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1. 发明申请

US20090111707A1 MARKERS FOR THE PREDICTION OF OUTCOME OF ANTHRACYCLINE TREATMENT 有权
标题翻译：预防治疗精神分裂症患者的标志物
公开(公告)号：US20090111707A1
公开(公告)日：2009-04-30
申请号：US12067633
申请日：2006-09-21
申请人： John Foekens , John Martens , Serenella Eppenberger-Castori , Vincent Vuaroqueaux , Frederique Spyratos , Nadia Harbeck , Manfred Schmitt , Heinz Hoefler , Sabine Maier , Gunter Weiss , Ralf Lesche , Thomas Hildmann , Achim Plum
发明人： John Foekens , John Martens , Serenella Eppenberger-Castori , Vincent Vuaroqueaux , Frederique Spyratos , Nadia Harbeck , Manfred Schmitt , Heinz Hoefler , Sabine Maier , Gunter Weiss , Ralf Lesche , Thomas Hildmann , Achim Plum
IPC分类号： C40B30/04 , C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/154 , C12Q2600/156 , C12Q2600/16
摘要： The present invention relates to methods for predicting the outcome of anthracycline treatment of cell proliferative disorder patients. This is achieved by determining the expression level of at least one gene selected from the group consisting of PITX2; TFF1 and PLAU. The invention also relates to sequences, oligonucleotides and antibodies which can be used within the described methods.
摘要翻译：本发明涉及预测细胞增殖性疾病患者蒽环类治疗结果的方法。这通过确定选自PITX2的至少一种基因的表达水平来实现; TFF1和PLAU。本发明还涉及可以在所述方法中使用的序列，寡核苷酸和抗体。

2. 发明授权

US10053735B2 Markers for the prediction of outcome of anthracycline treatment 有权
公开(公告)号：US10053735B2
公开(公告)日：2018-08-21
申请号：US12067633
申请日：2006-09-21
申请人： John Foekens , John W. Martens , Serenella Eppenberger-Castori , Vincent Vuaroqueaux , Frederique Spyratos , Nadia Harbeck , Manfred Schmitt , Heinz Hoefler , Sabine Maier , Gunter Weiss , Ralf Lesche , Thomas Hildmann , Achim Plum
发明人： John Foekens , John W. Martens , Serenella Eppenberger-Castori , Vincent Vuaroqueaux , Frederique Spyratos , Nadia Harbeck , Manfred Schmitt , Heinz Hoefler , Sabine Maier , Gunter Weiss , Ralf Lesche , Thomas Hildmann , Achim Plum
IPC分类号： C07H21/04 , C12Q1/68 , C12Q1/6886
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/154 , C12Q2600/156 , C12Q2600/16
摘要： The present invention relates to methods for predicting the outcome of anthracycline treatment of cell proliferative disorder patients. This is achieved by determining the expression level of at least one gene selected from the group consisting of PITX2; TFF1 and PLAU. The invention also relates to sequences, oligonucleotides and antibodies which can be used within the described methods.

3. 发明授权

US5885055A Collation assemblies 失效
标题翻译：整理大会
公开(公告)号：US5885055A
公开(公告)日：1999-03-23
申请号：US605139
申请日：1996-06-24
申请人： Frank Wojtalewicz , Helmut Rapp , Dietrich Thor Straten , Gunter Weiss , Peter Srostlik , Nicholas Lyons , Ronald Corbett Wainwright , Paul John Welfare , Rolf David Mears
发明人： Frank Wojtalewicz , Helmut Rapp , Dietrich Thor Straten , Gunter Weiss , Peter Srostlik , Nicholas Lyons , Ronald Corbett Wainwright , Paul John Welfare , Rolf David Mears
IPC分类号： B65G57/14 , B65G49/08 , B65G57/03 , B65H29/34 , B65H29/38 , B65H31/18
CPC分类号： B65G49/08 , B65G57/035
摘要： A conveyor-collator assembly for use in forming stacks of articles, e.g. concrete roof tiles (T) at speeds of up to 200 tiles per minute, is provided with a conveyor means (42) by which tiles (T) are fed seriatim to a velocity control means (72) whereby each tile (T) is transferred under "no-load" or substantially "no-load" conditions onto a falling shelf conveyor (140). Tiles (T) held in the conveyor (140) are thereafter deposited onto a support (26-28) of a stack forming means (24) under "no-load" or substantially "no-load" conditions whereby breakages of tiles (T) due to "shock loads" experienced hitherto in prior art arrangements is eliminated. The stack-forming means (24) of the conveyor-collator assembly is arranged with the supports (26, 28) thereof mounted for sequential movement through the same spacial path at rates consistent with ensuring that upon the completion of a stack of tiles (T) on one of said supports (26, 28) at a downstream end of the path the other of said supports (26, 28) is approaching an upstream end of said path for facilitating the stacking of tiles (T) in a subsequent stack thereof.
摘要翻译： PCT No.PCT / EP94 / 03066 Sec。 371日期1996年6月24日 102（e）1996年6月24日PCT 1994年9月13日PCT PCT。公开号WO95 / 08501 日期1995年3月30日用于形成物品堆叠的输送机整理机组件具有高达200瓦/分钟速度的混凝土屋顶瓦（T）设置有输送装置（42），瓦片（T）通过该传送装置被顺序地送入速度控制装置（72），从而每个瓦片（T）被传送在“空载”或基本上“空载”的条件下在下降的货架输送机（140）上。保持在输送机（140）中的瓦（T）然后在“空载”或基本上“空载”的条件下沉积到堆叠形成装置（24）的支撑件（26-28）上，从而破坏瓦（T ）由于迄今为止在现有技术装置中经历的“冲击载荷”被消除。输送机 - 整理机组件的堆叠形成装置（24）被布置成其支撑件（26,28）安装成用于顺序移动通过相同的空间路径，速率与确保在堆叠的瓦片（T ）在所述路径的下游端的一个所述支撑件（26,28）中，所述支撑件（26,28）中的另一个正在接近所述路径的上游端，以便于随后的堆叠中的瓦片（T）的堆叠。

4. 发明申请

US20090197250A1 METHODS AND NUCLEIC ACIDS FOR THE ANALYSIS OF GENE EXPRESSION ASSOCIATED WITH THE PROGNOSIS OF PROSTATE CELL PROLIFERATIVE DISORDERS 审中-公开
标题翻译：与预后细胞增殖性疾病相关的基因表达分析的方法和核酸
公开(公告)号：US20090197250A1
公开(公告)日：2009-08-06
申请号：US11720744
申请日：2005-12-02
申请人： Susan Cottrell , Fabian Model , Carolina Haefliger , Gunter Weiss , Juergen Distler , Andrew Z. Sledziewski , Xiaoling Song , Thomas L. Skillman , Jeffrey G. Thomas
发明人： Susan Cottrell , Fabian Model , Carolina Haefliger , Gunter Weiss , Juergen Distler , Andrew Z. Sledziewski , Xiaoling Song , Thomas L. Skillman , Jeffrey G. Thomas
IPC分类号： C12Q1/68 , G01N1/30 , C40B30/04 , C07H21/04
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/154 , C12Q2600/158 , C12Q2600/16 , G01N33/57434 , G01N2800/60
摘要： Particular aspects provide novel methods and compositions (e.g., nucleic acids, kits, etc.) having substantial utility for providing a prognosis of prostate cell proliferative disorders. In particular aspects, this is achieved by the analysis of the expression status of a panel of genes, or subsets thereof.
摘要翻译：具体方面提供具有用于提供前列腺细胞增殖性疾病的预后的实质性用途的新型方法和组合物（例如，核酸，试剂盒等）。在特定方面，这通过分析一组基因或其子集的表达状态来实现。

5. 发明申请

US20110245087A1 METHOD FOR OPTIMIZING AND VALIDATING AN ASSAY FOR DETERMINING THE PRESENCE OR ABSENCE OF A MEDICAL CONDITION 审中-公开
标题翻译：用于优化和验证用于确定医学条件的存在或不存在的测定方法
公开(公告)号：US20110245087A1
公开(公告)日：2011-10-06
申请号：US12736212
申请日：2009-03-18
申请人： Gunter Weiss
发明人： Gunter Weiss
IPC分类号： C40B30/00 , C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/154 , C12Q2600/156 , C12Q2600/16
摘要： The invention relates to a method for validation of an assay for determining the presence or absence of a medical condition, wherein the nucleic acid has been treated such that all unmethylated cytosine bases are converted to uracils. According to the invention, the method comprises: a) measuring the concentration of the nucleic acid in biological samples; b) allotting the samples based on the measured concentration of the nucleic acid in the sample to a first sample group if the concentration of the nucleic acid is below a given threshold value, or to a second sample group if the concentration of the nucleic acid is above the given threshold value; c) performing an assay for determining the methylation status of the nucleic acid in the sample obtaining methylation signals, and d) applying a first algorithm to the value if the sample was allotted to the first sample group, or a second algorithm if the sample was allotted to the second sample group.
摘要翻译：本发明涉及用于确定用于确定是否存在医学病症的测定法的方法，其中所述核酸已经被处理，使得所有未甲基化的胞嘧啶碱基被转化成尿嘧啶。根据本发明，该方法包括：a）测量生物样品中核酸的浓度; b）如果所述核酸的浓度低于给定的阈值，则将所述样品基于所述样品中的所述核酸的测量浓度分配给第一样品组，或者如果所述核酸的浓度为高于给定的阈值; c）进行用于确定样品中核酸甲基化状态的测定，得到甲基化信号，以及d）如果样品被分配给第一样品组，则应用第一算法，如果样品为分配给第二个样本组。

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