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1. 发明申请

US20060062698A1 MEMS actuator and method of manufacture for MEMS particle sorting device 有权
标题翻译： MEMS致动器及MEMS粒子分选装置的制造方法
公开(公告)号：US20060062698A1
公开(公告)日：2006-03-23
申请号：US11260367
申请日：2005-10-28
申请人： John Foster , John Harley , Steven Hovey , Richard Martin , Hung Nguyen , Paul Rubel
发明人： John Foster , John Harley , Steven Hovey , Richard Martin , Hung Nguyen , Paul Rubel
IPC分类号： B01L3/00
CPC分类号： B01L3/502707 , A61M1/3633 , A61M1/3678 , B01L3/5027 , B01L3/50273 , B01L3/502761 , B01L2200/0647 , B01L2300/0864 , B01L2400/0484 , C12M47/04 , G01N21/6428 , G01N2015/0288 , G01N2015/149 , Y10T436/11 , Y10T436/112499 , Y10T436/2575
摘要： A micromechanical particle sorting chip uses an actuator divided into two parts to direct a component of interest into one of a plurality of possible exit paths, based on detection of a fluorescent signal emanating from the component of interest. The two-part actuator may include a force-generating portion and a microactuator portion. The microactuator portion may be disposable, whereas the force-generating portion may be reuseable. By bringing the force-generating portion into proximity to the microactuator portion, the microactuator is induced to move, thereby separating the component of interest from the rest of the fluid stream. The force-generating portion and the microactuator portion may be optimized and fabricated separately, thereby leading to faster, more reliable and less expensive particle sorting.
摘要翻译：微机械粒子分选芯片基于从感兴趣的部件发出的荧光信号的检测，使用分成两部分的致动器将感兴趣的部件引导到多个可能的出口路径中的一个。两部分致动器可以包括力产生部分和微致动器部分。微致动器部分可以是一次性的，而力产生部分可以是可再利用的。通过使力产生部分靠近微致动器部分，微致动器被诱导移动，从而将感兴趣的部件与流体流的其余部分分离。力产生部分和微致动器部分可以分开优化和制造，从而导致更快，更可靠和更便宜的颗粒分选。

2. 发明申请

US20060266692A1 Microfabricated cross flow filter and method of manufacture 审中-公开
标题翻译：微型交叉流过滤器及其制造方法
公开(公告)号：US20060266692A1
公开(公告)日：2006-11-30
申请号：US11136552
申请日：2005-05-25
申请人： John Foster , John Harley , Steven Hovey , Richard Martin , Paul Rubel , Hung Nguyen
发明人： John Foster , John Harley , Steven Hovey , Richard Martin , Paul Rubel , Hung Nguyen
IPC分类号： B01D63/00
CPC分类号： B01D61/14 , B01D63/00 , B01D65/08 , B01D67/0062 , B01D69/02 , B01D2321/2058 , G01N1/4077
摘要： A microfabricated cross flow filter may have multiple filtration stages. The filtration stages may include microfabricated filter barriers and gaps created in a substrate, thereby allowing very tight tolerances in the filter barrier and gap dimensions to be maintained. Using the microfabrication techniques, the filter barriers can be made having arbitrary shapes, and arranged at an angle or curved with respect to the flow direction, making the pressure drop across the filtration stage more uniform in the cross flow direction.
摘要翻译：微制造的交叉流过滤器可以具有多个过滤阶段。过滤阶段可以包括微制造的过滤器屏障和在衬底中产生的间隙，从而允许保持过滤器屏障和间隙尺寸的非常严格的公差。使用微细加工技术，过滤器屏障可以制成具有任意形状，并且以相对于流动方向成一定角度或弯曲的方式布置，使跨越过滤台的压降在横向方向上更均匀。

3. 发明申请

US20050282151A1 Method and apparatus for sorting particles with a MEMS device 有权
标题翻译：用MEMS装置分选颗粒的方法和装置
公开(公告)号：US20050282151A1
公开(公告)日：2005-12-22
申请号：US11196291
申请日：2005-08-04
申请人： John Foster , John Harley , Steven Hovey , Richard Martin , Hung Nguyen , Paul Rubel
发明人： John Foster , John Harley , Steven Hovey , Richard Martin , Hung Nguyen , Paul Rubel
IPC分类号： A61M1/36 , B01L3/00 , C12M1/34 , C12Q1/00 , G01N15/02 , G01N21/05 , G01N21/64 , H01L21/00
CPC分类号： C12M47/04 , A61M1/36 , A61M1/3633 , A61M1/3678 , A61M2202/0437 , B01L3/5027 , G01N21/6428 , G01N2015/0288 , G01N2015/149 , Y10T436/11 , Y10T436/112499 , Y10T436/2575
摘要： A micromechanical particle sorting chip uses laser light directed through at least one of a reflective and refractive surface to come to a focus in an optically transparent layer. The laser light impinges on a particle of interest, causing it to fluoresce. Upon detecting the fluorescence, a micromemchanical actuator is activated, which directs the particle of interest into one of a plurality of possible exit paths.
摘要翻译：微机械粒子分选芯片使用通过反射和折射表面中的至少一个引导的激光在光学透明层中进行聚焦。激光照射在感兴趣的颗粒上，使其发出荧光。在检测到荧光时，微机械致动器被激活，其将感兴趣的颗粒引导到多个可能的出口路径中的一个。

4. 发明申请

US20060027524A1 Microfabricated two-pin liquid sample dispensing system 审中-公开
公开(公告)号：US20060027524A1
公开(公告)日：2006-02-09
申请号：US11240715
申请日：2005-09-30
申请人： John Gilbert , John Harley
发明人： John Gilbert , John Harley
IPC分类号： C23F1/00
CPC分类号： B01L3/0244 , B01L3/0248 , B01L2200/143 , B01L2200/147 , B01L2400/0439 , G01N2035/1037 , Y10T436/119163 , Y10T436/25625 , Y10T436/2575
摘要： A two-pin liquid sample dispensing system is provided. The two-pin dispensing system comprises a pair of separately movable pins for holding a droplet of liquid therebetween. Each pin includes a tip spaced predetermined distance from the other pin to define a sample acquisition region. The pins acquire and hold a droplet of the liquid sample in the sample acquisition region formed in the space between the tips and apply the droplet to a selected sample handing system. The distance between the tips is variable to accommodate different liquid samples having varying physical properties and to vary the volume of the acquired droplet.

5. 发明申请

US20070269827A1 Predicting and Diagnosing Patients With Autoimmune Disease 审中-公开
标题翻译：自身免疫性疾病的预测与诊断
公开(公告)号：US20070269827A1
公开(公告)日：2007-11-22
申请号：US11750729
申请日：2007-05-18
申请人： John Harley
发明人： John Harley
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156
摘要： The present invention provides methods for the prediction and diagnosis of autoimmune diseases including Systemic Lupus Erythematosus using a panel of single nucleotide polymorphisms (SNPs).
摘要翻译：本发明提供了使用单核苷酸多态性（SNP）小组预测和诊断包括系统性红斑狼疮的自身免疫性疾病的方法。

6. 发明申请

US20060257427A1 Assays and therapies for latent viral infection 失效
标题翻译：潜伏病毒感染的检测和疗法
公开(公告)号：US20060257427A1
公开(公告)日：2006-11-16
申请号：US11405355
申请日：2006-04-17
申请人： John Harley , Judith James , Kenneth Kaufman
发明人： John Harley , Judith James , Kenneth Kaufman
IPC分类号： A61K39/25 , A61K39/245
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/245 , A61K2039/545 , A61K2039/55566 , C07K16/085 , C12N2710/16222 , C12N2710/16234 , Y02A50/386 , Y02A50/414
摘要： Compositions that bind viral proteins that are specifically expressed during the latent stage of the viral life cycle are disclosed. These compositions bind the latent viral proteins while the viral proteins are expressed in their cellular host, and provide a means for targeting cells that harbor latent virus. In a preferred embodiment the compositions are antibodies which bind the extracellular region of the latent viral protein, most preferably LMP-2A, an EBV latent protein, which are conjugated to a diagnostic or cytotoxic agent or immobilized to a solid support for removal of the infected cells. These antibodies are capable of distinguishing cells expressing EBV DNA from cells which are not expressing EBV DNA. Compositions that can be used to elicit production of these antibodies, or as a vaccine, are also disclosed. Methods for generating diagnostic or cytotoxic reagents and vaccines based on the viral epitopes that identify cells harboring latent virus are also disclosed. The antibody conjugates can be used in diagnostic assays to identify cells expressing latent viral protein and people who are harboring latent viral particles. The antibody conjugates can also be used to remove the infected cells or to kill the infected the cells. Alternatively, or in addition, the viral proteins or portions thereof can be used as a vaccine to induce an immune reaction by the host to kill the infected cells. These methods can be used to detect or treat patients harboring latent viruses like EBV and who are at risk of developing a disease such as an autoimmune disease like systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA).
摘要翻译：公开了结合在病毒生命周期的潜在阶段中特异性表达的病毒蛋白质的组合物。这些组合物结合潜在的病毒蛋白质，同时病毒蛋白质在其细胞宿主中表达，并提供靶向隐藏潜伏病毒的细胞的手段。在优选的实施方案中，组合物是结合潜伏病毒蛋白质的细胞外区域，最优选LMP-2A，EBV潜伏蛋白的抗体，其与诊断性或细胞毒性剂缀合或固定在固体支持物上以去除感染的细胞。这些抗体能够区分表达EBV DNA的细胞与不表达EBV DNA的细胞。还可以公开可用于引发这些抗体或疫苗生产的组合物。还公开了用于产生诊断或细胞毒素试剂和基于鉴定携带潜伏病毒的细胞的病毒表位的疫苗的方法。抗体缀合物可用于诊断测定以鉴定表达潜伏性病毒蛋白的细胞和携带潜伏病毒颗粒的人。抗体缀合物也可用于去除被感染的细胞或杀死被感染的细胞。或者或另外，病毒蛋白质或其部分可以用作疫苗以诱导宿主杀死受感染细胞的免疫反应。这些方法可用于检测或治疗患有EBV等潜伏病毒的患者，以及患有诸如系统性红斑狼疮（SLE）和类风湿性关节炎（RA）等自身免疫性疾病的疾病的风险。

7. 发明申请

US20060257428A1 Assays and therapies for latent viral infection 审中-公开
公开(公告)号：US20060257428A1
公开(公告)日：2006-11-16
申请号：US11405365
申请日：2006-04-17
申请人： John Harley , Judith James , Kenneth Kaufman
发明人： John Harley , Judith James , Kenneth Kaufman
IPC分类号： A61K39/25 , A61K39/245
CPC分类号： A61K39/245 , A61K39/12 , A61K2039/545 , A61K2039/55566 , A61K2039/57 , C07K14/005 , C07K16/085 , C12N2710/16222 , C12N2710/16234
摘要： Compositions that bind viral proteins that are specifically expressed during the latent stage of the viral life cycle are disclosed. These compositions bind the latent viral proteins while the viral proteins are expressed in their cellular host, and provide a means for targeting cells that harbor latent virus. In a preferred embodiment the compositions are antibodies which bind the extracellular region of the latent viral protein, most preferably LMP-2A, an EBV latent protein, which are conjugated to a diagnostic or cytotoxic agent or immobilized to a solid support for removal of the infected cells. These antibodies are capable of distinguishing cells expressing EBV DNA from cells which are not expressing EBV DNA. Compositions that can be used to elicit production of these antibodies, or as a vaccine, are also disclosed. Methods for generating diagnostic or cytotoxic reagents and vaccines based on the viral epitopes that identify cells harboring latent virus are also disclosed. The antibody conjugates can be used in diagnostic assays to identify cells expressing latent viral protein and people who are harboring latent viral particles. The antibody conjugates can also be used to remove the infected cells or to kill the infected the cells. Alternatively, or in addition, the viral proteins or portions thereof can be used as a vaccine to induce an immune reaction by the host to kill the infected cells. These methods can be used to detect or treat patients harboring latent viruses like EBV and who are at risk of developing a disease such as an autoimmune disease like systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA).

8. 发明授权

US07041257B2 Microfabricated two-pin liquid sample dispensing system 有权
公开(公告)号：US07041257B2
公开(公告)日：2006-05-09
申请号：US10027171
申请日：2001-12-21
申请人： John Gilbert , John Harley
发明人： John Gilbert , John Harley
IPC分类号： B01L3/02 , B01N3/00 , G01N15/06 , G01N1/10 , G01N1/04
CPC分类号： B01L3/0244 , B01L3/0248 , B01L2200/143 , B01L2200/147 , B01L2400/0439 , G01N2035/1037 , Y10T436/119163 , Y10T436/25625 , Y10T436/2575
摘要： A two-pin liquid sample dispensing system is provided. The two-pin dispensing system comprises a pair of separately movable pins for holding a droplet of liquid therebetween. Each pin includes a tip spaced predetermined distance from the other pin to define a sample acquisition region. The pins acquire and hold a droplet of the liquid sample in the sample acquisition region formed in the space between the tips and apply the droplet to a selected sample handing system. The distance between the tips is variable to accommodate different liquid samples having varying physical properties and to vary the volume of the acquired droplet.

9. 发明申请

US20050074751A1 Assays and therapies for latent viral infection 失效
标题翻译：潜伏病毒感染的检测和疗法
公开(公告)号：US20050074751A1
公开(公告)日：2005-04-07
申请号：US10646132
申请日：2003-08-22
申请人： John Harley , Judith James , Kenneth Kaufman
发明人： John Harley , Judith James , Kenneth Kaufman
IPC分类号： C12Q1/02 , A61K38/00 , A61K39/00 , A61K39/12 , A61K39/245 , A61K39/395 , A61K45/00 , A61P1/00 , A61P1/04 , A61P1/18 , A61P3/10 , A61P5/14 , A61P7/04 , A61P7/06 , A61P9/00 , A61P11/06 , A61P13/12 , A61P15/00 , A61P17/00 , A61P17/14 , A61P19/02 , A61P21/00 , A61P21/04 , A61P25/00 , A61P29/00 , A61P31/22 , A61P35/00 , A61P37/08 , C07K14/05 , C07K16/08 , C12Q1/70 , A61K39/42
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/245 , A61K2039/545 , A61K2039/55566 , C07K16/085 , C12N2710/16222 , C12N2710/16234 , Y02A50/386 , Y02A50/414
摘要： Compositions that bind viral proteins that are specifically expressed during the latent stage of the viral life cycle are disclosed. These compositions bind the latent viral proteins while the viral proteins are expressed in their cellular host, and provide a means for targeting cells that harbor latent virus. In a preferred embodiment the compositions are antibodies which bind the extracellular region of the latent viral protein, most preferably LMP-2A, an EBV latent protein, which are conjugated to a diagnostic or cytotoxic agent or immobilized to a solid support for removal of the infected cells. These antibodies are capable of distinguishing cells expressing EBV DNA from cells which are not expressing EBV DNA. Compositions that can be used to elicit production of these antibodies, or as a vaccine, are also disclosed. Methods for generating diagnostic or cytotoxic reagents and vaccines based on the viral epitopes that identify cells harboring latent virus are also disclosed. The antibody conjugates can be used in diagnostic assays to identify cells expressing latent viral protein and people who are harboring latent viral particles. The antibody conjugates can also be used to remove the infected cells or to kill the infected the cells. Alternatively, or in addition, the viral proteins or portions thereof can be used as a vaccine to induce an immune reaction by the host to kill the infected cells. These methods can be used to detect or treat patients harboring latent viruses like EBV and who are at risk of developing a disease such as an autoimmune disease like systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA).
摘要翻译：公开了结合在病毒生命周期的潜在阶段中特异性表达的病毒蛋白质的组合物。这些组合物结合潜在的病毒蛋白质，同时病毒蛋白质在其细胞宿主中表达，并提供靶向隐藏潜伏病毒的细胞的手段。在优选的实施方案中，组合物是结合潜伏病毒蛋白质的细胞外区域，最优选LMP-2A，EBV潜伏蛋白的抗体，其与诊断性或细胞毒性剂缀合或固定在固体支持物上以去除感染的细胞。这些抗体能够区分表达EBV DNA的细胞与不表达EBV DNA的细胞。还可以公开可用于引发这些抗体或疫苗生产的组合物。还公开了用于产生诊断或细胞毒素试剂和基于鉴定携带潜伏病毒的细胞的病毒表位的疫苗的方法。抗体缀合物可用于诊断测定以鉴定表达潜伏性病毒蛋白的细胞和携带潜伏病毒颗粒的人。抗体缀合物也可用于去除被感染的细胞或杀死被感染的细胞。或者或另外，病毒蛋白质或其部分可以用作疫苗以诱导宿主杀死受感染细胞的免疫反应。这些方法可用于检测或治疗患有EBV等潜伏病毒的患者，以及患有诸如系统性红斑狼疮（SLE）和类风湿性关节炎（RA）等自身免疫性疾病的疾病的风险。

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