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1. 发明授权

US06379319B1 Systems and methods for directing and snaring guidewires 有权
标题翻译：引导线和引导线的系统和方法
公开(公告)号：US06379319B1
公开(公告)日：2002-04-30
申请号：US09179737
申请日：1998-10-27
申请人： John Garibotto , Steven W. Kim , Jason Whitt , J. Christopher Flaherty , Joshua Makower , Motoya Hayase , John Chang
发明人： John Garibotto , Steven W. Kim , Jason Whitt , J. Christopher Flaherty , Joshua Makower , Motoya Hayase , John Chang
IPC分类号： A61B500
CPC分类号： A61B17/11 , A61B17/00491 , A61B17/0643 , A61B17/12022 , A61B17/12109 , A61B17/12136 , A61B17/221 , A61B17/32056 , A61B17/3417 , A61B18/00 , A61B18/1492 , A61B90/39 , A61B90/40 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/00504 , A61B2017/1107 , A61B2017/1139 , A61B2017/22035 , A61B2017/22094 , A61B2017/2212 , A61B2017/306 , A61B2017/347 , A61B2018/00392 , A61F2/064 , A61F2/07 , A61F2/90 , A61F2002/061 , A61F2002/30079 , A61F2002/825 , A61F2210/009 , A61M25/0105 , A61M25/0133 , A61M2025/0076 , A61M2025/0161 , A61M2025/1052
摘要： Devices and methods for achieving directed placement of guidewires or other flexible rails over which other catheters or other devices may be introduced to a targeted location. A guidewire directing device includes a lumen extending between a proximal end and a distal peripheral opening for directing a guidewire laterally from the device, and may have a deflecting member with a predetermined deflection angle in the lumen adjacent the peripheral opening. A snaring device is also provided that includes one or more lumens through which a snare or other grasping member is directed for releasably capturing or coupling to a guidewire. The snaring and target guidewire devices may include cooperating end effectors for releasably coupling or securing the devices together. The devices may be used for directing, snaring and/or manipulating one or more guidewires between two blood vessels connected by an interstitial channel, for example, to “floss” a guidewire through the coronary arterial and venous systems between two percutaneous entry sites and/or to bypass a lesion in a vessel using proximal and distal interstitial channels communicating with an adjacent vessel.
摘要翻译：用于实现导线或其它柔性导轨的定向放置的装置和方法，其它导管或其它装置可以通过其引导到目标位置。导丝引导装置包括在近端和远侧外围开口之间延伸的腔，用于将导丝从装置横向引导，并且可具有在邻近周边开口的内腔中具有预定偏转角的偏转构件。还提供了一种包围一个或多个腔的扼流装置，一个圈套或其他把持件被引导通过该腔，用于可释放地捕获或连接到导丝。牵引和目标导丝装置可以包括用于可释放地将装置连接或固定在一起的协作的端部执行器。这些装置可用于引导，扼制和/或操纵通过间质通道连接的两个血管之间的一个或多个导线，例如通过两个经皮进入部位之间的冠状动脉和静脉系统“引导”导丝，和/ 或绕过与相邻血管连通的近端和远端间隙通道的血管中的病变。

2. 发明授权

US07316655B2 Systems and methods for directing and snaring guidewires 有权
标题翻译：引导线和引导线的系统和方法
公开(公告)号：US07316655B2
公开(公告)日：2008-01-08
申请号：US10136929
申请日：2002-04-30
申请人： John Garibotto , Steven W. Kim , Jason Whitt , J. Christopher Flaherty , Joshua Makower , Motoya Hayase , John Chang
发明人： John Garibotto , Steven W. Kim , Jason Whitt , J. Christopher Flaherty , Joshua Makower , Motoya Hayase , John Chang
IPC分类号： A61B5/00 , A61M25/00
CPC分类号： A61B17/11 , A61B17/00491 , A61B17/0643 , A61B17/12022 , A61B17/12109 , A61B17/12136 , A61B17/221 , A61B17/32056 , A61B17/3417 , A61B18/00 , A61B18/1492 , A61B90/39 , A61B90/40 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/00504 , A61B2017/1107 , A61B2017/1139 , A61B2017/22035 , A61B2017/22094 , A61B2017/2212 , A61B2017/306 , A61B2017/347 , A61B2018/00392 , A61F2/064 , A61F2/07 , A61F2/90 , A61F2002/061 , A61F2002/30079 , A61F2002/825 , A61F2210/009 , A61M25/0105 , A61M25/0133 , A61M2025/0076 , A61M2025/0161 , A61M2025/1052
摘要： Devices and methods for achieving directed placement of guidewires or other flexible rails over which other catheters or other devices may be introduced to a targeted location. A guidewire directing device includes a lumen extending between a proximal end and a distal peripheral opening for directing a guidewire laterally from the device, and may have a deflecting member with a predetermined deflection angle in the lumen adjacent the peripheral opening. A snaring device is also provided that includes one or more lumens through which a snare or other grasping member is directed for releasably capturing or coupling to a guidewire. The snaring and target guidewire devices may include cooperating end effectors for releasably coupling or securing the devices together. The devices may be used for directing, snaring and/or manipulating one or more guidewires between two blood vessels connected by an interstitial channel, for example, to “floss” a guidewire through the coronary arterial and venous systems between two percutaneous entry sites and/or to bypass a lesion in a vessel using proximal and distal interstitial channels communicating with an adjacent vessel.
摘要翻译：用于实现导线或其它柔性导轨的定向放置的装置和方法，其它导管或其它装置可以通过其引导到目标位置。导丝引导装置包括在近端和远侧外围开口之间延伸的腔，用于将导丝从装置横向引导，并且可具有在邻近周边开口的内腔中具有预定偏转角的偏转构件。还提供了一种包围一个或多个腔的扼流装置，一个圈套或其他把持件被引导通过该腔，用于可释放地捕获或连接到导丝。牵引和目标导丝装置可以包括用于可释放地将装置连接或固定在一起的协作的端部执行器。这些装置可用于引导，扼制和/或操纵通过间质通道连接的两个血管之间的一个或多个导线，例如通过两个经皮进入部位之间的冠状动脉和静脉系统“引导”导丝，和/ 或绕过与相邻血管连通的近端和远端间隙通道的血管中的病变。

3. 发明授权

US07955343B2 Methods and apparatus for blocking flow through blood vessel 有权
标题翻译：阻塞流经血管的方法和装置
公开(公告)号：US07955343B2
公开(公告)日：2011-06-07
申请号：US11924758
申请日：2007-10-26
申请人： Joshua Makower , J. Christopher Flaherty , Timothy Machold , Jason Whitt , Philip Evard , Patrick Macaulay , John Garibotto , Marc Jensen
发明人： Joshua Makower , J. Christopher Flaherty , Timothy Machold , Jason Whitt , Philip Evard , Patrick Macaulay , John Garibotto , Marc Jensen
IPC分类号： A61B17/34
CPC分类号： A61B1/3137 , A61B17/00234 , A61B17/00491 , A61B17/0643 , A61B17/11 , A61B17/12022 , A61B17/12045 , A61B17/12109 , A61B17/12131 , A61B17/12136 , A61B17/12159 , A61B17/12172 , A61B17/12186 , A61B17/1219 , A61B17/3417 , A61B17/3496 , A61B18/00 , A61B18/1445 , A61B18/1477 , A61B18/1492 , A61B18/24 , A61B90/361 , A61B90/40 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/00504 , A61B2017/0641 , A61B2017/0647 , A61B2017/0649 , A61B2017/1107 , A61B2017/1139 , A61B2017/1205 , A61B2017/12127 , A61B2017/22038 , A61B2017/22077 , A61B2017/306 , A61B2017/347 , A61B2017/3488 , A61B2018/00392 , A61B2018/00404 , A61B2018/00869 , A61B2018/1425 , A61B2018/1475 , A61B2090/378 , A61B2090/3925 , A61B2090/3929 , A61B2090/3958 , A61F2/07 , A61F2/2493 , A61F2/90 , A61F2/95 , A61F2002/075 , A61F2002/30079 , A61F2002/8486 , A61F2210/009 , A61M2025/0076 , A61M2025/0096 , A61M2025/1052
摘要： Methods and apparatus for occluding blood flow within a blood vessel. In a first series of embodiments, the present invention comprises a plurality of embolic devices deployable through the lumen of a conventional catheter such that when deployed, said embolic devices remain resident and occlude blood flow at a specific site within the lumen of the blood vessel. Such embolic devices comprise either mechanical embolic devices that become embedded within or compress against the lumen of the vessel or chemical vaso-occlusive agents that seal off blood flow at a given site. A second embodiment of the present invention comprises utilization of a vacuum/cauterizing device capable of sucking in the lumen of the vessel about the device to maintain the vessel in a closed condition where there is then applied a sufficient amount of energy to cause the tissue collapsed about the device to denature into a closure. In a third series of embodiments, the present invention comprises the combination of an embolization facilitator coupled with the application of an energy force to form an intraluminal closure at a specified site within a vessel.
摘要翻译：阻塞血管内血流的方法和装置。在第一系列实施例中，本发明包括可以通过常规导管的内腔部署的多个栓塞装置，使得当展开时，所述栓塞装置保持驻留并阻塞在血管腔内的特定部位处的血流。这种栓塞装置包括机械栓塞装置，其嵌入或压缩容器的内腔或封闭给定部位的血流的化学血管闭塞剂。本发明的第二个实施方案包括使用能够吸收容器内腔的设备的真空/烧灼装置，以将容器保持在闭合状态，在那里然后施加足够量的能量以使组织折叠关于器件变性成闭合。在第三系列实施方案中，本发明包括栓塞促进剂与施加能量力的组合，以在血管内的指定部位形成腔内闭合。

4. 发明申请

US20080045996A1 Methods and Apparatus for Blocking Flow Through Blood Vessel 有权
标题翻译：阻塞流经血管的方法和装置
公开(公告)号：US20080045996A1
公开(公告)日：2008-02-21
申请号：US11924758
申请日：2007-10-26
申请人： Joshua Makower , J. Christopher Flaherty , Timothy Machold , Jason Whitt , Philip Evard , Patrick Macaulay , John Garibotto , Marc Jensen
发明人： Joshua Makower , J. Christopher Flaherty , Timothy Machold , Jason Whitt , Philip Evard , Patrick Macaulay , John Garibotto , Marc Jensen
IPC分类号： A61M29/02
CPC分类号： A61B1/3137 , A61B17/00234 , A61B17/00491 , A61B17/0643 , A61B17/11 , A61B17/12022 , A61B17/12045 , A61B17/12109 , A61B17/12131 , A61B17/12136 , A61B17/12159 , A61B17/12172 , A61B17/12186 , A61B17/1219 , A61B17/3417 , A61B17/3496 , A61B18/00 , A61B18/1445 , A61B18/1477 , A61B18/1492 , A61B18/24 , A61B90/361 , A61B90/40 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/00504 , A61B2017/0641 , A61B2017/0647 , A61B2017/0649 , A61B2017/1107 , A61B2017/1139 , A61B2017/1205 , A61B2017/12127 , A61B2017/22038 , A61B2017/22077 , A61B2017/306 , A61B2017/347 , A61B2017/3488 , A61B2018/00392 , A61B2018/00404 , A61B2018/00869 , A61B2018/1425 , A61B2018/1475 , A61B2090/378 , A61B2090/3925 , A61B2090/3929 , A61B2090/3958 , A61F2/07 , A61F2/2493 , A61F2/90 , A61F2/95 , A61F2002/075 , A61F2002/30079 , A61F2002/8486 , A61F2210/009 , A61M2025/0076 , A61M2025/0096 , A61M2025/1052
摘要： Methods and apparatus for occluding blood flow within a blood vessel. In a first series of embodiments, the present invention comprises a plurality of embolic devices deployable through the lumen of a conventional catheter such that when deployed, said embolic devices remain resident and occlude blood flow at a specific site within the lumen of the blood vessel. Such embolic devices comprise either mechanical embolic devices that become embedded within or compress against the lumen of the vessel or chemical vaso-occlusive agents that seal off blood flow at a given site. A second embodiment of the present invention comprises utilization of a vacuum/cauterizing device capable of sucking in the lumen of the vessel about the device to maintain the vessel in a closed condition where there is then applied a sufficient amount of energy to cause the tissue collapsed about the device to denature into a closure. In a third series of embodiments, the present invention comprises the combination of an embolization facilitator coupled with the application of an energy force to form an intraluminal closure at a specified site within a vessel.
摘要翻译：阻塞血管内血流的方法和装置。在第一系列实施例中，本发明包括可以通过常规导管的内腔部署的多个栓塞装置，使得当展开时，所述栓塞装置保持驻留并且阻塞在血管腔内的特定位置处的血流。这种栓塞装置包括机械栓塞装置，其嵌入或压缩容器的内腔或封闭给定部位的血流的化学血管闭塞剂。本发明的第二个实施方案包括使用能够吸收容器内腔的设备的真空/烧灼装置，以将容器保持在闭合状态，在那里然后施加足够量的能量以使组织折叠关于器件变性成闭合。在第三系列实施方案中，本发明包括栓塞促进剂与施加能量力的组合，以在血管内的指定部位形成腔内闭合。

5. 发明授权

US06613081B2 Deformable scaffolding multicellular stent 失效
公开(公告)号：US06613081B2
公开(公告)日：2003-09-02
申请号：US09933295
申请日：2001-08-20
申请人： Steven W. Kim , Joshua Makower , J. Christopher Flaherty
发明人： Steven W. Kim , Joshua Makower , J. Christopher Flaherty
IPC分类号： A61F206
CPC分类号： A61B17/11 , A61B17/00491 , A61B17/0643 , A61B17/12022 , A61B17/12045 , A61B17/12109 , A61B17/12136 , A61B17/3417 , A61B18/00 , A61B18/1477 , A61B18/1492 , A61B90/40 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/00504 , A61B2017/1107 , A61B2017/1139 , A61B2017/1205 , A61B2017/12127 , A61B2017/306 , A61B2017/347 , A61B2018/00392 , A61B2018/1425 , A61F2/064 , A61F2/07 , A61F2/2493 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2/958 , A61F2002/061 , A61F2002/30079 , A61F2002/825 , A61F2002/91508 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2002/91575 , A61F2002/91591 , A61F2210/009 , A61F2250/0048 , A61M2025/0076 , A61M2025/009 , A61M2025/1052
摘要： A plastically deformable stent for implantation within a body passage includes a plurality of cylindrical segments, and a plurality of connectors extending between adjacent segments. Each segment has an alternating pattern of curvilinear elements extending about its circumference, including first and second sets of curvilinear elements having different resistances to expansion, and preferably defining “U” shapes with alternating lengths that are connected to one another to define a substantially sinusoidal pattern. The connectors define a sinusoidal shape adapted to extend and compress axially substantially evenly when the adjacent segments are subjected to bending. The stent may be delivered on a device including an elongate member with a nose cone, an expandable member, and a proximal shoulder thereon, and an outer sheath for slidably receiving the elongate member therein. The outer sheath and/or nose cone may have perfusion holes for allowing continued perfusion of fluid during stent delivery. The device may be used in a method for implanting a stent within a curved region of a body passage, particularly for creating and/or maintaining a channel connecting a vein to an adjacent artery, preferably in the coronary system.

6. 发明授权

US06863684B2 Deformable scaffolding multicellular stent 有权
标题翻译：可变形支架多细胞支架
公开(公告)号：US06863684B2
公开(公告)日：2005-03-08
申请号：US10617105
申请日：2003-07-09
申请人： Steven W. Kim , Joshua Makower , J. Christopher Flaherty
发明人： Steven W. Kim , Joshua Makower , J. Christopher Flaherty
IPC分类号： A61B17/00 , A61B17/064 , A61B17/11 , A61B17/12 , A61B17/30 , A61B17/34 , A61B18/00 , A61B18/14 , A61B19/00 , A61F2/00 , A61F2/02 , A61F2/06 , A61F2/82 , A61F2/90 , A61M25/00 , A61M25/095
CPC分类号： A61B17/11 , A61B17/00491 , A61B17/0643 , A61B17/12022 , A61B17/12045 , A61B17/12109 , A61B17/12136 , A61B17/3417 , A61B18/00 , A61B18/1477 , A61B18/1492 , A61B90/40 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/00504 , A61B2017/1107 , A61B2017/1139 , A61B2017/1205 , A61B2017/12127 , A61B2017/306 , A61B2017/347 , A61B2018/00392 , A61B2018/1425 , A61F2/064 , A61F2/07 , A61F2/2493 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2/958 , A61F2002/061 , A61F2002/30079 , A61F2002/825 , A61F2002/91508 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2002/91575 , A61F2002/91591 , A61F2210/009 , A61F2250/0048 , A61M2025/0076 , A61M2025/009 , A61M2025/1052
摘要： A plastically deformable stent for implantation within a body passage includes a plurality of cylindrical segments, and a plurality of connectors extending between adjacent segments. Each segment has an alternating pattern of curvilinear elements extending about its circumference, including first and second sets of curvilinear elements having different resistances to expansion, and preferably defining “U” shapes with alternating lengths that are connected to one another to define a substantially sinusoidal pattern. The connectors define a sinusoidal shape adapted to extend and compress axially substantially evenly when the adjacent segments are subjected to bending. The stent may be delivered on a device including an elongate member with a nose cone, an expandable member, and a proximal shoulder thereon, and an outer sheath for slidably receiving the elongate member therein. The outer sheath and/or nose cone may have perfusion holes for allowing continued perfusion of fluid during stent delivery. The device may be used in a method for implanting a stent within a curved region of a body passage, particularly for creating and/or maintaining a channel connecting a vein to an adjacent artery, preferably in the coronary system.
摘要翻译：用于在体通道内植入的塑性可变形支架包括多个圆柱形段和在相邻段之间延伸的多个连接件。每个段具有围绕其圆周延伸的曲线元素的交替图案，包括具有不同的膨胀电阻的第一组曲线元件和第二组曲线元件，并且优选地限定具有彼此连接以限定基本上正弦曲线图案的交替长度的“U”形。连接器限定正弦形状，其适于当相邻的片段经受弯曲时基本均匀地轴向地延伸和压缩。支架可以在包括具有鼻锥体，可扩张构件和近侧肩部的细长构件的装置上递送，以及用于在其中可滑动地容纳细长构件的外护套。外护套和/或鼻锥体可以具有用于在支架输送期间持续灌注流体的灌注孔。该装置可以用于将支架植入身体通道的弯曲区域的方法，特别是用于产生和/或维持连接静脉至相邻动脉，优选地在冠状动脉系统中的通道。

7. 发明授权

US08672920B2 Devices, systems and methods for acute or chronic delivery of substances or apparatus to extravascular treatment sites 有权
标题翻译：用于急性或慢性传播物质或器械至血管外治疗部位的装置，系统和方法
公开(公告)号：US08672920B2
公开(公告)日：2014-03-18
申请号：US11927888
申请日：2007-10-30
申请人： Joshua Makower , Theodore Lamson , J. Christopher Flaherty , John Reggie , John Chang , Joseph Catanese , David Tholfsen
发明人： Joshua Makower , Theodore Lamson , J. Christopher Flaherty , John Reggie , John Chang , Joseph Catanese , David Tholfsen
IPC分类号： A61M31/00
CPC分类号： A61M25/0108 , A61B6/12 , A61M5/007 , A61M25/0084 , A61M2025/0086 , A61M2025/0087 , A61M2025/009 , A61M2210/12
摘要： Methods and apparatus for delivery of substances or apparatus to target sites located outside blood vessel lumens. A penetrating catheter is inserted into a blood vessel lumen and a penetrator is advanced from the catheter in the direction of the target site. Thereafter, a delivery catheter is passed through a lumen of the penetrator to the target site. A desired substance or apparatus is then delivered to or obtained from the target site. In some applications, the delivery catheter may remain in place for chronic or continuous delivery of substance(s) to and/or obtaining of information or samples from the target site. Alternatively, a delivery catheter having an occlusion member may be advanced into a vein or venule and used to occlude the lumen of the vein or venule during and after injection of a substance such that the substance will not be carried away by normal venous blood flow.
摘要翻译：用于将物质或设备运送到位于血管内腔外的靶位置的方法和装置。将穿透性导管插入血管内腔中，并且穿透器沿导向器朝向目标部位的方向前进。此后，输送导管穿过穿透器的内腔到目标部位。然后将所需的物质或装置输送到目标部位或从目标部位获得。在一些应用中，输送导管可以保持在适当位置以便从目标部位慢慢或连续地输送物质到和/或获得信息或样品。或者，具有闭塞构件的输送导管可以推入静脉或小静脉中，并用于在注射物质期间和之后闭塞静脉或小静脉的内腔，使得物质不会被正常的静脉血流带走。

8. 发明授权

US08090430B2 Methods and apparatus for acute or chronic delivery or substances or apparatus to extravascular treatment sites 有权
标题翻译：用于急性或慢性传播的方法和装置或血管外治疗部位的物质或装置
公开(公告)号：US08090430B2
公开(公告)日：2012-01-03
申请号：US12567915
申请日：2009-09-28
申请人： Joshua Makower , Theodore C. Lamson , J. Christopher Flaherty , John Reggie , John Chang , Joseph Catanese, III , David Tholfsen
发明人： Joshua Makower , Theodore C. Lamson , J. Christopher Flaherty , John Reggie , John Chang , Joseph Catanese, III , David Tholfsen
IPC分类号： A61B6/00
CPC分类号： A61M25/065 , A61B17/00491 , A61B17/0057 , A61B17/12022 , A61B17/12109 , A61B17/12122 , A61B17/12136 , A61B17/12186 , A61B18/24 , A61B2017/00243 , A61B2017/00247 , A61B2017/00575 , A61B2018/00392 , A61M25/0069 , A61M25/0084 , A61M25/0102 , A61M2025/018
摘要： Methods and apparatus for delivery of substances or apparatus to target sites within the body of a human or animal patient. A vessel wall penetrating catheter is inserted into the vasculature, positioned and oriented within a blood vessel near the target extravascular site and a penetrator is advanced from the catheter in the direction of the target site. Thereafter, a delivery catheter is passed through a lumen of the penetrator to the target site. A desired substance or apparatus is then delivered to or obtained from the target site.
摘要翻译：用于将物质或装置输送到人或动物患者体内靶向部位的方法和装置。将血管壁穿透导管插入脉管系统中，定位并定向在目标血管外部位附近的血管内，并且穿透器从导管沿目标部位的方向前进。此后，输送导管穿过穿透器的内腔到目标部位。然后将所需的物质或装置输送到目标部位或从目标部位获得。

9. 发明申请

US20080051756A1 Devices, Systems and Methods for Acute or Chronic Delivery of Substances or Apparatus to Extravascular Treatment Sites 有权
标题翻译：用于急性或慢性输送物质或装置用于血管外治疗部位的装置，系统和方法
公开(公告)号：US20080051756A1
公开(公告)日：2008-02-28
申请号：US11927888
申请日：2007-10-30
申请人： Joshua Makower , Theodore Lamson , J. Christopher Flaherty , John Reggie , John Chang , Joseph Catanese , David Tholfsen
发明人： Joshua Makower , Theodore Lamson , J. Christopher Flaherty , John Reggie , John Chang , Joseph Catanese , David Tholfsen
IPC分类号： A61M5/178 , A61M31/00
CPC分类号： A61M25/0108 , A61B6/12 , A61M5/007 , A61M25/0084 , A61M2025/0086 , A61M2025/0087 , A61M2025/009 , A61M2210/12
摘要： Methods and apparatus for delivery of substances or apparatus to target sites located outside blood vessels within the body of a human or animal patient. A vessel wall penetrating catheter is inserted into the vasculature, positioned and oriented within a blood vessel near the target extravascular site and a penetrator is advanced from the catheter so as to penetrate outwardly through the wall of the blood vessel in the direction of the target site. Thereafter, a delivery catheter is passed through a lumen of the penetrator to the target site. A desired substance or apparatus is then delivered to or obtained from the target site. In some applications, the penetrator may be retracted into the vessel wall penetrating catheter and the vessel wall penetrating catheter may be removed, leaving the delivery catheter in place for chronic or continuous delivery of substance(s) to and/or obtaining of information or samples from the target site. Alternatively, a delivery catheter having an occlusion member or balloon may be advanced into a vein or venule and the occlusion member or balloon may be used to occlude the lumen of the vein or venule during and after injection of a substance through the catheter, such that the substance will not be carried away by normal venous blood flow and will remain in the vein or venule for a sufficient period of time to have its intended effect (e.g. to enter adjacent tissues through capillary beds drained by that vein or venule).
摘要翻译：用于将物质或装置输送到位于人或动物患者体内的血管外的位置的方法和装置。将血管壁穿透导管插入脉管系统中，定位并定向在目标血管外部位附近的血管内，并且穿透器从导管前进，以便沿目标部位的方向向外穿过血管壁。此后，输送导管穿过穿透器的内腔到目标部位。然后将所需的物质或装置输送到目标部位或从目标部位获得。在一些应用中，穿透器可以缩回到穿过导管的血管壁中，并且可以移除穿透导管的血管壁，使输送导管留在适当位置，以便将物质慢慢地或连续地递送到和/或获得信息或样品从目标网站。或者，具有闭塞构件或气囊的输送导管可以推入静脉或小静脉中，并且阻塞构件或气囊可以在通过导管注入物质期间和之后用于闭塞静脉或小静脉的腔，使得该物质不会被正常的静脉血流带走，并将在静脉或小静脉中保持足够的时间以达到其预期效果（例如，通过由该静脉或小静脉排出的毛细血管床进入相邻组织）。

10. 发明申请

US20120209173A1 MATERIAL REMOVAL CATHETER AND METHOD 审中-公开
标题翻译：材料去除导管和方法
公开(公告)号：US20120209173A1
公开(公告)日：2012-08-16
申请号：US13369969
申请日：2012-02-09
申请人： Motoya Hayase , J. Christopher Flaherty
发明人： Motoya Hayase , J. Christopher Flaherty
IPC分类号： A61M25/00
CPC分类号： A61M25/0054 , A61B17/22 , A61B2017/22079 , A61M25/0069 , A61M25/0108 , A61M25/0155 , A61M2025/0063
摘要： A catheter device and methods useable to extract material from a body conduit, e.g., a blood vessel, are provided. The catheter comprises a flexible catheter advanceable into the body conduit, an opening in a wall of the catheter in fluid communication with a material collection chamber, and a controllably arcuate segment near the distal tip of the catheter and the opening. The catheter may include a sliding member, located within a lumen of the catheter, used to move the material entering the catheter through the arcuate segment opening, into the material collection chamber and away from said opening. The catheter may include a single mechanism utilized to both generate a vacuum to cause material to enter the catheter at the arcuate segment opening and also cause the sliding member to travel, inside the catheter, moving material away from the opening and into the material collection chamber.
摘要翻译：提供了可用于从身体导管例如血管提取物质的导管装置和方法。导管包括可进入身体导管的柔性导管，在导管的壁中与材料收集室流体连通的开口，以及靠近导管的远侧末端和开口处的可控弧形段。导管可以包括位于导管的腔内的滑动构件，用于将进入导管的材料通过弧形段开口移动到材料收集室中并远离所述开口。导管可以包括用于产生真空以使材料在弓形段开口处进入导管的单一机构，并且还使得滑动构件在导管内行进移动材料远离开口进入材料收集室。

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