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1. 发明授权

US08263040B2 Metal chelates having a perfluorinated PEG radical, processes for their preparation, and their use 失效
标题翻译：具有全氟化PEG基团的金属螯合物，其制备方法及其用途
公开(公告)号：US08263040B2
公开(公告)日：2012-09-11
申请号：US11873986
申请日：2007-10-17
申请人： Johannes Platzek , Heiko Schirmer , Hanns-Joachim Weinmann , Bernd Misselwitz , Ludwig Zorn
发明人： Johannes Platzek , Heiko Schirmer , Hanns-Joachim Weinmann , Bernd Misselwitz , Ludwig Zorn
IPC分类号： A61K51/00
CPC分类号： C07D257/02 , A61K49/0433 , A61K49/085 , A61K49/126 , A61K51/0474 , C07D213/81
摘要： The invention relates to the subjects characterized in the patent claims, namely metal chelates having a perfluorinated PEG radical, processes for their preparation, and their use, processes for their preparation and their use in NMR and X-ray diagnosis, radiodiagnosis and radiotherapy, and in MRT lymphography.
摘要翻译：本发明涉及专利权利要求所述的受试者，即具有全氟化PEG基团的金属螯合物，其制备方法及其用途，其制备方法及其在NMR和X射线诊断，放射诊断和放射治疗中的用途，以及在MRT淋巴瘤中。

2. 发明授权

US07618957B2 Perfluoroalkyl-containing complexes, process for their production as well as their use 失效
标题翻译：含全氟烷基的络合物，其制备方法及其用途
公开(公告)号：US07618957B2
公开(公告)日：2009-11-17
申请号：US11487604
申请日：2006-07-17
申请人： Heiko Schirmer , Hanns-Joachim Weinmann , Johannes Platzek , Ludwig Zorn , Bernd Misselwitz , Joerg Meding , Heribert Schmitt-Willich , Thomas Brumby
发明人： Heiko Schirmer , Hanns-Joachim Weinmann , Johannes Platzek , Ludwig Zorn , Bernd Misselwitz , Joerg Meding , Heribert Schmitt-Willich , Thomas Brumby
IPC分类号： A01N43/00 , A61K31/33 , C07D245/00
CPC分类号： C07D257/02 , A61K49/0002 , A61K49/04 , A61K49/103 , A61K49/106 , A61K51/0478 , A61K51/0482
摘要： The invention relates to the subjects that are characterized in the claims, namely perfluoroalkyl-containing metal complexes with nitrogen-containing radicals of general formula I, process for their production and their use in NMR and x-ray diagnosis, radiodiagnosis, and radiotherapy, as well as in MRT lymphography and in blood-pool imaging.
摘要翻译：本发明涉及权利要求所述的受试者，即具有通式I的含氮基团的全氟烷基金属络合物，其制备方法及其在NMR和X射线诊断，放射诊断和放射治疗中的用途，如如在MRT淋巴瘤和血液池成像中。

3. 发明申请

US20080159954A1 METAL CHELATES HAVING A PERFLUORINATED PEG RADICAL, PROCESSES FOR THEIR PREPARATION, AND THEIR USE 失效
标题翻译：具有全氟代PEG辐射的金属螯合物，其制备方法及其使用
公开(公告)号：US20080159954A1
公开(公告)日：2008-07-03
申请号：US11873986
申请日：2007-10-17
申请人： Johannes Platzek , Heiko Schirmer , Hanns-Joachim Weinmann , Bernd Misselwitz , Ludwig Zorn
发明人： Johannes Platzek , Heiko Schirmer , Hanns-Joachim Weinmann , Bernd Misselwitz , Ludwig Zorn
IPC分类号： A61K49/00 , C07C229/00 , C07H15/00
CPC分类号： C07D257/02 , A61K49/0433 , A61K49/085 , A61K49/126 , A61K51/0474 , C07D213/81
摘要： The invention relates to the subjects characterized in the patent claims, namely metal chelates having a perfluorinated PEG radical, processes for their preparation, and their use, processes for their preparation and their use in NMR and X-ray diagnosis, radiodiagnosis and radiotherapy, and in MRT lymphography.
摘要翻译：本发明涉及专利权利要求所述的受试者，即具有全氟化PEG基团的金属螯合物，其制备方法及其用途，其制备方法及其在NMR和X射线诊断，放射诊断和放射治疗中的用途，以及在MRT淋巴瘤中。

4. 发明申请

US20070189969A1 Perfluoroalkyl-containing complexes, process for their production as well as their use 失效
标题翻译：含全氟烷基的络合物，其制备方法及其用途
公开(公告)号：US20070189969A1
公开(公告)日：2007-08-16
申请号：US11487604
申请日：2006-07-17
申请人： Heiko Schirmer , Hanns-Joachim Weinmann , Johannes Platzek , Ludwig Zorn , Bernd Misselwitz , Joerg Meding , Heribert Schmitt-Willich , Thomas Brumby
发明人： Heiko Schirmer , Hanns-Joachim Weinmann , Johannes Platzek , Ludwig Zorn , Bernd Misselwitz , Joerg Meding , Heribert Schmitt-Willich , Thomas Brumby
IPC分类号： A61B5/055 , A61K49/04 , C07D257/02
CPC分类号： C07D257/02 , A61K49/0002 , A61K49/04 , A61K49/103 , A61K49/106 , A61K51/0478 , A61K51/0482
摘要： The invention relates to the subjects that are characterized in the claims, namely perfluoroalkyl-containing metal complexes with nitrogen-containing radicals of general formula I, process for their production and their use in NMR and x-ray diagnosis, radiodiagnosis, and radiotherapy, as well as in MRT lymphography and in blood-pool imaging.
摘要翻译：本发明涉及权利要求中特征的受试者，即具有通式I的含氮基团的全氟烷基金属络合物，其制备方法及其在NMR和X射线诊断，放射诊断和放射治疗中的用途，如如在MRT淋巴瘤和血液池成像中。

5. 发明申请

US20070020183A1 Perfluoroalkyl-containing complexes, process for their production as well as their use 审中-公开
标题翻译：含全氟烷基的络合物，其制备方法及其用途
公开(公告)号：US20070020183A1
公开(公告)日：2007-01-25
申请号：US11486396
申请日：2006-07-14
申请人： Heiko Schirmer , Hanns-Joachim Weinmann , Johannes Platzek , Ludwig Zorn , Bernd Misselwitz , Joerg Meding , Heribert Schmitt-Willich , Thomas Brumby
发明人： Heiko Schirmer , Hanns-Joachim Weinmann , Johannes Platzek , Ludwig Zorn , Bernd Misselwitz , Joerg Meding , Heribert Schmitt-Willich , Thomas Brumby
IPC分类号： A61K49/10 , C07F5/00 , C07D257/02
CPC分类号： A61K49/0002 , A61K49/10 , A61K49/103 , A61K49/106 , A61K51/0482 , A61K51/0497 , C07D257/02 , C07D405/06
摘要： The invention relates to the subjects that are characterized in the claims, namely perfluoroalkyl-containing metal complexes with an N-alkyl group of general formula 1, process for their production and their use in NMR and x-ray diagnosis, radiodiagnosis, and radiotherapy, as well as in MRT lymphography.
摘要翻译：本发明涉及权利要求中特征的受试者，即具有通式1的N-烷基的全氟烷基金属络合物，其制备方法及其在NMR和X射线诊断，放射诊断和放射治疗中的应用，以及MRT淋巴瘤。

6. 发明申请

US20080213187A1 NOVEL CASCADE POLYMER COMPLEXES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM 审中-公开
标题翻译：新型聚合物复合物，其制备方法和包含它们的药物组合物
公开(公告)号：US20080213187A1
公开(公告)日：2008-09-04
申请号：US12015769
申请日：2008-01-17
申请人： Heribert SCHMITT-WILLICH , Heiko Schirmer , Bernd Misselwitz , Hanns-Joachim Weinmann , Peter Caravan
发明人： Heribert SCHMITT-WILLICH , Heiko Schirmer , Bernd Misselwitz , Hanns-Joachim Weinmann , Peter Caravan
IPC分类号： A61K49/06 , C07C69/76 , C07C39/04
CPC分类号： A61K49/085 , A61K49/124
摘要： The invention relates to novel cascade polymer complexes, to compositions comprising these compounds, to the use of the complexes in NMR diagnosis, and to processes for preparing these compounds and compositions. The complex-forming cascade polymer complexes according to the invention can be described by general formula I: R-L-A-{X—[Y-(Z-{W—Kw}z)y]x}a−1 (I) where R=is an HSA-binding unit, L=is a linker or a bond, A=is a nitrogen-containing cascade core of base multiplicity a, X and Y are independently of one another a direct linkage or a cascade reproduction unit of reproduction multiplicity x and y, respectively, Z and W=are independently of one another a direct linkage or a cascade reproduction unit of reproduction multiplicity z and w, respectively, K is the residue of a complexing agent, a=is numbers 2 to 12, and x, y, z and w are independently of one another the numbers 1 to 4, with the proviso that exactly one multiplicity of the base multiplicity a of the cascade core A represents exactly one point of linkage to L, and with the proviso that the cascade polymer complexes comprise in the complexing agent residue K in total at least 4 ions of an element of atomic number 20 to 29, 39, 42 to 44 or 57 to 83 and comprise where appropriate cations of inorganic and/or organic bases, amino acids or amino amides.
摘要翻译：本发明涉及新颖的级联聚合物复合物，包含这些化合物的组合物，在NMR诊断中使用复合物，以及制备这些化合物和组合物的方法。根据本发明的络合物形成级联聚合物复合物可以由通式I描述：<？in-line-formula description =“In-line Formulas”end =“lead”？> RLA- {X- [Y-（ a-1 （I）<？in-line-formula description =“In-line Formulas”end =“tail”？>其中R =是HSA结合单元，L =是接头或键，A = 包含碱基多重性a的级联核心，X和Y彼此独立地是再现倍数x和y的直接联动或级联再现单元，Z和W =彼此独立地是直接联动或级联再现单元分别是繁殖多重度z和w，K是络合剂的残基，a =数字2至12，x，y，z和w彼此独立地为数字1至4，条件是准确地级联核心A的碱基多重性a的一个多重性恰好代表连接点t的一个点 o L，条件是级联聚合物络合物在配位剂中含有总共至少4个原子序数为20至29,39,42至44或57至83的元素的残基K，并且包含适当的阳离子无机和/或有机碱，氨基酸或氨基酰胺。

7. 发明申请

US20060120965A1 Trimeric, macrocyclically substituted aminoisophthalic acid-halo-benzene derivatives 审中-公开
标题翻译：三环，大环环取代的氨基间苯二甲酸 - 卤代苯衍生物
公开(公告)号：US20060120965A1
公开(公告)日：2006-06-08
申请号：US11274895
申请日：2005-11-16
申请人： Johannes Platzek , Heiko Schirmer , Hanns-Joachim Weinmann , Jose Martin , Juan Harto
发明人： Johannes Platzek , Heiko Schirmer , Hanns-Joachim Weinmann , Jose Martin , Juan Harto
IPC分类号： A61K49/10 , A61K49/04 , C07F5/00
CPC分类号： A61K49/0438 , A61K49/085 , A61K49/106 , C07D257/02
摘要： The metal complexes of general formula I in which Hal stands for bromine or iodine, and A1 and A2 have different meanings, are suitable as contrast media.
摘要翻译：其中Hal代表溴或碘的通式I的金属络合物和具有不同含义的A 1和A 2都适用作造影剂。

8. 发明申请

US20070014725A1 Conjugates of macrocyclic metal complexes with biomolecules and their use for the production of agents for NMR diagnosis and radiodiagnosis as well as radiotherapy 审中-公开
标题翻译：大环金属配合物与生物分子的共轭物及其用于生产核磁共振诊断和放射诊断以及放射治疗剂的用途
公开(公告)号：US20070014725A1
公开(公告)日：2007-01-18
申请号：US11390414
申请日：2006-03-28
申请人： Johannes Platzek , Heribert Schmitt-Willich , Gunther Michl , Thomas Frenzel , Detlev Sulzle , Hans Bauer , Bernd Raduchel , Hanns-Joachim Weinmann , Heiko Schirmer
发明人： Johannes Platzek , Heribert Schmitt-Willich , Gunther Michl , Thomas Frenzel , Detlev Sulzle , Hans Bauer , Bernd Raduchel , Hanns-Joachim Weinmann , Heiko Schirmer
IPC分类号： A61K51/00 , A61K49/10 , C07K14/47 , C07F5/00
CPC分类号： A61K49/14 , A61K49/0002 , A61K49/085 , A61K49/143
摘要： The invention relates to conjugates that consist of macrocyclic metal complexes with biomolecules and their production. The conjugates are suitable as contrast media in NMR diagnosis and radiodiagnosis as well as as agents for radiotherapy. High relaxivity is achieved by a special liganding of macrocyclic compounds, and a fine-tuning of the relaxivity is made possible.
摘要翻译：本发明涉及由大环金属配合物与生物分子组成的共轭物及其生产。缀合物适用于核磁共振诊断和放射诊断中的造影剂以及放射治疗剂。通过大环化合物的特殊结合实现高的放松性，并且可以进行微调的松弛度。

9. 发明申请

US20070009442A1 Macrocyclic metal complexes and their use for the production of conjugates with biomolecules 审中-公开
公开(公告)号：US20070009442A1
公开(公告)日：2007-01-11
申请号：US11390472
申请日：2006-03-28
申请人： Johannes Platzek , Heribert Schmitt-Willich , Gunther Michl , Thomas Frenzel , Detlev Sulzle , Hans Bauer , Bernd Raduchel , Hanns-Joachim Weinmann , Heiko Schirmer
发明人： Johannes Platzek , Heribert Schmitt-Willich , Gunther Michl , Thomas Frenzel , Detlev Sulzle , Hans Bauer , Bernd Raduchel , Hanns-Joachim Weinmann , Heiko Schirmer
IPC分类号： A61K49/10 , C07K14/47 , C07H21/04 , C07D257/02 , C07D487/22
CPC分类号： A61K49/10 , A61K47/54 , A61K47/547 , A61K49/0002 , A61K49/085 , A61K49/14 , A61K49/143 , C07D257/02
摘要： The invention relates to macrocyclic metal complexes and their production and use for the production of conjugates with biomolecules. The conjugates are suitable as contrast media in NMR diagnosis and radiodiagnosis as well as for radiotherapy. High relaxivity is achieved by a special liganding of macrocyclic compounds, and a fine-tuning of the relaxivity is made possible.

10. 发明授权

US07164016B2 Macrocyclic metal complexes and their use for the production of conjugates with biomolecules 失效
标题翻译：大环金属络合物及其与生物分子生产缀合物的用途
公开(公告)号：US07164016B2
公开(公告)日：2007-01-16
申请号：US10198046
申请日：2002-07-19
申请人： Johannes Platzek , Heribert Schmitt-Willich , Günther Michl , Thomas Frenzel , Detlev Sülzle , Hans Bauer , Bernd Radüchel , Hanns-Joachim Weinmann , Heiko Schirmer
发明人： Johannes Platzek , Heribert Schmitt-Willich , Günther Michl , Thomas Frenzel , Detlev Sülzle , Hans Bauer , Bernd Radüchel , Hanns-Joachim Weinmann , Heiko Schirmer
IPC分类号： C07D257/02
CPC分类号： A61K49/10 , A61K47/54 , A61K47/547 , A61K49/0002 , A61K49/085 , A61K49/14 , A61K49/143 , C07D257/02
摘要： The invention relates to macrocyclic metal complexes and their production and use for the production of conjugates with biomolecules. The conjugates are suitable as contrast media in NMR diagnosis and radiodiagnosis as well as for radiotherapy. High relaxivity is achieved by a special liganding of macrocyclic compounds, and a fine-tuning of the relaxivity is made possible.
摘要翻译：本发明涉及大环金属络合物及其生产和用于与生物分子生产缀合物的用途。缀合物适用于NMR诊断和放射诊断以及放射治疗中的造影剂。通过大环化合物的特殊结合实现高的放松性，并且可以进行微调的松弛度。

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