditions. In particular, the invention provides compositions for treating inflammatory and/or cardiovascular conditions in an animal subject by inhibiting p38α MAP kinase and/or HMG-CoA reductase, as well as providing formulations and modes of administering such compositions. The invention further provides methods for the rational design of inhibitors of MAP kinase, HMG-CoA reductase, or both for use in the practice of the present invention.
摘要翻译：本发明提供了用于治疗MAP激酶相关病症和/或HMG-CoA还原酶相关病症的物质，试剂盒和方法的组合物。特别地，本发明提供了通过抑制p38alpha MAP激酶和/或HMG-CoA还原酶来治疗动物受试者的炎性和/或心血管疾病的组合物，以及提供施用这种组合物的制剂和模式。本发明还提供了用于实施本发明的MAP激酶，HMG-CoA还原酶抑制剂或两者的合理设计的方法。

5. 发明授权

US07163945B2 Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase 失效
公开(公告)号：US07163945B2
公开(公告)日：2007-01-16
申请号：US11118064
申请日：2005-04-29
申请人： John Griffin , Guido Lanza , Jessen Yu
发明人： John Griffin , Guido Lanza , Jessen Yu
IPC分类号： A01N43/58
CPC分类号： A61K31/4178 , A61K31/4439 , A61K31/506
摘要： The present invention provides compositions of matter, kits and methods for their use in the treatment of MAP kinase-related conditions and/or HMG-CoA reductase-related conditions. In particular, the invention provides compositions for treating inflammatory and/or cardiovascular conditions in an animal subject by inhibiting p38α MAP kinase and/or HMG-CoA reductase, as well as providing formulations and modes of administering such compositions. The invention further provides methods for the rational design of inhibitors of MAP kinase, HMG-CoA reductase, or both for use in the practice of the present invention.

6. 发明申请

US20070004758A1 COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE 审中-公开
标题翻译：用于抑制激素和/或HMG-COA还原的组合物和治疗
公开(公告)号：US20070004758A1
公开(公告)日：2007-01-04
申请号：US11469417
申请日：2006-08-31
申请人： John Griffin , Guido Lanza , Jessen Yu
发明人： John Griffin , Guido Lanza , Jessen Yu
IPC分类号： A61K31/506 , A61K31/4439 , A61K31/4178
CPC分类号： A61K31/4439 , A61K31/4172 , A61K31/4178 , A61K31/506 , C07D401/04 , C07D403/04 , C07D405/14 , Y02A50/409
摘要： The present invention provides compositions of matter, kits and methods for their use in the treatment of MAP kinase-related conditions and/or HMG-CoA reductase-related conditions. In particular, the invention provides compositions for treating inflammatory and/or cardiovascular conditions in an animal subject by inhibiting p38α MAP kinase and/or HMG-CoA reductase, as well as providing formulations and modes of administering such compositions. The invention further provides methods for the rational design of inhibitors of MAP kinase, HMG-CoA reductase, or both for use in the practice of the present invention.
摘要翻译：本发明提供了用于治疗MAP激酶相关病症和/或HMG-CoA还原酶相关病症的物质，试剂盒和方法的组合物。特别地，本发明提供了通过抑制p38alpha MAP激酶和/或HMG-CoA还原酶来治疗动物受试者的炎性和/或心血管疾病的组合物，以及提供施用这种组合物的制剂和模式。本发明还提供了用于实施本发明的MAP激酶，HMG-CoA还原酶抑制剂或两者的合理设计的方法。

7. 发明申请

US20050277653A1 Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase 失效
标题翻译：用于抑制激酶和/或HMG-CoA还原酶的组合物和治疗
公开(公告)号：US20050277653A1
公开(公告)日：2005-12-15
申请号：US11118065
申请日：2005-04-29
申请人： John Griffin , Guido Lanza , Jessen Yu
发明人： John Griffin , Guido Lanza , Jessen Yu
IPC分类号： A61K31/4172 , A61K31/4178 , A61K31/4439 , A61K31/506 , C07D233/60 , C07D401/04 , C07D403/04 , C07D405/14 , C07D45/02
CPC分类号： A61K31/4439 , A61K31/4172 , A61K31/4178 , A61K31/506 , C07D401/04 , C07D403/04 , C07D405/14 , Y02A50/409
摘要： The present invention provides compositions of matter, kits and methods for their use in the treatment of MAP kinase-related conditions and/or HMG-CoA reductase-related conditions. In particular, the invention provides compositions for treating inflammatory and/or cardiovascular conditions in an animal subject by inhibiting p38α MAP kinase and/or HMG-CoA reductase, as well as providing formulations and modes of administering such compositions. The invention further provides methods for the rational design of inhibitors of MAP kinase, HMG-CoA reductase, or both for use in the practice of the present invention.
摘要翻译：本发明提供了用于治疗MAP激酶相关病症和/或HMG-CoA还原酶相关病症的物质，试剂盒和方法的组合物。特别地，本发明提供了通过抑制p38alpha MAP激酶和/或HMG-CoA还原酶来治疗动物受试者的炎性和/或心血管疾病的组合物，以及提供施用这种组合物的制剂和模式。本发明还提供了用于实施本发明的MAP激酶，HMG-CoA还原酶抑制剂或两者的合理设计的方法。

8. 发明申请

US20080021054A1 COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE 审中-公开
标题翻译：用于抑制激素和/或HMG-COA还原的组合物和治疗
公开(公告)号：US20080021054A1
公开(公告)日：2008-01-24
申请号：US11469424
申请日：2006-12-05
申请人： John Griffin , Guido Lanza , Jessen Yu
发明人： John Griffin , Guido Lanza , Jessen Yu
IPC分类号： A61K31/505 , A61K31/40 , C07D207/30 , C07D401/00 , C07D239/02 , A61K31/44
CPC分类号： A61K31/40 , A61K31/4025 , A61K31/44 , A61K31/505 , A61K31/557 , C07D401/04 , C07D403/04 , C07D405/06 , Y02A50/409
摘要： The present invention provides compositions of matter, kits and methods for their use in the treatment of MAP kinase-related conditions and/or HMG-CoA reductase-related conditions. In particular, the invention provides compositions for treating inflammatory and/or cardiovascular conditions in an animal subject by inhibiting p38α MAP kinase and/or HMG-CoA reductase, as well as providing formulations and modes of administering such compositions. The invention further provides methods for the rational design of inhibitors of MAP kinase, HMG-COA reductase, or both for use in the practice of the present invention.
摘要翻译：本发明提供了用于治疗MAP激酶相关病症和/或HMG-CoA还原酶相关病症的物质，试剂盒和方法的组合物。特别地，本发明提供了通过抑制p38alpha MAP激酶和/或HMG-CoA还原酶来治疗动物受试者的炎性和/或心血管疾病的组合物，以及提供施用这种组合物的制剂和模式。本发明还提供了合理设计MAP激酶抑制剂，HMG-COA还原酶或两者用于本发明实践的方法。

9. 发明授权

US07183285B2 Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase 失效
公开(公告)号：US07183285B2
公开(公告)日：2007-02-27
申请号：US11118066
申请日：2005-04-29
申请人： John Griffin , Guido Lanza , Jessen Yu
发明人： John Griffin , Guido Lanza , Jessen Yu
IPC分类号： A01N43/58
CPC分类号： A61K31/40 , A61K31/4025 , A61K31/44 , A61K31/505 , A61K31/557 , C07D401/04 , C07D403/04 , C07D405/06 , Y02A50/409
摘要： The present invention provides compositions of matter, kits and methods for their use in the treatment of MAP kinase-related conditions and/or HMG-CoA reductase-related conditions. In particular, the invention provides compositions for treating inflammatory and/or cardiovascular conditions in an animal subject by inhibiting p38α MAP kinase and/or HMG-CoA reductase, as well as providing formulations and modes of administering such compositions. The invention further provides methods for the rational design of inhibitors of MAP kinase, HMG-CoA reductase, or both for use in the practice of the present invention.

10. 发明申请

US20070015779A1 COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE 审中-公开
标题翻译：用于抑制激素和/或HMG-COA还原的组合物和治疗
公开(公告)号：US20070015779A1
公开(公告)日：2007-01-18
申请号：US11469419
申请日：2006-08-31
申请人： John Griffin , Guido Lanza , Jessen Yu
发明人： John Griffin , Guido Lanza , Jessen Yu
IPC分类号： A61K31/506 , A61K31/4439 , A61K31/4178 , C07D403/04 , C07D405/14
CPC分类号： C07D403/04 , A61K31/4178 , A61K31/4439 , A61K31/506 , C07D401/04 , C07D401/14 , C07D405/14 , Y02A50/409
摘要： The present invention provides compositions of matter; kits and methods for their use in the treatment of MAP kinase-related conditions and/or HMG-CoA reductase-related conditions. In particular, the invention provides compositions for treating inflammatory and/or cardiovascular conditions in an animal subject by inhibiting p38α MAP kinase and/or HMG-CoA reductase, as well as providing formulations and modes of administering such compositions. The invention further provides methods for the rational design of inhibitors of MAP kinase, HMG-CoA reductase, or both for use in the practice of the present invention.
摘要翻译：本发明提供了一种物质组合物; 用于治疗MAP激酶相关病症和/或HMG-CoA还原酶相关病症的试剂盒和方法。特别地，本发明提供了通过抑制p38alpha MAP激酶和/或HMG-CoA还原酶来治疗动物受试者的炎性和/或心血管疾病的组合物，以及提供施用这种组合物的制剂和模式。本发明还提供了用于实施本发明的MAP激酶，HMG-CoA还原酶抑制剂或两者的合理设计的方法。

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