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1. 发明授权

US07922891B2 Methods for detection and quantification of analytes 失效
标题翻译：检测和定量分析物的方法
公开(公告)号：US07922891B2
公开(公告)日：2011-04-12
申请号：US10558052
申请日：2004-05-24
申请人： John Devens Gust, Jr. , Ana L. Moore , Thomas A. Moore , Alicia Brune
发明人： John Devens Gust, Jr. , Ana L. Moore , Thomas A. Moore , Alicia Brune
IPC分类号： G01N27/327 , H01M8/16
CPC分类号： G01N27/305
摘要： The present invention relates to a method for detecting and quantitating NADH/NAD+ and/or NADPH/NADP+ as well as NADHJNAD+ and/or NADPH/NADP+ dependent enzymes using a photoelectrochemical cell.
摘要翻译：本发明涉及使用光电化学电池检测和定量NADH / NAD +和/或NADPH / NADP +以及NADHJNAD +和/或NADPH / NADP +依赖性酶的方法。

2. 发明授权

US06274729B1 Use of long-wavelength electromagnetic radiation and photoprotective tumor localizing agents for diagnosis 失效
标题翻译：使用长波长电磁辐射和光保护肿瘤定位剂进行诊断
公开(公告)号：US06274729B1
公开(公告)日：2001-08-14
申请号：US09495838
申请日：2000-02-01
申请人： John Devens Gust, Jr. , Ana L. Moore , Thomas A. Moore , William H. Ralston
发明人： John Devens Gust, Jr. , Ana L. Moore , Thomas A. Moore , William H. Ralston
IPC分类号： A61B1000
CPC分类号： A61K49/0052 , A61K41/0071 , A61K49/0021 , A61K49/0036 , C07D487/22
摘要： A process of pathology or target tissue identification comprising administering an imaging material to a pathology or target tissue bearing mammalian host and irradiating the mammalian host with electromagnetic radiation having a wavelength between about 600 and 1100 nm, and especially in the region of 700 nm and longer wavelengths, whereupon the imaging material, which has been preferentially taken up by the pathology or target tissue, emits light and permits precise identification of the location, size and/or shape of the pathology or target tissue.
摘要翻译：一种病理学或靶组织鉴别过程，其包括向具有哺乳动物宿主的病理学或靶组织施用成像材料并用波长在约600和1100nm之间，特别是在700nm和更长的区域的电磁辐射照射哺乳动物宿主因此已被病理学或靶组织优先摄取的成像材料发光并允许精确识别病理学或靶组织的位置，大小和/或形状。

3. 发明授权

US06419897B1 Use of long-wavelength electromagnetic radiation and photoprotective tumor localizing agents for diagnosis 失效
标题翻译：使用长波长电磁辐射和光保护肿瘤定位剂进行诊断
公开(公告)号：US06419897B1
公开(公告)日：2002-07-16
申请号：US09625288
申请日：2000-07-25
申请人： John Devens Gust, Jr. , Ana L. Moore , Thomas A. Moore , William H. Ralston
发明人： John Devens Gust, Jr. , Ana L. Moore , Thomas A. Moore , William H. Ralston
IPC分类号： A61K4900
CPC分类号： A61K49/0052 , A61K41/0071 , A61K49/0021 , A61K49/0036 , C07D487/22
摘要： A process of pathology or target tissue identification comprising administering an imaging material to a pathology or target tissue bearing mammalian host and irradiating the mammalian host with electromagnetic radiation having a wavelength between about 600 and 1100 nm, and especially in the region of 700 nm and longer wavelengths, whereupon the imaging material, which has been preferentially taken up by the pathology or target tissue, emits light and permits precise identification of the location, size and/or shape of the pathology or target tissue.
摘要翻译：一种病理学或靶组织鉴定过程，其包括向具有哺乳动物宿主的病理学或靶组织施用成像材料，并用波长在约600和1100nm之间，特别是在700nm和更长的区域的电磁辐射照射哺乳动物宿主因此已被病理学或靶组织优先摄取的成像材料发光并允许精确识别病理学或靶组织的位置，大小和/或形状。

4. 发明授权

US06207821B1 Long-wavelength electromagnetic radiation and photoprotective tumor localizing agents for diagnosis 有权
标题翻译：长波电磁辐射和光保护肿瘤定位剂进行诊断
公开(公告)号：US06207821B1
公开(公告)日：2001-03-27
申请号：US09495837
申请日：2000-02-01
申请人： John Devens Gust, Jr. , Ana L. Moore , Thomas A. Moore , William H. Ralston
发明人： John Devens Gust, Jr. , Ana L. Moore , Thomas A. Moore , William H. Ralston
IPC分类号： C07B4700
CPC分类号： A61K49/0052 , A61K41/0071 , A61K49/0021 , A61K49/0036 , C07D487/22
摘要： A process of pathology or target tissue identification comprising administering an imaging material to a pathology or target tissue bearing mammalian host and irradiating the mammalian host with electromagnetic radiation having a wavelength between about 600 and 1100 nm, and especially in the region of 700 nm and longer wavelengths, whereupon the imaging material, which has been preferentially taken up by the pathology or target tissue, emits light and permits precise identification of the location, size and/or shape of the pathology or target tissue.
摘要翻译：一种病理学或靶组织鉴定过程，其包括向具有哺乳动物宿主的病理学或靶组织施用成像材料，并用波长在约600和1100nm之间，特别是在700nm和更长的区域的电磁辐射照射哺乳动物宿主因此已被病理学或靶组织优先摄取的成像材料发光并允许精确识别病理学或靶组织的位置，大小和/或形状。

5. 发明授权

US06183727B2 Use of long-wavelength electromagnetic radiation and photoprotective tumor localizing agents for diagnosis 有权
公开(公告)号：US06183727B2
公开(公告)日：2001-02-06
申请号：US09282610
申请日：1999-04-01
申请人： John Devens Gust, Jr. , Ana L. Moore , Thomas A. Moore , William H. Ralston
发明人： John Devens Gust, Jr. , Ana L. Moore , Thomas A. Moore , William H. Ralston
IPC分类号： A61B1000
CPC分类号： A61K49/0052 , A61K41/0071 , A61K49/0021 , A61K49/0036 , C07D487/22
摘要： A process of pathology or target tissue identification comprising administering an imaging material to a pathology or target tissue bearing mammalian host and irradiating the mammalian host with electromagnetic radiation having a wavelength between about 600 and 1100 nm, and especially in the region of 700 nm and longer wavelengths, whereupon the imaging material, which has been preferentially taken up by the pathology or target tissue, emits light and permits precise identification of the location, size and/or shape of the pathology or target tissue.

6. 发明授权

US06826321B1 Magnetic switching of charge separation lifetimes in artificial photosynthetic reaction centers 有权
标题翻译：人工光合反应中心电荷分离寿命的磁切换
公开(公告)号：US06826321B1
公开(公告)日：2004-11-30
申请号：US09806540
申请日：2001-03-30
申请人： John D. Gust, Jr. , Ana L. Moore , Thomas A. Moore
发明人： John D. Gust, Jr. , Ana L. Moore , Thomas A. Moore
IPC分类号： G02B626
CPC分类号： H01L51/0047 , B82Y10/00 , B82Y20/00 , H01L51/0077 , H01L51/0093 , H01L51/0595 , H01L51/42 , Y02E10/549
摘要： Excitation of a triad artificial photosynthetic reaction center consisting of a porphyrin (P) convalently linked to a fullerene electron acceptor (C60) and a carotenoid secondary donor (C) leads to the formation of a long-lived C+-P-C60− charge-separated state via photoinduced electron transfer. This reaction occurs in a frozen organic glass down to at least 8 K. At 77 K, charge recombination of C*+-P-C60− occurs on the &mgr;s time scale, and yields solely the carotenoid triplet state. In the presence of a small (20 mT) static magnetic field, the lifetime of the charge-separated state is increased by 50%. This is ascribed to the effect of the magnetic field on interconversion of the singlet and triplet biradicals. At zero field, the initially formed singlet biradical state is in equilibrium with the three triplet biradical sublevels, and all four states have comparable populations. Decay to the carotenoid triplet only occurs from the three triplet sublevels. In the presence of the field, the S and T0 states are still rapidly interconverting, but the T+ and T− states are isolated from the other two due to the electronic Zeeman interaction, and are not significantly populated. Under these conditions, recombination to the triplet occurs only from T0, and the lifetime of the charge-separated state increases. This effect can be used as the basis for a magnetically controlled optical or optoelectronic switch (e.g. AND gate).
摘要翻译：由与富勒烯电子受体（C60）和类胡萝卜素二次供体（C）共价连接的卟啉（P）组成的三元组人造光合反应中心的激发导致形成长寿命C ++ P-C60 - 通过光致电子转移的电荷分离状态。该反应发生在至少8K的冷冻有机玻璃中。在77K下，C * + -P-C60 - 的电荷重组发生在mus时间尺度上，仅产生类胡萝卜素三线态。在存在小（20mT）静态磁场的情况下，电荷分离状态的寿命增加了50％。这归因于磁场对单线态和三线态双向相互作用的影响。在零场，初始形成的单线态双态状态与三个三线态双向子水平平衡，并且所有四个状态具有可比较的群体。类胡萝卜素三联体的衰变仅发生在三个三线态亚层级。在场的存在下，S和T0状态仍然是快速相互转换的，但由于电子塞曼交互，T +和T-状态与另外两个状态隔离，并且没有显着的填充。在这些条件下，与三重态的复合只发生在T0，并且电荷分离状态的寿命增加。该效果可以用作磁控光电开关（例如与门）的基础。

7. 发明授权

US5286474A Use of carotenoporphyrins as tumor localizing agents for diagnosis 失效
标题翻译：使用胡萝卜素作为肿瘤定位剂进行诊断
公开(公告)号：US5286474A
公开(公告)日：1994-02-15
申请号：US966136
申请日：1992-10-22
申请人： John D. Gust, Jr. , Ana L. Moore , Thomas A. Moore , Giulio Jori , Elena Reddi
发明人： John D. Gust, Jr. , Ana L. Moore , Thomas A. Moore , Giulio Jori , Elena Reddi
IPC分类号： A61K31/40 , A61K49/00 , C07D487/22 , A61B5/00 , A61K31/555 , C07B47/00
CPC分类号： A61K49/0036 , A61K31/40 , A61K49/0052 , C07D487/22 , Y10S436/80
摘要： A process of tumor identification comprising administering a carotenoporphyrin to a tumor-bearing mammalian host and irradiating the mammalian host with light whereupon the carotenoporphyrin, which has been preferentially taken up by the tumor tissue, fluoresces and permits precise identification of the location, size and shape of the tumor tissue. An improved process of synthesizing carotenoporphyrins 1-5 is also provided.
摘要翻译：一种肿瘤鉴定过程，包括向含荷瘤的哺乳动物宿主施用胡萝卜素卟啉并用光照射哺乳动物宿主，其中优先被肿瘤组织吸收的胡萝卜素卟啉发亮并允许精确鉴定位置，大小和形状的肿瘤组织。还提供了合成胡萝卜素卟啉1-5的改进方法。

8. 再颁专利

USRE41693E1 Magnetic switching of charge separation lifetimes in artificial photosynthetic reaction centers 失效
标题翻译：人工光合反应中心电荷分离寿命的磁切换
公开(公告)号：USRE41693E1
公开(公告)日：2010-09-14
申请号：US11565506
申请日：2006-11-30
申请人： John D. Gust, Jr. , Ana L. Moore , Thomas Moore
发明人： John D. Gust, Jr. , Ana L. Moore , Thomas Moore
IPC分类号： G02B6/26 , G11C13/04 , H01R33/945 , F24J2/00
CPC分类号： H01L51/0047 , B82Y10/00 , B82Y20/00 , H01L51/0077 , H01L51/0093 , H01L51/0595 , H01L51/42 , Y02E10/549
摘要： Excitation of a triad artificial photosynthetic reaction center consisting of a porphyrin (P) convalently linked to a fullerene electron acceptor (C60) and a carotenoid secondary donor (C) leads to the formation of a long-lived C+-P-C60− charge-separated state via photoinduced electron transfer. This reaction occurs in a frozen organic glass down to at least 8 K. At 77 K, charge recombination of C*+-P-C60− occurs on the μs time scale, and yields solely the carotenoid triplet state. In the presence of a small (20 mT) static magnetic field, the lifetime of the charge-separated state is increased by 50%. This is ascribed to the effect of the magnetic field on interconversion of the singlet and triplet biradicals. At zero field, the initially formed singlet biradical state is in equilibrium with the three triplet biradical sublevels, and all four states have comparable populations. Decay to the carotenoid triplet only occurs from the three triplet sublevels. In the presence of the field, the S and T0 states are still rapidly interconverting, but the T+ and T− states are isolated from the other two due to the electronic Zeeman interaction, and are not significantly populated. Under these conditions, recombination to the triplet occurs only from T0, and the lifetime of the charge-separated state increases. This effect can be used as the basis for a magnetically controlled optical or optoelectronic switch (e.g. AND gate).
摘要翻译：由与富勒烯电子受体（C60）和类胡萝卜素二次供体（C）共价连接的卟啉（P）组成的三元组人造光合反应中心的激发导致形成长寿命的C + -P-C60-电荷 - 通过光电子转移分离状态。该反应发生在至少8K的冷冻有机玻璃中。在77K下，C * + -P-C60-的电荷重组发生在μs时间尺度上，仅产生类胡萝卜素三线态。在存在小（20mT）静态磁场的情况下，电荷分离状态的寿命增加了50％。这归因于磁场对单线态和三线态双向相互作用的影响。在零场，初始形成的单线态双态状态与三个三线态双向子水平平衡，并且所有四个状态具有可比较的群体。类胡萝卜素三联体的衰变仅发生在三个三线态亚层级。在场的存在下，S和T0状态仍然是快速相互转换的，但由于电子塞曼交互，T +和T-状态与另外两个状态隔离，并且没有显着的填充。在这些条件下，与三重态的复合只发生在T0，并且电荷分离状态的寿命增加。该效果可以用作磁控光电开关（例如与门）的基础。

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