专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20050209488A1 Stereoselective synthesis of certain trifluoromethyl-substituted alcohols 有权
标题翻译：某些三氟甲基取代的醇的立体选择性合成
公开(公告)号：US20050209488A1
公开(公告)日：2005-09-22
申请号：US11070462
申请日：2005-03-02
申请人： Jinhua Song , Zhulin Tan , Nathan Yee , Chris Senanayake , Jinghua Xu , Fabrice Gallou
发明人： Jinhua Song , Zhulin Tan , Nathan Yee , Chris Senanayake , Jinghua Xu , Fabrice Gallou
IPC分类号： C07C33/46 , C07C323/03 , C07D471/02 , C07D471/04
CPC分类号： C07D471/04 , C07B2200/07
摘要： A process for stereoselective synthesis of a compound of Formula (I) wherein R1, R2, R3, R4, and R5 are as described herein.
摘要翻译：用于立体选择性合成式（I）的化合物的方法，其中R 1，R 2，R 3，R 4， / SUP>和R 5 5如本文所述。

2. 发明申请

US20050131241A1 Stereoselective synthesis of certain trifluoromethyl-substituted alcohols 有权
标题翻译：某些三氟甲基取代的醇的立体选择性合成
公开(公告)号：US20050131241A1
公开(公告)日：2005-06-16
申请号：US10955165
申请日：2004-09-30
申请人： Jinhua Song , Zhulin Tan , Jinghua Xu , Nathan Yee , Chris Senanayake
发明人： Jinhua Song , Zhulin Tan , Jinghua Xu , Nathan Yee , Chris Senanayake
IPC分类号： C07D301/27 , C07D303/22 , C07F3/04
CPC分类号： C07D303/22
摘要： A process for stereoselective synthesis of compounds of Formula X wherein: R1 is an aryl or heteroaryl group, each optionally independently substituted with one to three substituent groups, wherein each substituent group of R1 is independently C1-C5 alkyl, C2-C5 alkenyl, C2-C5 alkynyl, C3-C8 cycloalkyl, heterocyclyl, aryl, heteroaryl, C1-C5 alkoxy, C2-C5 alkenyloxy, C2-C5 alkynyloxy, aryloxy, C1-C5 alkanoyloxy, C1-C5 alkanoyl, aroyl, trifluoromethyl, trifluoromethoxy, or C1-C5 alkylthio, wherein each substituent group of R1 is optionally independently substituted with one to three substituent groups selected from methyl, methoxy, fluoro, chloro, hydroxy, oxo, cyano, or amino; and R2 and R3 are each independently hydrogen or C1-C5 alkyl, or R2 and R3 together with the carbon atom they are commonly attached to form a C3-C8 spiro cycloalkyl ring.
摘要翻译：用于立体选择性合成式X化合物的方法，其中：R 1是芳基或杂芳基，每个任选地独立地被一至三个取代基取代，其中R 1， / SUP>独立地为C 1 -C 5烷基，C 2 -C 5链烯基，C _{2和R 3与它们通常连接的碳原子一起形成C 3 -C 8 - 螺环烷基环。}

3. 发明申请

US20080293972A1 Process for Preparing Substituted Anisidines 有权
标题翻译：制备取代苯胺的方法
公开(公告)号：US20080293972A1
公开(公告)日：2008-11-27
申请号：US12092454
申请日：2006-11-01
申请人： Fabrice Gallou , Heewon Lee , Chris Hugh Senanayake , Jinhua J. Song , Zhulin Tan , Jinghua Xu , Nathan K. Yee
发明人： Fabrice Gallou , Heewon Lee , Chris Hugh Senanayake , Jinhua J. Song , Zhulin Tan , Jinghua Xu , Nathan K. Yee
IPC分类号： C07C213/02 , C07C251/44
CPC分类号： C07C213/02 , C07C249/08 , C07C251/44 , C07C2601/16 , C07C217/84
摘要： Disclosed is a process for preparing substituted anisidines of formula I starting from substituted cyclic hydroxy-ketones II via aromatization through a substituted oxime intermediate IV in which R is C1-C6 alkyl or halogen, and Alk is C1-C6 alkyl. The substituted anisidines of formula I have been found to be useful as intermediates in the preparation of agents for the treatment of hepatitis C viral (HCV) infections.
摘要翻译：公开了通过芳族化通过其中R是C 1 -C 6烷基或卤素的取代的肟中间体IV和Alk是C 1 -C 6烷基的取代的环状羟基酮II制备取代的茴香胺的方法。已经发现式I的取代的茴香醚可用作制备用于治疗丙型肝炎病毒（HCV）感染的药剂的中间体。

4. 发明授权

US07179919B2 Stereoselective synthesis of certain trifluoromethyl-substituted alcohols 有权
标题翻译：某些三氟甲基取代的醇的立体选择性合成
公开(公告)号：US07179919B2
公开(公告)日：2007-02-20
申请号：US11070462
申请日：2005-03-02
申请人： Jinhua J. Song , Zhulin Tan , Nathan K. Yee , Chris Hugh Senanayake , Jinghua Xu , Fabrice Gallou
发明人： Jinhua J. Song , Zhulin Tan , Nathan K. Yee , Chris Hugh Senanayake , Jinghua Xu , Fabrice Gallou
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , C07B2200/07
摘要： A process for stereoselective synthesis of a compound of Formula (I) wherein R1, R2, R3, R4, and R5 are as described herein.
摘要翻译：用于立体选择性合成式（I）的化合物的方法，其中R 1，R 2，R 3，R 4， / SUP>和R 5 5如本文所述。

5. 发明授权

US07884246B2 Process for preparing substituted anisidines 有权
标题翻译：制备取代的茴香胺的方法
公开(公告)号：US07884246B2
公开(公告)日：2011-02-08
申请号：US12092454
申请日：2006-11-01
申请人： Fabrice Gallou , Heewon Lee , Chris Hugh Senanayake , Jinhua J. Song , Zhulin Tan , Jinghua Xu , Nathan K. Yee
发明人： Fabrice Gallou , Heewon Lee , Chris Hugh Senanayake , Jinhua J. Song , Zhulin Tan , Jinghua Xu , Nathan K. Yee
IPC分类号： C07C259/00
CPC分类号： C07C213/02 , C07C249/08 , C07C251/44 , C07C2601/16 , C07C217/84
摘要： Disclosed is a process for preparing substituted anisidines of formula I starting from substituted cyclic hydroxy-ketones II via aromatization through a substituted oxime intermediate IV in which R is C1-C6 alkyl or halogen, and Alk is C1-C6 alkyl. The substituted anisidines of formula I have been found to be useful as intermediates in the preparation of agents for the treatment of hepatitis C viral (HCV) infections.
摘要翻译：公开了通过芳族化通过其中R是C 1 -C 6烷基或卤素的取代的肟中间体IV和Alk是C 1 -C 6烷基的取代的环状羟基酮II制备取代的茴香胺的方法。已经发现式I的取代的茴香醚可用作制备用于治疗丙型肝炎病毒（HCV）感染的药剂的中间体。

6. 发明申请

US20070100142A1 Stereoselective Synthesis of Certain Trifluoromethyl-Substituted Alcohols 有权
标题翻译：某些三氟甲基取代醇的立体选择性合成
公开(公告)号：US20070100142A1
公开(公告)日：2007-05-03
申请号：US11537762
申请日：2006-10-02
申请人： Jinhua Song , Jonathan Reeves , Frank Roschangar , Zhulin Tan , Nathan Yee
发明人： Jinhua Song , Jonathan Reeves , Frank Roschangar , Zhulin Tan , Nathan Yee
IPC分类号： C07D487/02 , C07D471/02
CPC分类号： C07D471/04
摘要： A process for stereoselective synthesis of a compound of Formula (I) wherein R1, R2, R3, R4, and R5 are as described herein.
摘要翻译：用于立体选择性合成式（I）的化合物的方法，其中R 1，R 2，R 3，R 4， / SUP>和R 5 5如本文所述。

7. 发明授权

US07507843B2 Stereoselective synthesis of certain trifluoromethyl-substituted alcohols 有权
标题翻译：某些三氟甲基取代的醇的立体选择性合成
公开(公告)号：US07507843B2
公开(公告)日：2009-03-24
申请号：US10955165
申请日：2004-09-30
申请人： Jinhua J. Song , Zhulin Tan , Jinghua Xu , Nathan K. Yee , Chris H. Senanayake
发明人： Jinhua J. Song , Zhulin Tan , Jinghua Xu , Nathan K. Yee , Chris H. Senanayake
IPC分类号： C07D301/27
CPC分类号： C07D303/22
摘要： A process for stereoselective synthesis of compounds of Formula X wherein: R1 is an aryl or heteroaryl group, each optionally independently substituted with one to three substituent groups, wherein each substituent group of R1 is independently C1-C5 alkyl, C2-C5 alkenyl, C2-C5 alkynyl, C3-C8 cycloalkyl, heterocyclyl, aryl, heteroaryl, C1-C5 alkoxy, C2-C5 alkenyloxy, C2-C5 alkynyloxy, aryloxy, C1-C5 alkanoyloxy, C1-C5 alkanoyl, aroyl, trifluoromethyl, trifluoromethoxy, or C1-C5 alkylthio, wherein each substituent group of R1 is optionally independently substituted with one to three substituent groups selected from methyl, methoxy, fluoro, chloro, hydroxy, oxo, cyano, or amino; and R2 and R3 are each independently hydrogen or C1-C5 alkyl, or R2 and R3 together with the carbon atom they are commonly attached to form a C3-C8 spiro cycloalkyl ring.
摘要翻译：用于立体选择性合成式X化合物的方法，其中：R 1是芳基或杂芳基，各自任选地独立地被1至3个取代基取代，其中R 1的每个取代基独立地是C 1 -C 5烷基，C 2 -C 5烯基，C 2 -C 5炔基，C 3 -C 8环烷基，杂环基，芳基，杂芳基，C 1 -C 5烷氧基，C 2 -C 5烯氧基，C 2 -C 5炔氧基，芳氧基，C 1 -C 5烷酰氧基，C 1 -C 5烷酰基，芳酰基，三氟甲基，三氟甲氧基或C 1 -C 5烷硫基，其中R 1的每个取代基任选地被一至三个选自甲基，甲氧基，氟，氯，羟基，氧代，氰基或氨基的取代基独立地取代。并且R 2和R 3各自独立地为氢或C 1 -C 5烷基，或者R 2和R 3与它们通常连接的碳原子一起形成C 3 -C 8螺环烷基环。

8. 发明申请

US20110263844A1 METHOD FOR PREPARING MACROCYCLES 审中-公开
标题翻译：制备大分子的方法
公开(公告)号：US20110263844A1
公开(公告)日：2011-10-27
申请号：US12991238
申请日：2009-05-05
申请人： Chutian Shu , Chris Hugh Senanayake , Zhulin Tan , Nathan Yee , Xingzhong Zeng
发明人： Chutian Shu , Chris Hugh Senanayake , Zhulin Tan , Nathan Yee , Xingzhong Zeng
IPC分类号： C07D487/04 , C07D403/12
CPC分类号： C07K5/0804 , C07K1/107
摘要： The present invention is directed to a method for the preparation of macrocyclic compounds of formula (I), comprising the step of cyclizing a diene of formula (II), in the presence of a catalyst, wherein R1-R6, A, W and V are as defined herein. The present invention is also directed to intermediate compounds of formula II.
摘要翻译：本发明涉及一种制备式（I）的大环化合物的方法，包括在催化剂存在下使式（II）的二烯环化的步骤，其中R 1 -R 6，A，W和V 如本文所定义。本发明还涉及式II的中间体化合物。

9. 发明授权

US07879873B2 Azaindazole compounds as CCR1 receptor antagonists 有权
公开(公告)号：US07879873B2
公开(公告)日：2011-02-01
申请号：US12564129
申请日：2009-09-22
申请人： Brian Nicholas Cook , Darren DiSalvo , Daniel Robert Fandrick , Christian Harcken , Daniel Kuzmich , Thomas Wai-Ho Lee , Pingrong Liu , John Lord , Can Mao , Jochen Neu , Brian Christopher Raudenbush , Hossein Razavi , Jonathan Timothy Reeves , Jinhua J. Song , Alan David Swinamer , Zhulin Tan
发明人： Brian Nicholas Cook , Darren DiSalvo , Daniel Robert Fandrick , Christian Harcken , Daniel Kuzmich , Thomas Wai-Ho Lee , Pingrong Liu , John Lord , Can Mao , Jochen Neu , Brian Christopher Raudenbush , Hossein Razavi , Jonathan Timothy Reeves , Jinhua J. Song , Alan David Swinamer , Zhulin Tan
IPC分类号： A61K31/437 , C07D515/04
CPC分类号： C07D471/04
摘要： Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are methods of making and methods of using same.

10. 发明授权

US08648192B2 2-oxo-1,2-dihydropyridin-4-ylboronic acid derivatives 失效
标题翻译： 2-氧代-1,2-二氢吡啶-4-基硼酸衍生物
公开(公告)号：US08648192B2
公开(公告)日：2014-02-11
申请号：US13697862
申请日：2011-05-23
申请人： Zhulin Tan
发明人： Zhulin Tan
IPC分类号： C07F5/02
CPC分类号： C07F5/025 , C07D413/10
摘要： The present invention relates to a compound of formula (I) wherein R1, R2 and n are as defined herein. The invention also relates to processes for making the compounds of formula (I) and methods of using the compounds of formula (I) as reagents in organic synthesis.
摘要翻译：本发明涉及其中R 1，R 2和n如本文所定义的式（I）化合物。本发明还涉及制备式（I）化合物的方法和使用式（I）化合物作为有机合成中的试剂的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式