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1. 发明授权

US07626001B2 Card domain containing polypeptides, encoding nucleic acids, and methods of use 失效
公开(公告)号：US07626001B2
公开(公告)日：2009-12-01
申请号：US11728892
申请日：2007-03-26
申请人： John C. Reed , Frederick F. Pio , Adam Godzik , Christian Stehlik , Jason S. Damiano , Sug Hyung Lee , Vasco A. Oliveira , Hideki Hayashi , Kryzysztof Pawlowski
发明人： John C. Reed , Frederick F. Pio , Adam Godzik , Christian Stehlik , Jason S. Damiano , Sug Hyung Lee , Vasco A. Oliveira , Hideki Hayashi , Kryzysztof Pawlowski
IPC分类号： C07K14/00
CPC分类号： G06F17/3089 , C07K14/4702 , C07K2319/00 , G06F17/30699
摘要： The invention provides caspase recruitment domain (CARD)-containing polypeptides, CARD, NB-ARC, ANGIO-R, LRR and SAM domains therefrom, as well as encoding nucleic acid molecules and specific antibodies. The invention also provides related screening, diagnostic and therapeutic methods.

2. 发明申请

US20110008319A1 CARD DOMAIN CONTAINING POLYPEPTIDES, ENCODING NUCLEIC ACIDS, AND METHODS OF USE 审中-公开
标题翻译：含有多核苷酸的多核苷酸，编码核酸的方法和使用方法
公开(公告)号：US20110008319A1
公开(公告)日：2011-01-13
申请号：US12628136
申请日：2009-11-30
申请人： John C. Reed , Frederick F. Pio , Adam Godzik , Christian Stehlik , Jason S. Damiano , Sug Hyung Lee , Vasco A. Oliveira , Hideki Hayashi , Kryzysztof Pawlowski
发明人： John C. Reed , Frederick F. Pio , Adam Godzik , Christian Stehlik , Jason S. Damiano , Sug Hyung Lee , Vasco A. Oliveira , Hideki Hayashi , Kryzysztof Pawlowski
IPC分类号： A61K39/395 , C07H21/04 , C07K14/00 , C07K7/06 , A61P35/00 , C12N15/63 , C12N5/10
CPC分类号： G06F16/958 , C07K14/4702 , C07K2319/00 , G06F16/335
摘要： The invention provides caspase recruitment domain (CARD)-containing polypeptides, CARD, NB-ARC, ANGIO-R, LRR and SAM domains therefrom, as well as encoding nucleic acid molecules and specific antibodies. The invention also provides related screening, diagnostic and therapeutic methods.
摘要翻译：本发明提供了含有胱天蛋白酶募集区（CARD）的多肽，CARD，NB-ARC，ANGIO-R，LRR和SAM结构域，以及编码核酸分子和特异性抗体。本发明还提供了相关的筛选，诊断和治疗方法。

3. 发明授权

US07196182B2 Card domain containing polypeptides, encoding nucleic acids, and methods of use 失效
标题翻译：包含多肽的卡结构域，编码核酸和使用方法
公开(公告)号：US07196182B2
公开(公告)日：2007-03-27
申请号：US09864921
申请日：2001-05-23
申请人： John C. Reed , Frederick F. Pio , Adam Godzik , Christian Stehlik , Jason S. Damiano , Sug Hyung Lee , Vasco A. Oliveira , Hideki Hayashi , Krzysztof Pawlowski
发明人： John C. Reed , Frederick F. Pio , Adam Godzik , Christian Stehlik , Jason S. Damiano , Sug Hyung Lee , Vasco A. Oliveira , Hideki Hayashi , Krzysztof Pawlowski
IPC分类号： C07H21/02 , C12Q1/68
CPC分类号： G06F17/3089 , C07K14/4702 , C07K2319/00 , G06F17/30699
摘要： The invention provides caspase recruitment domain (CARD)-containing polypeptides, CARD, NB-ARC, ANGIO-R, LRR and SAM domains therefrom, as well as encoding nucleic acid molecules and specific antibodies. The invention also provides related screening, diagnostic and therapeutic methods.
摘要翻译：本发明提供了含有胱天蛋白酶募集区（CARD）的多肽，CARD，NB-ARC，ANGIO-R，LRR和SAM结构域，以及编码核酸分子和特异性抗体。本发明还提供了相关的筛选，诊断和治疗方法。

4. 发明申请

US20090011501A1 NOVEL DEATH DOMAIN PROTEINS 审中-公开
标题翻译：新的死亡蛋白质蛋白
公开(公告)号：US20090011501A1
公开(公告)日：2009-01-08
申请号：US12134169
申请日：2008-06-05
申请人： John C. Reed , Adam Godzik , Krzysztof Pawlowski , Loredana Fiorentino , Sug Hyung Lee , Wilfried Roth , Frank Stenner-Liewen
发明人： John C. Reed , Adam Godzik , Krzysztof Pawlowski , Loredana Fiorentino , Sug Hyung Lee , Wilfried Roth , Frank Stenner-Liewen
IPC分类号： C12N5/06 , C07K14/00 , C12N15/11 , C12N15/00
CPC分类号： C07K14/295 , C07K14/4747 , C07K2319/00
摘要： In accordance with the present invention, there are provided novel Death Domain (DD), Death Effector Domain (DED) and NB-ARC domain proteins. The invention also provides nucleic acid molecules encoding DD, DED and NB-ARC domain proteins, vectors containing these nucleic acid molecules and host cells containing the vectors. The invention also provides antibodies that can specifically bind to invention DDs, DEDs or NB-ARC domains. Such DDs, DEDs and NB-ARC domains and/or anti-DD, anti-DED or anti-NB-ARC domain antibodies are useful for discovery of drugs that suppress infection, autoimmunity, inflammation, allergy, allograft rejection, sepsis, and other diseases.
摘要翻译：根据本发明，提供了新的死亡域（DD），死亡效应域（DED）和NB-ARC结构域蛋白。本发明还提供编码DD，DED和NB-ARC结构域蛋白的核酸分子，含有这些核酸分子的载体和含有载体的宿主细胞。本发明还提供可以特异性结合发明DD，DED或NB-ARC结构域的抗体。这些DDs，DEDs和NB-ARC结构域和/或抗DD，抗DED或抗NB-ARC结构域抗体可用于发现抑制感染，自身免疫，炎症，过敏，同种异体移植排斥，败血症等的药物疾病

5. 发明授权

US06965023B2 Death domain proteins 失效
标题翻译：死亡域蛋白
公开(公告)号：US06965023B2
公开(公告)日：2005-11-15
申请号：US10001254
申请日：2001-11-15
申请人： John C. Reed , Adam Godzik , Krzysztof Pawlowski , Loredana Fiorentino , Sug Hyung Lee , Wilfried Roth , Frank Stenner-Liewen
发明人： John C. Reed , Adam Godzik , Krzysztof Pawlowski , Loredana Fiorentino , Sug Hyung Lee , Wilfried Roth , Frank Stenner-Liewen
IPC分类号： C07K14/295 , C07K14/47 , C07H21/02 , C12N5/00 , C12N15/00 , C12P21/06
CPC分类号： C07K14/295 , C07K14/4747 , C07K2319/00
摘要： In accordance with the present invention, there are provided novel Death Domain (DD), Death Effector Domain (DED) and NB-ARC domain proteins. The invention also provides nucleic acid molecules encoding DD, DED and NB-ARC domain proteins, vectors containing these nucleic acid molecules and host cells containing the vectors. The invention also provides antibodies that can specifically bind to invention DDs, DEDs or NB-ARC domains. Such DDs, DEDs and NB-ARC domains and/or anti-DD, anti-DED or anti-NB-ARC domain antibodies are useful for discovery of drugs that suppress infection, autoimmunity, inflammation, allergy, allograft rejection, sepsis, and other diseases.
摘要翻译：根据本发明，提供了新的死亡域（DD），死亡效应域（DED）和NB-ARC结构域蛋白。本发明还提供编码DD，DED和NB-ARC结构域蛋白的核酸分子，含有这些核酸分子的载体和含有载体的宿主细胞。本发明还提供可以特异性结合发明DD，DED或NB-ARC结构域的抗体。这些DDs，DEDs和NB-ARC结构域和/或抗DD，抗DED或抗NB-ARC结构域抗体可用于发现抑制感染，自身免疫，炎症，过敏，同种异体移植排斥，败血症等的药物疾病

6. 发明申请

US20110201780A1 NOVEL DEATH DOMAIN PROTEINS 审中-公开
标题翻译：新的死亡蛋白质蛋白
公开(公告)号：US20110201780A1
公开(公告)日：2011-08-18
申请号：US13050848
申请日：2011-03-17
申请人： John C. Reed , Adam Godzik , Krzysztof Pawlowski , Loredana Fiorentino , Sug Hyung Lee , Wilfried Roth , Frank Stenner-Liewen
发明人： John C. Reed , Adam Godzik , Krzysztof Pawlowski , Loredana Fiorentino , Sug Hyung Lee , Wilfried Roth , Frank Stenner-Liewen
IPC分类号： C07K14/295
CPC分类号： C07K14/295 , C07K14/4747 , C07K2319/00
摘要： In accordance with the present invention, there are provided novel Death Domain (DD), Death Effector Domain (DED) and NB-ARC domain proteins. The invention also provides nucleic acid molecules encoding DD, DED and NB-ARC domain proteins, vectors containing these nucleic acid molecules and host cells containing the vectors. The invention also provides antibodies that can specifically bind to invention DDs, DEDs or NB-ARC domains. Such DDs, DEDs and NB-ARC domains and/or anti-DD, anti-DED or anti-NB-ARC domain antibodies are useful for discovery of drugs that suppress infection, autoimmunity, inflammation, allergy, allograft rejection, sepsis, and other diseases.
摘要翻译：根据本发明，提供了新的死亡域（DD），死亡效应域（DED）和NB-ARC结构域蛋白。本发明还提供编码DD，DED和NB-ARC结构域蛋白的核酸分子，含有这些核酸分子的载体和含有载体的宿主细胞。本发明还提供可以特异性结合发明DD，DED或NB-ARC结构域的抗体。这些DDs，DEDs和NB-ARC结构域和/或抗DD，抗DED或抗NB-ARC结构域抗体可用于发现抑制感染，自身免疫，炎症，过敏，同种异体移植排斥，败血症等的药物疾病

7. 发明授权

US07638324B2 Bcl-G polypeptides, encoding nucleic acids and methods of use 失效
标题翻译： Bcl-G多肽，编码核酸和使用方法
公开(公告)号：US07638324B2
公开(公告)日：2009-12-29
申请号：US09738396
申请日：2000-12-14
申请人： John C. Reed , Adam Godzik , Bin Guo
发明人： John C. Reed , Adam Godzik , Bin Guo
IPC分类号： C07H21/02 , C07H21/04 , C12Q1/68 , C12N5/00 , A61K31/70
CPC分类号： C07K7/08 , C07K7/06 , C07K14/4747 , C07K2319/00
摘要： The invention provides Bcl-G polypeptides and encoding nucleic acids. Bcl-G polypeptides include Bcl-GL and Bcl-GS. The invention also provides mouse Bcl-G. The invention also provides vectors containing Bcl-G nucleic acids, host cells containing such vectors, Bcl-G anti-sense nucleic acids and related compositions. The invention additionally provides Bcl-G oligonucleotides that can be used to hybridize to or amplify a Bcl-G nucleic acid. Anti-Bcl-G specific antibodies are also provided. Further provided are kits containing Bcl-G nucleic acids or Bcl-G specific antibodies. Such kits and reagents can be used to diagnose cancer, monitor response to therapy, or predict the prognosis of a cancer patient. The invention additionally provides methods of modulating apoptosis using Bcl-G polypeptides, encoding nucleic acids, or compounds that modulate the activity or expression of Bcl-G polypeptides. The methods for modulating apoptosis can be used to treat diseases such as cancer.
摘要翻译：本发明提供了Bcl-G多肽和编码核酸。 Bcl-G多肽包括Bcl-GL和Bcl-GS。本发明还提供了小鼠Bcl-G。本发明还提供含有Bcl-G核酸的载体，含有这些载体的宿主细胞，Bcl-G反义核酸和相关组合物。本发明另外提供可用于与Bcl-G核酸杂交或扩增的Bcl-G寡核苷酸。还提供抗Bcl-G特异性抗体。还提供了含有Bcl-G核酸或Bcl-G特异性抗体的试剂盒。这样的试剂盒和试剂可用于诊断癌症，监测对治疗的反应或预测癌症患者的预后。本发明另外提供了使用调节Bcl-G多肽的活性或表达的Bcl-G多肽，编码核酸或化合物来调节凋亡的方法。调节凋亡的方法可用于治疗癌症等疾病。

8. 发明申请

US20080233638A1 PAAD domain-containing polypeptides, encoding nucleic acids, and methods of use 审中-公开
标题翻译：含PAAD结构域的多肽，编码核酸和使用方法
公开(公告)号：US20080233638A1
公开(公告)日：2008-09-25
申请号：US11977647
申请日：2007-10-24
申请人： John C. Reed , Adam Godzik
发明人： John C. Reed , Adam Godzik
IPC分类号： C12N5/06 , C07H21/04 , C12N15/00 , C12N5/00 , C07K14/435 , C07K16/18
CPC分类号： C07H21/04 , C07K14/4747 , Y10T436/143333
摘要： The invention provides isolated nucleic acid molecules encoding PAAD-domain containing polypeptides and functional fragments thereof, including fragments containing PAAD domains, NACHT domains and ARED domains, encoded polypeptides, and antibodies. Also provided are methods of identifying polypeptides and agents that associate with a PAAD-domain containing polypeptide or fragment thereof, or that alter an association of a PAAD domain-containing polypeptides. Further provided are methods of identifying agents that modulate PAAD domain-mediated inhibition of NFκB activity, or modulate an activity of a NACHT domain of a PAAD domain-containing polypeptide. Also provided are methods of modulating NFκB transcriptional activity in a cell, and methods of altering expression of a PAAD domain-containing polypeptide in a cell.
摘要翻译：本发明提供编码含有PAAD结构域的多肽及其功能片段的分离的核酸分子，包括含有PAAD结构域，NACHT结构域和ARED结构域，编码多肽和抗体的片段。还提供了鉴定与含PAAD结构域的多肽或其片段缔合的多肽和试剂的方法，或改变含PAAD结构域的多肽的缔合。还提供了鉴定调节PAAD结构域介导的NFκB活性抑制或调节含有PAAD结构域的多肽的NACHT结构域的活性的试剂的方法。还提供了调节细胞中NFκB转录活性的方法，以及改变细胞中含有PAAD结构域的多肽的表达的方法。

9. 发明申请

US20130224182A1 BCL-G POLYPEPTIDES, ENCODING NUCLEIC ACIDS AND METHODS OF USE 审中-公开
标题翻译： BCL-G多肽，编码核酸和使用方法
公开(公告)号：US20130224182A1
公开(公告)日：2013-08-29
申请号：US13247882
申请日：2011-09-28
申请人： John C. Reed , Adam Godzik
发明人： John C. Reed , Adam Godzik
IPC分类号： C07K7/08 , C07K7/06
CPC分类号： C07K7/08 , C07K7/06 , C07K14/4747 , C07K2319/00
摘要： The invention provides Bcl-G polypeptides and encoding nucleic acids. Bcl-G polypeptides include Bcl-GL and Bcl-GS. The invention also provides mouse Bcl-G. The invention also provides vectors containing Bcl-G nucleic acids, host cells containing such vectors, Bcl-G anti-sense nucleic acids and related compositions. The invention additionally provides Bcl-G oligonucleotides that can be used to hybridize to or amplify a Bcl-G nucleic acid. Anti-Bcl-G specific antibodies are also provided. Further provided are kits containing Bcl-G nucleic acids or Bcl-G specific antibodies. Such kits and reagents can be used to diagnose cancer, monitor response to therapy, or predict the prognosis of a cancer patient. The invention additionally provides methods of modulating apoptosis using Bcl-G polypeptides, encoding nucleic acids, or compounds that modulate the activity or expression of Bcl-G polypeptides. The methods for modulating apoptosis can be used to treat diseases such as cancer.
摘要翻译：本发明提供了Bcl-G多肽和编码核酸。 Bcl-G多肽包括Bcl-GL和Bcl-GS。本发明还提供了小鼠Bcl-G。本发明还提供含有Bcl-G核酸的载体，含有这些载体的宿主细胞，Bcl-G反义核酸和相关组合物。本发明另外提供可用于与Bcl-G核酸杂交或扩增的Bcl-G寡核苷酸。还提供抗Bcl-G特异性抗体。还提供了含有Bcl-G核酸或Bcl-G特异性抗体的试剂盒。这样的试剂盒和试剂可用于诊断癌症，监测对治疗的反应或预测癌症患者的预后。本发明另外提供了使用调节Bcl-G多肽的活性或表达的Bcl-G多肽，编码核酸或化合物来调节凋亡的方法。调节凋亡的方法可用于治疗癌症等疾病。

10. 发明申请

US20110071213A1 CARD-DOMAIN CONTAINING POLYPEPTIDES, ENCODING NUCLEIC ACIDS, AND METHODS OF USE 审中-公开
标题翻译：含有多核苷酸的多核苷酸，编码核酸的方法和使用方法
公开(公告)号：US20110071213A1
公开(公告)日：2011-03-24
申请号：US12917295
申请日：2010-11-01
申请人： Krzysztof Pawlowski , John C. Reed , Adam Godzik
发明人： Krzysztof Pawlowski , John C. Reed , Adam Godzik
IPC分类号： A61K31/7088 , C07H21/04 , C07H21/02 , C07K14/00 , C07K16/00 , C12N15/63 , C12N5/10 , C12P21/06 , C12N5/07 , G01N33/566 , C12N5/02
CPC分类号： C07K14/4702 , A01K2217/05 , A01K2227/105 , A61K38/00
摘要： The invention provides caspase recruitment domain (CARD)-containing polypeptides and functional fragments thereof, encoding nucleic acid molecules, and specific antibodies. Also provided are screening methods for identifying CARD-associated polypeptides (CAPs), and for identifying agents that alter the association of a CARD-containing polypeptide with itself or with a CAP. Further provided are methods of altering a biochemical process modulated by a CARD-containing polypeptide, and methods of diagnosing a pathology characterized by an increased or decreased level of a CARD-containing polypeptide.
摘要翻译：本发明提供了含有胱天蛋白酶募集区（CARD）的多肽及其功能片段，编码核酸分子和特异性抗体。还提供了用于鉴定CARD相关多肽（CAP）的筛选方法，以及用于鉴定改变含CARD的多肽与其自身或与CAP的缔合的试剂。还提供了改变由含CARD的多肽调节的生物化学过程的方法，以及诊断特征在于含CARD的多肽的水平升高或降低的病理学的方法。

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