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1. 发明授权

US06475212B2 Cryosurgical probe with sheath 有权
标题翻译：冷冻手术探头带护套
公开(公告)号：US06475212B2
公开(公告)日：2002-11-05
申请号：US09791415
申请日：2001-02-22
申请人： John D. Dobak, III , Kambiz Ghaerzadeh , Xiaoyu Yu
发明人： John D. Dobak, III , Kambiz Ghaerzadeh , Xiaoyu Yu
IPC分类号： A61B1818
CPC分类号： A61B18/02 , A61B17/42 , A61B18/0206 , A61B18/24 , A61B2017/00084 , A61B2017/0023 , A61B2017/00336 , A61B2018/00041 , A61B2018/00095 , A61B2018/00101 , A61B2018/00166 , A61B2018/0212 , A61B2018/0262 , A61B2090/306 , A61B2090/378 , A61B2218/002
摘要： A sheath for use on a closed loop Joule-Thomson cryosurgical probe, and the combination of the and the closed loop probe. The sheath is slipped over the probe, thereby separating the probe from the environment. The sheath has a grip which fits over the handle of the cryosurgical probe, and an extendible shroud which can be longitudinally extended to cover tubing and which are attached to the handle. The sheath has a hollow multi-lumen catheter shaped and sized to fit snugly over the cannula of the cryosurgical probe. The catheter is not thermally conductive, preventing transfer of heat from the ambient to the gas mixture, and preventing the freezing of tissues at undesired locations along the catheter. A thermally conductive cap or tip is attached to the distal end of the hollow catheter. The thermally conductive cap or tip fits snugly over the cold tip on the probe, and it efficiently transfers heat from the target tissue to the cold tip, which in turn transfers heat to the expanded gas mixture. Various forms of auxiliary instrumentation can be mounted on the catheter or conductive tip, such as a temperature sensor, a heater, an ultrasonic transducer, or an optical element of a viewing, illumination, or laser system. Connections between the instrumentation near the distal end of the catheter and the probe are made via a plurality of lumens passing longitudinally through the wall of the catheter.
摘要翻译：用于闭环焦耳汤姆逊冷冻手术探针的鞘，以及闭环探针的组合。护套滑过探头，从而将探头与环境分开。护套具有装配在冷冻手术探针的手柄上的把手，以及可延伸的护罩，其可以纵向延伸以覆盖管道并且附接到手柄。护套具有中空的多腔导管，其形状和尺寸适于紧贴在冷冻手术探针的套管上方。导管不是导热的，防止热量从环境转移到气体混合物，并且防止沿着导管在不期望的位置处冷冻组织。导热帽或尖端连接到中空导管的远端。导热盖或尖端紧贴在探针上的冷尖端上，并且有效地将热量从目标组织传递到冷尖端，冷尖端又将热量传递到膨胀气体混合物。各种形式的辅助仪器可以安装在导管或导电尖端上，例如温度传感器，加热器，超声波换能器或观察，照明或激光系统的光学元件。在导管远端附近的仪器与探针之间的连接通过纵向穿过导管的壁的多个管腔制成。

2. 发明授权

US6070415A Precooling system for Joule-Thomson probe 失效
公开(公告)号：US6070415A
公开(公告)日：2000-06-06
申请号：US75374
申请日：1998-05-07
申请人： John D. Dobak, III , Terry L. Brown , Kambiz Ghaerzadeh , Xiaoyu Yu
发明人： John D. Dobak, III , Terry L. Brown , Kambiz Ghaerzadeh , Xiaoyu Yu
摘要： A miniature refrigeration system and method of operation. A primary refrigerant is pressurized by a compressor to a relatively low pressure, for safety reasons. The compressed primary refrigerant is passed through a primary-to-secondary heat exchanger, to precool the gas mixture. The secondary side of the primary-to-secondary heat exchanger is cooled by a secondary refrigeration system. The primary refrigerant exiting the primary outlet of the primary-to-secondary heat exchanger passes to a primary Joule-Thomson expansion element where the high pressure gas is expanded to a lower temperature. This low temperature gas cools a heat transfer element mounted in the outer wall of the catheter or cryoprobe, to cool surrounding tissue. Return gas can flow back through a distal primary-to-primary heat exchanger to further cool the incoming high pressure gas mixture. A proximal primary-to-primary heat exchanger can be added between the primary-to-secondary heat exchanger and the primary compressor.

3. 发明授权

US5910104A Cryosurgical probe with disposable sheath 失效
标题翻译：带一次性护套的冷冻手术探头
公开(公告)号：US5910104A
公开(公告)日：1999-06-08
申请号：US774148
申请日：1996-12-26
申请人： John D. Dobak, III , Kambiz Ghaerzadeh , Xiaoyu Yu
发明人： John D. Dobak, III , Kambiz Ghaerzadeh , Xiaoyu Yu
IPC分类号： A61B19/02 , A61B17/00 , A61B17/42 , A61B18/00 , A61B18/02 , A61B18/24 , A61B19/00 , A61B1/00
CPC分类号： A61B18/02 , A61B17/42 , A61B18/0206 , A61B18/24 , A61B2017/00084 , A61B2017/0023 , A61B2017/00336 , A61B2018/00041 , A61B2018/00095 , A61B2018/00101 , A61B2018/00166 , A61B2018/0212 , A61B2018/0262 , A61B2090/306 , A61B2090/378 , A61B2218/002
摘要： A disposable, sterilizable sheath for use on a closed loop Joule-Thomson cryosurgical probe, and the combination of the disposable sheath and the closed loop probe. The sheath is slipped over the probe, thereby separating the probe from the environment. The sheath has a grip which fits over the handle of the cryosurgical probe, and an extendible shroud which can be longitudinally extended to cover tubing and which are attached to the handle. The sheath has a hollow multi-lumen catheter shaped and sized to fit snugly over the cannula of the cryosurgical probe. The catheter is not thermally conductive, preventing transfer of heat from the ambient to the gas mixture, and preventing the freezing of tissues at undesired locations along the catheter. A thermally conductive cap or tip is attached to the distal end of the hollow catheter. The thermally conductive cap or tip fits snugly over the cold tip on the probe, and it efficiently transfers heat from the target tissue to the cold tip, which in turn transfers heat to the expanded gas mixture. Various forms of auxiliary instrumentation can be mounted on the catheter or conductive tip, such as a temperature sensor, a heater, an ultrasonic transducer, or an optical element of a viewing, illumination, or laser system. Connections between the instrumentation near the distal end of the catheter and the probe are made via a plurality of lumens passing longitudinally through the wall of the catheter.
摘要翻译：用于闭环焦耳汤姆逊冷冻手术探针的一次性灭菌鞘，以及一次性鞘和闭环探针的组合。护套滑过探头，从而将探头与环境分开。护套具有装配在冷冻手术探针的手柄上的把手，以及可延伸的护罩，其可以纵向延伸以覆盖管道并且附接到手柄。护套具有中空的多腔导管，其形状和尺寸适于紧贴在冷冻手术探针的套管上方。导管不是导热的，防止热量从环境转移到气体混合物，并且防止沿着导管在不期望的位置处冷冻组织。导热帽或尖端连接到中空导管的远端。导热盖或尖端紧贴在探针上的冷尖端上，并且有效地将热量从目标组织传递到冷尖端，冷尖端又将热量传递到膨胀气体混合物。各种形式的辅助仪器可以安装在导管或导电尖端上，例如温度传感器，加热器，超声波换能器或观察，照明或激光系统的光学元件。在导管远端附近的仪器与探针之间的连接通过纵向穿过导管的壁的多个管腔制成。

4. 发明授权

US06530234B1 Precooling system for Joule-Thomson probe 失效
标题翻译：焦耳汤姆森探头预冷系统
公开(公告)号：US06530234B1
公开(公告)日：2003-03-11
申请号：US09075374
申请日：1998-05-07
申请人： John D. Dobak, III , Terry L. Brown , Kambiz Ghaerzadeh , Xiaoyu Yu
发明人： John D. Dobak, III , Terry L. Brown , Kambiz Ghaerzadeh , Xiaoyu Yu
IPC分类号： F17C702
CPC分类号： C09K5/045 , A61B18/02 , A61B2018/0212 , A61B2018/0275 , A61B2018/0281 , C09K2205/22 , F25B7/00 , F25B9/006 , F25B9/02 , F25B2309/003 , F25B2309/021 , F25B2309/022 , F25B2309/023 , F25B2400/12
摘要： A miniature refrigeration system and method of operation. A primary refrigerant is pressurized by a compressor to a relatively low pressure, for safety reasons. The compressed primary refrigerant is passed through a primary-to-secondary heat exchanger, to precool the gas mixture. The secondary side of the primary-to-secondary heat exchanger is cooled by a secondary refrigeration system. The primary refrigerant exiting the primary outlet of the primary-to-secondary heat exchanger passes to a primary Joule-Thomson expansion element where the high pressure gas is expanded to a lower temperature. This low temperature gas cools a heat transfer element mounted in the outer wall of the catheter or cryoprobe, to cool surrounding tissue. Return gas can flow back through a distal primary-to-primary heat exchanger to further cool the incoming high pressure gas mixture. A proximal primary-to-primary heat exchanger can be added between the primary-to-secondary heat exchanger and the primary compressor.
摘要翻译：微型制冷系统及其操作方法。出于安全原因，一级制冷剂被压缩机加压至较低的压力。压缩的一次制冷剂通过一次 - 二次热交换器，以预冷气体混合物。一级到二级热交换器的次级侧由二次制冷系统冷却。从初级到二级热交换器的主出口排出的主要制冷剂通过一次焦耳汤姆森膨胀元件，其中高压气体膨胀到较低的温度。该低温气体冷却安装在导管或冷冻探针的外壁中的传热元件以冷却周围的组织。回流气体可以通过远端主 - 原热交换器回流，以进一步冷却进入的高压气体混合物。可以在初级到二级热交换器和主压缩机之间添加近端的初级至主要的热交换器。

5. 发明授权

US06193644B1 Cryosurgical probe with sheath 有权
公开(公告)号：US06193644B1
公开(公告)日：2001-02-27
申请号：US09262588
申请日：1999-03-04
申请人： John D. Dobak, III , Kambiz Ghaerzadeh , Xiaoyu Yu
发明人： John D. Dobak, III , Kambiz Ghaerzadeh , Xiaoyu Yu
IPC分类号： A61F558
CPC分类号： A61B18/02 , A61B17/42 , A61B18/0206 , A61B18/24 , A61B2017/00084 , A61B2017/0023 , A61B2017/00336 , A61B2018/00041 , A61B2018/00095 , A61B2018/00101 , A61B2018/00166 , A61B2018/0212 , A61B2018/0262 , A61B2090/306 , A61B2090/378 , A61B2218/002
摘要： A sheath for use on a closed loop Joule-Thomson cryosurgical probe, and the combination of the and the closed loop probe. The sheath is slipped over the probe, thereby separating the probe from the environment. The sheath has a grip which fits over the handle of the cryosurgical probe, and an extendible shroud which can be longitudinally extended to cover tubing and which are attached to the handle. The sheath has a hollow multi-lumen catheter shaped and sized to fit snugly over the cannula of the cryosurgical probe. The catheter is not thermally conductive, preventing transfer of heat from the ambient to the gas mixture, and preventing the freezing of tissues at undesired locations along the catheter. A thermally conductive cap or tip is attached to the distal end of the hollow catheter. The thermally conductive cap or tip fits snugly over the cold tip on the probe, and it efficiently transfers heat from the target tissue to the cold tip, which in turn transfers heat to the expanded gas mixture. Various forms of auxiliary instrumentation can be mounted on the catheter or conductive tip, such as a temperature sensor, a heater, an ultrasonic transducer, or an optical element of a viewing, illumination, or laser system. Connections between the instrumentation near the distal end of the catheter and the probe are made via a plurality of lumens passing longitudinally through the wall of the catheter.

6. 发明授权

US5758505A Precooling system for joule-thomson probe 失效
标题翻译：焦耳探头预冷系统
公开(公告)号：US5758505A
公开(公告)日：1998-06-02
申请号：US726770
申请日：1996-10-07
申请人： John D. Dobak, III , Terry L. Brown , Kambiz Ghaerzadeh , Xiaoyu Yu
发明人： John D. Dobak, III , Terry L. Brown , Kambiz Ghaerzadeh , Xiaoyu Yu
IPC分类号： F25D3/10 , A61B18/02 , C09K5/04 , F25B7/00 , F25B9/00 , F25B9/02 , F25B19/02
CPC分类号： F25B9/006 , A61B18/02 , C09K5/045 , F25B9/02 , A61B2018/0212 , A61B2018/0275 , A61B2018/0281 , C09K2205/12 , C09K2205/122 , C09K2205/13 , C09K2205/132 , F25B2309/003 , F25B2309/021 , F25B2309/022 , F25B2309/023 , F25B2400/12 , F25B7/00
摘要： A miniature mixed gas refrigeration system and method of operation are disclosed. An optimum gas mixture is formulated from a group of component fluids, according to calculated thermodynamic properties of a group of candidate fluid mixtures. The gas mixture is pressurized by a compressor to a pressure less than 420 psia, for safety reasons. The compressed gas mixture is passed through a primary heat exchanger, and then through a primary-to-secondary heat exchanger, to precool the gas mixture. The secondary side of the primary/secondary heat exchanger is cooled by a secondary Joule-Thomson refrigeration system. Properly sized flow restrictions in the primary side of the primary/secondary heat exchanger can solidify and trap liquid contaminants that may be in the gas mixture. The gas mixture exiting the primary outlet of the primary/secondary heat exchanger passes to a primary Joule-Thomson expansion element where the high pressure gas is expanded isenthalpically to a lower temperature at least as low as 183K. This low temperature gas cools a heat transfer element mounted in the outer wall of the catheter, to cool an external object. Return gas flows back through the primary heat exchanger to further pre-cool the incoming high pressure gas mixture. A distal primary heat exchanger can be added between the primary/secondary heat exchanger and the primary Joule-Thomson expansion element.
摘要翻译：公开了一种微型混合气体制冷系统和操作方法。根据一组候选流体混合物的计算的热力学性质，从一组组分流体配制最佳气体混合物。为了安全起见，气体混合物被压缩机压力低于420psia。将压缩气体混合物通过主要热交换器，然后通过初级 - 二级热交换器，以预冷气体混合物。一次/二次热交换器的二次侧通过二次焦耳 - 汤姆森制冷系统进行冷却。主/二次换热器初级侧的适当尺寸的流量限制可以凝固并捕获可能在气体混合物中的液体污染物。离开初级/二级热交换器的主出口的气体混合物通过到焦耳 - 汤姆逊膨胀元件，其中高压气体在等温下扩展至至少低至183K的较低温度。该低温气体冷却安装在导管的外壁中的传热元件，以冷却外部物体。回流气体通过主热交换器回流，以进一步预冷进入的高压气体混合物。可以在主/辅助热交换器和初级焦耳 - 汤姆森膨胀元件之间添加远端主热交换器。

7. 发明授权

US5820542A Modified circulatory assist device 失效
标题翻译：改良循环辅助装置
公开(公告)号：US5820542A
公开(公告)日：1998-10-13
申请号：US891545
申请日：1997-07-11
申请人： John D. Dobak, III , Kambiz Ghaerzadeh
发明人： John D. Dobak, III , Kambiz Ghaerzadeh
IPC分类号： A61M1/10 , A61M1/12 , A61B19/00
CPC分类号： A61M1/1072 , A61M1/1037 , A61M1/1062 , A61M1/122 , A61M1/125 , A61M1/106
摘要： A circulatory assist device, having a housing and a pumping membrane, with a control chamber and a pumping chamber. The device is mounted on a catheter, collapsed to a sufficiently small diameter to allow insertion into the vascular system of a patient. An expansion mechanism in the device, such as a stent, can be expanded to hold the housing in an expanded substantially rigid state, while control fluid is pumped into and evacuated from the control chamber to repeatedly deflect the pumping membrane. At least one opening is formed in the device, to allow vascular fluid to enter and exit the pumping chamber as the pumping membrane deflects. Introduction and evacuation of control fluid can be synchronized with the heart cycle of the patient. After use, the housing is contracted to a smaller diameter to allow withdrawal from the vascular system.
摘要翻译：具有壳体和泵送膜的循环辅助装置，其具有控制室和泵送室。该装置安装在导管上，塌陷至足够小的直径以允许插入患者的血管系统。可以扩展装置中的膨胀机构，例如支架，以将壳体保持在膨胀的基本上刚性的状态，同时将控制流体泵入并从控制室抽空以重复地偏转泵送膜。在装置中形成至少一个开口，以在泵送膜偏转时允许血液流体进入和离开泵送室。控制液的介绍和疏散可以与患者的心脏周期同步。使用后，外壳收缩到较小的直径以允许从血管系统撤出。

8. 发明授权

US5827171A Intravascular circulatory assist device 失效
标题翻译：血管内循环辅助装置
公开(公告)号：US5827171A
公开(公告)日：1998-10-27
申请号：US740657
申请日：1996-10-31
申请人： John D. Dobak, III , Kambiz Ghaerzadeh
发明人： John D. Dobak, III , Kambiz Ghaerzadeh
IPC分类号： A61M1/10 , A61M1/12 , A61B19/00
CPC分类号： A61M1/1037 , A61M1/1062 , A61M1/1072 , A61M1/122 , A61M1/125 , A61M1/106
摘要： A circulatory assist device, having an outer balloon and an inner balloon, with a control space between the outer and inner balloons. The device is mounted on a catheter, collapsed to a sufficiently small diameter to allow insertion into the vascular system of a patient. An expansion mechanism in the device, such as a stent, can be expanded to hold the outer balloon in an expanded state, while control fluid is pumped into and evacuated from the control space to repeatedly collapse and expand the inner balloon. At least one port is formed in the inner balloon, to allow vascular fluid to enter and exit the inner balloon as the inner balloon expands and contracts. After use, the expansion mechanism is contracted to a smaller diameter to allow withdrawal from the vascular system.
摘要翻译：具有外球囊和内球囊的循环辅助装置，其具有在外气囊和内球囊之间的控制空间。该装置安装在导管上，塌陷至足够小的直径以允许插入患者的血管系统。可以扩展装置（例如支架）中的膨胀机构以将外气囊保持在膨胀状态，同时将控制流体泵入并从控制空间排出以反复塌缩并膨胀内气囊。至少一个端口形成在内气囊中，以允许血管流体在内气囊膨胀和收缩时进入和离开内气球。使用后，膨胀机构收缩到较小的直径以允许从血管系统撤出。

9. 发明授权

US08838231B2 Neural Stimulation for treatment of metabolic syndrome and type 2 diabetes 有权
标题翻译：用于治疗代谢综合征和2型糖尿病的神经刺激
公开(公告)号：US08838231B2
公开(公告)日：2014-09-16
申请号：US13152777
申请日：2011-06-03
申请人： John D. Dobak, III
发明人： John D. Dobak, III
IPC分类号： A61N1/36
CPC分类号： A61N1/3615 , A61N1/36007 , A61N1/36085 , A61N1/36135 , A61N1/36167
摘要： Systems and methods are described for treating metabolic syndrome and/or Type 2 diabetes, and/or one or more of their attendant conditions, by neural stimulation. In one embodiment, an implantable pulse generator is electrically coupled to a peripheral nerve, such as the splanchnic nerve. Neural stimulation configured to either block transmission or stimulate transmission of the peripheral nerve may be used to treat metabolic syndrome and Type 2 diabetes.
摘要翻译：描述了通过神经刺激来治疗代谢综合征和/或2型糖尿病和/或其伴随状况中的一种或多种的系统和方法。在一个实施例中，可植入脉冲发生器电耦合到外周神经，例如内脏神经。配置为阻止传播或刺激周围神经传播的神经刺激可用于治疗代谢综合征和2型糖尿病。

10. 发明授权

US08295926B2 Dynamic nerve stimulation in combination with other eating disorder treatment modalities 有权
标题翻译：动态神经刺激与其他饮食失调治疗方式相结合
公开(公告)号：US08295926B2
公开(公告)日：2012-10-23
申请号：US12604953
申请日：2009-10-23
申请人： John D. Dobak, III
发明人： John D. Dobak, III
IPC分类号： A61N1/00
CPC分类号： A61N1/36085 , A61K31/135 , A61K38/2264 , A61K41/00 , A61K45/06 , A61N1/36007 , A61N1/36017 , A61K2300/00
摘要： A method for treatment of obesity or other disorders by electrical activation or inhibition of nerves is disclosed. This activation or inhibition can be accomplished by stimulating a nerve using an electrode. The method further comprises performing a surgical procedure and/or administering a weight loss drug.
摘要翻译：公开了一种通过电活化或抑制神经来治疗肥胖症或其它疾病的方法。这种激活或抑制可以通过使用电极刺激神经来实现。该方法还包括进行外科手术和/或施用减肥药。

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