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1. 发明申请

US20140057830A1 ALPHABODIES SPECIFICALLY BINDING TO CYTOKINES OR GROWTH FACTORS AND/OR CYTOKINE OR GROWTH FACTOR RECEPTORS 审中-公开
标题翻译： ALPHABODIES特异性结合细胞因子或生长因子和/或细胞因子或生长因子受体
公开(公告)号：US20140057830A1
公开(公告)日：2014-02-27
申请号：US13994107
申请日：2012-01-06
申请人： Ignace Lasters , Johan Desmet , Maria Henderikx , Anita Wehnert , Geert Meersseman
发明人： Ignace Lasters , Johan Desmet , Maria Henderikx , Anita Wehnert , Geert Meersseman
IPC分类号： C07K14/00
CPC分类号： C07K14/001 , C07K16/244 , C07K16/2866 , C07K2317/33 , C07K2318/20
摘要： Alphabodies that specifically bind to cytokines or growth factor and/or their receptors, as well as polypeptides that comprise or essentially consist of such Alphabodies. Further nucleic acids encoding such Alphabodies; methods for preparing such Alphabodies and polypeptides; host cells expressing or capable of expressing such Alphabodies and polypeptides; compositions, and in particular pharmaceutical compositions, that comprise such Alphabodies, polypeptides, nucleic acids and/or host cells; and uses of such Alphabodies or polypeptides, nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes.
摘要翻译：与细胞因子或生长因子和/或其受体特异性结合的抗体，以及包含或基本上由此类Alphabody组成的多肽。编码这样的阿片受体的另外的核酸; 制备此类抗体和多肽的方法; 表达或能够表达此类α受体和多肽的宿主细胞; 组合物，特别是药物组合物，其包含这样的阿片受体，多肽，核酸和/或宿主细胞; 以及这些阿拉伯抗体或多肽，核酸，宿主细胞和/或组合物的用途，特别是用于预防，治疗或诊断目的。

2. 发明授权

US09315805B2 Alphabody libraries and methods for producing the same 有权
标题翻译： Alphabody图书馆及其制作方法
公开(公告)号：US09315805B2
公开(公告)日：2016-04-19
申请号：US13994003
申请日：2011-01-06
申请人： Johan Desmet , Ignace Lasters , Maria Henderikx , Anita Wehnert
发明人： Johan Desmet , Ignace Lasters , Maria Henderikx , Anita Wehnert
IPC分类号： C40B50/06 , C12N15/10 , C07K14/00 , C07K16/24 , C07K16/00 , C40B50/12
CPC分类号： C07K16/244 , C07K14/001 , C07K16/00 , C07K16/005 , C07K2317/33 , C07K2318/20 , C12N15/1037 , C12N15/1055 , C40B40/10 , C40B50/12
摘要： The invention provides single-chain Alphabody library comprising at least 100 different-sequence single-chain Alphabody polypeptides, wherein said Alphabody polypeptides differ from each other in at least one of a defined set of 5 to 20 variegated amino acid residue positions, and wherein at least 70% but not all of said variegated amino acid residue positions are located either in the loop, helix surface or linker region of the Alphabody. The invention further provides methods for use of the Alphabody libraries and Alphabodies obtainable by the methods of the invention.
摘要翻译：本发明提供了包含至少100个不同序列单链Alphabody多肽的单链Alphabody文库，其中所述Alphabody多肽在至少一个5至20个杂化氨基酸残基位置中的至少一个中彼此不同，并且其中在至少70％但不是全部所述杂色氨基酸残基位置位于Alphabody的环，螺旋表面或接头区。本发明进一步提供了通过本发明方法可获得的使用阿尔法抗体文库和阿尔培布氏体的方法。

3. 发明申请

US20140066601A1 ALPHABODY LIBRARIES AND METHODS FOR PRODUCING THE SAME 有权
标题翻译： ALPHABODY LIBRARIES及其生产方法
公开(公告)号：US20140066601A1
公开(公告)日：2014-03-06
申请号：US13994003
申请日：2011-01-06
申请人： Johan Desmet , Ignace Lasters , Maria Henderikx , Anita Wehnert
发明人： Johan Desmet , Ignace Lasters , Maria Henderikx , Anita Wehnert
IPC分类号： C12N15/10 , C07K16/00
CPC分类号： C07K16/244 , C07K14/001 , C07K16/00 , C07K16/005 , C07K2317/33 , C07K2318/20 , C12N15/1037 , C12N15/1055 , C40B40/10 , C40B50/12
摘要： The invention provides single-chain Alphabody library comprising at least 100 different-sequence single-chain Alphabody polypeptides, wherein said Alphabody polypeptides differ from each other in at least one of a defined set of 5 to 20 variegated amino acid residue positions, and wherein at least 70% but not all of said variegated amino acid residue positions are located either in the loop, helix surface or linker region of the Alphabody. The invention further provides methods for use of the Alphabody libraries and Alphabodies obtainable by the methods of the invention.
摘要翻译：本发明提供了包含至少100个不同序列单链Alphabody多肽的单链Alphabody文库，其中所述Alphabody多肽在至少一个5至20个杂化氨基酸残基位置中的至少一个中彼此不同，并且其中在至少70％但不是全部所述杂色氨基酸残基位置位于Alphabody的环，螺旋表面或连接区中。本发明进一步提供了通过本发明方法可获得的使用阿尔法抗体文库和阿尔培布氏体的方法。

4. 发明授权

US09217011B2 Non-natural proteinaceous scaffold made of three non-covalently associated peptides 有权
标题翻译：非天然蛋白质支架由三个非共价相关肽组成
公开(公告)号：US09217011B2
公开(公告)日：2015-12-22
申请号：US12676783
申请日：2008-09-08
申请人： Johan Desmet , Ignace Lasters
发明人： Johan Desmet , Ignace Lasters
IPC分类号： C07K14/00 , C07K1/00 , C07K7/08
CPC分类号： C07K1/00 , C07K7/08 , C07K14/001 , C07K2318/20
摘要： The present invention is related to a non-natural, thermodynamically stable, proteinaceous scaffold consisting of three non-covalently associated peptides, wherein each peptide sequence comprises less than fifty amino acid residues and wherein at least 50% of the said residues are substitutable amino acids into at least ten different amino acid residue types. The present invention is further related to a non-natural, triple-stranded, parallel alpha-helical coiled coil scaffold wherein each of the three constituting peptide sequences comprise between 2 and 7 consecutive heptad repeats of the formula cxxcxxx (SEQ ID NO: 10), wherein at least 70% of the core c-residues are isoleucines, wherein all non-core x-residues are alanines, and wherein the constituting peptide sequences remain associated under physical conditions that are significantly different from physiological conditions.
摘要翻译：本发明涉及由三种非共价相关肽组成的非天然的热力学稳定的蛋白质支架，其中每个肽序列包含少于50个氨基酸的残基，并且其中至少50％的所述残基是可取代的氨基酸至少十种不同的氨基酸残基类型。本发明进一步涉及非天然的三链平行α-螺旋卷曲线圈支架，其中三个构成肽序列中的每一个包含2至7个连续的式cxxcxxx（SEQ ID NO：10）的七重复重复序列，其中至少70％的核心c残基是异亮氨酸，其中所有非核心x残基都是丙氨酸，并且其中构成的肽序列在与生理条件显着不同的物理条件下保持相关。

5. 发明申请

US20130013279A1 APPARATUS AND METHOD FOR STRUCTURE-BASED PREDICTION OF AMINO ACID SEQUENCES 审中-公开
标题翻译：用于氨基酸序列的结构预测的装置和方法
公开(公告)号：US20130013279A1
公开(公告)日：2013-01-10
申请号：US13472080
申请日：2012-05-15
申请人： Johan Desmet , Ignace Lasters , Dominique Vlieghe , Carlo Boutton , Philippe Stas
发明人： Johan Desmet , Ignace Lasters , Dominique Vlieghe , Carlo Boutton , Philippe Stas
IPC分类号： G06F19/16 , G06G7/48
CPC分类号： G16B15/00
摘要： The present invention provides methods and apparatus for analyzing a protein structure.
摘要翻译：本发明提供了分析蛋白质结构的方法和装置。

6. 发明申请

US20120202247A1 METHOD, COMPUTING ROUTINE, DEVICE FOR PREDICTING PROPERTIES OF MHC/PEPTIDE COMPLEXES, AND DATA AND PEPTIDES PRODUCED THEREFROM 审中-公开
标题翻译：方法，计算方法，用于预测MHC /肽复合物的性质的装置，以及其生产的数据和肽
公开(公告)号：US20120202247A1
公开(公告)日：2012-08-09
申请号：US13431282
申请日：2012-03-27
申请人： Ignace Lasters , Johan Desmet
发明人： Ignace Lasters , Johan Desmet
IPC分类号： C07K7/06 , G06G7/58 , C12P21/00 , C12N15/33 , C07K16/08
CPC分类号： G16B15/00 , G16B20/00
摘要： The present invention relates to a method for structure-based prediction of properties of peptides and peptide analogs in complex with major histocompatibility (MHC) class I and class II molecules. The said properties mainly relate to the three-dimensional structure of an MHC/peptide complex and the binding affinity of a peptide for an MHC receptor. The invention further relates to a computer program and a device therefor. The invention further relates to data produced by a method of the invention. The invention further relates to peptides and peptide analogs predicted to bind to target-MHC molecules. The present invention thus relates to the field of immunology, with possible applications in manufacture of vaccinates, de-immunization of proteins, and manufacture of therapeutic agents, especially immuno-therapeutic agents.
摘要翻译：本发明涉及与主要组织相容性（MHC）I类和II类分子复合的肽和肽类似物的基于结构的预测性质的方法。所述性质主要涉及MHC /肽复合物的三维结构和肽对MHC受体的结合亲和力。本发明还涉及一种计算机程序及其装置。本发明还涉及通过本发明的方法产生的数据。本发明还涉及预期与靶MHC分子结合的肽和肽类似物。因此，本发明涉及免疫学领域，可能应用于疫苗接种的制造，蛋白质的去免疫，以及治疗剂，特别是免疫治疗剂的制造。

7. 发明申请

US20140294828A1 ALPHABODIES SPECIFICALLY BINDING TO VIRAL PROTEINS AND METHODS FOR PRODUCING THE SAME 审中-公开
标题翻译：特异性绑定到病毒蛋白质的方法及其生产方法
公开(公告)号：US20140294828A1
公开(公告)日：2014-10-02
申请号：US13994106
申请日：2011-01-06
申请人： Johan Desmet , Ignace Lasters , Geert Meersseman , Sabrina Deroo
发明人： Johan Desmet , Ignace Lasters , Geert Meersseman , Sabrina Deroo
IPC分类号： C07K16/08
CPC分类号： C07K16/08 , A61K39/00 , C07K16/1063 , C07K2317/92 , C07K2318/20 , G01N33/56988 , Y02A50/53 , Y02A50/60
摘要： The invention provides methods for the production of single-chain Alphabody polypeptides having detectable binding affinity for, or detectable in vitro activity on, a viral protein of interest, which comprising the step of producing a single-chain Alphabody library comprising at least 100 different-sequence single-chain Alphabody polypeptides, wherein said Alphabody polypeptides differ from each other in at least one of a defined set of 5 to 20 variegated amino acid residue positions, and wherein said variegated amino acid residue positions are located at specific positions in one or more of the alpha-helices of the Alphabody or the linker fragment connecting two consecutive alpha-helices of the Alphabody polypeptides. The invention further provides Alphabodies obtainable by the methods of the invention and uses thereof.
摘要翻译：本发明提供了生产具有对感兴趣的病毒蛋白质具有可检测的结合亲和力或可检测的体外活性的单链阿拉伯糖苷多肽的方法，其包括产生包含至少100个不同序列的单链Alphabody文库的步骤，序列单链Alphabody多肽，其中所述Alphabody多肽在限定的5至20个杂化氨基酸残基位置中的至少一个中彼此不同，并且其中所述杂色氨基酸残基位置位于一个或多个的Alphabody的α-螺旋或连接Alphabody多肽的两个连续的α-螺旋的连接物片段。本发明还提供了可通过本发明的方法获得的阿尔培布本及其用途。

8. 发明申请

US20130261049A1 ALPHABODIES SPECIFICALLY BINDING TO CLASS-I VIRAL FUSION PROTEINS AND METHODS FOR PRODUCING THE SAME 审中-公开
标题翻译：字体特殊绑定到类别的病毒融合蛋白及其生产方法
公开(公告)号：US20130261049A1
公开(公告)日：2013-10-03
申请号：US13994102
申请日：2011-12-02
申请人： Johan Desmet , Ignace Lasters , Geert Meersseman , Sabrina Deroo
发明人： Johan Desmet , Ignace Lasters , Geert Meersseman , Sabrina Deroo
IPC分类号： C07K14/00
CPC分类号： C07K14/00 , C07K16/1027 , C07K16/1063 , C07K2317/76 , C07K2317/92 , C07K2318/20
摘要： Single-chain Alphabodies that comprise an alpha-helical binding region which mediates binding to a first fusion-driving region of a class-1 viral fusion protein and which structurally mimics a second fusion-driving region of said class-1 viral fusion protein, wherein said first and second fusion-driving regions of said class-1 viral fusion protein are regions which interact to drive the fusion between a virus displaying said class-1 viral fusion protein and a target cell.
摘要翻译：包含α-螺旋结合区的单链抗体，其介导与第1类病毒融合蛋白的第一融合驱动区结合并且结构上模拟所述1类病毒融合蛋白的第二融合驱动区，其中所述1类病毒融合蛋白的第一和第二融合驱动区域是相互作用以驱动显示所述1类病毒融合蛋白的病毒与靶细胞之间的融合的区域。

9. 发明申请

US20120278054A1 METHOD FOR AFFINITY SCORING OF PEPTIDE/PROTEIN COMPLEXES 失效
标题翻译：肽/蛋白复合物的亲和性分选方法
公开(公告)号：US20120278054A1
公开(公告)日：2012-11-01
申请号：US13270931
申请日：2011-10-11
申请人： Johan Desmet , Geert Meersseman , Nathalie Boutonnet , Jurgen Pletinckx , Krista De Clercq , Ignace Lasters
发明人： Johan Desmet , Geert Meersseman , Nathalie Boutonnet , Jurgen Pletinckx , Krista De Clercq , Ignace Lasters
IPC分类号： G06F19/12
CPC分类号： G06F19/16 , G06F19/18
摘要： The present invention is related to a quantitative structure-based affinity scoring method for peptide/protein complexes. More specifically, the present invention comprises a method that operates on the basis of a highly specific force field function (e.g. CHARMM) that is applied to all-atom structural representations of peptide/receptor complexes. Peptide side-chain contributions to total affinity are scored after detailed rotameric sampling followed by controlled energy refinement. The method of the invention further comprises a de novo approach to estimate dehydration energies from the simulation of individual amino acids in a solvent box filled with explicit water molecules and applying the same force field function as used to evaluate peptide/receptor complex interactions.
摘要翻译：本发明涉及肽/蛋白复合物的基于定量结构的亲和评分方法。更具体地说，本发明包括一种基于应用于肽/受体复合物的全原子结构表示的高度特异性的力场函数（例如CHARMM）来操作的方法。在详细的旋转异构体取样之后进行受控能量细化，对总亲和力的肽侧链贡献进行评分。本发明的方法还包括从填充有显性水分子的溶剂盒中的各个氨基酸的模拟估算脱水能量并应用用于评估肽/受体复合物相互作用的相同的力场函数的从头方法。

10. 发明申请

US20110137617A1 METHOD FOR GENERATING INFORMATION RELATED TO THE MOLECULAR STRUCTURE OF A BIOMOLECULE 有权
标题翻译：用于产生与生物分子的分子结构相关的信息的方法
公开(公告)号：US20110137617A1
公开(公告)日：2011-06-09
申请号：US12959224
申请日：2010-12-02
申请人： Johan DESMET , Ignace Lasters , Dominique Vlieghe , Carlo Boutton , Philippe Stas , Jan Spriet
发明人： Johan DESMET , Ignace Lasters , Dominique Vlieghe , Carlo Boutton , Philippe Stas , Jan Spriet
IPC分类号： G06F17/50
CPC分类号： G06F19/16 , B01J2219/00689 , B01J2219/00695 , B01J2219/007 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , C07K1/00 , C07K2299/00 , C40B40/06 , C40B40/10 , C40B40/12
摘要： A method for generating information related to the molecular structure of a biomolecule, comprising the steps of: (a) receiving a three-dimensional representation of said molecular structure, comprising a first set of residue portions and a template; and (b) modifying the representation of step (a) by at least one optimization cycle. Each optimization cycle comprises the steps of: (b1) perturbing a first representation of the molecular structure by modifying the structure of one or more of the first set of residue portions; (b2) relaxing the perturbed representation by optimizing the structure of one or more of the non-perturbed residue portions of the first set with respect to the one or more perturbed residue portions; (b3) evaluating the perturbed and relaxed representation of the molecular structure by using an energetic cost function and replacing the first representation by the perturbed and relaxed representation if the latter's global energy is more optimal than that of the first representation; and the method further comprises the steps of (c) terminating the optimization process according to step (b) when a predetermined termination criterion is reached; and (d) outputting to a storage medium or to a consecutive method a data structure comprising information extracted from step (b).
摘要翻译：一种用于产生与生物分子的分子结构相关的信息的方法，包括以下步骤：（a）接收所述分子结构的三维表示，包括第一组残基部分和模板; 和（b）通过至少一个优化周期来修改步骤（a）的表示。每个优化周期包括以下步骤：（b1）通过修改第一组残留部分中的一个或多个的结构扰乱分子结构的第一表示; （b2）通过相对于一个或多个扰动残余部分优化第一组的非扰动残余部分的一个或多个的结构来放松扰动表示; （b3）通过使用能量成本函数来评估分子结构的扰动和松弛表示，并且如果后者的全局能量比第一表示更为优化，则通过扰动和轻松表示来代替第一表示; 并且所述方法还包括以下步骤：（c）当达到预定的终止标准时，终止根据步骤（b）的优化过程; 以及（d）向存储介质或连续方法输出包括从步骤（b）提取的信息的数据结构。

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