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1. 发明申请

US20050080042A1 Synthetic heparin pentasaccharides 有权
标题翻译：合成肝素五糖
公开(公告)号：US20050080042A1
公开(公告)日：2005-04-14
申请号：US10488677
申请日：2002-09-06
申请人： Joachim Seifert , Latika Singh , Tracie Ramsdale , Michael West , Nicholas Drinnan
发明人： Joachim Seifert , Latika Singh , Tracie Ramsdale , Michael West , Nicholas Drinnan
IPC分类号： C07H15/18 , A61K31/7028 , A61K31/7034 , A61K31/7072 , A61P7/02 , A61P9/10 , C07H3/06 , C07H7/033 , C07H11/00 , C07H15/203 , C07H15/26 , C07H23/00 , A61K31/727 , C07H11/04 , C08B37/10
CPC分类号： C07H9/00 , C07H3/06 , C07H5/04 , C07H7/033 , C07H11/00 , C07H13/04 , C07H13/08 , C07H15/10 , C07H15/18
摘要： Preparation of synthetic monosaccharides, disaccharides, trisaccharides, tetrasaccharides and pentasaccharides for use in the preparation of synthetic heparinoids.
摘要翻译：制备用于制备合成类肝素的合成单糖，二糖，三糖，四糖和五糖。

2. 发明申请

US20060167237A1 Derivatives of monosaccharides for drug discovery 有权
标题翻译：用于药物发现的单糖衍生物
公开(公告)号：US20060167237A1
公开(公告)日：2006-07-27
申请号：US10524048
申请日：2003-08-08
申请人： Michael West , Peter Andrews , Tracie Ramsdale , Wim Meutermans , Giang Thanh Le , Chris Clark , Giovanni Abbenante , Ligong Liu
发明人： Michael West , Peter Andrews , Tracie Ramsdale , Wim Meutermans , Giang Thanh Le , Chris Clark , Giovanni Abbenante , Ligong Liu
IPC分类号： C07H5/04
CPC分类号： C07H23/00 , C07H5/06 , C07H15/18
摘要： New compounds and methods for the preparation of combinatorial libraries of potentially biologically active compounds are based on monosaccharides of formula I being a derivative of a furanose or pyranose form of a monosaccharide,
摘要翻译：用于制备潜在生物活性化合物的组合文库的新化合物和方法基于式I的单糖，其为呋喃糖或吡喃糖形式的单糖衍生物，

3. 发明申请

US20060121530A1 Disaccharides for drug discovery 有权
标题翻译：用于药物发现的二糖
公开(公告)号：US20060121530A1
公开(公告)日：2006-06-08
申请号：US10513286
申请日：2003-04-24
申请人： Wim Meutermans , Michael West , George Adamson , Giang Thanh Le , Nicholas Drinnan , Giovani Abbenante , Bernd Becker , Matthias Grathwohl , Premraj Rajaratnam , Gerald Tometzki
发明人： Wim Meutermans , Michael West , George Adamson , Giang Thanh Le , Nicholas Drinnan , Giovani Abbenante , Bernd Becker , Matthias Grathwohl , Premraj Rajaratnam , Gerald Tometzki
IPC分类号： C40B40/02 , C07H15/04 , C07H11/04
CPC分类号： C07H3/04 , C07H3/02 , C40B40/12 , C40B50/14
摘要： Methods are described for the preparation of combinatorial libraries of potentially biologically active disaccharide compounds. These compounds are variously functionalized, with a view to varying lipid solubility size, function an other properties, with the particular aim of discovering novel drug or drug-like compounds, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of disaccharides, variously functionalized about the sugar ring, including the addition of aromaticity and charge, and the placement of pharmaceutically useful groups and isosteres.
摘要翻译：描述了用于制备潜在的生物活性二糖化合物的组合文库的方法。为了改变脂质溶解度大小，这些化合物被多种功能化，起到其它特性的作用，特别是发现新的药物或药物样化合物或具有有用特性的化合物。本发明提供了关于糖环的各种功能化的二糖的溶液或固相合成的中间体，方法和合成策略，包括添加芳香性和电荷，以及放置药学上有用的基团和等体积体。

4. 发明申请

US20140235486A1 Methods and Compositions for the Treatment and Diagnosis of Breast Cancer 审中-公开
标题翻译：乳腺癌治疗和诊断的方法和组成
公开(公告)号：US20140235486A1
公开(公告)日：2014-08-21
申请号：US14238726
申请日：2012-08-16
申请人： Karen Chapman , Joseph Wagner , Michael West , Jennifer Lorrie Kidd , Maria Prendes
发明人： Karen Chapman , Joseph Wagner , Michael West , Jennifer Lorrie Kidd , Maria Prendes
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/158 , G01N33/57415
摘要： The invention provides for methods of diagnosis, prognosis and treatment of cancer including, but not limited to, breast cancer.
摘要翻译：本发明提供了诊断，预后和治疗癌症的方法，包括但不限于乳腺癌。

5. 发明申请

US20140141996A1 Methods and Compositions for the Treatment and Diagnosis of Cancer 审中-公开
标题翻译：癌症治疗和诊断的方法和组成
公开(公告)号：US20140141996A1
公开(公告)日：2014-05-22
申请号：US14127913
申请日：2012-06-23
申请人： Karen Chapman , Joseph Wagner , Michael West , Markus Daniel Lacher , Jennifer Lorie Kidd , Maria Prendes
发明人： Karen Chapman , Joseph Wagner , Michael West , Markus Daniel Lacher , Jennifer Lorie Kidd , Maria Prendes
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , G01N33/57407 , G01N33/57415 , G01N33/57484
摘要： Embodiments of the disclosure are directed to methods of diagnosis, prognosis and treatment of cancer. In some embodiments, the methods include targeting a marker that is expressed at abnormal levels in bladder cancer tissue in comparison to normal somatic tissue. Some embodiments are directed to methods of treating cancer comprising administering a composition including a therapeutic that affects the expression or function of a target marker. Some embodiments are directed to methods of detecting cancer comprising detecting a level of a target marker associated with the cancer,
摘要翻译：本公开的实施方案涉及癌症的诊断，预后和治疗方法。在一些实施方案中，所述方法包括靶向与正常体细胞组织相比在膀胱癌组织中以异常水平表达的标记。一些实施方案涉及治疗癌症的方法，包括施用包含影响靶标志的表达或功能的治疗剂的组合物。一些实施方案涉及检测癌症的方法，包括检测与癌症相关的靶标志的水平，

6. 发明申请

US20070224289A1 Multi-component biocide composition for wood protection 有权
标题翻译：用于木材保护的多组分杀生物剂组合物
公开(公告)号：US20070224289A1
公开(公告)日：2007-09-27
申请号：US11726359
申请日：2007-03-21
申请人： Carol Clausen , Vina Yang , Michael West , Elene West
发明人： Carol Clausen , Vina Yang , Michael West , Elene West
IPC分类号： A01N43/64 , A01N59/16 , A01N37/30 , A01N37/00 , A01N59/14
CPC分类号： A01N59/14 , B27K3/163 , B27K3/34 , B27K3/343 , B27K3/50 , B27K3/52 , A01N31/02 , A01N33/12 , A01N37/02 , A01N43/653 , A01N43/78 , A01N2300/00
摘要： The present disclosure generally relates to a multi-component biocide composition comprising a borate component in combination with an azole component to both inhibit mold fungi, decay fungi, such as brown-rot fungi and white-rot fungi, and to resist insect infestation.
摘要翻译：本公开内容一般涉及一种多组分杀生物剂组合物，其包含与唑类成分组合以抑制霉菌真菌，腐烂真菌如褐腐真菌和白腐真菌的硼酸盐组分，以及抵抗昆虫侵袭。

7. 发明申请

US20060026694A1 Method for generating immune-compatible cells and tissues using nuclear transfer techniques 审中-公开
公开(公告)号：US20060026694A1
公开(公告)日：2006-02-02
申请号：US11130979
申请日：2005-05-17
申请人： Robert Lanza , Michael West
发明人： Robert Lanza , Michael West
IPC分类号： A01K67/027
CPC分类号： C12N15/873 , A01K67/0271 , A01K2217/05 , A01K2227/101 , A01K2227/105 , A01K2267/025 , A61K49/0008 , C12N15/8771 , C12N2517/04
摘要： This invention relates to methods for making immune compatible tissues and cells for the purpose of transplantation and tissue engineering, using the techniques of nuclear transfer and cloning. Also encompassed are methods for determining the effect on immune compatibility of expressed transgenes and other genetic manipulations of the engineered cells and tissues.

8. 发明申请

US20050265976A1 Method of differentiation of morula or inner cell mass cells and method of making lineage-defective embryonic stem cells 审中-公开
标题翻译：桑ula或内细胞群细胞的分化方法及其谱系缺陷胚胎干细胞的制备方法
公开(公告)号：US20050265976A1
公开(公告)日：2005-12-01
申请号：US11025893
申请日：2004-12-29
申请人： Jose Cibelli , Michael West , Robert Lanza
发明人： Jose Cibelli , Michael West , Robert Lanza
IPC分类号： C12N15/09 , A61K35/12 , A61K35/28 , A61K35/30 , A61K35/48 , A61P1/16 , A61P3/10 , A61P9/00 , A61P9/02 , A61P11/00 , A61P13/02 , A61P17/02 , A61P19/04 , A61P21/04 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/28 , A61P31/18 , A61P35/00 , A61P37/06 , C12N5/0735 , C12N5/10 , A61K48/00 , C12N5/08
CPC分类号： C12N5/16 , A61K35/12 , C12N5/0606 , C12N2510/00
摘要： An improved method of producing differentiated progenitor cells comprising obtaining inner cell mass cells from a blastocyst and inducing differentiation of the inner cell mass cells to produce differentiated progenitor cells. The differentiated progenitor cells may be transfected such that there is an addition, deletion or alteration of a desired gene. The differentiated progenitor cells are useful in cell therapy and as a I source of cells for the production of tissues and organs for transplantation. Also provided is a method of producing a lineage-defective human embryonic stem cell.
摘要翻译：一种改进的产生分化祖细胞的方法，包括从囊胚获得内细胞质量细胞并诱导内细胞大量细胞的分化以产生分化祖细胞。可以转染分化的祖细胞，使得存在所需基因的添加，缺失或改变。分化的祖细胞可用于细胞治疗和作为用于产生移植组织和器官的细胞的I来源。还提供了产生谱系缺陷型人胚胎干细胞的方法。

9. 发明申请

US20050255596A1 Methods of repairing tandemly repeated DNA sequences and extending cell life-span nuclear transfer 审中-公开
标题翻译：修复串联重复DNA序列和延长细胞寿命核转移的方法
公开(公告)号：US20050255596A1
公开(公告)日：2005-11-17
申请号：US11079930
申请日：2005-03-09
申请人： Michael West , Robert Lanza , Jose Cibelli
发明人： Michael West , Robert Lanza , Jose Cibelli
IPC分类号： C12N5/08 , C12N15/63 , C12N15/85 , C12Q1/68
CPC分类号： C12N15/85 , C12N2517/04
摘要： This invention relates to methods for rejuvenating normal somatic cells and for making normal somatic cells of a different type having the same genotype as a normal somatic cell of interest. These cells have particular application in cell and tissue transplantation. Also encompassed are methods of re-cloning cloned animals, particularly methods where the offspring of cloned mammals are designed to be genetically altered in comparison to their cloned parent, e.g., that are “hyper-young.” These animals should be healthier and possess desirable properties relative to their cloned parent. Also included are methods for activating endogenous telomerase, EPC-1 activity, and or the ALT pathway and/or extending the life-span of a normal somatic cell, and other genes associated with cell aging and proliferation capacity.
摘要翻译：本发明涉及用于恢复正常体细胞和用于制备具有与感兴趣的正常体细胞相同基因型的不同类型的正常体细胞的方法。这些细胞在细胞和组织移植中具有特殊应用。还包括重新克隆克隆动物的方法，特别是其克隆的哺乳动物的后代被设计为与其克隆的亲本（例如“超年龄”）相比被遗传改变的方法。这些动物应该更健康，并且相对于其克隆的亲本具有所需的性质。还包括用于激活内源性端粒酶，EPC-1活性和/或ALT途径和/或延长正常体细胞的寿命和与细胞衰老和增殖能力相关的其它基因的方法。

10. 发明申请

US20050053672A1 Synergistic metal salt-cationic surfactant-organic biocide composition 审中-公开
标题翻译：协同金属盐 - 阳离子表面活性剂 - 有机杀菌剂组合物
公开(公告)号：US20050053672A1
公开(公告)日：2005-03-10
申请号：US10657030
申请日：2003-09-08
申请人： Michael West
发明人： Michael West
IPC分类号： A01N59/06 , A01N59/16
CPC分类号： A01N59/06 , A01N43/653 , A01N33/08 , A01N25/30 , A01N2300/00
摘要： A biocide composition comprising (a) about 0.05% to about 75% of an acidic metal salt selected from the metal group consisting of aluminum, iron, manganese, and zirconium; (b) about 0.05% to about 75% of a cationic surfactant; and (c) about 0.0001% to about 25% of an organic biocide.
摘要翻译：一种杀生物剂组合物，其包含（a）约0.05％至约75％的选自铝，铁，锰和锆的金属中的酸性金属盐; （b）约0.05％至约75％的阳离子表面活性剂; 和（c）约0.0001％至约25％的有机杀生物剂。

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