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1. 发明授权

US08486371B2 Quantitative two-photon flow cytometry 有权
标题翻译：定量双光子流式细胞术
公开(公告)号：US08486371B2
公开(公告)日：2013-07-16
申请号：US11662835
申请日：2005-09-16
申请人： Jing Yong Ye , Theodore B. Norris , Cheng Frank Zhong , James R. Baker
发明人： Jing Yong Ye , Theodore B. Norris , Cheng Frank Zhong , James R. Baker
IPC分类号： A61K49/00
CPC分类号： G01N15/1459 , G01N15/1404 , G01N15/1484 , G01N2015/1075 , G01N2015/145 , G01N2015/1472 , G01N2015/1493
摘要： A method and apparatus of multi-dye analysis of particles using flow cytometer. The method includes dying particles to be detected using two or more dyes; urging the particles through a capillary in a non-uniform flow; exciting a first of the particles within the capillary using a multiphoton excitation laser beam causing the two or more dyes each to fluoresce thereby producing a first output signal and a second output signal respectively; and detecting the first output signal and the second output signal. A second of the particles within the capillary being excited using the multiphoton excitation laser beam causing the two or more dyes each to fluoresce thereby producing a third output signal and a forth output signal respectively. The method finally includes comparing a ratio of the first output signal and the second output signal to a ratio of the third output signal and the forth output signal to detect a desired change in the particles.
摘要翻译：使用流式细胞仪对颗粒进行多染色分析的方法和装置。该方法包括使用两种或更多种染料染色待检测的颗粒; 以不均匀的流动促使颗粒通过毛细管; 使用多光子激发激光束激发毛细管内的第一颗粒，使得两种或更多种染料各自发荧光，从而分别产生第一输出信号和第二输出信号; 以及检测第一输出信号和第二输出信号。使用多光子激发激光束激发毛细管内的第二颗粒，使得两种或更多种染料各自发出荧光，从而分别产生第三输出信号和第四输出信号。该方法最后包括将第一输出信号和第二输出信号的比率与第三输出信号和第四输出信号的比率进行比较，以检测颗粒中期望的变化。

2. 发明授权

US07474919B2 Laser-based method and system for enhancing optical breakdown 有权
标题翻译：用于增强光学击穿的基于激光的方法和系统
公开(公告)号：US07474919B2
公开(公告)日：2009-01-06
申请号：US10637343
申请日：2003-08-08
申请人： Jing Yong Ye , Theodore B. Norris , James R. Baker, Jr. , Lajos P. Balogh
发明人： Jing Yong Ye , Theodore B. Norris , James R. Baker, Jr. , Lajos P. Balogh
IPC分类号： A61N1/30
CPC分类号： B82Y15/00 , A61B5/0095 , A61B8/481 , G01N21/718 , G01N29/2418 , G01N2291/02433 , G01N2291/02475 , G01N2291/02491
摘要： An additive, preferably in the form of metal nanoparticles or nanodomains, greatly improves a laser-based method and system for inducing optical breakdown. The use of ultrashort laser pulses to induce laser-induced breakdown (LIB) in metal nanoparticles or nanocomposites makes it possible to reduce significantly the threshold laser energy required for LIB. Such nanoscale (submicron) metallic particles allows one to control the LIB process. The nanoparticles can be synthesized so as to target specific biological structures or tissues (dendrimer nanoparticles are one system for which this has been demonstrated). This opens up the possibility of performing LIB for targeted cancer treatment or microsurgery.
摘要翻译：优选以金属纳米颗粒或纳米域的形式的添加剂大大改进了用于诱导光学击穿的基于激光的方法和系统。使用超短激光脉冲来诱导金属纳米颗粒或纳米复合材料中的激光诱发击穿（LIB）使得可以显着降低LIB所需的阈值激光能量。这种纳米尺度（亚微米）金属颗粒允许控制LIB工艺。可以合成纳米颗粒以靶向特定的生物结构或组织（树状聚合物纳米颗粒是已经证明其的一个体系）。这开辟了进行靶向癌症治疗或显微手术的LIB的可能性。

3. 发明授权

US07277169B2 Whole spectrum fluorescence detection with ultrafast white light excitation 有权
标题翻译：全光谱荧光检测与超快白光激发
公开(公告)号：US07277169B2
公开(公告)日：2007-10-02
申请号：US11355387
申请日：2006-02-16
申请人： Jing Yong Ye , Theodore B. Norris , James R. Baker, Jr.
发明人： Jing Yong Ye , Theodore B. Norris , James R. Baker, Jr.
IPC分类号： G01N21/64
CPC分类号： G01J3/4406 , G01J3/10 , G01J3/2889 , G01N21/6408 , G01N21/6458
摘要： A fluorescence detection system for testing a sample having at least one fluorophore. The fluorescence detection system comprises a white light generation system outputting a white light pulse. The white light pulse has a first frequency range and a first time duration. The white light pulse excites the at least one fluorophore of the sample to emit a fluorescence. The fluorescence has a second frequency range and a second time duration, wherein the first time duration is less than the second time duration. A time-resolving detector receives the fluorescence and at least a portion of the white light pulse and separates the fluorescence from the portion of the white light pulse.
摘要翻译：一种用于测试具有至少一个荧光团的样品的荧光检测系统。荧光检测系统包括输出白光脉冲的白光发生系统。白光脉冲具有第一频率范围和第一持续时间。白光脉冲激发样品的至少一个荧光团以发射荧光。荧光具有第二频率范围和第二持续时间，其中第一持续时间小于第二持续时间。时间分辨检测器接收荧光和白光脉冲的至少一部分，并将荧光与白光脉冲的该部分分离。

4. 发明授权

US07639362B2 Photonic crystal sensor 失效
标题翻译：光子晶体传感器
公开(公告)号：US07639362B2
公开(公告)日：2009-12-29
申请号：US11881040
申请日：2007-07-25
申请人： Jing Yong Ye , Yunbo Guo , Theodore B. Norris , James R. Baker, Jr.
发明人： Jing Yong Ye , Yunbo Guo , Theodore B. Norris , James R. Baker, Jr.
IPC分类号： G01N21/55
CPC分类号： G01N21/648 , B82Y20/00 , G01N21/6408 , G01N21/7743 , G02B1/005
摘要： A photonic crystal sensor for outputting an output signal using a light source. The photonic crystal sensor includes a photonic crystal structure and a defect member disposed adjacent the photonic crystal structure. The defect member defines an operative surface. An input light signal from the light source is inputted to the photonic crystal structure and defect member and is internally reflected to thereby output the output signal. Also, the output signal relates to a condition at the operative surface.
摘要翻译：一种用于使用光源输出输出信号的光子晶体传感器。光子晶体传感器包括光子晶体结构和邻近光子晶体结构设置的缺陷部件。缺陷构件限定了操作表面。来自光源的输入光信号被输入到光子晶体结构和缺陷部件，并被内反射，从而输出输出信号。另外，输出信号与操作面的状态有关。

5. 发明申请

US20080292555A1 Quantitative Two-Photon Flow Cytometry 有权
标题翻译：定量双光子流式细胞术
公开(公告)号：US20080292555A1
公开(公告)日：2008-11-27
申请号：US11662835
申请日：2005-09-16
申请人： Jing Yong Ye , Theodore B. Norris , Cheng F. Zhong , James R. Baker
发明人： Jing Yong Ye , Theodore B. Norris , Cheng F. Zhong , James R. Baker
IPC分类号： A61K49/00 , C12Q1/02 , A61B5/00
CPC分类号： G01N15/1459 , G01N15/1404 , G01N15/1484 , G01N2015/1075 , G01N2015/145 , G01N2015/1472 , G01N2015/1493
摘要： A method and apparatus of multi-dye analysis of particles using flow cytometer. The method includes dying particles to be detected using two or more dyes; urging the particles through a capillary in a non-uniform flow; exciting a first of the particles within the capillary using a multiphoton excitation laser beam causing the two or more dyes each to fluoresce thereby producing a first output signal and a second output signal respectively; and detecting the first output signal and the second output signal. A second of the particles within the capillary being excited using the multiphoton excitation laser beam causing the two or more dyes each to fluoresce thereby producing a third output signal and a forth output signal respectively. The method finally includes comparing a ratio of the first output signal and the second output signal to a ratio of the third output signal and the forth output signal to detect a desired change in the particles.
摘要翻译：使用流式细胞仪对颗粒进行多染色分析的方法和装置。该方法包括使用两种或更多种染料染色待检测的颗粒; 以不均匀的流动促使颗粒通过毛细管; 使用多光子激发激光束激发毛细管内的第一颗粒，使得两种或更多种染料各自发荧光，从而分别产生第一输出信号和第二输出信号; 以及检测第一输出信号和第二输出信号。使用多光子激发激光束激发毛细管内的第二颗粒，使得两种或更多种染料各自发出荧光，从而分别产生第三输出信号和第四输出信号。该方法最后包括将第一输出信号和第二输出信号的比率与第三输出信号和第四输出信号的比率进行比较，以检测颗粒中期望的变化。

6. 发明授权

US07367948B2 Acoustic monitoring method and system in laser-induced optical breakdown (LIOB) 有权
标题翻译：激光诱导光学击穿中的声学监测方法和系统（LIOB）
公开(公告)号：US07367948B2
公开(公告)日：2008-05-06
申请号：US10643659
申请日：2003-08-19
申请人： Matthew O'Donnell , Jing Yong Ye , Theodore B. Norris , James R. Baker, Jr. , Lajos P. Balogh , Susanne M. Milas , Stanislav Y. Emelianov , Kyle W. Hollman
发明人： Matthew O'Donnell , Jing Yong Ye , Theodore B. Norris , James R. Baker, Jr. , Lajos P. Balogh , Susanne M. Milas , Stanislav Y. Emelianov , Kyle W. Hollman
IPC分类号： A61B8/00 , A61B8/12 , A61B8/14 , A61B6/00 , A61H1/00
CPC分类号： B82Y15/00 , A61B5/0095 , A61B8/481 , G01N21/1702 , G01N21/718 , G01N29/2418 , G01N2291/02433 , G01N2291/02475 , G01N2291/02491 , G01N2291/02827
摘要： An acoustic monitoring method and system in laser-induced optical breakdown (LIOB) provides information which characterize material which is broken down, microbubbles in the material, and/or the microenvironment of the microbubbles. In one embodiment of the invention, femtosecond laser pulses are focused just inside the surface of a volume of aqueous solution which may include dendrimer nanocomposite (DNC) particles. A tightly focused, high frequency, single-element ultrasonic transducer is positioned such that its focus coincides axially and laterally with this laser focus. When optical breakdown occurs, a microbubble forms and a shock or pressure wave is emitted (i.e., acoustic emission). In addition to this acoustic signal, the microbubble may be actively probed with pulse-echo measurements from the same transducer. After the microbubble forms, received pulse-echo signals have an extra pulse, describing the microbubble location and providing a measure of axial microbubble size. Wavefield plots of successive recordings illustrate the generation, growth, and collapse of microbubbles due to optical breakdown. These same plots can also be used to quantify LIOB thresholds.
摘要翻译：激光诱导光学击穿（LIOB）中的声学监测方法和系统提供表征材料中的材料，材料中的微泡和/或微泡的微环境的信息。在本发明的一个实施例中，飞秒激光脉冲恰好聚集在一定体积的水溶液的表面内，该溶液可包括树枝状聚合物纳米复合物（DNC）颗粒。紧密聚焦的高频单元超声波换能器被定位成使得其焦点与该激光焦点轴向和横向重合。当发生光学击穿时，形成微泡并发射冲击或压力波（即声发射）。除了这种声学信号之外，微泡可以通过来自相同换能器的脉冲回波测量来主动探测。在形成微泡后，接收的脉冲回波信号具有额外的脉冲，描述微泡位置并提供轴向微泡尺寸的量度。连续记录的波场图说明了由于光学破坏引起的微泡的产生，生长和崩溃。这些相同的图也可以用于量化LIOB阈值。

7. 发明申请

US20080225293A1 Photonic crystal sensor 失效
标题翻译：光子晶体传感器
公开(公告)号：US20080225293A1
公开(公告)日：2008-09-18
申请号：US11881040
申请日：2007-07-25
申请人： Jing Yong Ye , Yunbo Guo , Theodore B. Norris , James R. Baker
发明人： Jing Yong Ye , Yunbo Guo , Theodore B. Norris , James R. Baker
IPC分类号： G01J4/00 , G01N21/41
CPC分类号： G01N21/648 , B82Y20/00 , G01N21/6408 , G01N21/7743 , G02B1/005
摘要： A photonic crystal sensor for outputting an output signal using a light source. The photonic crystal sensor includes a photonic crystal structure and a defect member disposed adjacent the photonic crystal structure. The defect member defines an operative surface. An input light signal from the light source is inputted to the photonic crystal structure and defect member and is internally reflected to thereby output the output signal. Also, the output signal relates to a condition at the operative surface.
摘要翻译：一种用于使用光源输出输出信号的光子晶体传感器。光子晶体传感器包括光子晶体结构和邻近光子晶体结构设置的缺陷部件。缺陷构件限定了操作表面。来自光源的输入光信号被输入到光子晶体结构和缺陷部件，并被内反射，从而输出输出信号。另外，输出信号与操作面的状态有关。

8. 发明授权

US07362500B2 Double-clad fiber scanning microscope 有权
标题翻译：双包层光纤扫描显微镜
公开(公告)号：US07362500B2
公开(公告)日：2008-04-22
申请号：US10556620
申请日：2004-05-28
申请人： Jing Yong Ye , Theodore B. Norris
发明人： Jing Yong Ye , Theodore B. Norris
IPC分类号： G02B21/00 , G02B21/06
CPC分类号： G02B6/02366 , G01N21/6458 , G01N2021/6484 , G01N2021/656 , G02B6/02042 , G02B6/02342 , G02B6/03622 , G02B6/04 , G02B6/32 , G02B21/0024 , G02B21/0076
摘要： A scanning microscope having a laser outputting an excitation laser beam and a fiber member having a first core and a second core. The second core is generally disposed within the first core and is operable to receive the excitation laser beam from the laser and transmit the excitation laser beam to a sample to be tested. A moveable stage supports an end of the fiber member and/or a sample to be tested and is operable to move the end of the fiber member and the sample to be tested relative to each other.
摘要翻译：一种具有输出激发激光束的激光和具有第一芯和第二芯的光纤部件的扫描显微镜。第二芯通常设置在第一芯内，并且可操作以从激光器接收激发激光束并将激发激光束传输到待测样品。可移动台支撑纤维构件和/或待测试样品的端部并且可操作以相对于彼此移动待测试的纤维构件和样品的端部。

9. 发明授权

US07236673B2 Enhancing fiber-optic sensing technique using a dual-core fiber 失效
标题翻译：使用双芯光纤增强光纤传感技术
公开(公告)号：US07236673B2
公开(公告)日：2007-06-26
申请号：US11372425
申请日：2006-03-09
申请人： Jing Yong Ye , Theodore Norris , James R. Baker, Jr. , Thomas Thommey , Mon Myaing
发明人： Jing Yong Ye , Theodore Norris , James R. Baker, Jr. , Thomas Thommey , Mon Myaing
IPC分类号： G02B6/02
CPC分类号： G02B6/02366 , G01N21/645 , G01N2021/6439 , G01N2021/6484 , G01N2201/0697 , G02B6/02042 , G02B6/02047 , G02B6/02357 , G02B6/02371
摘要： An optical fiber for use in fiber optic sensing of a test sample includes a first core and a second core. The second core is generally coaxially disposed within the first core and is sized smaller than the first core. The second core is capable of delivering pulsed laser energy from the laser for nonlinear optical excitation of the test sample. Nonlinear optical feedback signals can then be collected in both the first core and second core for improved detection efficiency relative to conventional single-mode and multi-mode fibers.
摘要翻译：用于测试样品的光纤感测的光纤包括第一芯和第二芯。第二芯体通常同轴地设置在第一芯体内并且其尺寸小于第一芯体。第二个核能够从激光器提供脉冲激光能量用于测试样品的非线性光学激发。然后可以将非线性光学反馈信号收集在第一芯和第二芯中，以提高相对于常规单模和多模光纤的检测效率。

10. 发明授权

US07046888B2 Enhancing fiber-optic sensing technique using a dual-core fiber 有权
公开(公告)号：US07046888B2
公开(公告)日：2006-05-16
申请号：US10738828
申请日：2003-12-17
申请人： Jing Yong Ye , Theodore Norris , James R. Baker, Jr. , Thomas Thommey , Mon Myaing
发明人： Jing Yong Ye , Theodore Norris , James R. Baker, Jr. , Thomas Thommey , Mon Myaing
IPC分类号： G02B6/02
CPC分类号： G02B6/02366 , G01N21/645 , G01N2021/6439 , G01N2021/6484 , G01N2201/0697 , G02B6/02042 , G02B6/02047 , G02B6/02357 , G02B6/02371
摘要： An optical fiber for use in fiber optic sensing of a test sample includes a first core and a second core. The second core is generally coaxially disposed within the first core and is sized smaller than the first core. The second core is capable of delivering pulsed laser energy from the laser for nonlinear optical excitation of the test sample. Nonlinear optical feedback signals can then be collected in both the first core and second core for improved detection efficiency relative to conventional single-mode and multi-mode fibers.

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