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1. 发明授权

US08173163B2 Polymeric drug delivery compositions and methods for treating ophthalmic diseases 有权
标题翻译：聚合物药物递送组合物和治疗眼科疾病的方法
公开(公告)号：US08173163B2
公开(公告)日：2012-05-08
申请号：US12390255
申请日：2009-02-20
申请人： Joachim B. Kohn , Isaac John Khan , Carmine P. Lovine
发明人： Joachim B. Kohn , Isaac John Khan , Carmine P. Lovine
IPC分类号： A61K9/14
CPC分类号： A61K9/0051 , A61K31/00 , A61K47/14 , A61K47/34
摘要： Degradable polymeric compositions containing water-insoluble drugs blended with copolymers of biocompatible diphenol compound monomer units with pendant carboxylic acid groups polymerized with biocompatible diphenol com-pound monomer units with pendant carboxylic acid ester groups and poly(alkylene oxide) blocks, wherein the molar fraction in the copolymer of biocompatible diphenol compound monomer units with pendant carboxylic acid groups and poly(alkylene oxide) blocks relative to the weight percentage of the drug in the composition is effective to provide pseudo-zero order release of the drug from the composition during the sustained-release phase of drug delivery under physiological conditions. Ocular treatment methods and manufacturing methods are also disclosed.
摘要翻译：可降解的聚合物组合物含有与生物相容性双酚化合物单体单元与侧链羧酸基团的共聚物共混物的水不溶性药物，其与具有侧链羧酸酯基团和聚（环氧烷）嵌段的生物相容性双酚单体单元聚合的侧链羧酸基团，其中摩尔分数生物相容性双酚化合物单体单元与侧链羧酸基团和聚（环氧烷）嵌段的共聚物相对于组合物中药物的重量百分比是有效的，以提供药物在组合物中的假零级释放，生理条件下药物释放期。还公开了眼部治疗方法和制造方法。

2. 发明申请

US20090238858A1 Compositions and Methods for Treating Ophthalmic Diseases 有权
标题翻译：治疗眼科疾病的组合物和方法
公开(公告)号：US20090238858A1
公开(公告)日：2009-09-24
申请号：US12390255
申请日：2009-02-20
申请人： Joachim B. Kohn , Isaac John Khan , Carmine P. Iovine
发明人： Joachim B. Kohn , Isaac John Khan , Carmine P. Iovine
IPC分类号： A61K9/00 , A61K47/34 , A61K38/02 , A61K38/12 , A61K31/7052 , A61K31/56 , A61K9/14 , A61P27/02
CPC分类号： A61K9/0051 , A61K31/00 , A61K47/14 , A61K47/34
摘要： Degradable polymeric compositions containing water-insoluble drugs blended with copolymers of biocompatible diphenol compound monomer units with pendant carboxylic acid groups polymerized with biocompatible diphenol com-pound monomer units with pendant carboxylic acid ester groups and poly(alkylene oxide) blocks, wherein the molar fraction in the copolymer of biocompatible diphenol compound monomer units with pendant carboxylic acid groups and poly(alkylene oxide) blocks relative to the weight percentage of the drug in the composition is effective to provide pseudo-zero order release of the drug from the composition during the sustained-release phase of drug delivery under physiological conditions. Ocular treatment methods and manufacturing methods are also disclosed.
摘要翻译：可降解的聚合物组合物含有与生物相容性双酚化合物单体单元与侧链羧酸基团的共聚物共混物的水不溶性药物，其与具有侧链羧酸酯基团和聚（环氧烷）嵌段的生物相容性双酚单体单元聚合的侧链羧酸基团，其中摩尔分数生物相容性双酚化合物单体单元与侧链羧酸基团和聚（环氧烷）嵌段的共聚物相对于组合物中药物的重量百分比是有效的，以提供药物在组合物期间的假零级释放，生理条件下药物释放期。还公开了眼部治疗方法和制造方法。

3. 发明授权

US08367110B2 Polymeric drug delivery compositions and methods for treating ophthalmic diseases 有权
标题翻译：聚合物药物递送组合物和治疗眼科疾病的方法
公开(公告)号：US08367110B2
公开(公告)日：2013-02-05
申请号：US13439969
申请日：2012-04-05
申请人： Joachim B. Kohn , Isaac John Khan , Carmine P. Iovine
发明人： Joachim B. Kohn , Isaac John Khan , Carmine P. Iovine
IPC分类号： A61K9/14
CPC分类号： A61K9/0051 , A61K31/00 , A61K47/14 , A61K47/34
摘要： Degradable polymeric compositions containing water-insoluble drugs blended with copolymers of biocompatible diphenol compound monomer units with pendant carboxylic acid groups polymerized with biocompatible diphenol compound monomer units with pendant carboxylic acid ester groups and poly(alkylene oxide) blocks, wherein the molar fraction in the copolymer of biocompatible diphenol compound monomer units with pendant carboxylic acid groups and poly(alkylene oxide) blocks relative to the weight percentage of the drug in the composition is effective to provide pseudo-zero order release of the drug from the composition during the sustained-release phase of drug delivery under physiological conditions. Ocular treatment methods and manufacturing methods are also disclosed.
摘要翻译：与生物相容性双酚化合物单体单元与侧链羧酸基团的共聚物共混的可降解聚合物组合物与具有侧链羧酸酯基团和聚（环氧烷）嵌段的生物相容性双酚化合物单体单元聚合的共聚物，其中共聚物中的摩尔分数具有侧链羧酸基团和聚（环氧烷）嵌段的生物相容性双酚化合物单体单元相对于组合物中药物的重量百分比有效地在缓释期期间从组合物中提供假零级释放药物在生理条件下的药物递送。还公开了眼部治疗方法和制造方法。

4. 发明申请

US20120207796A1 POLYMERIC DRUG DELIVERY COMPOSITIONS AND METHODS FOR TREATING OPHTHALMIC DISEASES 有权
标题翻译：聚合物药物输送组合物及治疗眼底疾病的方法
公开(公告)号：US20120207796A1
公开(公告)日：2012-08-16
申请号：US13439969
申请日：2012-04-05
申请人： Joachim B. Kohn , Isaac John Khan , Carmine P. Iovine
发明人： Joachim B. Kohn , Isaac John Khan , Carmine P. Iovine
IPC分类号： A61K38/12 , A61P27/02 , A61P35/00 , A61P31/00 , A61K9/00 , A61P27/06 , B82Y5/00
CPC分类号： A61K9/0051 , A61K31/00 , A61K47/14 , A61K47/34
摘要： Degradable polymeric compositions containing water-insoluble drugs blended with copolymers of biocompatible diphenol compound monomer units with pendant carboxylic acid groups polymerized with biocompatible diphenol compound monomer units with pendant carboxylic acid ester groups and poly(alkylene oxide) blocks, wherein the molar fraction in the copolymer of biocompatible diphenol compound monomer units with pendant carboxylic acid groups and poly(alkylene oxide) blocks relative to the weight percentage of the drug in the composition is effective to provide pseudo-zero order release of the drug from the composition during the sustained-release phase of drug delivery under physiological conditions. Ocular treatment methods and manufacturing methods are also disclosed.
摘要翻译：与生物相容性双酚化合物单体单元与侧链羧酸基团的共聚物共混的可降解聚合物组合物与具有侧链羧酸酯基团和聚（环氧烷）嵌段的生物相容性双酚化合物单体单元聚合的共聚物，其中共聚物中的摩尔分数具有侧链羧酸基团和聚（环氧烷）嵌段的生物相容性双酚化合物单体单元相对于组合物中药物的重量百分比有效地在缓释期期间从组合物中提供假零级释放药物在生理条件下的药物递送。还公开了眼部治疗方法和制造方法。

5. 发明授权

US08685367B2 Inherently radiopaque polymeric products for embolotherapy 有权
标题翻译：固有的不透射线聚合物产品用于电击治疗
公开(公告)号：US08685367B2
公开(公告)日：2014-04-01
申请号：US10952274
申请日：2004-09-27
申请人： Donald K. Brandom , Eric Schmid , Joan Zeltinger , Durgadas Bolikal , Joachim B. Kohn
发明人： Donald K. Brandom , Eric Schmid , Joan Zeltinger , Durgadas Bolikal , Joachim B. Kohn
IPC分类号： A61K51/00 , A61M36/14
CPC分类号： A61K31/785 , A61K49/0442
摘要： Preferred embodiments relate to compositions of inherently radiopaque, biocompatible, bioresorbable polymeric particles and methods of using them for embolizing a body lumen.
摘要翻译：优选的实施方案涉及固有的不透射线的，生物相容的，生物可再吸收的聚合物颗粒的组合物和使用它们来栓塞体腔的方法。

6. 发明授权

US08415449B2 Bioresorbable polymers synthesized from monomer analogs of natural metabolites 有权
标题翻译：由天然代谢物的单体类似物合成的生物可吸收聚合物
公开(公告)号：US08415449B2
公开(公告)日：2013-04-09
申请号：US13387798
申请日：2010-07-31
申请人： Joachim B. Kohn , Durgadas Bolikal , Ramiro Rojas
发明人： Joachim B. Kohn , Durgadas Bolikal , Ramiro Rojas
IPC分类号： C08G64/00 , C08G63/02
CPC分类号： C08G79/02 , A61K47/59 , A61K47/60 , C08G79/025
摘要： This invention discloses biocompatible polymers prepared from monomers (IV), and (IVa), or derivatives thereof, for which the variables are described in the claims and specification. These polymers may be bioresorbable and thus useful for manufacture of medical devices. Therefore, methods for preparing these polymers and medical devices prepared therefrom are also encompassed by this disclosure.
摘要翻译：本发明公开了由权利要求和说明书中描述的变体描述的由单体（IV）和（IVa）或其衍生物制备的生物相容性聚合物。这些聚合物可以是生物可再吸收的，因此可用于制造医疗器械。因此，制备这些聚合物的方法和由其制备的医疗装置也包括在本公开中。

7. 发明申请

US20120135523A1 PREPARATION AND USES OF POLYARYLATES 有权
标题翻译：聚氨酯的制备和用途
公开(公告)号：US20120135523A1
公开(公告)日：2012-05-31
申请号：US13361268
申请日：2012-01-30
申请人： Ken James , Brochini Stephen , Varawut Tangpasuthadol , Joachim B. Kohn
发明人： Ken James , Brochini Stephen , Varawut Tangpasuthadol , Joachim B. Kohn
IPC分类号： C12N5/071 , C08G63/685 , C07C237/20
CPC分类号： C08G63/78 , A61L17/10 , A61L27/18 , A61L27/34 , A61L31/06 , A61L31/10 , B01J2219/00722 , C08G63/19 , C08G63/6856 , C08G63/6858 , C08G64/045 , C08G64/12 , C40B40/14 , C08L69/00
摘要： The present invention is directed to polyarylates comprising repeating units having the structure: as well as their preparation and use as cell growth substrates.
摘要翻译：本发明涉及包含具有以下结构的重复单元的聚芳酯：以及它们作为细胞生长底物的制备和用途。

8. 发明申请

US20090285895A1 Pharmaceutical Formulation for Regulating the Timed Release of Biologically Active Compounds Based on a Polymer Matrix 审中-公开
标题翻译：用于调节基于聚合物基质的生物活性化合物的定时释放的药物制剂
公开(公告)号：US20090285895A1
公开(公告)日：2009-11-19
申请号：US12426902
申请日：2009-04-20
申请人： Joachim B. Kohn , Deborah M. Schachter
发明人： Joachim B. Kohn , Deborah M. Schachter
IPC分类号： A61K38/02 , A61K9/14
CPC分类号： A61K47/14 , A61K38/12
摘要： A formulation containing a biologically active compound having a structure with hydrogen bonding sites is blended with a polymer having a structure with complementary hydrogen bonding sites, the polymer forming hydrolytic degradation products that promote the release of the biologically active compound from the polymer.
摘要翻译：含有具有氢键合位点结构的生物活性化合物的制剂与具有互补氢键位置结构的聚合物共混，所述聚合物形成促进生物活性化合物从聚合物释放的水解降解产物。

9. 发明授权

US07585929B2 Preparation and uses for polyarylates 有权
标题翻译：聚芳酯的制备和用途
公开(公告)号：US07585929B2
公开(公告)日：2009-09-08
申请号：US10889914
申请日：2004-07-13
申请人： Ken James , Stephen Brocchini , Varawut Tangpasuthadol , Joachim B. Kohn
发明人： Ken James , Stephen Brocchini , Varawut Tangpasuthadol , Joachim B. Kohn
IPC分类号： C08G63/06
CPC分类号： C08G63/78 , A61L17/10 , A61L27/18 , A61L27/34 , A61L31/06 , A61L31/10 , B01J2219/00722 , C08G63/19 , C08G63/6856 , C08G63/6858 , C08G64/045 , C08G64/12 , C40B40/14 , C08L69/00
摘要： The present invention is directed to polyarylates comprising repeating units having the structure: as well as their preparation and use as cell growth substrates.
摘要翻译：本发明涉及包含具有以下结构的重复单元的聚芳酯：以及它们作为细胞生长底物的制备和用途。

10. 发明申请

US20080187567A1 N-SUBSTITUTED MONOMERS AND POLYMERS 有权
标题翻译： N-取代的单体和聚合物
公开(公告)号：US20080187567A1
公开(公告)日：2008-08-07
申请号：US11873979
申请日：2007-10-17
申请人： Joachim B. Kohn , Durgadas Bolikal , Jaap Schut , Ernest G. Baluca
发明人： Joachim B. Kohn , Durgadas Bolikal , Jaap Schut , Ernest G. Baluca
IPC分类号： A61F2/00 , C08G63/06 , C07C233/01
CPC分类号： A61L31/06 , A61L31/10 , A61L31/16 , A61L2300/00 , B33Y70/00 , B33Y80/00 , C08G63/6856 , C08G64/045 , C08G64/12 , C08G64/183 , C08G64/186 , C08G79/04 , C08L85/02 , C08L69/00
摘要： Biocompatible, bioresorbable polymers comprising a plurality of monomeric repeating units containing an amide group, wherein said amide groups are N-substituted and the N-substituent and degree of N-substitution are effective to lower the melt viscosity, the solution viscosity, or both, compared to the same polymer without N-substitution.
摘要翻译：包含多个含有酰胺基团的单体重复单元的生物相容性生物可吸收聚合物，其中所述酰胺基团是N-取代的，N-取代基和N-取代度对降低熔体粘度，溶液粘度或两者均有效，与没有N-取代的相同聚合物相比。

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