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1. 发明授权

US07474920B2 Method and apparatus for delaying a ventricular tachycardia therapy 有权
标题翻译：延迟室性心动过速治疗的方法和装置
公开(公告)号：US07474920B2
公开(公告)日：2009-01-06
申请号：US11302092
申请日：2005-12-12
申请人： John E. Burnes , Paul J. Degroot
发明人： John E. Burnes , Paul J. Degroot
IPC分类号： A61N1/39 , A61B5/0464
CPC分类号： A61N1/3621 , A61N1/3962
摘要： A device and method to detect slow ventricular tachycardia, deliver anti-tachycardia pacing therapies, and delay a scheduled shock therapy if the ventricular tachycardia is not terminated or accelerated. Preferably, a shock therapy is delayed after verifying hemodynamic stability based on a hemodynamic sensor. After a shock is delayed, the device operates in a high alert mode for redetecting an accelerated tachycardia. Anti-tachycardia pacing therapies are repeated during the shock delay. A number of conditions can trigger delivery of the delayed shock therapy including a specified period of elapsed time; determination that the patient is likely to be asleep; detection of myocardial ischemia; detection of compromised hemodynamics, or detection of a substantially prone position or sudden change in position. A delayed shock therapy may be triggered by the patient and repeated delivery of painful shock therapies in patients that are not seriously compromised by a recurring, slow ventricular tachycardia is avoided.
摘要翻译：一种检测慢性心室性心动过速的装置和方法，提供抗心动过速起搏治疗，并且如果室性心动过速未终止或加速则延迟预定的休克疗法。优选地，在基于血液动力学传感器验证血液动力学稳定性之后延迟了休克疗法。在休克被延迟之后，该装置在高警戒模式下操作以重新检测加速的心动过速。抗心动过速起搏治疗在休克延迟期间重复。许多情况可以触发迟发性休克疗法的输送，包括指定的经过时间; 确定患者可能睡着了; 检测心肌缺血; 检测受损的血液动力学，或检测到基本上俯卧位或突然改变位置。延迟性休克疗法可能由患者触发，并且在不被重复的慢性室性心动过速严重损害的患者中重复递送疼痛性休克疗法。

2. 发明授权

US07010344B2 Method and apparatus for delaying a ventricular tachycardia therapy 有权
公开(公告)号：US07010344B2
公开(公告)日：2006-03-07
申请号：US10134352
申请日：2002-04-26
申请人： John E. Burnes , Paul J. DeGroot
发明人： John E. Burnes , Paul J. DeGroot
IPC分类号： A61N1/39
CPC分类号： A61N1/3621 , A61N1/3962
摘要： A device and method to detect slow ventricular tachycardia, deliver anti-tachycardia pacing therapies, and delay a scheduled shock therapy if the ventricular tachycardia is not terminated or accelerated. Preferably, a shock therapy is delayed after verifying hemodynamic stability based on a hemodynamic sensor. After a shock is delayed, the device operates in a high alert mode for redetecting an accelerated tachycardia. Anti-tachycardia pacing therapies are repeated during the shock delay. A number of conditions can trigger delivery of the delayed shock therapy including a specified period of elapsed time; determination that the patient is likely to be asleep; detection of myocardial ischemia; detection of compromised hemodynamics, or detection of a substantially prone position or sudden change in position. A delayed shock therapy may be triggered by the patient and repeated delivery of painful shock therapies in patients that are not seriously compromised by a recurring, slow ventricular tachycardia is avoided.

3. 发明授权

US08611996B2 Implantable medical device crosstalk evaluation and mitigation 有权
公开(公告)号：US08611996B2
公开(公告)日：2013-12-17
申请号：US12362842
申请日：2009-01-30
申请人： William T. Donofrio , John E. Burnes , Paul G. Krause , Xiaohong Zhou , Gerald P. Arne , David J. Peichel , James D. Reinke
发明人： William T. Donofrio , John E. Burnes , Paul G. Krause , Xiaohong Zhou , Gerald P. Arne , David J. Peichel , James D. Reinke
IPC分类号： A61N1/00
CPC分类号： A61N1/3706 , A61B5/04288 , A61B5/7217 , A61N1/025 , A61N1/0551 , A61N1/36114 , A61N1/36185 , A61N1/3686 , A61N1/3702 , A61N1/3718 , A61N1/37247 , A61N1/37288 , A61N1/3962
摘要： Electrical crosstalk between two implantable medical devices or two different therapy modules of a common implantable medical device may be evaluated, and, in some examples, mitigated. In some examples, one of the implantable medical devices or therapy modules delivers electrical stimulation to a nonmyocardial tissue site or a nonvascular cardiac tissue site, and the other implantable medical device or therapy module delivers cardiac rhythm management therapy to a heart of the patient.

4. 发明授权

US08428716B2 Apparatus and methods for automatic adjustment of AV interval to ensure delivery of cardiac resynchronization therapy 有权
标题翻译：用于自动调整AV间隔以确保心脏再同步治疗的传递的装置和方法
公开(公告)号：US08428716B2
公开(公告)日：2013-04-23
申请号：US12505925
申请日：2009-07-20
申请人： Thomas J. Mullen , John E. Burnes , Aleksandrew T. Sambelashvili
发明人： Thomas J. Mullen , John E. Burnes , Aleksandrew T. Sambelashvili
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： A method of left ventricular pacing including automated adjustment of a atrio-ventricular (AV) pacing delay interval and intrinsic AV nodal conduction testing. It includes—upon expiration or reset of a programmable AV Evaluation Interval (AVEI)—performing the following: temporarily increasing a paced AV interval and a sensed AV interval and testing for adequate AV conduction and measuring an intrinsic atrio-ventricular (PR) interval for a right ventricular (RV) chamber. In the event that the AV conduction test reveals an AV conduction block condition then a pacing mode-switch to a bi-ventricular (Bi-V) pacing mode occurs and the magnitude of the AVEI is increased.
摘要翻译：一种左心室起搏的方法，包括自动调节心房（AV）起搏延迟间隔和内部AV节点传导测试。它包括 - 可编程AV评估间隔（AVEI）的到期或复位 - 执行以下操作：临时增加节奏的AV间隔和感测到的AV间隔，并测试足够的AV传导并测量内在的心房（PR）间隔右心室（RV）室。在AV导通测试显示AV传导阻滞条件的情况下，起搏模式切换到双心室（Bi-V）起搏模式并且AVEI的幅度增加。

5. 发明申请

US20100114216A1 INTERFERENCE MITIGATION FOR IMPLANTABLE DEVICE RECHARGING 有权
公开(公告)号：US20100114216A1
公开(公告)日：2010-05-06
申请号：US12610053
申请日：2009-10-30
申请人： Paul G. Krause , William T. Donofrio , Gerald P. Arne , James D. Reinke , David J. Peichel , Timothy Davis , John E. Burnes
发明人： Paul G. Krause , William T. Donofrio , Gerald P. Arne , James D. Reinke , David J. Peichel , Timothy Davis , John E. Burnes
IPC分类号： A61N1/08 , A61N1/378 , A61N1/39 , A61N1/37
CPC分类号： A61N1/3787 , A61N1/3704 , A61N1/3718 , A61N1/37264 , A61N1/37288
摘要： A therapy or monitoring system may implement one or more techniques to mitigate interference between operation of a charging device that charges a first implantable medical device (IMD) implanted in a patient and a second IMD implanted in the patient. In some examples, the techniques may include modifying an operating parameter of the charging device in response to receiving an indication that a second IMD is implanted in the patient. The techniques also may include modifying an operating parameter of the second IMD in response to detecting the presence or operation of the charging device.

6. 发明申请

US20100114209A1 COMMUNICATION BETWEEN IMPLANTABLE MEDICAL DEVICES 审中-公开
标题翻译：可植入医疗器械之间的通讯
公开(公告)号：US20100114209A1
公开(公告)日：2010-05-06
申请号：US12363215
申请日：2009-01-30
申请人： Paul G. Krause , William T. Donofrio , Gerald P. Arne , John E. Burnes , David J. Peichel , Xiaohong Zhou
发明人： Paul G. Krause , William T. Donofrio , Gerald P. Arne , John E. Burnes , David J. Peichel , Xiaohong Zhou
IPC分类号： A61N1/08
CPC分类号： A61N1/37288 , A61N1/36082 , A61N1/362 , A61N1/3706 , A61N1/37217 , A61N1/3727
摘要： A first implantable medical device (IMD) implanted within a patient may communicate with a second IMD implanted within the patient by encoding information in an electrical stimulation signal. The delivery of the electrical stimulation signal may provide therapeutic benefits to the patient. The second IMD may sense the electrical stimulation signal, which may be presented as an artifact in a sensed cardiac signal, and process the sensed signal to retrieve the encoded information. The second IMD may modify its operation based on the received therapy information. Crosstalk between the first and second IMDs may be reduced using various techniques described herein. For example, the first IMD may generate the electrical stimulation signal to include a spread spectrum energy distribution or a predetermined signal signature. The second IMD may effectively remove a least some of the signal artifact in a sensed cardiac signal based on the predetermined signal signature.
摘要翻译：植入在患者体内的第一可植入医疗装置（IMD）可以通过对电刺激信号中的信息进行编码来与植入患者内的第二IMD进行通信。电刺激信号的传递可以为患者提供治疗益处。第二IMD可以感测电刺激信号，其可以被呈现为感测到的心脏信号中的伪像，并且处理感测到的信号以检索经编码的信息。第二IMD可以基于接收到的治疗信息修改其操作。可以使用本文所述的各种技术来减少第一和第二IMD之间的串扰。例如，第一IMD可以产生电刺激信号以包括扩频能量分布或预定信号特征。基于预定的信号签名，第二IMD可以有效地去除感测到的心脏信号中的至少一些信号伪像。

7. 发明申请

US20100114203A1 IMPLANTABLE MEDICAL DEVICE CROSSTALK EVALUATION AND MITIGATION 有权
公开(公告)号：US20100114203A1
公开(公告)日：2010-05-06
申请号：US12362859
申请日：2009-01-30
申请人： John E. Burnes , Paul G. Krause , William T. Donofrio , Gerald P. Arne , David J. Peichel , Xiaohong Zhou , James D. Reinke
发明人： John E. Burnes , Paul G. Krause , William T. Donofrio , Gerald P. Arne , David J. Peichel , Xiaohong Zhou , James D. Reinke
IPC分类号： A61N1/362 , A61N1/39
CPC分类号： A61N1/36114 , A61B5/0424 , A61B5/0452 , A61B5/046 , A61B5/0464 , A61B5/7217 , A61B2560/0271 , A61N1/36185 , A61N1/3622 , A61N1/365 , A61N1/3686 , A61N1/37247 , A61N1/37288 , A61N1/3962 , A61N2001/083
摘要： Electrical crosstalk between two implantable medical devices or two different therapy modules of a common implantable medical device may be evaluated, and, in some examples, mitigated. In some examples, one of the implantable medical devices or therapy modules delivers electrical stimulation to a nonmyocardial tissue site or a nonvascular cardiac tissue site, and the other implantable medical device or therapy module delivers cardiac rhythm management therapy to a heart of the patient.

8. 发明申请

US20100114198A1 IMPLANTABLE MEDICAL DEVICE CROSSTALK EVALUATION AND MITIGATION 有权
公开(公告)号：US20100114198A1
公开(公告)日：2010-05-06
申请号：US12362781
申请日：2009-01-30
申请人： William T. Donofrio , John E. Burnes , Paul G. Krause , Xiaohong Zhou , Gerald P. Arne , David J. Peichel , James D. Reinke
发明人： William T. Donofrio , John E. Burnes , Paul G. Krause , Xiaohong Zhou , Gerald P. Arne , David J. Peichel , James D. Reinke
IPC分类号： A61N1/365 , A61N1/37 , A61B5/00
CPC分类号： A61N1/36114 , A61B5/04288 , A61B5/7217 , A61N1/3621 , A61N1/36521 , A61N1/3688 , A61N1/3702 , A61N1/37247 , A61N1/37282 , A61N1/3962 , A61N2001/083
摘要： Electrical crosstalk between two implantable medical devices or two different therapy modules of a common implantable medical device may be evaluated, and, in some examples, mitigated. In some examples, one of the implantable medical devices or therapy modules delivers electrical stimulation to a nonmyocardial tissue site or a nonvascular cardiac tissue site, and the other implantable medical device or therapy module delivers cardiac rhythm management therapy to a heart of the patient.

9. 发明授权

US07697985B2 System and method for providing alternative pacing modality selection 有权
标题翻译：提供替代起搏模式选择的系统和方法
公开(公告)号：US07697985B2
公开(公告)日：2010-04-13
申请号：US11189488
申请日：2005-07-26
申请人： Daniel R. Kaiser , John E. Burnes , Thomas J. Mullen
发明人： Daniel R. Kaiser , John E. Burnes , Thomas J. Mullen
IPC分类号： A61N1/362
CPC分类号： A61N1/368 , A61N1/3627 , A61N1/3684 , A61N1/371 , A61N2001/083
摘要： An implantable medical device (IMD) identifies lead performance issues and provides alternative lead configurations to continue with the programmed therapy. In the absence of an appropriate alternatively lead configuration, the IMD determines alternative mechanisms to provide a similar therapy or to determine a secondary therapy.
摘要翻译：可植入医疗器械（IMD）可以识别铅的性能问题，并提供替代的导线配置来继续编程治疗。在没有适当的替代引导配置的情况下，IMD确定提供类似疗法或确定次级治疗的替代机制。

10. 发明申请

US20090275998A1 EXTRA-CARDIAC IMPLANTABLE DEVICE WITH FUSION PACING CAPABILITY 审中-公开
标题翻译：具有融合能力的外部可植入装置
公开(公告)号：US20090275998A1
公开(公告)日：2009-11-05
申请号：US12432502
申请日：2009-04-29
申请人： John E. Burnes , Becky Lynn Dolan
发明人： John E. Burnes , Becky Lynn Dolan
IPC分类号： A61N1/365 , A61N1/39
CPC分类号： A61N1/368 , A61N1/0587 , A61N1/3682
摘要： According to this disclosure, a non-transvenous pacing and, optionally defibrillation, therapy device is implanted subcutaneously and oriented to provide cardiac sensing from electrodes spaced from a heart and deliver pacing and/or defibrillation from one or more non-transvenous electrodes (e.g., an epicardial or pericardial electrode or electrode patch). A subject receiving a device according to this disclosure is monitored to confirm a relatively stable bundle branch block (i.e., delayed activation) of one ventricle. The subcutaneous device has electrodes disposed on the housing and/or having an electrode on a subcutaneous medical lead is oriented so that the pacing (and sensing) vector impinges mainly upon the one ventricle, and/or optionally an epicardial or pericardial lead is deployed to a last-to-depolarize ventricle (e.g., a left ventricle) so that single-ventricular pacing is delivered to achieve fusion depolarization of both ventricles.
摘要翻译：根据本公开，非静脉起搏和（可选地除颤）治疗装置被植入皮下并取向以从与心脏间隔开的电极提供心脏感测，并且从一个或多个非经静脉电极（例如，心外膜或心包电极或电极贴片）。监测接收根据本公开的装置的受试者以确认一个心室的相对稳定的束支传导阻滞（即，延迟激活）。皮下装置具有设置在壳体上和/或具有皮下医疗引线上的电极的电极被定向成使得起搏（和感测）载体主要照射在一个心室上，和/或可选地将心外膜或心包引线部署到最终到去极化的心室（例如，左心室），以便输送单心室起搏以实现两个心室的融合去极化。

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