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1. 发明申请

US20100074866A1 INTERFERON ALPHA MUTANT AND ITS POLYETHYLENE GLYCOL DERIVATIVE 有权
标题翻译：干ON HA ANT ANT TIVE TIVE TIVE TIVE TIVE TIVE TIVE TIVE TIVE TIVE TIVE
公开(公告)号：US20100074866A1
公开(公告)日：2010-03-25
申请号：US12519917
申请日：2007-12-21
申请人： Jinyi Liu , Xiaoxia Niu , Minyi Zhou , Yi Yang , Jianbo Sun , Yongqing Cheng
发明人： Jinyi Liu , Xiaoxia Niu , Minyi Zhou , Yi Yang , Jianbo Sun , Yongqing Cheng
IPC分类号： A61K38/21 , C07K14/56 , C07H21/04
CPC分类号： C07K14/56 , A61K38/00 , A61K47/60
摘要： IFN-alpha mutants are obtained by substituting Cys for Tyr at position 85 or 86 in existing IFN-alpha. Their polyethylene glycol derivatives with high in vitro antiviral activity and prolonged in vivo half-life are also provided, wherein a polyethylene glycol moiety is covalently bound to the free Cys residue of an IFN-alpha mutant. The preparation methods of PEG derivatives of IFN-alpha mutants and medical compositions comprising the derivatives are also provided. The test results showed that the IFN-alpha mutants of the present invention are ready to prepare and have high activity; their polyethylene glycol derivatives have extended lifetime in the body and low clearance rate.
摘要翻译：通过将Cys替换为现有IFN-α中85或86位的Tyr获得IFN-α突变体。还提供了具有高体外抗病毒活性和延长体内半衰期的聚乙二醇衍生物，其中聚乙二醇部分与IFN-α突变体的游离Cys残基共价结合。还提供了IFN-α突变体的PEG衍生物和包含衍生物的医药组合物的制备方法。试验结果表明，本发明的IFN-α突变体准备准备并具有高活性; 它们的聚乙二醇衍生物在体内具有延长的使用寿命和较低的清除率。

2. 发明授权

US08901277B2 Interferon alpha mutant and its polyethylene glycol derivative 有权
标题翻译：干扰素α突变体及其聚乙二醇衍生物
公开(公告)号：US08901277B2
公开(公告)日：2014-12-02
申请号：US13431226
申请日：2012-03-27
申请人： Jinyi Liu , Xiaoxia Niu , Minyi Zhou , Yi Yang , Jianbo Sun , Yongqing Cheng
发明人： Jinyi Liu , Xiaoxia Niu , Minyi Zhou , Yi Yang , Jianbo Sun , Yongqing Cheng
IPC分类号： C07K14/52 , C12N15/00 , A61K38/21 , C07K1/00 , C12P21/04 , C07K14/56 , A61K47/48 , A61K38/00
CPC分类号： C07K14/56 , A61K38/00 , A61K47/60
摘要： IFN-alpha mutants are obtained by substituting Cys for Tyr at position 85 or 86 in existing IFN-alpha. Their polyethylene glycol derivatives with high in vitro antiviral activity and prolonged in vivo half-life are also provided, wherein a polyethylene glycol moiety is covalently bound to the free Cys residue of an IFN-alpha mutant. The preparation methods of PEG derivatives of IFN-alpha mutants and medical compositions comprising the derivatives are also provided. The test results showed that the IFN-alpha mutants of the present invention are ready to prepare and have high activity; their polyethylene glycol derivatives have extended lifetime in the body and low clearance rate.
摘要翻译：通过将Cys替换为现有IFN-α中85或86位的Tyr获得IFN-α突变体。还提供了具有高体外抗病毒活性和延长体内半衰期的聚乙二醇衍生物，其中聚乙二醇部分与IFN-α突变体的游离Cys残基共价结合。还提供了IFN-α突变体的PEG衍生物和包含衍生物的医药组合物的制备方法。试验结果表明，本发明的IFN-α突变体准备准备并具有高活性; 它们的聚乙二醇衍生物在体内具有延长的使用寿命和较低的清除率。

3. 发明授权

US08168751B2 Interferon alpha mutant and its polyethylene glycol derivative 有权
标题翻译：干扰素α突变体及其聚乙二醇衍生物
公开(公告)号：US08168751B2
公开(公告)日：2012-05-01
申请号：US12519917
申请日：2007-12-21
申请人： Jinyi Liu , Xiaoxia Niu , Minyi Zhou , Yi Yang , Jianbo Sun , Yongqing Cheng
发明人： Jinyi Liu , Xiaoxia Niu , Minyi Zhou , Yi Yang , Jianbo Sun , Yongqing Cheng
IPC分类号： C07K14/52 , C07K1/00 , C12N15/00 , A61K38/21 , C12P21/04
CPC分类号： C07K14/56 , A61K38/00 , A61K47/60
摘要： IFN-alpha mutants are obtained by substituting Cys for Tyr at position 85 or 86 in existing IFN-alpha. Their polyethylene glycol derivatives with high in vitro antiviral activity and prolonged in vivo half-life are also provided, wherein a polyethylene glycol moiety is covalently bound to the free Cys residue of an IFN-alpha mutant. The preparation methods of PEG derivatives of IFN-alpha mutants and medical compositions comprising the derivatives are also provided. The test results showed that the IFN-alpha mutants of the present invention are ready to prepare and have high activity; their polyethylene glycol derivatives have extended lifetime in the body and low clearance rate.
摘要翻译：通过将Cys替换为现有IFN-α中85或86位的Tyr获得IFN-α突变体。还提供了具有高体外抗病毒活性和延长体内半衰期的聚乙二醇衍生物，其中聚乙二醇部分与IFN-α突变体的游离Cys残基共价结合。还提供了IFN-α突变体的PEG衍生物和包含衍生物的医药组合物的制备方法。试验结果表明，本发明的IFN-α突变体准备准备并具有高活性; 它们的聚乙二醇衍生物在体内具有延长的使用寿命和较低的清除率。

4. 发明申请

US20110316543A1 METHOD AND CIRCUITS FOR SHORT-CIRCUIT PROTECTION OF LED SYSTEMS 有权
标题翻译： LED系统短路保护的方法和电路
公开(公告)号：US20110316543A1
公开(公告)日：2011-12-29
申请号：US13005402
申请日：2011-01-12
申请人： Zhengdong Zhang , Jianbo Sun , Li Zhang , Yun Lu , Xuguang Zhang
发明人： Zhengdong Zhang , Jianbo Sun , Li Zhang , Yun Lu , Xuguang Zhang
IPC分类号： G01R31/00
CPC分类号： H05B33/0893 , Y02B20/341
摘要： An embodiment of the present invention relates to a method for detection of short circuit conditions in an LED array having one or more LED strings, each of which includes one or more LED devices. The method includes determining a minimum voltage that is the lowest of voltages associated with cathode terminals of the one or more LED strings. The method also includes determining if said minimum voltage is between a lower limit voltage and an upper voltage limit. If said minimum voltage is between the lower limit voltage and the upper voltage limit, then a result of a short circuit testing can be considered valid. Here, the short circuit testing includes comparing a sampled voltage associated with a cathode voltage of one of the LED strings with a short-circuit reference voltage.
摘要翻译：本发明的实施例涉及一种用于检测具有一个或多个LED串的LED阵列中的短路状况的方法，每个LED串包括一个或多个LED器件。该方法包括确定与一个或多个LED串的阴极端子相关联的最低电压的最小电压。该方法还包括确定所述最小电压是否在下限电压和上限电压之间。如果所述最小电压在下限电压和上限电压之间，则短路测试的结果可以被认为是有效的。这里，短路测试包括将与一个LED串的阴极电压相关联的采样电压与短路参考电压进行比较。

5. 发明申请

US20110215727A1 Drive Circuit For Parallel Array of Light Emitting Diodes 有权
标题翻译：用于并联发光二极管阵列的驱动电路
公开(公告)号：US20110215727A1
公开(公告)日：2011-09-08
申请号：US12777079
申请日：2010-05-10
申请人： Zutao Liu , Kun Cheng , Jianbo Sun , Gang Shi
发明人： Zutao Liu , Kun Cheng , Jianbo Sun , Gang Shi
IPC分类号： H05B37/02
CPC分类号： H05B33/0845 , H05B33/0818 , H05B33/0827
摘要： The present invention relates to a parallel light emitting diode (“LED”) drive circuit and provides a drive circuit configured to drive a parallel array of LEDs. The drive circuit comprises: a plurality of switches, a plurality of sampling resistors, and a plurality of chopper amplifiers. Each switch is coupled to a respective LED in the LED array. Each chopper operational amplifier configured to receive a reference voltage and a switching control signal and generate an input offset voltage. Each chopper operational amplifier includes a differential amplifier including an input transistor pair and a current mirror transistor pair, of which the electrical positions can be reserved when the switching control signal is switched between a first state and a second state, wherein the offset voltage, which causes the lightness mismatching in a parallel LED circuit, can be cancelled.
摘要翻译：本发明涉及一种并行发光二极管（“LED”）驱动电路，并提供配置成驱动LED平行排列的驱动电路。驱动电路包括：多个开关，多个采样电阻器和多个斩波放大器。每个开关耦合到LED阵列中的相应LED。每个斩波运算放大器被配置为接收参考电压和开关控制信号并产生输入失调电压。每个斩波运算放大器包括差分放大器，该差分放大器包括输入晶体管对和电流镜晶体管对，当开关控制信号在第一状态和第二状态之间切换时，电位置可被保留，其中偏移电压导致并联LED电路的亮度不匹配，可以取消。

6. 发明申请

US20110215726A1 Dynamically Controllable Drive Circuit For Parallel Array Of Light Emitting Diodes 有权
标题翻译：用于发光二极管并联阵列的动态可控驱动电路
公开(公告)号：US20110215726A1
公开(公告)日：2011-09-08
申请号：US12777073
申请日：2010-05-10
申请人： Zutao Liu , Kun Cheng , Jianbo Sun , Gang Shi
发明人： Zutao Liu , Kun Cheng , Jianbo Sun , Gang Shi
IPC分类号： H05B37/02
CPC分类号： H05B33/0845 , H05B33/0818 , H05B33/0827
摘要： The present invention relates to a parallel light emitting diode (“LED”) drive circuit and provides a drive circuit configured to drive a parallel array of LEDs. The drive circuit comprises: a switching control signal generator, a plurality of switches, a plurality of sampling resistors, and a plurality of chopper amplifiers. Each switch is coupled to a respective LED in the LED array. Each chopper operational amplifier configured to receive a reference voltage and a switching control signal generated by the switching control signal generator and generate an input offset voltage. Each chopper operational amplifier includes a differential amplifier including an input transistor pair and a current mirror transistor pair, of which the electrical positions can be reserved when the switching control signal is switched between a first state and a second state, wherein the offset voltage, which causes the lightness mismatching in a parallel LED circuit, can be cancelled.
摘要翻译：本发明涉及一种并行发光二极管（“LED”）驱动电路，并提供配置成驱动LED平行排列的驱动电路。驱动电路包括：开关控制信号发生器，多个开关，多个采样电阻器和多个斩波放大器。每个开关耦合到LED阵列中的相应LED。每个斩波运算放大器被配置为接收由开关控制信号发生器产生的参考电压和开关控制信号，并产生输入偏移电压。每个斩波运算放大器包括差分放大器，该差分放大器包括输入晶体管对和电流镜晶体管对，当开关控制信号在第一状态和第二状态之间切换时，电位置可被保留，其中偏移电压导致并联LED电路的亮度不匹配，可以取消。

7. 发明申请

US20070243542A1 RAPID AND EFFICIENT CAPTURE OF DNA FROM SAMPLE WITHOUT USING CELL LYSING REAGENT 有权
标题翻译：没有使用细胞检测试剂的样品中DNA的快速和有效捕获
公开(公告)号：US20070243542A1
公开(公告)日：2007-10-18
申请号：US11613475
申请日：2006-12-20
申请人： Robert Belly , Jianbo Sun
发明人： Robert Belly , Jianbo Sun
IPC分类号： C07H21/04 , C12Q1/68
CPC分类号： C12N15/1003 , C12Q1/6806 , C12Q1/6886 , C12Q2600/156 , C12Q2600/16 , C12Q2527/125 , C12Q2527/119
摘要： Nucleic acids can be made available for amplification or other treatment after admixture of a sample with specific weakly basic polymers to form a precipitate with the nucleic acids at acidic pH. After removing non-precipitated materials, the pH is then made basic, thereby releasing the nucleic acids from the polymer. This method for preparing specimen samples is simple and quite rapid, and the released nucleic acids can be further treated in hybridization assays or amplification procedures. No surfactant or other cell lysing reagents are employed. The weakly basic polymers are water-soluble and cationic at acidic pH, but neutral in charge at basic pH.
摘要翻译：在将样品与特定弱碱性聚合物混合后，核酸可以用于扩增或其它处理，以在酸性pH下与核酸形成沉淀。除去非沉淀物后，将pH调至碱性，从而将聚合物中的核酸释放出来。制备标本样品的这种方法是简单且相当快速的，并且释放的核酸可以在杂交测定或扩增程序中进一步处理。不使用表面活性剂或其它细胞裂解试剂。弱碱性聚合物在酸性pH下为水溶性和阳离子型，而在碱性pH下为负电荷。

8. 发明授权

US08593149B2 Method and circuits for short-circuit protection of LED systems 有权
标题翻译： LED系统短路保护方法和电路
公开(公告)号：US08593149B2
公开(公告)日：2013-11-26
申请号：US13005402
申请日：2011-01-12
申请人： Zhengdong Zhang , Jianbo Sun , Li Zhang , Yun Lu , Xuguang Zhang
发明人： Zhengdong Zhang , Jianbo Sun , Li Zhang , Yun Lu , Xuguang Zhang
IPC分类号： G01R31/00
CPC分类号： H05B33/0893 , Y02B20/341
摘要： An embodiment of the present invention relates to a method for detection of short circuit conditions in an LED array having one or more LED strings, each of which includes one or more LED devices. The method includes determining a minimum voltage that is the lowest of voltages associated with cathode terminals of the one or more LED strings. The method also includes determining if said minimum voltage is between a lower limit voltage and an upper voltage limit. If said minimum voltage is between the lower limit voltage and the upper voltage limit, then a result of a short circuit testing can be considered valid. Here, the short circuit testing includes comparing a sampled voltage associated with a cathode voltage of one of the LED strings with a short-circuit reference voltage.
摘要翻译：本发明的实施例涉及一种用于检测具有一个或多个LED串的LED阵列中的短路状况的方法，每个LED串包括一个或多个LED器件。该方法包括确定与一个或多个LED串的阴极端子相关联的最低电压的最小电压。该方法还包括确定所述最小电压是否在下限电压和上限电压之间。如果所述最小电压在下限电压和上限电压之间，则短路测试的结果可以被认为是有效的。这里，短路测试包括将与一个LED串的阴极电压相关联的采样电压与短路参考电压进行比较。

9. 发明授权

US08373348B2 Dynamically controllable drive circuit for parallel array of light emitting diodes 有权
标题翻译：用于并联发光二极管阵列的动态可控驱动电路
公开(公告)号：US08373348B2
公开(公告)日：2013-02-12
申请号：US12777073
申请日：2010-05-10
申请人： Zutao Liu , Kun Cheng , Jianbo Sun , Gang Shi
发明人： Zutao Liu , Kun Cheng , Jianbo Sun , Gang Shi
IPC分类号： H05B37/02
CPC分类号： H05B33/0845 , H05B33/0818 , H05B33/0827
摘要： The present invention relates to a parallel light emitting diode (“LED”) drive circuit and provides a drive circuit configured to drive a parallel array of LEDs. The drive circuit comprises: a switching control signal generator, a plurality of switches, a plurality of sampling resistors, and a plurality of chopper amplifiers. Each switch is coupled to a respective LED in the LED array. Each chopper operational amplifier configured to receive a reference voltage and a switching control signal generated by the switching control signal generator and generate an input offset voltage. Each chopper operational amplifier includes a differential amplifier including an input transistor pair and a current mirror transistor pair, of which the electrical positions can be reserved when the switching control signal is switched between a first state and a second state, wherein the offset voltage, which causes the lightness mismatching in a parallel LED circuit, can be cancelled.
摘要翻译：并联发光二极管（LED）驱动电路技术领域本发明涉及一种并行发光二极管（LED）驱动电路，并且提供一种驱动电路，该驱动电路配置成驱动驱动电路包括：开关控制信号发生器，多个开关，多个采样电阻器和多个斩波放大器。每个开关耦合到LED阵列中的相应LED。每个斩波运算放大器被配置为接收由开关控制信号发生器产生的参考电压和开关控制信号，并产生输入偏移电压。每个斩波运算放大器包括差分放大器，该差分放大器包括输入晶体管对和电流镜晶体管对，当开关控制信号在第一状态和第二状态之间切换时，电位置可被保留，其中偏移电压导致并联LED电路的亮度不匹配，可以取消。

10. 发明授权

US07262006B1 Rapid and efficient capture of DNA from sample without using cell lysing reagent 有权
标题翻译：从样品中快速高效地捕获DNA，无需使用细胞裂解试剂
公开(公告)号：US07262006B1
公开(公告)日：2007-08-28
申请号：US10019514
申请日：2000-05-01
申请人： Robert T. Belly , Jianbo Sun
发明人： Robert T. Belly , Jianbo Sun
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , C12Q2527/125
摘要： Nucleic acids can be made available for amplification or other treatment after admixture of a sample with specific weakly basic polymers to form a precipitate with the nucleic acids at acidic pH. After removing non-precipitated materials, the pH is then made basic, thereby releasing the nucleic acids from the polymer. This method for preparing specimen samples is simple and quite rapid, and the released nucleic acids can be further treated in hybridization assays or amplification procedures. No surfactant or other cell lysing reagents are employed. The weakly basic polymers are water-soluble and cationic at acidic pH, but neutral in charge at basic pH.
摘要翻译：在将样品与特定弱碱性聚合物混合后，核酸可以用于扩增或其它处理，以在酸性pH下与核酸形成沉淀。除去非沉淀物后，将pH调至碱性，从而将聚合物中的核酸释放出来。制备标本样品的这种方法是简单且相当快速的，并且释放的核酸可以在杂交测定或扩增程序中进一步处理。不使用表面活性剂或其它细胞裂解试剂。弱碱性聚合物在酸性pH下为水溶性和阳离子型，而在碱性pH下为负电荷。

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