专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06737635B2 Apparatus for combining light and confocal scanning microscope 有权
标题翻译：用于组合光和共焦扫描显微镜的装置
公开(公告)号：US06737635B2
公开(公告)日：2004-05-18
申请号：US09825273
申请日：2001-04-03
申请人： Johann Engelhardt , Juergen Hoffmann , Rafael Storz , Heinrich Ulrich , Joerg Bewersdorf , Holger Birk
发明人： Johann Engelhardt , Juergen Hoffmann , Rafael Storz , Heinrich Ulrich , Joerg Bewersdorf , Holger Birk
IPC分类号： H01J4014
CPC分类号： G02B21/0068 , G02B21/0032 , G02B21/0056 , G02B27/283
摘要： The present invention concerns an apparatus for combining light from at least two laser light sources, preferably in the context of confocal scanning microscopy, and in order to make laser light sources of low output power usable as light sources, in particular for confocal scanning microscopy, is characterized in that the light from the laser light sources has at least approximately the same wavelength; and that at least one beam combining unit that combines the light beams in at least largely lossless fashion is provided.
摘要翻译：本发明涉及一种用于组合来自至少两个激光源的光的装置，优选在共聚焦扫描显微镜的上下文中，并且为了使得可用作光源的低输出功率的激光光源，特别是用于共聚焦扫描显微镜，其特征在于，来自激光光源的光具有至少大致相同的波长; 并且提供以至少大部分无损方式组合光束的至少一个光束组合单元。

2. 发明授权

US06570705B2 Optical arrangement for illuminating objects and double—confocal scanning microscope 有权
标题翻译：用于照明物体的光学布置和双共焦扫描显微镜
公开(公告)号：US06570705B2
公开(公告)日：2003-05-27
申请号：US09954018
申请日：2001-09-18
申请人： Joerg Bewersdorf , Hilmar Gugel , Juergen Hoffmann
发明人： Joerg Bewersdorf , Hilmar Gugel , Juergen Hoffmann
IPC分类号： G02B2106
CPC分类号： G02B21/0076 , G02B21/0032 , G02B21/088 , G02B26/06
摘要： The present invention relates to an optical arrangement for illuminating objects (1), in particular fluorescent objects, preferably in conjunction with a confocal or a double-confocal scanning microscope, having an illuminating beam path (2) of a light source (3), a detection beam path (4) of a detector (5), and a component (6) which unifies the detection beam path (4). For the purpose of at least largely loss-free union of the light coming from the object (1) into a propagation direction (19), the optical arrangement according to the invention is characterized in that with reference to the beam cross section active for the detector, light of the fist and second partial detection beam can be united at least largely in an overlapping fashion into one propagation direction (19) at the component (6) thereby providing an unified the detection beam path (4).
摘要翻译：本发明涉及一种用于照射物体（1）的光学装置，特别是荧光物体，优选与共聚焦或双共焦扫描显微镜结合，具有光源（3）的照明光束路径（2）检测器（5）的检测光束路径（4）和统一检测光路（4）的部件（6）。为了将来自物体（1）的光至少在很大程度上无损地结合到传播方向（19）中，根据本发明的光学装置的特征在于，参考对于检测器，第一部分检测光束和第二部分检测光束的光可以至少大部分地以组合（6）的一个传播方向（19）重叠地组合在一起，从而提供统一的检测光束路径（4）。

3. 发明申请

US20050078361A1 Microscope having a reference specimen 审中-公开
标题翻译：显微镜具有参考标本
公开(公告)号：US20050078361A1
公开(公告)日：2005-04-14
申请号：US10919899
申请日：2004-08-17
申请人： Joerg Bewersdorf , Hilmar Gugel
发明人： Joerg Bewersdorf , Hilmar Gugel
IPC分类号： G02B21/34 , G02B21/00
CPC分类号： G02B21/0024 , G02B21/006 , G02B21/0076
摘要： The present invention concerns a microscope, in particular a confocal or double confocal scanning microscope, as well as a method for operating a microscope, at least one specimen support unit associated with the specimen being provided, at least one reference specimen of known configuration being provided, and the reference specimen being detectable by light microscopy for calibration, alignment or adjustment of the microscope. With the microscope according to the present invention and the method according to the invention for operating a microscope, drift-related changes can be detected and compensated for. Auxiliary means with which a specimen can easily and reliably be focused are also provided.
摘要翻译：本发明涉及显微镜，特别是共聚焦或双共聚焦扫描显微镜，以及用于操作显微镜的方法，至少一个与所述样本相关联的样本支撑单元，提供了至少一个已知构造的参考样本，并且通过光学显微镜检测参考样品用于显微镜的校准，对准或调整。利用根据本发明的显微镜和用于操作显微镜的根据本发明的方法，可以检测和补偿漂移相关的变化。还提供了可以容易且可靠地聚焦的试样的辅助装置。

4. 发明授权

US06552795B2 Method and apparatus for illuminating a transparent specimen 有权
标题翻译：用于照射透明样品的方法和装置
公开(公告)号：US06552795B2
公开(公告)日：2003-04-22
申请号：US09794982
申请日：2001-02-27
申请人： Joerg Bewersdorf
发明人： Joerg Bewersdorf
IPC分类号： G02B2100
CPC分类号： G02B21/0056 , G02B21/0032 , G02B21/0076
摘要： A method and an apparatus for illuminating a transparent specimen (1), in particular for use in double confocal scanning microscopy, wherein for illumination of a point of the specimen (1), two light waves of a coherent light source (4) focused from opposite directions (2, 3) onto the point interfere to form an illumination pattern, and in order to eliminate the causes of the problems of the reconstruction method, at least two additional coherent light waves traveling toward one another are superimposed in order to minimize the secondary maxima (11, 12) of the illumination pattern.
摘要翻译：一种用于照亮透明样品（1）的方法和装置，特别是用于双共聚焦扫描显微镜，其中为了照射样品（1）的点，相干光源（4）的两个光波从在该点上的相反方向（2,3）干涉以形成照明图案，并且为了消除重建方法的问题的原因，叠加至少两个彼此相向的附加相干光波，以使照明图案的次要最大值（11,12）。

5. 发明申请

US20130147916A1 MICROSCOPY SYSTEM AND METHOD FOR CREATING THREE DIMENSIONAL IMAGES USING PROBE MOLECULES 有权
标题翻译：使用探针分子创建三维图像的微观系统和方法
公开(公告)号：US20130147916A1
公开(公告)日：2013-06-13
申请号：US13257588
申请日：2010-03-18
申请人： Brian Thomas Bennett , Joerg Bewersdorf , Erik Jorgensen , Sam Hess , Travis Gould , Mudalige Siyath Gunewardene
发明人： Brian Thomas Bennett , Joerg Bewersdorf , Erik Jorgensen , Sam Hess , Travis Gould , Mudalige Siyath Gunewardene
IPC分类号： G02B21/36
CPC分类号： G02B21/367 , G01B11/24 , G02B21/0056 , G02B21/0064 , G02B21/0068 , G02B21/0076 , G02B21/008 , G02B21/16 , G02B21/22
摘要： A system (100) and method for creating three dimensional images using probe molecules is disclosed and described. A sample is mounted on a stage (160). The sample has a plurality of probe molecules. The sample is illuminated with light, causing the probe molecules to luminesce. The probe luminescence can be split into at least four paths corresponding to at least four detection planes corresponding to object planes in the sample. The at least four detection planes are detected via a camera (155). Object planes in corresponding recorded regions of interest are recorded in the camera (155). A signal from the regions of interest is combined into a three dimensional image.
摘要翻译：公开并描述了使用探针分子产生三维图像的系统（100）和方法。样品安装在台架（160）上。样品具有多个探针分子。样品用光照射，导致探针分子发光。探针发光可以分成至少四个对应于样品中与物平面对应的四个检测平面的路径。通过照相机（155）检测至少四个检测平面。相关记录的感兴趣区域中的对象平面被记录在相机（155）中。来自感兴趣区域的信号被组合成三维图像。

6. 发明申请

US20120193520A1 BEAM SPLITTER MODULE 失效
标题翻译：光束分离器模块
公开(公告)号：US20120193520A1
公开(公告)日：2012-08-02
申请号：US13363030
申请日：2012-01-31
申请人： Joerg Bewersdorf , Brian Thomas Bennett
发明人： Joerg Bewersdorf , Brian Thomas Bennett
IPC分类号： G01J1/04 , G01J3/51
CPC分类号： G02B27/145 , G02B19/0028 , G02B19/0057 , G02B19/0066 , G02B27/1006 , G02B27/14 , G02B27/141 , G02B27/144
摘要： A primary beam splitter (310) of an optical apparatus (300) can be used to split an incident light beam (305) into a primary plurality of light beams and to direct a first beam of the primary plurality of light beams in a first direction and a second beam of the primary plurality of light beams in a second direction orthogonal to the first direction. Secondary beam splitters (315a,b) positioned in beam paths of the first and second beams can be used to split the first and second beams of the primary plurality of light beams into a secondary plurality of light beams (320a,b) and to split the second beam of the primary plurality of light beams into a tertiary plurality of light beams (325a,b). A primary plurality of beam reflectors (335a,b/340a,b/345a,b) can be positioned and used to redirect the secondary and tertiary plurality of light beams toward a common detector (355).
摘要翻译：可以使用光学设备（300）的主分束器（310）将入射光束（305）分裂成主要的多个光束并且将第一个多个光束的第一光束沿第一方向以及在与第一方向正交的第二方向上的主多个光束的第二光束。定位在第一和第二光束的光束路径中的次级光束分离器（315a，b）可用于将主要多个光束的第一和第二光束分成次级多个光束（320a，b）并分裂所述主多个光束的第二光束成为第三多个光束（325a，b）。可以将主要的多个光束反射器（335a，b / 340a，b / 345a，b）定位并用于将次级和第三级光束朝着公共检测器（355）重定向。

7. 发明申请

US20100265318A1 3D Biplane Microscopy 失效
标题翻译： 3D双平面显微镜
公开(公告)号：US20100265318A1
公开(公告)日：2010-10-21
申请号：US12826422
申请日：2010-06-29
申请人： Joerg Bewersdorf , Manuel F. Juette , Travis Gould , Sam T. Hess
发明人： Joerg Bewersdorf , Manuel F. Juette , Travis Gould , Sam T. Hess
IPC分类号： H04N13/02
CPC分类号： G02B21/367 , G02B21/16 , G02B21/361 , G02B27/58 , H04N13/218 , H04N13/254 , H04N2013/0085
摘要： A microscopy system is configured for creating 3D images from individually localized probe molecules. The microscopy system includes a sample stage, an activation light source, a readout light source, a beam splitting device, at least one camera, and a controller. The activation light source activates probes of at least one probe subset of photo-sensitive luminescent probes, and the readout light source causes luminescence light from the activated probes. The beam splitting device splits the luminescence light into at least two paths to create at least two detection planes that correspond to the same or different number of object planes of the sample. The camera detects simultaneously the at least two detection planes, the number of object planes being represented in the camera by the same number of recorded regions of interest. The controller is programmable to combine a signal from the regions of interest into a 3D data.
摘要翻译：配置显微镜系统以从单独定位的探针分子创建3D图像。显微镜系统包括样品台，激活光源，读出光源，分束装置，至少一个照相机和控制器。活化光源激活光敏发光探针的至少一个探针子集的探针，并且读出的光源引起来自激活的探针的发光。分束装置将发光分成至少两条路径，以产生对应于样品的相同或不同数目的物平面的至少两个检测平面。相机同时检测至少两个检测平面，相机中相同数量的记录感兴趣区域的对象平面数目被表示在相机中。控制器是可编程的，以将来自感兴趣区域的信号组合成3D数据。

8. 发明授权

US07772569B2 3D biplane microscopy 有权
标题翻译： 3D双平面显微镜
公开(公告)号：US07772569B2
公开(公告)日：2010-08-10
申请号：US12060730
申请日：2008-04-01
申请人： Joerg Bewersdorf , Manuel F. Juette , Travis Gould , Sam T. Hess
发明人： Joerg Bewersdorf , Manuel F. Juette , Travis Gould , Sam T. Hess
IPC分类号： G01J1/58 , G02B21/06
CPC分类号： G02B21/367 , G02B21/16 , G02B21/361 , G02B27/58 , H04N13/218 , H04N13/254 , H04N2013/0085
摘要： A microscopy system is configured for creating 3D images from individually localized probe molecules. The microscopy system includes a sample stage, an activation light source, a readout light source, a beam splitting device, at least one camera, and a controller. The activation light source activates probes of at least one probe subset of photo-sensitive luminescent probes, and the readout light source causes luminescence light from the activated probes. The beam splitting device splits the luminescence light into at least two paths to create at least two detection planes that correspond to the same or different number of object planes of the sample. The camera detects simultaneously the at least two detection planes, the number of object planes being represented in the camera by the same number of recorded regions of interest. The controller is programmable to combine a signal from the regions of interest into a 3D data.
摘要翻译：配置显微镜系统以从单独定位的探针分子创建3D图像。显微镜系统包括样品台，激活光源，读出光源，分束装置，至少一个照相机和控制器。活化光源激活光敏发光探针的至少一个探针子集的探针，并且读出的光源引起来自激活的探针的发光。分束装置将发光分成至少两条路径，以产生对应于样品的相同或不同数目的物平面的至少两个检测平面。相机同时检测至少两个检测平面，相机中相同数量的记录感兴趣区域的对象平面数目被表示在相机中。控制器是可编程的，以将来自感兴趣区域的信号组合成3D数据。

9. 发明授权

US07742226B2 Interference microscope, and method for operating an interference microscope 失效
标题翻译：干涉显微镜和干涉显微镜的操作方法
公开(公告)号：US07742226B2
公开(公告)日：2010-06-22
申请号：US11458914
申请日：2006-07-20
申请人： Joerg Bewersdorf , Hilmar Gugel
发明人： Joerg Bewersdorf , Hilmar Gugel
IPC分类号： G02B21/06 , G02B21/00
CPC分类号： G02B21/082 , G02B21/06 , G02B21/18 , G02B21/34
摘要： The present invention concerns an interference microscope and a method for operating an interference microscope, in particular a 4π microscope, standing wave field microscope, or I2M, I3M, or I5M microscope, at least one specimen support unit associated with the specimen being provided. For determination of the phase position of the interfering light in the specimen region, on the basis of which the interference microscope can be aligned, the interference microscope is characterized in that for determination of the illumination state in the specimen region of the interference microscope, at least one planar area of the specimen support unit is configured to be detectable by light microscopy.
摘要翻译：本发明涉及一种干涉显微镜和用于操作干涉显微镜的方法，特别是涉及一种干涉显微镜，显微镜，驻波场显微镜或I2M，I3M或I5M显微镜，提供至少一个与样品相关的样品支撑单元。为了确定样本区域中的干涉光的相位位置，基于干涉显微镜可以对准，干涉显微镜的特征在于，为了确定干涉显微镜的样本区域中的照明状态，样本支撑单元的至少一个平面区域被配置为可通过光学显微镜检测。

10. 发明授权

US06798569B2 Microscope and method for operating a microscope 有权
标题翻译：显微镜和操作显微镜的方法
公开(公告)号：US06798569B2
公开(公告)日：2004-09-28
申请号：US10037851
申请日：2002-01-04
申请人： Joerg Bewersdorf , Hilmar Gugel
发明人： Joerg Bewersdorf , Hilmar Gugel
IPC分类号： G02B2100
CPC分类号： G02B21/0024 , G02B21/006 , G02B21/0076
摘要： The present invention concerns a microscope, in particular a confocal or double confocal scanning microscope, as well as a method for operating a microscope, at least one specimen support unit associated with the specimen being provided, at least one reference specimen of known configuration being provided, and the reference specimen being detectable by light microscopy for calibration, alignment or adjustment of the microscope. With the microscope according to the present invention and the method according to the invention for operating a microscope, drift-related changes can be detected and compensated for. Auxiliary means with which a specimen can easily and reliably be focused are also provided.
摘要翻译：本发明涉及显微镜，特别是共聚焦或双共聚焦扫描显微镜，以及用于操作显微镜的方法，至少一个与所述样本相关联的样本支撑单元，提供了至少一个已知构造的参考样本，并且通过光学显微镜检测参考样品用于显微镜的校准，对准或调整。利用根据本发明的显微镜和用于操作显微镜的根据本发明的方法，可以检测和补偿漂移相关的变化。还提供了可以容易且可靠地聚焦的试样的辅助装置。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式