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1. 发明申请

US20110129860A1 CALPROTECTIN AND HEMOGLOBIN/HAPTOGLOBIN COMPLEX FROM STOOL SAMPLE TO ASSESS COLORECTAL CANCER 审中-公开
标题翻译： CALPROTECTIN和HEMOGLOBIN / HAPTOGLOBIN复合物从STOOL样品到评估彩色癌
公开(公告)号：US20110129860A1
公开(公告)日：2011-06-02
申请号：US12783256
申请日：2010-05-19
申请人： Johann Karl , Norbert Wild , Ursula Garczarek
发明人： Johann Karl , Norbert Wild , Ursula Garczarek
IPC分类号： G01N33/68
CPC分类号： G01N33/57419 , G01N33/721 , G01N2333/4727 , G01N2333/805
摘要： The present invention relates to a method aiding in the assessment of colorectal cancer. The method especially is used in assessing the absence or presence of colorectal cancer in vitro. The method is for example practiced by analyzing biochemical markers, comprising measuring in a stool sample the concentration of the hemoglobin/haptoglobin complex and calprotectin and correlating the concentrations determined to the absence or presence of colorectal cancer. To further improve the assessment of colorectal cancer based on a method of this invention the level of one or more additional marker may be determined together with the hemoglobin/haptoglobin complex and calprotectin in a stool sample and be correlated to the absence or presence of colorectal cancer. The invention also relates to the use of a marker panel comprising the hemoglobin/haptoglobin complex and calprotectin in the early diagnosis of colorectal cancer and it teaches a kit for performing the method of the invention.
摘要翻译：本发明涉及一种协助评估结肠直肠癌的方法。该方法特别用于评估体外存在或不存在结肠直肠癌。该方法例如通过分析生物化学标记来实施，包括在粪便样品中测量血红蛋白/触珠蛋白复合物和钙卫蛋白的浓度，并将确定的浓度与不存在或存在结肠直肠癌相关联。为了进一步改进基于本发明方法的结肠直肠癌的评估，可以在粪便样品中与血红蛋白/触珠蛋白复合物和钙卫蛋白一起测定一种或多种另外的标记物的水平，并与结肠直肠癌的存在或不存在相关。本发明还涉及包含血红蛋白/触珠蛋白复合物和钙卫蛋白的标记物在早期诊断结肠直肠癌中的用途，并且其教导了用于实施本发明方法的试剂盒。

2. 发明申请

US20100240068A1 MARKER PANEL FOR COLORECTAL CANCER 审中-公开
标题翻译：用于彩色癌症的标记面板
公开(公告)号：US20100240068A1
公开(公告)日：2010-09-23
申请号：US12791929
申请日：2010-06-02
申请人： Johann Karl , Herbert Andres , Ursula Garczarek , Wolfgang Rollinger , Norbert Wild
发明人： Johann Karl , Herbert Andres , Ursula Garczarek , Wolfgang Rollinger , Norbert Wild
IPC分类号： G01N33/573
CPC分类号： G01N33/57419
摘要： The present invention relates to a method for assessing colorectal cancer (CRC) in vitro including measuring in a sample the concentration and/or activity of a seprase polypeptide and/or fragments thereof and of either anti-p53 and/or osteopontin and/or ferritin, of optionally one or more other marker of CRC, and using the combined measurement result in the assessment of CRC. Furthermore, it especially relates to a method for assessing CRC from a liquid sample, derived from an individual by measuring seprase and at least anti-p53, ferritin and/or osteopontin in the sample. The method according to the present invention can, e.g., be used in the early detection of cancer by screening of asymptomatic individuals or in the surveillance of patients who undergo surgery.
摘要翻译：本发明涉及体外评估结肠直肠癌（CRC）的方法，包括在样品中测量seprase多肽和/或其片段和抗p53和/或骨桥蛋白和/或铁蛋白的浓度和/或活性，可选地一个或多个CRC的其他标志物，并且使用组合的测量结果来评估CRC。此外，它特别涉及通过测量样品中的seprase和至少抗p53，铁蛋白和/或骨桥蛋白来评估来自个体的液体样品的CRC的方法。根据本发明的方法可以例如通过筛选无症状个体或在进行手术的患者的监视中用于癌症的早期检测。

3. 发明申请

US20100159479A1 TIMP-1 AS A MARKER FOR COLORECTAL CANCER 审中-公开
标题翻译： TIMP-1作为彩色癌的标记
公开(公告)号：US20100159479A1
公开(公告)日：2010-06-24
申请号：US12613760
申请日：2009-11-06
申请人： Wolfgang Rollinger , Johann Karl , Norbert Wild , Herbert Andres , Peter Heiss , Ursula Garczarek , Andrea Geistanger , Friedemann Krause
发明人： Wolfgang Rollinger , Johann Karl , Norbert Wild , Herbert Andres , Peter Heiss , Ursula Garczarek , Andrea Geistanger , Friedemann Krause
IPC分类号： G01N33/573
CPC分类号： G01N33/57419 , G01N2333/8146
摘要： The present invention relates to the diagnosis of colorectal cancer. It discloses the use of protein TIMP-1 (tissue inhibitor of metalloproteinase 1) as a marker molecule in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a stool sample, derived from an individual, the method involving measuring TIMP-1 in the sample. Measurement of TIMP-1 can, e.g., be used in the early detection or diagnosis of colorectal cancer.
摘要翻译：本发明涉及结肠直肠癌的诊断。它公开了使用蛋白质TIMP-1（金属蛋白酶1的组织抑制剂）作为结直肠癌诊断中的标记分子。本发明涉及从个体得到的粪便样品中诊断结肠直肠癌的方法，该方法涉及在样品中测量TIMP-1。 TIMP-1的测定可以例如用于结肠直肠癌的早期检测或诊断。

4. 发明申请

US20090286328A1 USE OF PROTEIN S100A12 AS A MARKER FOR COLORECTAL CANCER 审中-公开
标题翻译：使用蛋白S100A12作为彩色癌的标记
公开(公告)号：US20090286328A1
公开(公告)日：2009-11-19
申请号：US12264324
申请日：2008-11-04
申请人： Norbert Wild , Herbert Andres , Ursula Garczarek , Andrea Geistanger , Marie-Luise Hagmann , Johan Karl , Freidemann Krause , Michael Pfeffer , Wolfgang Rollinger , Michael Tacke , Michael Thiefolf
发明人： Norbert Wild , Herbert Andres , Ursula Garczarek , Andrea Geistanger , Marie-Luise Hagmann , Johan Karl , Freidemann Krause , Michael Pfeffer , Wolfgang Rollinger , Michael Tacke , Michael Thiefolf
IPC分类号： G01N33/566
CPC分类号： G01N33/57419 , C12Q1/6886 , G01N2333/4727 , G01N2333/805 , G01N2333/8146 , G01N2333/9121
摘要： The present invention relates to the diagnosis of colorectal cancer. It discloses the use of protein S100A12 in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a stool sample, derived from an individual by measuring S100A12 in said sample. Measurement of S100A12 can, e.g., be used in the early detection or diagnosis of colorectal cancer.
摘要翻译：本发明涉及结肠直肠癌的诊断。它公开了蛋白质S100A12在结肠直肠癌诊断中的应用。它涉及一种通过测量所述样品中的S100A12从粪便样品中诊断结直肠癌的方法。 S100A12的测定可以例如用于结肠直肠癌的早期检测或诊断。

5. 发明授权

US07676329B2 Method and system for processing multi-dimensional measurement data 失效
标题翻译：用于处理多维测量数据的方法和系统
公开(公告)号：US07676329B2
公开(公告)日：2010-03-09
申请号：US11112919
申请日：2005-04-22
申请人： Ursula Garczarek , Pavel Kubalec , Wolfgang Hösel
发明人： Ursula Garczarek , Pavel Kubalec , Wolfgang Hösel
IPC分类号： G01N33/48
CPC分类号： G01N30/8624 , G01N30/8682 , G01N2030/862 , H01J49/0027
摘要： The invention provides a method for grouping measurement data obtained by effecting two or more techniques to provide characterization data characterizing at least one sample with respect to characterizing substances. According to one aspect of the invention, the grouping is effected on the basis of at least one statistical distribution of deviations (Δm/zi) of a respective characterizing measurement value. According to another aspect of the invention, the grouping is effected on the basis of at least one collective characteristic of a plurality of respective quantitative measurement values (Ii).
摘要翻译：本发明提供了一种用于对通过实施两种或多种技术获得的测量数据进行分组的方法，以提供表征关于特征物质的至少一个样品的表征数据。根据本发明的一个方面，基于各个特征测量值的偏差（＆Dgr; m / zi）的至少一个统计分布进行分组。根据本发明的另一方面，基于多个相应的定量测量值（Ii）的至少一个集合特征进行分组。

6. 发明申请

US20060080040A1 Method and system for processing multi-dimensional measurement data 失效
标题翻译：用于处理多维测量数据的方法和系统
公开(公告)号：US20060080040A1
公开(公告)日：2006-04-13
申请号：US11112919
申请日：2005-04-22
申请人： Ursula Garczarek , Pavel Kubalec , Wolfgang Hosel
发明人： Ursula Garczarek , Pavel Kubalec , Wolfgang Hosel
IPC分类号： G06F19/00
CPC分类号： G01N30/8624 , G01N30/8682 , G01N2030/862 , H01J49/0027
摘要： The invention provides a method for grouping measurement data obtained by effecting two or more techniques to provide characterization data characterizing at least one sample with respect to characterizing substances. According to one aspect of the invention, the grouping is effected on the basis of at least one statistical distribution of deviations (Δm/zi) of a respective characterizing measurement value. According to another aspect of the invention, the grouping is effected on the basis of at least one collective characteristic of a plurality of respective quantitative measurement values (Ii).
摘要翻译：本发明提供了一种用于对通过实施两种或多种技术获得的测量数据进行分组的方法，以提供表征关于特征物质的至少一个样品的表征数据。根据本发明的一个方面，基于相应特征测量值的偏差的至少一个统计分布（Deltam / zI i），进行分组。根据本发明的另一方面，基于多个相应的定量测量值（I SUB）的至少一个集合特征进行分组。

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