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1. 发明授权

US07783442B2 System and methods for calibrating physiological characteristic sensors 有权
标题翻译：用于校准生理特征传感器的系统和方法
公开(公告)号：US07783442B2
公开(公告)日：2010-08-24
申请号：US11931866
申请日：2007-10-31
申请人： John C. Mueller, Jr. , Desmond Barry Keenan , Lu Wang , John J. Mastrototaro
发明人： John C. Mueller, Jr. , Desmond Barry Keenan , Lu Wang , John J. Mastrototaro
IPC分类号： G06F17/40 , G06F17/00
CPC分类号： A61B5/14532 , A61B5/14865 , A61B2560/0223
摘要： A method of calibrating glucose monitor data includes collecting the glucose monitor data over a period of time at predetermined intervals, obtaining reference glucose values from a reference source that temporally correspond with the glucose monitor data obtained at the predetermined intervals, calculating the calibration characteristics using the reference glucose values and corresponding glucose monitor data to regress the obtained glucose monitor data, and calibrating the obtained glucose monitor data using the calibration characteristics. In additional embodiments, calculation of the calibration characteristics includes linear regression and, in particular embodiments, least squares linear regression. Alternatively, calculation of the calibration characteristics includes non-linear regression. Data integrity may be verified and the data may be filtered.
摘要翻译：一种校准葡萄糖监测数据的方法包括以预定间隔在一段时间内收集葡萄糖监测数据，从参考源获取参考葡萄糖值，该参考源在时间上与以预定间隔获得的葡萄糖监测数据相对应，使用参考葡萄糖值和相应的葡萄糖监测数据，以回收所获得的葡萄糖监测数据，并使用校准特征校准获得的葡萄糖监测数据。在另外的实施例中，校准特性的计算包括线性回归，并且在特定实施例中包括最小二乘线性回归。或者，校准特性的计算包括非线性回归。可以验证数据完整性，并且可以对数据进行过滤。

2. 发明授权

US08306766B2 Systems and methods for calibrating physiological characteristic sensors 有权
标题翻译：用于校准生理特征传感器的系统和方法
公开(公告)号：US08306766B2
公开(公告)日：2012-11-06
申请号：US12827851
申请日：2010-06-30
申请人： John C. Mueller, Jr. , Desmond Barry Keenan , Lu Wang , John J. Mastrototaro
发明人： John C. Mueller, Jr. , Desmond Barry Keenan , Lu Wang , John J. Mastrototaro
IPC分类号： G01N33/66 , G06F17/40
CPC分类号： A61B5/14532 , A61B5/14865 , A61B2560/0223
摘要： A method of calibrating glucose monitor data includes collecting the glucose monitor data over a period of time at predetermined intervals, obtaining reference glucose values from a reference source that temporally correspond with the glucose monitor data obtained at the predetermined intervals, calculating the calibration characteristics using the reference glucose values and corresponding glucose monitor data to regress the obtained glucose monitor data, and calibrating the obtained glucose monitor data using the calibration characteristics. In additional embodiments, calculation of the calibration characteristics includes linear regression and, in particular embodiments, least squares linear regression. Alternatively, calculation of the calibration characteristics includes non-linear regression. Data integrity may be verified and the data may be filtered.
摘要翻译：一种校准葡萄糖监测数据的方法包括以预定间隔在一段时间内收集葡萄糖监测数据，从参考源获取参考葡萄糖值，该参考源在时间上与以预定间隔获得的葡萄糖监测数据相对应，使用参考葡萄糖值和相应的葡萄糖监测数据，以回收所获得的葡萄糖监测数据，并使用校准特征校准获得的葡萄糖监测数据。在另外的实施例中，校准特性的计算包括线性回归，并且在特定实施例中包括最小二乘线性回归。或者，校准特性的计算包括非线性回归。可以验证数据完整性，并且可以对数据进行过滤。

3. 发明授权

US07727148B2 Sensing system with auxiliary display 有权
标题翻译：带辅助显示屏的感应系统
公开(公告)号：US07727148B2
公开(公告)日：2010-06-01
申请号：US11980149
申请日：2007-10-30
申请人： Cary D. Talbot , John J. Mastrototaro , Rajiv Shah , Edward Chernoff , John C. Mueller, Jr. , Varaz Shahmirian , Richard E. Purvis , Wayne A. Morgan , Rebecca K. Gottlieb
发明人： Cary D. Talbot , John J. Mastrototaro , Rajiv Shah , Edward Chernoff , John C. Mueller, Jr. , Varaz Shahmirian , Richard E. Purvis , Wayne A. Morgan , Rebecca K. Gottlieb
IPC分类号： A61B5/00
CPC分类号： A61B5/0002 , A61B5/145 , A61B5/14532 , A61B5/412 , A61B2560/0209 , A61B2560/0443 , A61B2560/0456
摘要： A system is provided for sensing blood glucose data of a patient. The system includes a sensor, user interface, and an optional auxiliary device. If the connection between the sensor and user interface is by a wire, the sensor remains powered when the wire is disconnected. The communication between the sensor and the user interface may be wireless. The auxiliary device can be a patient monitor or other display or signal device, which displays information about the blood glucose data collected by the sensor. The sensor is connected to sensor electronics, which include a sensor power supply, a voltage regulator, and optionally a memory and processor.
摘要翻译：提供了一种用于感测患者血糖数据的系统。该系统包括传感器，用户界面和可选的辅助设备。如果传感器和用户界面之间的连接是通过导线连接的，那么当导线断开时，传感器保持供电。传感器和用户界面之间的通信可能是无线的。辅助装置可以是患者监视器或其他显示器或信号装置，其显示关于由传感器收集的血糖数据的信息。传感器连接到传感器电子设备，其中包括传感器电源，电压调节器以及可选的存储器和处理器。

4. 发明授权

US09320471B2 Algorithm sensor augmented bolus estimator for semi-closed loop infusion system 有权
公开(公告)号：US09320471B2
公开(公告)日：2016-04-26
申请号：US13529278
申请日：2012-06-21
申请人： Andrew C. Hayes , John J. Mastrototaro , Sheldon B. Moberg , John C. Mueller, Jr. , H. Bud Clark , Mike Charles Vallet Tolle , Gary L. Williams , Bihong Wu , Garry M. Steil
发明人： Andrew C. Hayes , John J. Mastrototaro , Sheldon B. Moberg , John C. Mueller, Jr. , H. Bud Clark , Mike Charles Vallet Tolle , Gary L. Williams , Bihong Wu , Garry M. Steil
IPC分类号： A61B5/145 , A61M5/172 , A61B5/00 , A61M5/142 , G06F19/00
CPC分类号： A61B5/7239 , A61B5/14532 , A61M5/1723 , A61M2005/14208 , A61M2205/18 , A61M2205/35 , A61M2230/201 , G06F19/00 , G06F19/3468 , G16H40/63 , G16H50/50 , A61M2230/005
摘要： An infusion system is for infusing a fluid into the body of a patient. The infusion system includes at least one sensor for monitoring blood glucose concentration of the patient and an infusion device for delivering fluid to the patient. The sensor produces at least one sensor signal input. The infusion device uses the at least one sensor signal input and a derivative predicted algorithm to determine future blood glucose levels. The infusion device delivers fluid to the patient when future blood glucose levels are in a patient's target range. The infusion device is capable of suspending and resuming fluid delivery based on future blood glucose levels and a patient's low shutoff threshold. The infusion device suspends fluid delivery when future blood glucose levels falls below the low shutoff threshold. The infusion device resumes fluid delivery when a future blood glucose level is above the low shutoff threshold.

5. 发明授权

US08226556B2 Algorithm sensor augmented bolus estimator for semi-closed loop infusion system 有权
标题翻译：用于半闭环输注系统的算法传感器增强推注估计器
公开(公告)号：US08226556B2
公开(公告)日：2012-07-24
申请号：US12436308
申请日：2009-05-06
申请人： Andrew C. Hayes , John J. Mastrototaro , Sheldon B. Moberg , John C. Mueller, Jr. , H. Bud Clark , Mike Charles Vallet Tolle , Gary L. Williams , Bihong Wu , Garry M. Steil
发明人： Andrew C. Hayes , John J. Mastrototaro , Sheldon B. Moberg , John C. Mueller, Jr. , H. Bud Clark , Mike Charles Vallet Tolle , Gary L. Williams , Bihong Wu , Garry M. Steil
IPC分类号： A61B5/00 , A61M31/00
CPC分类号： A61B5/7239 , A61B5/14532 , A61M5/1723 , A61M2005/14208 , A61M2205/18 , A61M2205/35 , A61M2230/201 , G06F19/00 , G06F19/3468 , G16H40/63 , G16H50/50 , A61M2230/005
摘要： An infusion system is for infusing a fluid into the body of a patient. The infusion system includes at least one sensor for monitoring blood glucose concentration of the patient and an infusion device for delivering fluid to the patient. The sensor produces at least one sensor signal input. The infusion device uses the at least one sensor signal input and a derivative predicted algorithm to determine future blood glucose levels. The infusion device delivers fluid to the patient when future blood glucose levels are in a patient's target range. The infusion device is capable of suspending and resuming fluid delivery based on future blood glucose levels and a patient's low shutoff threshold. The infusion device suspends fluid delivery when future blood glucose levels falls below the low shutoff threshold. The infusion device resumes fluid delivery when a future blood glucose level is above the low shutoff threshold.
摘要翻译：输液系统用于将流体注入患者体内。输注系统包括至少一个用于监测患者的血糖浓度的传感器和用于将流体输送给患者的输注装置。传感器产生至少一个传感器信号输入。输注装置使用至少一个传感器信号输入和导数预测算法来确定未来的血糖水平。当未来的血糖水平处于患者的目标范围内时，输注装置向患者输送流体。输液装置能够基于将来的血糖水平和患者的低关闭阈值来暂停和恢复流体输送。当未来的血糖水平低于低关闭阈值时，输液装置暂停流体输送。当未来的血糖水平高于低关闭阈值时，输注装置恢复流体输送。

6. 发明授权

US07547281B2 Algorithm sensor augmented bolus estimator for semi-closed loop infusion system 有权
标题翻译：用于半闭环输注系统的算法传感器增强推注估计器
公开(公告)号：US07547281B2
公开(公告)日：2009-06-16
申请号：US11322489
申请日：2005-12-30
申请人： Andrew C. Hayes , John J. Mastrototaro , Sheldon B. Moberg , John C. Mueller, Jr. , H. Bud Clark , Mike Charles Vallet Tolle , Gary L. Williams , Bihong Wu , Garry M. Steil
发明人： Andrew C. Hayes , John J. Mastrototaro , Sheldon B. Moberg , John C. Mueller, Jr. , H. Bud Clark , Mike Charles Vallet Tolle , Gary L. Williams , Bihong Wu , Garry M. Steil
IPC分类号： A61B5/00 , A61B5/05 , A61M1/00 , A61M31/00
CPC分类号： A61B5/7239 , A61B5/14532 , A61M5/1723 , A61M2005/14208 , A61M2205/18 , A61M2205/35 , A61M2230/201 , G06F19/00 , G06F19/3468 , G16H40/63 , G16H50/50 , A61M2230/005
摘要： An infusion system is for infusing a fluid into the body of a patient. The infusion system includes at least one sensor for monitoring blood glucose concentration of the patient and an infusion device for delivering fluid to the patient. The sensor produces at least one sensor signal input. The infusion device uses the at least one sensor signal input and a derivative predicted algorithm to determine future blood glucose levels. The infusion device delivers fluid to the patient when future blood glucose levels are in a patient's target range. The infusion device is capable of suspending and resuming fluid delivery based on future blood glucose levels and a patient's low shutoff threshold. The infusion device suspends fluid delivery when future blood glucose levels falls below the low shutoff threshold. The infusion device resumes fluid delivery when a future blood glucose level is above the low shutoff threshold.
摘要翻译：输液系统用于将流体注入患者体内。输注系统包括至少一个用于监测患者的血糖浓度的传感器和用于将流体输送给患者的输注装置。传感器产生至少一个传感器信号输入。输注装置使用至少一个传感器信号输入和导数预测算法来确定未来的血糖水平。当未来的血糖水平处于患者的目标范围内时，输注装置向患者输送流体。输液装置能够基于将来的血糖水平和患者的低关闭阈值来暂停和恢复流体输送。当未来的血糖水平低于低关闭阈值时，输液装置暂停流体输送。当未来的血糖水平高于低关闭阈值时，输注装置恢复流体输送。

7. 发明授权

US08512276B2 System for providing blood glucose measurements to an infusion device 有权
标题翻译：用于向输注装置提供血糖测量的系统
公开(公告)号：US08512276B2
公开(公告)日：2013-08-20
申请号：US10867529
申请日：2004-06-14
申请人： Cary D. Talbot , Mark C. Estes , John J. Mastrototaro , Sheldon B. Moberg , John C. Mueller, Jr. , “Mike” Charles Vallet Tolle , Gary L. Williams
发明人： Cary D. Talbot , Mark C. Estes , John J. Mastrototaro , Sheldon B. Moberg , John C. Mueller, Jr. , “Mike” Charles Vallet Tolle , Gary L. Williams
IPC分类号： A61M5/30
CPC分类号： A61M5/1723 , A61B5/0002 , A61B5/01 , A61B5/031 , A61B5/14532 , A61B2562/0295 , A61M5/14244 , A61M2005/1405 , A61M2205/18 , A61M2205/3576 , A61M2205/3584 , A61M2205/3592 , A61M2205/52 , A61M2209/01 , A61M2230/201
摘要： An infusion system includes an infusion device and a sensing device. The infusion system may further include a characteristic determining device. The infusion device also includes a communication system for transmitting to and receiving communications from the sensing device or a computer. The sensing device may sense an analyte of a bodily fluid of the user. The analyte may be calibrated using data from the infusion device and from a characteristic determining device. The system may be set up to automatically call for assistance when analytes reach a certain level.
摘要翻译：输液系统包括输液装置和感测装置。输注系统还可以包括特征确定装置。输注装置还包括用于向感测装置或计算机发送和接收通信的通信系统。感测装置可感测使用者体液的分析物。可以使用来自输注装置和特征确定装置的数据校准分析物。当分析物达到一定水平时，系统可以设置为自动寻求帮助。

8. 发明授权

US07344500B2 Sensing system with auxiliary display 有权
标题翻译：带辅助显示屏的感应系统
公开(公告)号：US07344500B2
公开(公告)日：2008-03-18
申请号：US10899623
申请日：2004-07-27
申请人： Cary D. Talbot , John J. Mastrototaro , Rajiv Shah , Edward Chernoff , John C. Mueller, Jr. , Varaz Shahmirian , Richard E. Purvis , Wayne A. Morgan , Rebecca K. Gottlieb
发明人： Cary D. Talbot , John J. Mastrototaro , Rajiv Shah , Edward Chernoff , John C. Mueller, Jr. , Varaz Shahmirian , Richard E. Purvis , Wayne A. Morgan , Rebecca K. Gottlieb
IPC分类号： A61B5/00
CPC分类号： A61B5/0002 , A61B5/145 , A61B5/14532 , A61B5/412 , A61B2560/0209 , A61B2560/0443 , A61B2560/0456
摘要： A system is provided for sensing blood glucose data of a patient. The system includes a sensor, user interface, and an optional auxiliary device. If the connection between the sensor and user interface is by a wire, the sensor remains powered when the wire is disconnected. The communication between the sensor and the user interface may be wireless. The auxiliary device can be a patient monitor or other display or signal device, which displays information about the blood glucose data collected by the sensor. The sensor is connected to sensor electronics, which include a sensor power supply, a voltage regulator, and optionally a memory and processor.
摘要翻译：提供了一种用于感测患者血糖数据的系统。该系统包括传感器，用户界面和可选的辅助设备。如果传感器和用户界面之间的连接是通过导线连接的，那么当导线断开时，传感器保持供电。传感器和用户界面之间的通信可能是无线的。辅助装置可以是患者监视器或其他显示器或信号装置，其显示关于由传感器收集的血糖数据的信息。传感器连接到传感器电子设备，其中包括传感器电源，电压调节器以及可选的存储器和处理器。

9. 发明授权

US07704226B2 External infusion device with programmable capabilities to time-shift basal insulin and method of using the same 有权
标题翻译：具有可移植基础胰岛素的可编程能力的外部输注装置及其使用方法
公开(公告)号：US07704226B2
公开(公告)日：2010-04-27
申请号：US11282453
申请日：2005-11-17
申请人： John C. Mueller, Jr. , Carol L. Davis , Paul H. Kovelman , Mike Charles Vallet Tolle , Gary L. Williams , Linda I. Torres
发明人： John C. Mueller, Jr. , Carol L. Davis , Paul H. Kovelman , Mike Charles Vallet Tolle , Gary L. Williams , Linda I. Torres
IPC分类号： A61M5/172
CPC分类号： A61M5/14244 , A61M2005/14208 , A61M2205/3576 , G06F19/00 , G06F19/3468
摘要： An external infusion device for delivering insulin from a reservoir into a body of a user includes the capability to deliver time-shifted basal insulin. The external infusion device includes at least one drive mechanism operatively couplable to the reservoir to deliver insulin into the body of the user, at least one processor to control the external infusion device, at least one power supply, at least one display device operatively coupled to the processor to provide visual information to the user, at least one input device operatively coupled to the processor to allow the user to command the processor, and a housing. Time-shifting of basal insulin occurs when a portion of basal insulin is added to a bolus, to a current basal rate, or to a bolus and a current basal rate.
摘要翻译：用于将胰岛素从储存器输送到使用者体内的外部输注装置包括递送时移基础胰岛素的能力。外部输注装置包括至少一个驱动机构，其可操作地连接到储存器，以将胰岛素输送到使用者的身体中，至少一个处理器来控制外部输注装置，至少一个电源，至少一个显示装置，所述处理器向用户提供视觉信息，至少一个输入设备，可操作地耦合到处理器以允许用户命令处理器和外壳。当将基础胰岛素的一部分加入到丸剂中时，基础胰岛素的时间转移发生，当前的基础速率，或推注和当前的基础速率。

10. 发明授权

US07399277B2 System for monitoring physiological characteristics 有权
标题翻译：监测生理特征的系统
公开(公告)号：US07399277B2
公开(公告)日：2008-07-15
申请号：US10860114
申请日：2004-06-03
申请人： Frank Saidara , John Joseph Mastrototaro , Charles Vallet Tolle , John C. Mueller, Jr. , Jeff B. Sanders , Edward S. Nielsen
发明人： Frank Saidara , John Joseph Mastrototaro , Charles Vallet Tolle , John C. Mueller, Jr. , Jeff B. Sanders , Edward S. Nielsen
IPC分类号： A61B5/00
CPC分类号： A61B5/0002 , A61B5/14532 , A61B5/1468 , A61B5/1486 , A61B5/1495 , A61B5/7275 , A61B5/7282 , A61B5/746 , A61B2560/0223 , A61B2560/0252 , A61B2560/045 , G01N33/48792 , G06F19/00 , G06F19/3418 , G06F19/3456 , G16H15/00 , G16H40/63
摘要： Apparatuses and methods for medical monitoring physiological characteristic values such as blood glucose levels for the treatment of diabetes, are presented. The apparatuses and methods provide for preventing any negative consequence in the operation of a monitor and/or infusion device as a result of disorientation that may occur from waking from slumber with a low blood glucose level. In addition, a graphical display is disclosed incorporating a variety of enhancements which readily conveys to the user historical as well as real time information regarding the measured characteristic value.
摘要翻译：提出了用于医学监测生理特征值（例如用于治疗糖尿病的血糖水平）的装置和方法。这些装置和方法提供了防止由于从具有低血糖水平的睡眠中醒来可能发生的定向障碍导致监视器和/或输注装置的操作中的任何负面后果。此外，公开了一种图形显示，其包括易于传达给用户历史的各种增强以及关于测量的特征值的实时信息。

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