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1. 发明申请

US20110183358A1 METHODS AND COMPOSITIONS FOR DEREPRESSION OF IAP-INHIBITED CASPASE 审中-公开
标题翻译：用于抑制IAP抑制CASPASE的方法和组合物
公开(公告)号：US20110183358A1
公开(公告)日：2011-07-28
申请号：US11886385
申请日：2006-03-17
申请人： John C. Reed , Richard A. Houghten , Adel Nefzi , John M. Ostresh , Kate Welsh , Clemencia Pinilla
发明人： John C. Reed , Richard A. Houghten , Adel Nefzi , John M. Ostresh , Kate Welsh , Clemencia Pinilla
IPC分类号： G01N33/53
CPC分类号： C07D207/09 , A61K38/00
摘要： The invention provides isolated agents having novel chemical structures and possessing superior activity as derepressors of IAP inhibited caspase. The invention further provides a method of derepressing an IAP-inhibited caspase. The invention further provides assay methods employing labeled compounds of the invention, especially fluorescent labeled compounds.
摘要翻译：本发明提供了具有新化学结构并且作为IAP抑制剂抑制半胱天冬酶具有优异活性的分离剂。本发明还提供了一种去抑制IAP抑制的半胱天冬酶的方法。本发明还提供了使用本发明的标记化合物，特别是荧光标记的化合物的测定方法。

2. 发明申请

US20090043099A1 Methods and compositions for derepression of IAP-inhibited caspase 审中-公开
标题翻译：用于抑制IAP抑制半胱天冬酶的方法和组合物
公开(公告)号：US20090043099A1
公开(公告)日：2009-02-12
申请号：US11982317
申请日：2007-10-31
申请人： John C. Reed , Richard A. Houghten , Adel Nefzi , John M. Ostresh , Clemencia Pinilla , Kate Welsh
发明人： John C. Reed , Richard A. Houghten , Adel Nefzi , John M. Ostresh , Clemencia Pinilla , Kate Welsh
IPC分类号： C07D241/08 , C07C275/42 , C07D207/09
CPC分类号： C07D207/09 , C07C275/28 , C07D241/08
摘要： The invention provides isolated agents having novel chemical structures and possessing superior activity as derepressors of IAP inhibited caspase. The invention further provides a method of derepressing an IAP-inhibited caspase. The invention further provides assay methods employing labeled compounds of the invention, especially fluorescent labeled compounds.
摘要翻译：本发明提供了具有新化学结构并且作为IAP抑制剂抑制半胱天冬酶具有优异活性的分离剂。本发明还提供了一种去抑制IAP抑制的半胱天冬酶的方法。本发明还提供了使用本发明的标记化合物，特别是荧光标记的化合物的测定方法。

3. 发明授权

US07217688B2 Methods and compositions for derepression of IAP-inhibited caspase 失效
标题翻译：用于抑制IAP抑制半胱天冬酶的方法和组合物
公开(公告)号：US07217688B2
公开(公告)日：2007-05-15
申请号：US11186629
申请日：2005-07-19
申请人： John C. Reed , Richard A. Houghten , Adel Nefzi , John M. Ostresh , Clemencia Pinilla , Kate Welsh
发明人： John C. Reed , Richard A. Houghten , Adel Nefzi , John M. Ostresh , Clemencia Pinilla , Kate Welsh
IPC分类号： A01N37/18
CPC分类号： C07D207/09 , A61K38/00
摘要： The invention provides isolated agents having novel chemical structures and possessing superior activity as derepressors of IAP inhibited caspase. The invention further provides a method of derepressing an IAP-inhibited caspase. The invention further provides assay methods employing labeled compounds of the invention, especially fluorescent labeled compounds.
摘要翻译：本发明提供了具有新化学结构并且作为IAP抑制剂抑制半胱天冬酶具有优异活性的分离剂。本发明还提供了一种去抑制IAP抑制的半胱天冬酶的方法。本发明还提供了使用本发明的标记化合物，特别是荧光标记的化合物的测定方法。

4. 发明授权

US06911426B2 Methods and compositions for derepression of IAP-inhibited caspase 失效
标题翻译：用于抑制IAP抑制半胱天冬酶的方法和组合物
公开(公告)号：US06911426B2
公开(公告)日：2005-06-28
申请号：US10302811
申请日：2002-11-21
申请人： John C. Reed , Richard A. Houghten , Adel Nefzi , John M. Ostresh , Clemencia Pinilla , Kate Welsh
发明人： John C. Reed , Richard A. Houghten , Adel Nefzi , John M. Ostresh , Clemencia Pinilla , Kate Welsh
IPC分类号： C12Q1/02 , A61K38/00 , A61P1/04 , A61P3/10 , A61P5/16 , A61P9/10 , A61P17/06 , A61P19/02 , A61P21/00 , A61P21/04 , A61P25/00 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/02 , A61P43/00 , C07K5/10 , C07K5/103 , C07K5/107 , C07K5/11 , C07K5/117 , C07K7/04 , C07K7/06 , C12Q1/37
CPC分类号： C07K7/06 , A61K38/00 , C07K5/1008 , C07K5/1016 , C07K5/1019 , C07K5/1024 , C07K5/1027
摘要： The invention provides isolated agents having a core peptide selected from the group consisting of Core peptides 5 through 39 and 42 through 55, wherein the agent derepresses an IAP-inhibited caspase. Also provided is an isolated agent having a core structure selected from any of the structures shown in FIGS. 5, 9, 10, 14B, and 21-24 wherein said agent derepresses an IAP-inhibited caspase. The invention further provides a method of derepressing an IAP-inhibited caspase. The method consists of contacting an IAP-inhibited caspase with an effective amount of an agent to derepress an IAP-inhibited caspase, the agent having a core motif selected from the group consisting of a core peptide having a sequence set forth in any of Core peptides 4 through 39 and 42 through 55, and a core structure selected from the group consisting of TPI759, TPI882, TPI914 or TPI927. The methods of the invention also can be used for promoting apoptosis in a cell and for reducing the severity of a pathology characterized by reduced levels of apoptosis. Methods for identifying agents that derepress an IAP-inhibited caspase are also provided.
摘要翻译：本发明提供了具有选自核心肽5至39和42至55的核心肽的分离的试剂，其中所述试剂减阻IAP抑制的半胱天冬酶。还提供了一种隔离剂，其具有选自图1和图2所示的任何结构的芯结构。 5,9,10,14B和21-24，其中所述试剂去抑制IAP抑制的半胱天冬酶。本发明还提供了一种去抑制IAP抑制的半胱天冬酶的方法。该方法包括使IAP抑制的半胱天冬酶与有效量的试剂接触以对抑制IAP-抑制的半胱天冬酶进行脱保护，该试剂具有选自核心肽的核心基序，所述核心基序具有核心肽 4至39和42至55，以及选自TPI759，TPI882，TPI914或TPI927的核心结构。本发明的方法还可用于促进细胞凋亡和降低以凋亡水平降低为特征的病理学的严重性。还提供了用于鉴定抑制IAP抑制的半胱天冬酶的药剂的方法。

5. 发明授权

US09115061B2 Naphthalene-based inhibitors of anti-apoptotic proteins 有权
标题翻译：基于萘的抗凋亡蛋白抑制剂
公开(公告)号：US09115061B2
公开(公告)日：2015-08-25
申请号：US12253918
申请日：2008-10-17
申请人： Maurizio Pellecchia , John C. Reed
发明人： Maurizio Pellecchia , John C. Reed
IPC分类号： C07C239/00 , C07C39/14 , C07C47/575 , C07C49/83 , C07C49/84 , C07C235/66 , C07C311/29 , C07D277/64
CPC分类号： C07C39/14 , C07C47/575 , C07C49/83 , C07C49/84 , C07C235/66 , C07C311/29 , C07C2601/08 , C07C2601/14 , C07D277/64
摘要： Methods of using apogossypol and its derivatives for treating inflammation is disclosed. Also, there is described a group of compounds having structure A, or a pharmaceutically acceptable salt, hydrate, N-oxide, or solvate thereof are provided: wherein each R is independently selected from the group consisting of H, C(O)X, C(O)NHX, NH(CO)X, SO2NHX, and NHSO2X, wherein X is selected from the group consisting of an alkyl, a substituted alkyl, an aryl, a substituted aryl, an alkylaryl, and a heterocycle. Compounds of group A may be used for treating various diseases or disorders, such as cancer.
摘要翻译：公开了使用果糖酚及其衍生物治疗炎症的方法。此外，提供了一组具有结构A的化合物或其药学上可接受的盐，水合物，N-氧化物或溶剂合物：其中每个R独立地选自H，C（O）X， C（O）NHX，NH（CO）X，SO2NHX和NHSO2X，其中X选自烷基，取代的烷基，芳基，取代的芳基，烷基芳基和杂环。 A组的化合物可用于治疗各种疾病或病症，例如癌症。

6. 发明申请

US20130224182A1 BCL-G POLYPEPTIDES, ENCODING NUCLEIC ACIDS AND METHODS OF USE 审中-公开
标题翻译： BCL-G多肽，编码核酸和使用方法
公开(公告)号：US20130224182A1
公开(公告)日：2013-08-29
申请号：US13247882
申请日：2011-09-28
申请人： John C. Reed , Adam Godzik
发明人： John C. Reed , Adam Godzik
IPC分类号： C07K7/08 , C07K7/06
CPC分类号： C07K7/08 , C07K7/06 , C07K14/4747 , C07K2319/00
摘要： The invention provides Bcl-G polypeptides and encoding nucleic acids. Bcl-G polypeptides include Bcl-GL and Bcl-GS. The invention also provides mouse Bcl-G. The invention also provides vectors containing Bcl-G nucleic acids, host cells containing such vectors, Bcl-G anti-sense nucleic acids and related compositions. The invention additionally provides Bcl-G oligonucleotides that can be used to hybridize to or amplify a Bcl-G nucleic acid. Anti-Bcl-G specific antibodies are also provided. Further provided are kits containing Bcl-G nucleic acids or Bcl-G specific antibodies. Such kits and reagents can be used to diagnose cancer, monitor response to therapy, or predict the prognosis of a cancer patient. The invention additionally provides methods of modulating apoptosis using Bcl-G polypeptides, encoding nucleic acids, or compounds that modulate the activity or expression of Bcl-G polypeptides. The methods for modulating apoptosis can be used to treat diseases such as cancer.
摘要翻译：本发明提供了Bcl-G多肽和编码核酸。 Bcl-G多肽包括Bcl-GL和Bcl-GS。本发明还提供了小鼠Bcl-G。本发明还提供含有Bcl-G核酸的载体，含有这些载体的宿主细胞，Bcl-G反义核酸和相关组合物。本发明另外提供可用于与Bcl-G核酸杂交或扩增的Bcl-G寡核苷酸。还提供抗Bcl-G特异性抗体。还提供了含有Bcl-G核酸或Bcl-G特异性抗体的试剂盒。这样的试剂盒和试剂可用于诊断癌症，监测对治疗的反应或预测癌症患者的预后。本发明另外提供了使用调节Bcl-G多肽的活性或表达的Bcl-G多肽，编码核酸或化合物来调节凋亡的方法。调节凋亡的方法可用于治疗癌症等疾病。

7. 发明申请

US20110318362A1 NOVEL CARD PROTEINS INVOLVED IN CELL DEATH REGULATION 审中-公开
标题翻译：参与细胞死亡调控的新型卡片蛋白质
公开(公告)号：US20110318362A1
公开(公告)日：2011-12-29
申请号：US13205566
申请日：2011-08-08
申请人： John C. Reed
发明人： John C. Reed
IPC分类号： A61K39/395 , C12N5/10 , C12N1/21 , C12N1/19 , A61K38/45 , A61P29/00 , C12N5/071 , G01N33/574 , C12N9/96 , C07K14/47 , C07K19/00 , A61P35/00 , C07K16/40 , G01N33/566
CPC分类号： C07K14/4747 , A01K2217/05 , A61K38/00 , A61K2039/505 , C07K2319/00
摘要： The present invention provides NB-ARC and CARD-containing proteins (NACs), nucleic acid molecules encoding NACs and antibodies specific for at least one NAC. The invention further provides chimeric NAC proteins. The invention also provides screening assays for identifying an agent that can effectively alter the association of a NAC with a NAC-associated protein. The invention further provides methods of modulating apoptosis in a cell by introducing into the cell a nucleic acid molecule encoding a NAC or an antisense nucleotide sequence. The invention also provides a method of using a reagent that can specifically bind to a NAC to diagnose a pathology that is characterized by an increased or decreased level of apoptosis in a cell.
摘要翻译：本发明提供NB-ARC和含CARD蛋白（NAC），编码NAC的核酸分子和对至少一种NAC特异的抗体。本发明还提供了嵌合NAC蛋白。本发明还提供用于鉴定可有效改变NAC与NAC相关蛋白的缔合的试剂的筛选试验。本发明还提供了通过将编码NAC或反义核苷酸序列的核酸分子引入细胞来调节细胞凋亡的方法。本发明还提供了使用可以特异性结合NAC的试剂来诊断细胞凋亡水平升高或降低的病理学的方法。

8. 发明授权

US07994282B2 Card proteins involved in cell death regulation 失效
标题翻译：卡蛋白参与细胞死亡调节
公开(公告)号：US07994282B2
公开(公告)日：2011-08-09
申请号：US11874139
申请日：2007-10-17
申请人： John C. Reed
发明人： John C. Reed
IPC分类号： C07K5/00
CPC分类号： C07K14/4747 , A01K2217/05 , A61K38/00 , A61K2039/505 , C07K2319/00
摘要： The present invention provides NB-ARC and CARD-containing proteins (NACs), nucleic acid molecules encoding NACs and antibodies specific for at least one NAC. The invention further provides chimeric NAC proteins. The invention also provides screening assays for identifying an agent that can effectively alter the association of a NAC with a NAC-associated protein. The invention further provides methods of modulating apoptosis in a cell by introducing into the cell a nucleic acid molecule encoding a NAC or an antisense nucleotide sequence. The invention also provides a method of using a reagent that can specifically bind to a NAC to diagnose a pathology that is characterized by an increased or decreased level of apoptosis in a cell.
摘要翻译：本发明提供NB-ARC和含CARD蛋白（NAC），编码NAC的核酸分子和对至少一种NAC特异的抗体。本发明还提供了嵌合NAC蛋白。本发明还提供用于鉴定可有效改变NAC与NAC相关蛋白的缔合的试剂的筛选试验。本发明还提供了通过将编码NAC或反义核苷酸序列的核酸分子引入细胞来调节细胞凋亡的方法。本发明还提供了使用可以特异性结合NAC的试剂来诊断细胞凋亡水平升高或降低的病理学的方法。

9. 发明授权

US07927832B2 Nucleic acid encoding proteins involved in protein degradation, products and methods related thereto 失效
标题翻译：涉及蛋白质降解的核酸编码蛋白质，与其有关的产品和方法
公开(公告)号：US07927832B2
公开(公告)日：2011-04-19
申请号：US12132565
申请日：2008-06-03
申请人： John C. Reed , Matsuzawa Shu-ichi
发明人： John C. Reed , Matsuzawa Shu-ichi
IPC分类号： C12P21/06 , C07H17/00 , C07K14/00
CPC分类号： C07K14/47 , C07K14/00 , Y10T436/143333
摘要： In accordance with the present invention, there are provided novel Siah-Mediated-Degradation-Proteins (SMDPs) and/or SCF-Complex Proteins (SCPs). Nucleic acid sequences encoding such proteins and assays employing same are also disclosed. The invention SMDPs and/or SCPs can be employed in a variety of ways, for example, for the production of anti-SMDP and/or SCP antibodies thereto, in therapeutic compositions, and methods employing such proteins and/or antibodies for drug screening, functional genomics and other applications. Also provided are transgenic non-human mammals that express the invention protein.
摘要翻译：根据本发明，提供了新型的Siah介导的降解蛋白（SMDP）和/或SCF-复合蛋白（SCP）。还公开了编码这种蛋白质的核酸序列和使用其的测定法。本发明SMDP和/或SCP可以以各种方式使用，例如用于在治疗组合物中生产抗SMDP和/或SCP抗体，以及使用这种蛋白质和/或抗体用于药物筛选的方法，功能基因组学等应用。还提供了表达本发明蛋白质的转基因非人哺乳动物。

10. 发明申请

US20110071213A1 CARD-DOMAIN CONTAINING POLYPEPTIDES, ENCODING NUCLEIC ACIDS, AND METHODS OF USE 审中-公开
标题翻译：含有多核苷酸的多核苷酸，编码核酸的方法和使用方法
公开(公告)号：US20110071213A1
公开(公告)日：2011-03-24
申请号：US12917295
申请日：2010-11-01
申请人： Krzysztof Pawlowski , John C. Reed , Adam Godzik
发明人： Krzysztof Pawlowski , John C. Reed , Adam Godzik
IPC分类号： A61K31/7088 , C07H21/04 , C07H21/02 , C07K14/00 , C07K16/00 , C12N15/63 , C12N5/10 , C12P21/06 , C12N5/07 , G01N33/566 , C12N5/02
CPC分类号： C07K14/4702 , A01K2217/05 , A01K2227/105 , A61K38/00
摘要： The invention provides caspase recruitment domain (CARD)-containing polypeptides and functional fragments thereof, encoding nucleic acid molecules, and specific antibodies. Also provided are screening methods for identifying CARD-associated polypeptides (CAPs), and for identifying agents that alter the association of a CARD-containing polypeptide with itself or with a CAP. Further provided are methods of altering a biochemical process modulated by a CARD-containing polypeptide, and methods of diagnosing a pathology characterized by an increased or decreased level of a CARD-containing polypeptide.
摘要翻译：本发明提供了含有胱天蛋白酶募集区（CARD）的多肽及其功能片段，编码核酸分子和特异性抗体。还提供了用于鉴定CARD相关多肽（CAP）的筛选方法，以及用于鉴定改变含CARD的多肽与其自身或与CAP的缔合的试剂。还提供了改变由含CARD的多肽调节的生物化学过程的方法，以及诊断特征在于含CARD的多肽的水平升高或降低的病理学的方法。

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