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1. 发明授权

US07091313B2 Synthesis of template-fixed β-hairpin loop mimetics 有权
标题翻译：模板固定β-发夹环模拟物的合成
公开(公告)号：US07091313B2
公开(公告)日：2006-08-15
申请号：US11029331
申请日：2005-01-05
申请人： John A. Robinson , Daniel Obrecht
发明人： John A. Robinson , Daniel Obrecht
IPC分类号： A61K38/00
CPC分类号： C07K7/06 , C07K1/04 , C07K7/02 , C07K7/08 , C07K7/64
摘要： Template-fixed β-hairpin loop mimetics comprising a template corresponding to one of the structures (a), (b), (c), (d), (e), (f), (g), (h) and a template-fixed chain of 4 to 20 α-amino acid residues which, if their α-C atom is asymmetric, have L-configuration can be manufactured by a novel process which is based on a mixed solid- and solution phase synthetic strategy. If desired, this process can be modified to give the enantiomers of these template-fixed β-hairpin loop mimetics. These enantiomers are novel compounds, and many of said template-fixed β-hairpin loop mimetics themselves are also novel compounds. The template-fixed β-hairpin loop mimetics and their enantiomers can mimic flat surfaces of proteins and thus be used to probe large surface protein-protein interactions. Accordingly they can serve as lead finding tools for protein targets where it is difficult to find small-molecular-weight lead compounds.
摘要翻译：模板固定的β-发夹环模拟物，其包含对应于结构（a），（b），（c），（d），（e），（f），（g），（h）和 4至20个α-氨基酸残基的模板固定链，如果它们的α-C原子是不对称的，则具有L-构型可以通过基于混合固相和溶液相合成策略的新方法制备。如果需要，可以修饰该方法以得到这些模板固定的β-发夹环模拟物的对映异构体。这些对映体是新化合物，许多所述模板固定的β-发夹环模拟物本身也是新的化合物。模板固定的β-发夹环模拟物及其对映体可以模拟蛋白质的平坦表面，因此可用于探测大的表面蛋白质 - 蛋白质相互作用。因此，它们可以作为难以发现小分子量铅化合物的蛋白质靶标的主要发现工具。

2. 发明授权

US06878804B1 Synthesis of template-fixed β-hairpin loop mimetics 有权
标题翻译：模板固定β-发夹环模拟物的合成
公开(公告)号：US06878804B1
公开(公告)日：2005-04-12
申请号：US10070217
申请日：1999-08-30
申请人： John A. Robinson , Daniel Obrecht
发明人： John A. Robinson , Daniel Obrecht
IPC分类号： C07K5/10 , C07H21/04 , C07K1/04 , C07K7/02 , C07K7/06 , C07K7/08 , C07K7/64 , C07K14/00 , G01N33/53 , A61K38/04 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00
CPC分类号： C07K7/06 , C07K1/04 , C07K7/02 , C07K7/08 , C07K7/64
摘要： Template-fixed β-hairpin loop mimetics comprising a template corresponding to one of the structures (a), (b), (c), (d), (e), (f), (g), (h) and a template-fixed chain of 4 to 20 α-amino acid residues which, if their α-C atom is asymmetric, have L-configuration can be manufactured by a novel process which is based on a mixed solid- and solution phase synthetic strategy. If desired, this process can be modified to give the enantiomers of these template-fixed β-hairpin loop mimetics. These enantiomers are novel compounds, and many of said template-fixed β-hairpin loop mimetics themselves are also novel compounds. The template-fixed β-hairpin loop mimetics and their enantiomers can mimick flat surfaces of proteins and thus be used to probe large surface protein-protein interactions. Accordingly they can serve as lead finding tools for protein targets where it is difficult to find small-molecular-weight lead compounds.
摘要翻译：模板固定的β-发夹环模拟物，其包含对应于结构（a），（b），（c），（d），（e），（f），（g），（h）和 4至20个α-氨基酸残基的模板固定链，如果它们的α-C原子是不对称的，则具有L-构型可以通过基于混合固相和溶液相合成策略的新方法制备。如果需要，可以修饰该方法以得到这些模板固定的β-发夹环模拟物的对映异构体。这些对映体是新化合物，许多所述模板固定的β-发夹环模拟物本身也是新的化合物。模板固定的β-发夹环模拟物及其对映异构体可以模拟蛋白质的平坦表面，因此可用于探测大表面蛋白质 - 蛋白质相互作用。因此，它们可以作为难以发现小分子量铅化合物的蛋白质靶标的主要发现工具。

3. 发明授权

US07647467B1 Tuning DRAM I/O parameters on the fly 有权
标题翻译：即时调整DRAM I / O参数
公开(公告)号：US07647467B1
公开(公告)日：2010-01-12
申请号：US11642368
申请日：2006-12-19
申请人： Brian D. Hutsell , Sameer M. Gauria , Philip R. Manela , John A. Robinson
发明人： Brian D. Hutsell , Sameer M. Gauria , Philip R. Manela , John A. Robinson
IPC分类号： G06F12/00
CPC分类号： G06F13/4239
摘要： On the fly tuning of parameters used in an interface between a memory (e.g. high speed memory such as DRAM) and a processor requesting access to the memory. In an operational mode, a memory controller couples the processor to the memory. The memory controller can also inhibit the operational mode to initiate a training mode. In the training mode, the memory controller tunes one or more parameters (voltage references, timing skews, etc.) used in an upcoming operational mode. The access to the memory may be from an isochronous process running on a graphics processor. The memory controller determines whether the isochronous process may be inhibited before entering the training mode. If memory buffers for the isochronous process are such that the training mode will not impact the isochronous process, then the memory controller can enter the training mode to tune the interface parameters without negatively impacting the process.
摘要翻译：在用于存储器（例如，诸如DRAM的高速存储器）和请求访问存储器的处理器之间的接口中使用的参数的飞行调谐。在操作模式中，存储器控制器将处理器耦合到存储器。存储器控制器还可以禁止操作模式启动训练模式。在训练模式下，存储器控制器调节在即将到来的操作模式中使用的一个或多个参数（电压参考，时序偏移等）。对存储器的访问可以来自在图形处理器上运行的同步进程。存储器控制器确定在进入训练模式之前是否可以禁止同步过程。如果同步过程的存储器缓冲器使得训练模式不会影响同步过程，则存储器控制器可以进入训练模式以调整接口参数而不会不利地影响该过程。

4. 发明申请

US20100015173A1 COILED-COIL LIPOPEPTIDE HELICAL BUNDLES AND SYNTHETIC VIRUS-LIKE PARTICLES 有权
标题翻译：卷线圈纤维蛋白胆固醇和合成病毒颗粒
公开(公告)号：US20100015173A1
公开(公告)日：2010-01-21
申请号：US12518269
申请日：2007-12-06
申请人： Francesca Boato , Annabelle Freund , Arin Ghasparian , Kerstin Moehle , John A. Robinson , Richard M. Thomas
发明人： Francesca Boato , Annabelle Freund , Arin Ghasparian , Kerstin Moehle , John A. Robinson , Richard M. Thomas
IPC分类号： A61K39/385 , C07K14/00 , C07K19/00 , C07K1/00 , A61P37/00 , A61P31/12
CPC分类号： C12N7/00 , A61K39/015 , A61K39/12 , A61K39/21 , A61K2039/5258 , A61K2039/545 , A61K2039/55516 , A61K2039/55566 , C07K14/005 , C12N2740/16023 , C12N2740/16122 , C12N2740/16134 , Y02A50/412
摘要： The invention relates to lipopeptide building blocks consisting of a peptide chain comprising a coiled-coil domain, linked covalently to a lipid moiety comprising long alkyl or alkenyl chains, and optionally linked to an antigen; and to helical lipopeptide bundles and synthetic virus-like particles formed by aggregation. The nanometer size and shape of these bundles and particles, their stability under aqueous physiological conditions, their chemical composition, the possibility to incorporate B- and T-cell epitopes, and their production by chemical synthesis, make them highly suitable as vaccine delivery vehicles.
摘要翻译：本发明涉及由包含卷曲螺旋结构域的肽链组成的脂肽结构单元，其与包含长烷基或烯基链的脂质部分共价连接，并任选与抗原连接; 以及通过聚集形成的螺旋脂肽束和合成病毒样颗粒。这些束和颗粒的纳米尺寸和形状，它们在水性生理条件下的稳定性，它们的化学组成，结合B-和T细胞表位的可能性及其通过化学合成的生产，使得它们非常适合作为疫苗递送载体。

5. 发明授权

US06289627B1 Folding stowable trolling rig for multiple fishing rods 失效
标题翻译：用于多个钓鱼竿的折叠收起拖钓机
公开(公告)号：US06289627B1
公开(公告)日：2001-09-18
申请号：US09431592
申请日：1999-11-01
申请人： Louis L. Gibbs , John A. Robinson , George R. Davenport
发明人： Louis L. Gibbs , John A. Robinson , George R. Davenport
IPC分类号： A01K9710
CPC分类号： A01K97/10
摘要： A folding stowable trolling rig for removably mounting a plurality of fishing rods in desired, operable positions above the deck of a boat, such rig mounting atop a standard fishing seat pedestal of the type found on bass boats and requiring no tools or special hardware for installation. It is comprised of a plurality of longitudinally spaced rod holders pivotally mounted to a pair of folding support arms, one end of each being pivotally attached to either side of a central mounting base, the underside of which having a post that inserts into the seat mounting socket atop the fishing seat pedestal. Automatic alignment of each rod holder, both in folded and opened positions, is controlled by a pair of alignment bars pivotally mounted to the holders and to either side of the mounting base just above and parallel to the support arms. The rod holders and the support arms all fold together into compact alignment for transporting or stowing.
摘要翻译：一种可折叠收起的拖钓机，用于可拆卸地将多个钓鱼杆安装在船的甲板上方的期望的可操作位置，这种钻机安装在低音船上发现的标准钓鱼座椅底座上方，并且不需要用于安装的工具或特殊硬件。它由多个纵向隔开的杆保持器组成，其可枢转地安装到一对折叠支撑臂上，每个的一端可枢转地附接到中央安装基座的任一侧，其下侧具有插入座椅安装件钓鱼座座顶上的插座。每个杆保持器在折叠和打开位置的自动对准由一对对准杆控制，该对对准杆枢转地安装到保持器上并且在安装基座的任一侧刚好在支撑臂上方并平行。杆保持器和支撑臂全部折叠成紧凑的对准以便运输或收起。

6. 发明授权

US5699497A Rendering global macro texture, for producing a dynamic image, as on computer generated terrain, seen from a moving viewpoint 失效
标题翻译：渲染全局宏纹理，用于生成动态图像，如计算机生成的地形，从移动的角度看
公开(公告)号：US5699497A
公开(公告)日：1997-12-16
申请号：US613893
申请日：1996-03-11
申请人： Alan C. Erdahl , John A. Robinson
发明人： Alan C. Erdahl , John A. Robinson
IPC分类号： G06T15/04 , G06T15/00
CPC分类号： G06T15/04
摘要： A dynamic terrain display is created from digitized grid post data as a height field, that is textured using maps embracing progressively larger areas with increasing remoteness from the viewpoint. A truncated pyramid is defined by map parts for each level that are maintained in active memory. The map parts or fragments are stored in rectangular configurations to be updated row-by-row or column-by-column, by overwriting obsolete data in a circular manner to reflect changes in the viewpoint. Levels of the map parts accordingly are paged independently of each other from database storage. Not all levels are required to have texture in that if a level is not available, a lower level can be employed. Theme cells also can be utilized.
摘要翻译：从数字化网格帖子数据创建动态地形显示，作为高度场，使用包含逐渐变大的区域的地图进行纹理化，从视点越来越远。截断的金字塔由维护在活动内存中的每个级别的映射部分定义。映射部分或片段以矩形配置存储，以逐行或逐列更新，通过以循环方式覆盖过时的数据以反映视点的变化。地图部分的级别相应地从数据库存储中独立地分页。并非所有级别都需要纹理，如果级别不可用，则可以使用较低级别。也可以使用主题细胞。

7. 发明授权

US08450284B2 Coiled-coil lipopeptide helical bundles and synthetic virus-like particles 有权
标题翻译：线圈脂肽螺旋束和合成病毒样颗粒
公开(公告)号：US08450284B2
公开(公告)日：2013-05-28
申请号：US12518269
申请日：2007-12-06
申请人： Francesca Boato , Anabelle Freund , Arin Ghasparian , Kerstin Möhle , John A. Robinson , Richard M. Thomas
发明人： Francesca Boato , Anabelle Freund , Arin Ghasparian , Kerstin Möhle , John A. Robinson , Richard M. Thomas
IPC分类号： A61K38/16 , A61K38/00
CPC分类号： C12N7/00 , A61K39/015 , A61K39/12 , A61K39/21 , A61K2039/5258 , A61K2039/545 , A61K2039/55516 , A61K2039/55566 , C07K14/005 , C12N2740/16023 , C12N2740/16122 , C12N2740/16134 , Y02A50/412
摘要： The invention relates to lipopeptide building blocks consisting of a peptide chain comprising a coiled-coil domain, linked covalently to a lipid moiety comprising long alkyl or alkenyl chains, and optionally linked to an antigen; and to helical lipopeptide bundles and synthetic virus-like particles formed by aggregation. The nanometer size and shape of these bundles and particles, their stability under aqueous physiological conditions, their chemical composition, the possibility to incorporate B- and T-cell epitopes, and their production by chemical synthesis, make them highly suitable as vaccine delivery vehicles.
摘要翻译：本发明涉及由包含卷曲螺旋结构域的肽链组成的脂肽结构单元，其与包含长烷基或烯基链的脂质部分共价连接，并任选与抗原连接; 以及通过聚集形成的螺旋脂肽束和合成病毒样颗粒。这些束和颗粒的纳米尺寸和形状，它们在水性生理条件下的稳定性，它们的化学组成，结合B-和T细胞表位的可能性及其通过化学合成的生产，使得它们非常适合作为疫苗递送载体。

8. 发明授权

US07700101B2 Reagents and method for modulating Dkk-mediated interactions 失效
标题翻译：用于调节Dkk介导的相互作用的试剂和方法
公开(公告)号：US07700101B2
公开(公告)日：2010-04-20
申请号：US11655924
申请日：2007-01-22
申请人： Kristina M. Allen , Anthony Anisowicz , Veronique Damagnez , John A. Robinson , Paul J. Yaworsky , Bheem M. Bhat
发明人： Kristina M. Allen , Anthony Anisowicz , Veronique Damagnez , John A. Robinson , Paul J. Yaworsky , Bheem M. Bhat
IPC分类号： A61K39/395
CPC分类号： C07K16/28 , C07K16/18 , C07K16/2863 , C07K16/30 , C07K2317/34 , G01N33/5041 , G01N33/6887 , G01N2333/4715 , G01N2500/02
摘要： The present invention provides reagents, compounds, compositions, and methods relating to novel interactions of the extracellular domain of LRP5, HBM (a variant of LRP5), and/or LRP6 with Dkk, including Dkk-1. The various nucleic acids, polypeptides, antibodies, assay methods, diagnostic methods, and methods of treatment of the present invention are related to and impact on Dkk, LRP5, LRP6, HBM, and Wnt signaling. Dkk, LRP5, LRP6, HBM, and Wnt are implicated in bone and lipid cellular signaling. Thus, the present invention provides reagents and methods for modulating lipid levels and/or bone mass and is useful in the treatment and diagnosis of abnormal lipid levels and bone mass disorders, such as osteoporosis.
摘要翻译：本发明提供了与LRP5，HBM（LRP5的变体）和/或LRP6与Dkk（包括Dkk-1）的细胞外结构域的新的相互作用有关的试剂，化合物，组合物和方法。本发明的各种核酸，多肽，抗体，测定方法，诊断方法和治疗方法与Dkk，LRP5，LRP6，HBM和Wnt信号传导有关并对其影响。 Dkk，LRP5，LRP6，HBM和Wnt涉及骨和脂质细胞信号传导。因此，本发明提供用于调节脂质水平和/或骨量的试剂和方法，并且可用于治疗和诊断异常脂质水平和骨质量障碍，例如骨质疏松症。

9. 发明授权

US5427424A Single handle post hole digger 失效
标题翻译：单把手挖孔机
公开(公告)号：US5427424A
公开(公告)日：1995-06-27
申请号：US269136
申请日：1994-06-30
申请人： John A. Robinson
发明人： John A. Robinson
IPC分类号： A01B1/18 , E21B11/00
CPC分类号： E21B11/005 , A01B1/18
摘要： Disclosed is a new single handle post hole digger for excavating a constant diameter shaft in the ground for setting fence posts and the like. The single handle post hole digger comprises a stationary arcuate shovel blade pivotally connected to a movable arcuate shovel blade. The movable blade has an earth piercing position wherein the movable blade lies parallel to the stationary blade such that the extended arcs of the blades describe a cylinder. The movable blade also has an earth removing position wherein the lower edge of the movable blade is angled inwardly toward the stationary blade to define a scoop. An elongated gripping handle extends longitudinally from the blades. Blade control is accomplished with an actuator lever, pivotally mounted on the gripping handle, connected to the movable shovel blade by a control rod. Moving the lever in one direction positions the movable blade for earth piercing whereas moving the lever in the other direction positions the movable blade for earth removing.
摘要翻译：公开了一种用于在地面上用于设置围栏柱等的用于挖掘恒定直径的轴的新的单手柄钻孔挖掘机。单把手钻孔挖掘机包括一个可枢转地连接到可移动弓形铲铲刀的固定弓形铲刀。可移动刀片具有地球穿刺位置，其中可动刀片平行于固定刀片，使得刀片的延伸弧形成圆柱体。可移动刀片还具有接地去除位置，其中可动刀片的下边缘朝向固定刀片向内倾斜以限定勺子。细长的把手从叶片纵向延伸。刀片控制是通过一个致动器杠杆实现的，该致动器杆枢转地安装在把手上，通过控制杆连接到可动铲刀上。在一个方向上移动杠杆将可移动刀片定位以进行地球穿孔，而沿另一方向移动杆将位置可移动刀片移除。

10. 发明授权

US4323300A Optical fibre connectors 失效
标题翻译：光纤连接器
公开(公告)号：US4323300A
公开(公告)日：1982-04-06
申请号：US106040
申请日：1979-12-21
申请人： William J. Stewart , John A. Robinson , Richard Carpenter
发明人： William J. Stewart , John A. Robinson , Richard Carpenter
IPC分类号： G02B6/38 , G02B7/26
CPC分类号： G02B6/3843 , G02B6/3885
摘要： It is important that in an optical fibre connector the ends of the fibres should contact or very nearly contact to avoid excessive optical losses. They must be accurately aligned and lateral movements, causing varying optical output, be minimized. In this invention, the fibre or fibres are secured in grooves formed in flat surfaces in two abutting blocks and the blocks are clamped together with their flat surfaces in contact with a further flat surfaced member. The clamp consists of a cam surface formed in a housing which is adapted to contact a portion of the further member when the blocks are introduced into the housing.
摘要翻译：重要的是，在光纤连接器中，纤维的端部应该接触或非常接近，以避免过多的光损耗。它们必须精确对准，并且可以最小化侧向运动，导致变化的光输出。在本发明中，纤维或纤维被固定在两个邻接块中形成在平坦表面中的槽中，并且块被平坦地夹紧在一起，与另一个平坦的表面部件接触。夹具包括形成在壳体中的凸轮表面，当凸块被引入到壳体中时，该凸轮表面适于接触另一个构件的一部分。

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