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1. 发明申请

US20070191259A1 Inhibition of s6 kinaze activity for the treatment of insulin resistance 审中-公开
标题翻译：抑制s6基因活性治疗胰岛素抵抗
公开(公告)号：US20070191259A1
公开(公告)日：2007-08-16
申请号：US10568637
申请日：2004-08-20
申请人： Johan Auwerx , Francesca Frigerio , Stefan Fumagalli , Sara Kozma , Frederic Picard , Melanie Sticker-Jantscheff , George Thomas , Sung Um , Mitsuhiro Watanabe
发明人： Johan Auwerx , Francesca Frigerio , Stefan Fumagalli , Sara Kozma , Frederic Picard , Melanie Sticker-Jantscheff , George Thomas , Sung Um , Mitsuhiro Watanabe
IPC分类号： C12Q1/68 , G01N33/48 , G01N33/537 , C12Q1/48
CPC分类号： G01N33/6893 , C12Q1/485 , G01N2500/00 , G01N2500/04 , G01N2800/042
摘要： This invention provides screening methods for agents effective in treating insulin resistance through specific inhibition of S6 kinase 1 activity. Also provided are methods of treating insulin resistance by administering an effective amount of an inhibitor specific for S6 kinase 1.
摘要翻译：本发明提供了通过特异性抑制S6激酶1活性有效治疗胰岛素抵抗的药剂的筛选方法。还提供了通过施用有效量的针对S6激酶1特异性的抑制剂来治疗胰岛素抵抗的方法。

2. 发明申请

US20070053910A1 Modulation of s6 kinase activity for the treatment of obesity 审中-公开
标题翻译：调节s6激酶活性治疗肥胖
公开(公告)号：US20070053910A1
公开(公告)日：2007-03-08
申请号：US10531515
申请日：2003-10-17
申请人： Francesca Frigerio , Stefano Fumagalli , Sara Kozma , Melanie Sticker-Jantscheff , George Thomas , Sung Um
发明人： Francesca Frigerio , Stefano Fumagalli , Sara Kozma , Melanie Sticker-Jantscheff , George Thomas , Sung Um
IPC分类号： A61K39/395 , C12Q1/68 , G01N33/53 , C12Q1/48 , A61K48/00
CPC分类号： C12N9/12 , A01K2217/075 , A01K2227/105 , A01K2267/0362 , C12N15/1137 , C12N2310/14 , C12Q1/485 , G01N2500/00 , G01N2800/044
摘要： This invention provides screening methods for agents effective in treating obesity through specific inhibition of S6 kinase 1 activity. Also provided are methods of treating obesity by administering an effective amount of an inhibitor specific for S6 kinase 1.
摘要翻译：本发明提供了通过特异性抑制S6激酶1活性有效治疗肥胖症的药物的筛选方法。还提供了通过施用有效量的对S6激酶1特异性的抑制剂来治疗肥胖症的方法。

3. 发明授权

US06833255B1 Drosophila melanogaster p70 S6 kinase 失效
标题翻译：果蝇果蝇p70 S6激酶
公开(公告)号：US06833255B1
公开(公告)日：2004-12-21
申请号：US10355724
申请日：2003-01-31
申请人： Mary Stewart , Sara Kozma , George Thomas
发明人： Mary Stewart , Sara Kozma , George Thomas
IPC分类号： C12P2106
CPC分类号： C12N9/1205 , A01K67/0339 , A01K2217/05
摘要： The invention provides Drosophila melanogaster p70S6K, as well as nucleic acids encoding this kinase. The sequence of Drosophila p70S6K and the gene encoding it are represented in SEQ ID No. 2 and 1 respectively. The invention moreover provides mutated forms of Drosophila p70S6K, including constitutively active and dominant negative forms thereof, which are useful in the study of p70S6K activity. Furthermore, the invention provides expression systems which produce Drosophila p70S6K in Drosophila and other organisms, and in particular systems in which expression of Drosophila p70S6K has been modulated so as to facilitate the study of its activity.
摘要翻译：本发明提供黑腹果蝇p70 以及编码该激酶的核酸。果蝇p70 的序列和编码它的基因分别表示在SEQ ID No.2和1中。此外，本发明提供了可用于研究p70 活性的果蝇p70 的突变形式，其包括组成型活性和显性负性形式。此外，本发明提供了在果蝇和其他生物体中产生果蝇p70 的表达系统，特别是已经调节果蝇p70 的表达以便于研究其活性的系统。

4. 发明申请

US20050004068A1 Modulation of tor 审中-公开
标题翻译：调制
公开(公告)号：US20050004068A1
公开(公告)日：2005-01-06
申请号：US10491945
申请日：2002-10-11
申请人： Patrick Dennis , Anja Jaeschke , Sara Kozma , Masao Saitoh , George Thomas
发明人： Patrick Dennis , Anja Jaeschke , Sara Kozma , Masao Saitoh , George Thomas
IPC分类号： G01N33/50 , A61K31/36 , A61K31/44 , A61K31/70 , A61K45/00 , A61P9/00 , A61P29/00 , A61P35/00 , A61P37/06 , C12Q1/02 , C12Q1/48 , C12Q1/66 , G01N33/15 , G01N33/573 , G01N33/574 , A61K31/522 , A61K31/7076
CPC分类号： C12Q1/485 , A61K31/36 , A61K31/44 , A61K31/70 , G01N33/5735 , G01N33/574 , G01N2500/10
摘要： Methods for screening for potential modulators of mammalian target of rapamycin (mTOR) are provided based on detecting cellular ATP levels. Also provided are compositions useful in treating diseases or conditions dependent on mTOR signaling, including cancer, rheumatoid arthritis, restinosis and transplant rejection.
摘要翻译：基于检测细胞ATP水平提供筛选哺乳动物雷帕霉素靶标（mTOR）的潜在调节剂的方法。还提供了可用于治疗依赖于mTOR信号传导的疾病或病症的组合物，包括癌症，类风湿性关节炎，再狭窄和移植排斥反应。

5. 发明授权

US06534311B2 Drosophila melanogaster p70S6 kinase 失效
标题翻译：黑腹果蝇p70S6激酶
公开(公告)号：US06534311B2
公开(公告)日：2003-03-18
申请号：US09817310
申请日：2001-03-26
申请人： Mary Stewart , Sara Kozma , George Thomas
发明人： Mary Stewart , Sara Kozma , George Thomas
IPC分类号： C12N500
CPC分类号： C12N9/1205 , A01K67/0333 , A01K67/0339 , A01K2217/05
摘要： The invention provides Drosophila melanogaster p70S6K, as well as nucleic acids encoding this kinase. The sequence of Drosophila p70S6K and the gene encoding it are represented in SEQ ID No. 2 and 1 respectively. The invention moreover provides mutated forms of Drosophila p70S6K, including constitutively active and dominant negative forms thereof, which are useful in the study of p70S6K activity. Furthermore, the invention provides expression systems which produce Drosophila p70S6K in Drosophila and other organisms, and in particular systems in which expression of Drosophila p70S6K has been modulated so as to facilitate the study of its activity.
摘要翻译：本发明提供了黑腹果蝇p70S6K以及编码该激酶的核酸。果蝇p70S6K的序列和编码它的基因分别表示在SEQ ID No.2和1中。本发明还提供了突变形式的果蝇p70S6K，其包括组成型活性和显性负性形式，其可用于研究p70S6K活性。此外，本发明提供了在果蝇和其他生物体中产生果蝇p70S6K的表达系统，特别是调节果蝇p70S6K的表达以便于研究其活性的系统。

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