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1. 发明申请

US20050067583A1 Method and system for automated focus-distance determination for molecular array scanners 审中-公开
标题翻译：分子阵列扫描仪的自动聚焦距离测定方法和系统
公开(公告)号：US20050067583A1
公开(公告)日：2005-03-31
申请号：US10910562
申请日：2004-08-02
申请人： John Corson , Stanley Woods , Russell Parker , Xiangyang Zhou , Bo Curry
发明人： John Corson , Stanley Woods , Russell Parker , Xiangyang Zhou , Bo Curry
IPC分类号： G01N21/64
CPC分类号： G01N21/6452 , G01N21/6458 , G01N2021/6463
摘要： An automated method and system for determining an optimal focus distance for scanning a molecular array by a molecular array scanner. Blocks of rows of a reference array are automatically scanned at successively greater distances of the stage from a light gathering medium, such as an optical fiber, or z-positions, to produce data providing a functional relationship between z-position and measured signal intensities. The data is then processed by a peak-height-based, or window-based, focus-finding routine that selects an optimal focus-distance for data scans.
摘要翻译：一种用于通过分子阵列扫描仪确定用于扫描分子阵列的最佳聚焦距离的自动化方法和系统。参考阵列的行的块自动地从阶段相对较远的距离光收集介质（诸如光纤或z位置）扫描，以产生提供z位置和测量的信号强度之间的功能关系的数据。然后通过基于峰值高度或基于窗口的聚焦寻找程序处理数据，该程序为数据扫描选择最佳聚焦距离。

2. 发明申请

US20050233337A1 Chemical arrays and methods of producing the same 审中-公开
标题翻译：化学阵列及其制备方法
公开(公告)号：US20050233337A1
公开(公告)日：2005-10-20
申请号：US10828357
申请日：2004-04-19
申请人： Bill Peck , Eric Leproust , David Adaskin , Guang Chen , William Chesk , Donald Schremp , Stanley Woods
发明人： Bill Peck , Eric Leproust , David Adaskin , Guang Chen , William Chesk , Donald Schremp , Stanley Woods
IPC分类号： B01J19/00 , B01L3/02 , C40B40/06 , C40B40/10 , C40B60/14 , C12Q1/68 , B05D3/00 , C12M1/34
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/00378 , B01J2219/00529 , B01J2219/00596 , B01J2219/00603 , B01J2219/00659 , B01J2219/00695 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B60/14
摘要： Methods and devices for fabricating a chemical array are provided. Embodiments include determining a chemical array layout in which each feature in the layout has a size that is chosen based on its composition and fabricating a chemical array according to the chemical array layout. In certain embodiments, at least two features of an array fabricated according to the subject methods are of different sizes. Embodiments also include chemical arrays having features of different sizes, e.g., fabricated according to the subject methods. Also provided are embodiments that include fluid deposition devices capable of fabricating chemical arrays having features of different sizes, e.g., for use in practicing the subject methods. Algorithms present on computer readable mediums for use in practicing the subject methods may also be provided in certain embodiments. Embodiments of the subject invention may also include systems and kits for use in practicing the subject methods.
摘要翻译：提供了用于制造化学阵列的方法和装置。实施例包括确定化学阵列布局，其中布局中的每个特征具有基于其组成选择的尺寸，并根据化学阵列布局制造化学阵列。在某些实施例中，根据本发明方法制造的阵列的至少两个特征具有不同的尺寸。实施例还包括具有不同尺寸特征的化学阵列，例如根据本发明方法制造的。还提供了包括能够制造具有不同尺寸特征的化学阵列的流体沉积装置的实施例，例如用于实践本发明方法。在某些实施例中也可以提供存在于用于实践主题方法的计算机可读介质上的算法。本发明的实施方案还可以包括用于实践本发明方法的系统和试剂盒。

3. 发明申请

US20050214775A1 Generalized pulse jet ejection head control model 有权
标题翻译：广义脉冲喷射头控制模型
公开(公告)号：US20050214775A1
公开(公告)日：2005-09-29
申请号：US10809981
申请日：2004-03-26
申请人： David Adaskin , Bill Peck , Stanley Woods , William Chesk
发明人： David Adaskin , Bill Peck , Stanley Woods , William Chesk
IPC分类号： B01J19/00 , C12Q1/68 , G01N33/48 , G01N33/50
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00378 , B01J2219/00527 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00659 , B01J2219/00675 , B01J2219/00677 , B01J2219/00689 , B01J2219/00691 , B01J2219/00693 , B01J2219/00695 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01J2219/00731 , Y10T436/11 , Y10T436/114998 , Y10T436/2575
摘要： A generalized printhead control model is provided herein as a basis for configuring printhead control software that will operate any selected printhead or group of printheads. The subject model covers a hierarchy of classes for the attributes of software that controls the printheads in a system, such as for producing a biopolymer array.
摘要翻译：本文提供了广义的打印头控制模型，作为配置打印头控制软件的基础，打印头控制软件将操作任何所选的打印头或打印头组。主题模型涵盖了控制系统中的打印头的软件的属性的类的层次结构，例如用于生产生物聚合物阵列。

4. 发明申请

US20060270059A1 Modular printing of biopolymer arrays 审中-公开
标题翻译：生物聚合物阵列的模块化印刷
公开(公告)号：US20060270059A1
公开(公告)日：2006-11-30
申请号：US11140084
申请日：2005-05-27
申请人： Xiaohua Huang , Eric Leproust , Bill Peck , Lawrence DaQuino , Kyle Schleifer , Stanley Woods
发明人： Xiaohua Huang , Eric Leproust , Bill Peck , Lawrence DaQuino , Kyle Schleifer , Stanley Woods
IPC分类号： B01L3/00
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00378 , B01J2219/00527 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00662 , B01J2219/00675 , B01J2219/00722 , B01J2219/00725 , G01N2035/1041 , Y10T436/2575
摘要： Methods and apparatus are disclosed for preparing an array of polymeric compounds on a substrate. Drops of polymer subunits are dispensed to a surface of a substrate from two or more drop dispensing modules wherein each module comprises dispensers for dispensing a respective polymer-forming reagent. At least two of the modules and a substrate are brought into drop dispensing relationship in at least one step prior to conducting the step of preparing the surface for repeating the drop-dispensing step. Next, the surface is subjected to reagents to prepare the surface for repeating the drop-dispensing step. The above steps are repeated for a sufficient number of cycles to prepare the array of polymeric compounds.
摘要翻译：公开了用于在衬底上制备聚合物化合物阵列的方法和装置。聚合物子单元的滴从两个或更多个滴分配模块分配到基板的表面，其中每个模块包括用于分配相应的聚合物形成试剂的分配器。在进行制备用于重复滴落步骤的表面的步骤之前，至少两个模块和基底在至少一个步骤中进入滴液分配关系。接下来，对表面进行试剂以制备用于重复滴落步骤的表面。重复上述步骤足够的循环以制备聚合物化合物的阵列。

5. 发明申请

US20060063274A1 Methods for manufacturing and using chemical array calibration devices 审中-公开
标题翻译：制造和使用化学阵列校准装置的方法
公开(公告)号：US20060063274A1
公开(公告)日：2006-03-23
申请号：US10948886
申请日：2004-09-23
申请人： Donald Schremp , Bill Peck , Stanley Woods
发明人： Donald Schremp , Bill Peck , Stanley Woods
IPC分类号： G01N21/64
CPC分类号： G01N21/6452 , G01N21/278 , Y10T436/2575
摘要： The invention provides methods for manufacturing a chemical array reader calibration device. Embodiments include dispensing a volume of fluorescent dye coating composition from a pulse jet fluid deposition device onto a surface of a substrate to coat the surface with the fluorescent dye coating composition. Also provided are chemical array reader calibration devices and methods of using the subject chemical array reader calibration devices to calibrate a chemical array reader. Also provided are kits that include a chemical array reader calibration device.
摘要翻译：本发明提供了用于制造化学阵列阅读器校准装置的方法。实施例包括将一定体积的荧光染料涂料组合物从脉冲喷射流体沉积装置分配到基材的表面上以用荧光染料涂料组合物涂布表面。还提供了化学阵列读取器校准装置和使用主题化学阵列读取器校准装置来校准化学阵列读取器的方法。还提供了包括化学阵列读取器校准装置的试剂盒。

6. 发明申请

US20050063227A1 Devices for storing array data and methods of using the same 审中-公开
标题翻译：用于存储阵列数据的设备及其使用方法
公开(公告)号：US20050063227A1
公开(公告)日：2005-03-24
申请号：US10982130
申请日：2004-11-05
申请人： Stanley Woods
发明人： Stanley Woods
IPC分类号： G01N33/48 , G01N33/50 , G05B11/01 , G06F19/00 , G11C5/00
CPC分类号： G05B23/024
摘要： Devices and methods for storing data related to at least one array are provided. The subject devices are characterized by an array holder that holds a substrate having at least one array and a data storage element operatively coupled thereto and configured to receive and store data related to a held array. Stored data may include calibration data and/or the number of times the array is scanned. The data storage element may be configured to communicate with at least one external apparatus using a physical connection. In using the subject devices, a subject array holder holds a substrate having at least one array and data related to the at least one array is received and stored by the data storage element. The data storage element may communicate with at least one external apparatus using a physical connection. Also provided are kits for practicing the subject methods.
摘要翻译：提供了用于存储与至少一个阵列有关的数据的装置和方法。主题装置的特征在于阵列保持器，其保持具有至少一个阵列的基板和与其可操作地耦合的数据存储元件，并且被配置为接收和存储与保持阵列有关的数据。存储的数据可以包括校准数据和/或扫描阵列的次数。数据存储元件可以被配置为使用物理连接与至少一个外部设备进行通信。在使用主题装置时，对象阵列保持器保持具有至少一个阵列的基底，并且与该至少一个阵列相关的数据由数据存储元件接收和存储。数据存储元件可以使用物理连接与至少一个外部设备进行通信。还提供了用于实践主题方法的工具包。

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