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1. 发明授权

US07858666B2 IRE-1α inhibitors 有权
标题翻译： IRE-1α抑制剂
公开(公告)号：US07858666B2
公开(公告)日：2010-12-28
申请号：US12135571
申请日：2008-06-09
申请人： John B. Patterson , David G. Lonergan , Gary A. Flynn , Qingping Zeng , Peter V. Pallai
发明人： John B. Patterson , David G. Lonergan , Gary A. Flynn , Qingping Zeng , Peter V. Pallai
IPC分类号： A01N35/00 , A61K31/00 , C07C47/00
CPC分类号： C07C65/21 , A61K31/11 , A61K31/135 , A61K31/166 , A61K31/192 , A61K31/357 , A61K31/381 , A61K31/505 , A61K31/5375 , A61K31/5377 , C07C47/55 , C07C47/565 , C07C47/575 , C07C65/11 , C07C65/26 , C07C65/30 , C07C205/44 , C07C205/61 , C07C223/02 , C07C233/65 , C07C235/42 , C07C235/84 , C07C251/24 , C07C317/24 , C07C321/04 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D213/48 , C07D213/64 , C07D213/69 , C07D213/74 , C07D215/14 , C07D217/16 , C07D231/12 , C07D235/08 , C07D239/26 , C07D239/54 , C07D241/18 , C07D249/18 , C07D261/08 , C07D277/34 , C07D295/125 , C07D295/15 , C07D295/192 , C07D307/80 , C07D317/54 , C07D319/08 , C07D319/18 , C07D321/10 , C07D333/22 , C07D333/58 , C07D401/12 , C07D403/12 , C07D417/10 , Y02A50/389 , Y02A50/393
摘要： Compounds which directly inhibit IRE-1α activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response and can be used as single agents or in combination therapies.
摘要翻译：在体外直接抑制IRE-1α活性的化合物，其前药和药学上可接受的盐。这样的化合物和前药可用于治疗与未折叠的蛋白质应答相关的疾病，并可用作单一药剂或联合疗法。

2. 发明授权

US08689866B2 Automated systems and methods for make-up and break-out of tubulars 有权
公开(公告)号：US08689866B2
公开(公告)日：2014-04-08
申请号：US13096501
申请日：2011-04-28
申请人： John B. Patterson , Roman K. Nowak , Justin M. Jarski , Stanislaw C. Sulima
发明人： John B. Patterson , Roman K. Nowak , Justin M. Jarski , Stanislaw C. Sulima
IPC分类号： E21B19/16
CPC分类号： E21B19/165
摘要： An automated tubular handling system adapted to make-up or break-out tubulars that includes a rotary drive adapted to operatively grip a tubular to be connected to or disconnected from a tubular string, a controller adapted to receive and process data indicative of a rotation, torque, and minimum time value associated with a make-up or a break-out of the tubular string, and a user interface adapted to convey the received data, the predetermined values, or both, of the tubular make-up or break-out to an operator. The controller compares the rotation, torque, and minimum time values to acceptable predetermined values to determine when the make-up or the break-out is complete. Automated methods are also disclosed.

3. 发明申请

US20140076548A1 AUTOMATED SYSTEMS AND METHODS FOR MAKE-UP AND BREAK-OUT OF TUBULARS 有权
标题翻译：自动化系统和方法，用于管理和断开管道
公开(公告)号：US20140076548A1
公开(公告)日：2014-03-20
申请号：US14069060
申请日：2013-10-31
申请人： John B. Patterson , Roman A. Nowak , Justin M. Jarski , Stanislaw C. Sulima
发明人： John B. Patterson , Roman A. Nowak , Justin M. Jarski , Stanislaw C. Sulima
IPC分类号： E21B19/16
CPC分类号： E21B19/165
摘要： An automated tubular handling system adapted to make-up or break-out tubulars that includes a rotary drive adapted to operatively grip a tubular to be connected to or disconnected from a tubular string, a controller adapted to receive and process data indicative of a rotation, torque, and minimum time value associated with a make-up or a break-out of the tubular string, and a user interface adapted to convey the received data, the predetermined values, or both, of the tubular make-up or break-out to an operator. The controller compares the rotation, torque, and minimum time values to acceptable predetermined values to determine when the make-up or the break-out is complete. Automated methods are also disclosed.
摘要翻译：一种自动化管状处理系统，适用于组装或拆卸管状物，其包括旋转驱动装置，其适于操作地夹持要连接到管状管柱或从管状管线断开的管状物;适于接收和处理指示旋转的数据的控制器，扭矩和与管状串的组装或断裂相关联的最小时间值，以及适于传送管状构成或分离的接收数据，预定值或两者的用户界面给运营商控制器将旋转，扭矩和最小时间值与可接受的预定值进行比较，以确定化妆或分离完成时间。还公开了自动化方法。

4. 发明授权

US09206657B2 Weight-based interlock apparatus and methods 有权
标题翻译：基于重量的联锁装置和方法
公开(公告)号：US09206657B2
公开(公告)日：2015-12-08
申请号：US13296932
申请日：2011-11-15
申请人： Beat Küttel , John B. Patterson
发明人： Beat Küttel , John B. Patterson
IPC分类号： E21B19/16 , E21B41/00 , E21B19/06
CPC分类号： E21B19/165 , E21B19/06 , E21B41/0021
摘要： A weight-based tubular interlock apparatus adapted to determine whether a tubular is engagingly gripped by a rig-based hoisting device or a secondary gripping device is described. The apparatus includes at least two gripping mechanisms and an interlock system operatively connected that is adapted to measure a tubular load on at least one of the gripping mechanisms and to compare the tubular load to a predetermined load to deter nine whether the at least one gripping mechanism is gripping the tubular. The gripping mechanism is adapted to release the tubular only when the tubular load meets the predetermined load, upon which a release force sufficient to release the tubular from the gripping mechanism is applied to the tubular relative to the gripping mechanism. Methods of using the interlock apparatus are also described.
摘要翻译：描述了一种重量为基础的管状互锁装置，其适于确定管是否由基于钻机的提升装置或辅助夹紧装置啮合地夹紧。该装置包括至少两个抓握机构和可操作地连接的互锁系统，其适于测量至少一个夹持机构上的管状载荷，并将管状载荷与预定的载荷进行比较以阻止所述至少一个夹持机构正在抓住管状物。夹紧机构仅当管状负载满足预定负载时才释放管状物，在该预定负载上，相对于夹持机构将足以将管状件从夹紧机构释放的释放力施加到管状体上。还描述了使用联锁装置的方法。

5. 发明申请

US20130118760A1 WEIGHT-BASED INTERLOCK APPARATUS AND METHODS 有权
标题翻译：基于重量的互锁装置和方法
公开(公告)号：US20130118760A1
公开(公告)日：2013-05-16
申请号：US13296932
申请日：2011-11-15
申请人： Beat Küttel , John B. Patterson
发明人： Beat Küttel , John B. Patterson
IPC分类号： E21B19/02 , E21B23/00
CPC分类号： E21B19/165 , E21B19/06 , E21B41/0021
摘要： A weight-based tubular interlock apparatus adapted to determine whether a tubular is engagingly gripped by a rig-based hoisting device or a secondary gripping device is described. The apparatus includes at least two gripping mechanisms and an interlock system operatively connected that is adapted to measure a tubular load on at least one of the gripping mechanisms and to compare the tubular load to a predetermined load to deter nine whether the at least one gripping mechanism is gripping the tubular. The gripping mechanism is adapted to release the tubular only when the tubular load meets the predetermined load, upon which a release force sufficient to release the tubular from the gripping mechanism is applied to the tubular relative to the gripping mechanism. Methods of using the interlock apparatus are also described.
摘要翻译：描述了一种重量为基础的管状互锁装置，其适于确定管是否由基于钻机的提升装置或辅助夹紧装置啮合地夹紧。该装置包括至少两个抓握机构和可操作地连接的互锁系统，其适于测量至少一个夹持机构上的管状载荷，并将管状载荷与预定的载荷进行比较以阻止所述至少一个夹持机构正在抓住管状物。夹紧机构仅当管状负载满足预定负载时才释放管状物，在该预定负载上，相对于夹持机构将足以将管状件从夹紧机构释放的释放力施加到管状体上。还描述了使用联锁装置的方法。

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