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1. 发明申请

US20110114524A1 STORAGE-STABLE, FUNCTIONALLY INTACT FIBRINOGEN 有权
标题翻译：存储稳定，功能性的INTIF FIBRINOGEN
公开(公告)号：US20110114524A1
公开(公告)日：2011-05-19
申请号：US13000934
申请日：2009-06-22
申请人： Johann Eibl
发明人： Johann Eibl
IPC分类号： A61B17/00 , A61K38/17 , A61K9/00 , B82Y5/00
CPC分类号： A61K9/19 , A61K9/0019 , A61K47/183 , A61K47/26 , A61K47/46 , C07K14/75
摘要： Method for the production of a fibrinogen solution from an aqueous solution that contains functionally intact fibrinogen and is contaminated with profibrin and/or fibrin monomers and/or fibrin monomer complexes and/or fibrin split products, characterized in that the contaminations are precipitated using a non-denaturing precipitating agent at a temperature ranging from −4° to +4° and calcium ion activity not exceeding that of a 1,000 μM CaCl2 solution and are separated from the solution by means of filtering or centrifugation process.
摘要翻译：从含有功能完整的纤维蛋白原的水溶液生产纤维蛋白原溶液的方法，其被纤维蛋白和/或纤维蛋白单体和/或纤维蛋白单体复合物和/或纤维蛋白分离产物污染，其特征在于，使用非 - - 变性沉淀剂，温度范围为-4°至+ 4°，钙离子活性不超过1,000μMCaCl 2溶液，并通过过滤或离心过程与溶液分离。

2. 发明申请

US20090047616A1 Dental handpiece with a root canal length measurement function 有权
标题翻译：牙根手柄具有根管长度测量功能
公开(公告)号：US20090047616A1
公开(公告)日：2009-02-19
申请号：US12228406
申请日：2008-08-11
申请人： Johann Eibl , Andreas Brandstaetter
发明人： Johann Eibl , Andreas Brandstaetter
IPC分类号： A61C1/00 , A61C19/04
CPC分类号： A61C1/084 , A61C19/041
摘要： A handpiece for measuring root canal length comprises an outer sleeve that is substantially non-insulating, a connecting device, an instrument carrier, at least one transmission element within the outer sleeve, a length measuring circuit portion, a contact portion and an insulating portion. The instrument carrier is configured to receive a dental instrument. The transmission element transmits force to move the instrument carrier so that a dental instrument received in the instrument carrier executes a rotating, reciprocating and/or vibrating working movement. The length measuring circuit portion is disposed inside the handpiece and operable to transmit measuring signals for measuring length. The contact portion is operable to establish a conductive path between the dental instrument serving as an electrode and the length measuring circuit portion. The insulating portion insulates the length measurement circuit portion and the contact device, through which a voltage is applied during measurement, from the outer sleeve.
摘要翻译：用于测量根管长度的手柄包括基本上不绝缘的外套筒，连接装置，仪器载体，外套筒内的至少一个传动元件，长度测量电路部分，接触部分和绝缘部分。仪器载体被配置为接收牙科仪器。传递元件传递力以移动仪器载体，使得容纳在仪器载体中的牙科仪器执行旋转，往复和/或振动的工作运动。长度测量电路部分设置在手持件的内部并且可操作地传送用于测量长度的测量信号。接触部分可操作以在用作电极的牙科器械和长度测量电路部分之间建立导电路径。绝缘部分将长度测量电路部分和测量期间施加电压的接触装置与外部套管绝缘。

3. 发明授权

US07452208B2 Dental handpiece with a root canal length measurement function 失效
标题翻译：牙根手柄具有根管长度测量功能
公开(公告)号：US07452208B2
公开(公告)日：2008-11-18
申请号：US11239956
申请日：2005-09-29
申请人： Johann Eibl , Andreas Brandstaetter
发明人： Johann Eibl , Andreas Brandstaetter
IPC分类号： A61C19/04
CPC分类号： A61C1/084 , A61C19/041
摘要： A handpiece for measuring root canal length comprises an outer sleeve that is substantially non-insulating, a connecting device, an instrument carrier, at least one transmission element within the outer sleeve, a length measuring circuit portion, a contact portion and an insulating portion. The instrument carrier is configured to receive a dental instrument. The transmission element transmits force to move the instrument carrier so that a dental instrument received in the instrument carrier executes a rotating, reciprocating and/or vibrating working movement. The length measuring circuit portion is disposed inside the handpiece and operable to transmit measuring signals for measuring length. The contact portion is operable to establish a conductive path between the dental instrument serving as an electrode and the length measuring circuit portion. The insulating portion insulates the length measurement circuit portion and the contact device, through which a voltage is applied during measurement, from the outer sleeve.
摘要翻译：用于测量根管长度的手柄包括基本上不绝缘的外套筒，连接装置，仪器载体，外套筒内的至少一个传动元件，长度测量电路部分，接触部分和绝缘部分。仪器载体被配置为接收牙科仪器。传递元件传递力以移动仪器载体，使得容纳在仪器载体中的牙科仪器执行旋转，往复和/或振动的工作运动。长度测量电路部分设置在手持件的内部并且可操作地传送用于测量长度的测量信号。接触部分可操作以在用作电极的牙科器械和长度测量电路部分之间建立导电路径。绝缘部分将长度测量电路部分和测量期间施加电压的接触装置与外部套管绝缘。

4. 发明申请

US20060068356A1 Dental handpiece with a root canal length measurement function 失效
公开(公告)号：US20060068356A1
公开(公告)日：2006-03-30
申请号：US11239956
申请日：2005-09-29
申请人： Johann Eibl , Andreas Brandstaetter
发明人： Johann Eibl , Andreas Brandstaetter
IPC分类号： A61C1/00 , A61C19/04
CPC分类号： A61C1/084 , A61C19/041
摘要： A handpiece for measuring root canal length comprises an outer sleeve that is substantially non-insulating, a connecting device, an instrument carrier, at least one transmission element within the outer sleeve, a length measuring circuit portion, a contact portion and an insulating portion. The instrument carrier is configured to receive a dental instrument. The transmission element transmits force to move the instrument carrier so that a dental instrument received in the instrument carrier executes a rotating, reciprocating and/or vibrating working movement. The length measuring circuit portion is disposed inside the handpiece and operable to transmit measuring signals for measuring length. The contact portion is operable to establish a conductive path between the dental instrument serving as an electrode and the length measuring circuit portion. The insulating portion insulates the length measurement circuit portion and the contact device, through which a voltage is applied during measurement, from the outer sleeve.

5. 发明授权

US06924151B2 Stable factor VIII/vWF-complex 失效
标题翻译：稳定因子VIII / vWF-复合物
公开(公告)号：US06924151B2
公开(公告)日：2005-08-02
申请号：US09849484
申请日：2001-05-07
申请人： Bernhard Fischer , Artur Mitterer , Friedrich Dorner , Johann Eibl
发明人： Bernhard Fischer , Artur Mitterer , Friedrich Dorner , Johann Eibl
IPC分类号： A61K38/43 , A61K31/00 , A61K38/37 , A61P7/00 , A61P7/04 , C07K1/18 , C07K1/22 , C07K14/745 , C07K14/755 , G01N1/18
CPC分类号： C07K14/755 , Y10S514/834 , Y10T436/25375
摘要： There are disclosed a stable factor VIII/vWF-complex, particularly comprising high-molecular vWF multimers, being free from low-molecular vWF molecules and from proteolytic vWF degradation products, as well as a method of producing this complex.
摘要翻译：公开了稳定的因子VIII / vWF-复合物，特别是包含不含低分子vWF分子和蛋白水解vWF降解产物的高分子vWF多聚体，以及生产该复合物的方法。

6. 发明授权

US06831159B1 Method for purifying factor VIII/vWF company by cation-exchange chromatography 有权
标题翻译：通过阳离子交换色谱法纯化因子VIII / VWF-复合物的方法
公开(公告)号：US06831159B1
公开(公告)日：2004-12-14
申请号：US09367459
申请日：2000-05-08
申请人： Artur Mitterer , Bernhard Fischer , Öyvind L. Schönberger , Kathrin Thomas-Urban , Friedrich Dorner , Johann Eibl
发明人： Artur Mitterer , Bernhard Fischer , Öyvind L. Schönberger , Kathrin Thomas-Urban , Friedrich Dorner , Johann Eibl
IPC分类号： A23J100
CPC分类号： A61K38/37 , C07K14/755
摘要： Methods for recovering factor VIII/vWF-complex that involve binding factor VIII/vWF-complex from a protein solution to a cation exchanger and recovering factor VIII/vWF-complex by step-wise elution are disclosed. The recovered complex contains high-molecular vWF multimers. Compositions containing factor VIII/vWF-complex as purified by cation exchange chromatography are also provided.
摘要翻译：公开了将蛋白质溶液与阳离子交换剂结合的因子VIII / vWF-复合物的因子VIII / vWF-复合物的回收方法，通过逐步洗脱回收因子VIII / vWF-复合物。回收的复合物含有高分子vWF多聚体。还提供了通过阳离子交换层析纯化的含有因子VIII / vWF-络合物的组合物。

7. 发明授权

US06573071B1 Factor X analogues with a modified protease cleavage site 有权
标题翻译：具有修饰的蛋白酶切割位点的因子X类似物
公开(公告)号：US06573071B1
公开(公告)日：2003-06-03
申请号：US09367791
申请日：1999-11-12
申请人： Michele Himmelspach , Uwe Schlokat , Friedrich Dorner , Andreas Fisch , Johann Eibl
发明人： Michele Himmelspach , Uwe Schlokat , Friedrich Dorner , Andreas Fisch , Johann Eibl
IPC分类号： C12P2100
CPC分类号： C12N9/6432 , A61K38/00 , C12Y304/21006
摘要： Factor X analogues having a modification in the region of the natural Factor Xa activation cleavage site, said modification representing a processing site of a protease not naturally cleaving in this region of the Factor X sequence, preparations containing the Factor X analogues according to the invention, and processes for the preparation thereof are described.
摘要翻译：因子X类似物在天然因子Xa活化切割位点的区域具有修饰，所述修饰代表在因子X序列的该区域中不自然切割的蛋白酶的加工位点，所述制剂含有本发明的因子X类似物，并描述其制备方法。

8. 发明授权

US06465624B1 Purification of von-Willebrand factor by cation exchanger chromatography 有权
标题翻译：通过阳离子交换层析纯化冯维勒布兰德因子
公开(公告)号：US06465624B1
公开(公告)日：2002-10-15
申请号：US09367460
申请日：1999-10-21
申请人： Bernhard Fischer , Öyvind L. Schönberger , Artur Mitterer , Christian Fiedler , Friedrich Dorner , Johann Eibl
发明人： Bernhard Fischer , Öyvind L. Schönberger , Artur Mitterer , Christian Fiedler , Friedrich Dorner , Johann Eibl
IPC分类号： A23J100
CPC分类号： C07K14/755 , A61K38/00
摘要： Disclosed are a method of recovering vWF in which vWF at a low salt concentration is bound to a cation exchanger and vWF having a high specific activity is recovered by fractionated elution, as well as a preparation having purified vWF obtainable by this method.
摘要翻译：公开了一种回收vWF的方法，其中低盐浓度的vWF与阳离子交换剂结合，并且通过分级洗脱回收具有高比活性的vWF，以及通过该方法可获得纯化的vWF的制剂。

9. 发明授权

US6165711A Process for disintegrating nucleic acids and preparing biological products of guaranteed quality 失效
标题翻译：分解核酸并制备质量保证的生物制品的方法
公开(公告)号：US6165711A
公开(公告)日：2000-12-26
申请号：US155758
申请日：1998-11-18
申请人： Friedrich Dorner , Noel Barrett , Johann Eibl
发明人： Friedrich Dorner , Noel Barrett , Johann Eibl
IPC分类号： A61K39/12 , A61L2/00 , C12N7/04 , C12N15/10 , C12Q1/70 , C12Q1/68 , C12N5/00 , A01N63/00
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/55505 , A61L2/0011 , A61L2/08 , C12N7/00 , C12N15/10 , C12N2740/16034 , C12N2770/24034 , C12N2770/24061 , C12N2770/24134
摘要： The invention relates to a method for the disintegration of any biologically active nucleic acid in a biological material, wherein a biologically active material is exposed or multiply exposed to laser beam to disintegrate essentially all biologically active nucleic acid in said biological material, while the biological integrity and activity of said biological material is maintained.
摘要翻译： PCT No.PCT / AT97 / 00068 Sec。 371日期：1998年11月18日 102（e）1998年11月18日PCT PCT 1997年4月8日提交PCT公布。出版物WO97 / 37686 日期1997年10月16日本发明涉及一种生物材料中任何生物活性核酸分解的方法，其中将生物活性材料暴露于或多次暴露于激光束以分解所述生物材料中的所有生物活性核酸同时保持所述生物材料的生物完整性和活性。

10. 发明授权

US6103693A Method for isolation of highly pure von willebrand factor 失效
标题翻译：分离高纯度von willebrand因子的方法
公开(公告)号：US6103693A
公开(公告)日：2000-08-15
申请号：US898130
申请日：1997-07-22
申请人： Bernhard Fischer , Artur Mitterer , Friedrich Dorner , Hans-Peter Schwarz , Peter Turecek , Johann Eibl , Falko-Guenter Falkner , Uwe Schlokat , Wolfgang Mundt , Manfred Reiter , Renate Den-Bouwmeester
发明人： Bernhard Fischer , Artur Mitterer , Friedrich Dorner , Hans-Peter Schwarz , Peter Turecek , Johann Eibl , Falko-Guenter Falkner , Uwe Schlokat , Wolfgang Mundt , Manfred Reiter , Renate Den-Bouwmeester
IPC分类号： C12N15/09 , A61K35/14 , A61K38/00 , A61K38/43 , A61P7/04 , C07K1/18 , C07K1/22 , C07K14/47 , C07K14/755 , C12P21/00 , A61K38/17 , C07K14/745
CPC分类号： C07K14/755 , A61K38/00
摘要： The invention relates to a method for isolation of highly pure von Willebrand Factor in which recombinant von Willebrand Factor (rvWF) is chromatographically purified by anion exchange chromatography on an anion exchanger of the quaternary amino type in a buffer solution comprising buffer substances and optionally salt.The buffer solutions are preferably free of stabilizers, amino acids and other additives. According to this method, highly pure recombinant vWF can be obtained, which is free from blood plasma proteins, especially free from Factor VIII, and is physiologically active.Further, the invention relates to a pharmaceutical preparation that contains rvWF, which is comprised of multimers with a high structural integrity.
摘要翻译：本发明涉及一种用于分离高纯度血管性血友病因子的方法，其中重组血管性血友病因子（rvWF）通过阴离子交换色谱在季氨基型阴离子交换剂上在包含缓冲物质和任选盐的缓冲溶液中进行色谱纯化。缓冲溶液优选不含稳定剂，氨基酸和其它添加剂。根据该方法，可以获得高纯度的重组vWF，其不含血浆蛋白质，特别是不含因子VIII，且具有生理活性。此外，本发明涉及含有rvWF的药物制剂，其由具有高结构完整性的多聚体组成。

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